LOCUS       NM_001083913            4129 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens WW domain binding protein 1 like (WBP1L), transcript
            variant 1, mRNA.
ACCESSION   NM_001083913
VERSION     NM_001083913.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4129)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 4129)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 4129)
  AUTHORS   Guan,F., Ni,T., Han,W., Lin,H., Zhang,B., Chen,G., Zhu,L., Liu,D.
            and Zhang,T.
  TITLE     Evaluation of the relationships of the WBP1L gene with
            schizophrenia and the general psychopathology scale based on a
            case-control study
  JOURNAL   Am J Med Genet B Neuropsychiatr Genet 183 (3), 164-171 (2020)
   PUBMED   31840934
  REMARK    GeneRIF: Evaluation of the relationships of the WBP1L gene with
            schizophrenia and the general psychopathology scale based on a
            case-control study.
REFERENCE   4  (bases 1 to 4129)
  AUTHORS   Zhang,H., Mo,X., Zhou,Z., Zhu,Z., HuangFu,X., Guo,Z. and Zhang,Y.
  TITLE     Detection of Putative Functional Single Nucleotide Polymorphisms in
            Blood Pressure Loci and Validation of Association Between Single
            Nucleotide Polymorphism in WBP1L and Hypertension in the Chinese
            Han Population
  JOURNAL   J Cardiovasc Pharmacol 73 (1), 48-55 (2019)
   PUBMED   30422892
  REMARK    GeneRIF: WBP1L SNP rs176185 may be associated with hypertension in
            the Chinese Han population.
REFERENCE   5  (bases 1 to 4129)
  CONSRTM   Schizophrenia Working Group of the Psychiatric Genomics Consortium
  TITLE     Biological insights from 108 schizophrenia-associated genetic loci
  JOURNAL   Nature 511 (7510), 421-427 (2014)
   PUBMED   25056061
REFERENCE   6  (bases 1 to 4129)
  AUTHORS   Holleman,A., den Boer,M.L., Cheok,M.H., Kazemier,K.M., Pei,D.,
            Downing,J.R., Janka-Schaub,G.E., Gobel,U., Graubner,U.B., Pui,C.H.,
            Evans,W.E. and Pieters,R.
  TITLE     Expression of the outcome predictor in acute leukemia 1 (OPAL1)
            gene is not an independent prognostic factor in patients treated
            according to COALL or St Jude protocols
  JOURNAL   Blood 108 (6), 1984-1990 (2006)
   PUBMED   16709928
  REMARK    GeneRIF: OPAL1 expression may not be an independent prognostic
            feature in childhood ALL, and its previously reported prognostic
            impact appears to be treatment dependent.
REFERENCE   7  (bases 1 to 4129)
  AUTHORS   Wang,A.G., Yoon,S.Y., Oh,J.H., Jeon,Y.J., Kim,M., Kim,J.M.,
            Byun,S.S., Yang,J.O., Kim,J.H., Kim,D.G., Yeom,Y.I., Yoo,H.S.,
            Kim,Y.S. and Kim,N.S.
  TITLE     Identification of intrahepatic cholangiocarcinoma related genes by
            comparison with normal liver tissues using expressed sequence tags
  JOURNAL   Biochem Biophys Res Commun 345 (3), 1022-1032 (2006)
   PUBMED   16712791
REFERENCE   8  (bases 1 to 4129)
  AUTHORS   Grupe,A., Li,Y., Rowland,C., Nowotny,P., Hinrichs,A.L., Smemo,S.,
            Kauwe,J.S., Maxwell,T.J., Cherny,S., Doil,L., Tacey,K., van
            Luchene,R., Myers,A., Wavrant-De Vrieze,F., Kaleem,M.,
            Hollingworth,P., Jehu,L., Foy,C., Archer,N., Hamilton,G.,
            Holmans,P., Morris,C.M., Catanese,J., Sninsky,J., White,T.J.,
            Powell,J., Hardy,J., O'Donovan,M., Lovestone,S., Jones,L.,
            Morris,J.C., Thal,L., Owen,M., Williams,J. and Goate,A.
  TITLE     A scan of chromosome 10 identifies a novel locus showing strong
            association with late-onset Alzheimer disease
  JOURNAL   Am J Hum Genet 78 (1), 78-88 (2006)
   PUBMED   16385451
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   9  (bases 1 to 4129)
  AUTHORS   Deloukas,P., Earthrowl,M.E., Grafham,D.V., Rubenfield,M.,
            French,L., Steward,C.A., Sims,S.K., Jones,M.C., Searle,S.,
            Scott,C., Howe,K., Hunt,S.E., Andrews,T.D., Gilbert,J.G.,
            Swarbreck,D., Ashurst,J.L., Taylor,A., Battles,J., Bird,C.P.,
            Ainscough,R., Almeida,J.P., Ashwell,R.I., Ambrose,K.D.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Bates,K.,
            Beasley,H., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.C.,
            Burrill,W., Burton,J., Cahill,P., Camire,D., Carter,N.P.,
            Chapman,J.C., Clark,S.Y., Clarke,G., Clee,C.M., Clegg,S., Corby,N.,
            Coulson,A., Dhami,P., Dutta,I., Dunn,M., Faulkner,L., Frankish,A.,
            Frankland,J.A., Garner,P., Garnett,J., Gribble,S., Griffiths,C.,
            Grocock,R., Gustafson,E., Hammond,S., Harley,J.L., Hart,E.,
            Heath,P.D., Ho,T.P., Hopkins,B., Horne,J., Howden,P.J., Huckle,E.,
            Hynds,C., Johnson,C., Johnson,D., Kana,A., Kay,M., Kimberley,A.M.,
            Kershaw,J.K., Kokkinaki,M., Laird,G.K., Lawlor,S., Lee,H.M.,
            Leongamornlert,D.A., Laird,G., Lloyd,C., Lloyd,D.M., Loveland,J.,
            Lovell,J., McLaren,S., McLay,K.E., McMurray,A.,
            Mashreghi-Mohammadi,M., Matthews,L., Milne,S., Nickerson,T.,
            Nguyen,M., Overton-Larty,E., Palmer,S.A., Pearce,A.V., Peck,A.I.,
            Pelan,S., Phillimore,B., Porter,K., Rice,C.M., Rogosin,A.,
            Ross,M.T., Sarafidou,T., Sehra,H.K., Shownkeen,R., Skuce,C.D.,
            Smith,M., Standring,L., Sycamore,N., Tester,J., Thorpe,A.,
            Torcasso,W., Tracey,A., Tromans,A., Tsolas,J., Wall,M., Walsh,J.,
            Wang,H., Weinstock,K., West,A.P., Willey,D.L., Whitehead,S.L.,
            Wilming,L., Wray,P.W., Young,L., Chen,Y., Lovering,R.C.,
            Moschonas,N.K., Siebert,R., Fechtel,K., Bentley,D., Durbin,R.,
            Hubbard,T., Doucette-Stamm,L., Beck,S., Smith,D.R. and Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 10
  JOURNAL   Nature 429 (6990), 375-381 (2004)
   PUBMED   15164054
REFERENCE   10 (bases 1 to 4129)
  AUTHORS   Ohira,M., Morohashi,A., Inuzuka,H., Shishikura,T., Kawamoto,T.,
            Kageyama,H., Nakamura,Y., Isogai,E., Takayasu,H., Sakiyama,S.,
            Suzuki,Y., Sugano,S., Goto,T., Sato,S. and Nakagawara,A.
  TITLE     Expression profiling and characterization of 4200 genes cloned from
            primary neuroblastomas: identification of 305 genes differentially
            expressed between favorable and unfavorable subsets
  JOURNAL   Oncogene 22 (35), 5525-5536 (2003)
   PUBMED   12934113
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL391121.29, CX163170.1, AL358790.22 and AY656171.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001083913.1.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163657.62749.1,
                                           SRR1803616.34236.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000448841.7/ ENSP00000414721.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-22                AL391121.29        153298-153319
            23-144              AL391121.29        153320-153441
            145-876             CX163170.1         69-800
            877-3529            AL358790.22        40060-42712
            3530-4129           AY656171.1         3507-4106
FEATURES             Location/Qualifiers
     source          1..4129
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q24.32"
     gene            1..4129
                     /gene="WBP1L"
                     /gene_synonym="C10orf26; OPA1L; OPAL1"
                     /note="WW domain binding protein 1 like"
                     /db_xref="GeneID:54838"
                     /db_xref="HGNC:HGNC:23510"
                     /db_xref="MIM:611129"
     exon            1..196
                     /gene="WBP1L"
                     /gene_synonym="C10orf26; OPA1L; OPAL1"
                     /inference="alignment:Splign:2.1.0"
     CDS             107..1198
                     /gene="WBP1L"
                     /gene_synonym="C10orf26; OPA1L; OPAL1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; outcome predictor in acute leukemia 1"
                     /codon_start=1
                     /product="WW domain binding protein 1-like isoform 1
                     precursor"
                     /protein_id="NP_001077382.1"
                     /db_xref="CCDS:CCDS44473.1"
                     /db_xref="GeneID:54838"
                     /db_xref="HGNC:HGNC:23510"
                     /db_xref="MIM:611129"
                     /translation="MERRRLLGGMALLLLQALPSPLSARAEPPQDKEACVGTNNQSYI
                     CDTGHCCGQSQCCNYYYELWWFWLVWTIIIILSCCCVCHHRRAKHRLQAQQRQHEINL
                     IAYREAHNYSALPFYFRFLPNYLLPPYEEVVNRPPTPPPPYSAFQLQQQQLLPPQCGP
                     AGGSPPGIDPTRGSQGAQSSPLSEPSRSSTRPPSIADPDPSDLPVDRAATKAPGMEPS
                     GSVAGLGELDPGAFLDKDAECREELLKDDSSEHGAPDSKEKTPGRHRRFTGDSGIEVC
                     VCNRGHHDDDLKEFNTLIDDALDGPLDFCDSCHVRPPGDEEEGLCQSSEEQAREPGHP
                     HLPRPPACLLLNTINEQDSPNSQSSSSPS"
     exon            197..299
                     /gene="WBP1L"
                     /gene_synonym="C10orf26; OPA1L; OPAL1"
                     /inference="alignment:Splign:2.1.0"
     exon            300..461
                     /gene="WBP1L"
                     /gene_synonym="C10orf26; OPA1L; OPAL1"
                     /inference="alignment:Splign:2.1.0"
     exon            462..4129
                     /gene="WBP1L"
                     /gene_synonym="C10orf26; OPA1L; OPAL1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4109..4114
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WBP1L"
                     /gene_synonym="C10orf26; OPA1L; OPAL1"
                     /note="hexamer: AATAAA"
     polyA_site      4129
                     /gene="WBP1L"
                     /gene_synonym="C10orf26; OPA1L; OPAL1"
                     /note="major polyA site"
ORIGIN      
        1 gtcaaacagg aaaagaaggg aagaaggaag aagagggtag aggaggagag ggaggaggag
       61 gagggaggtg gcggcgccgt ggcggaggag caggagcagg agggggatgg agaggagaag
      121 gctcctgggt ggcatggcgc tcctgctcct ccaggcgctg cccagcccct tgtcagccag
      181 ggctgaaccc ccgcaggata aggaagcctg tgtgggtacc aacaatcaaa gctacatctg
      241 tgacacagga cactgctgtg gacagtctca gtgctgcaac tactactatg aactctggtg
      301 gttctggctg gtgtggacca tcatcatcat cctgagctgc tgctgtgttt gccaccaccg
      361 ccgagccaag caccgccttc aggcccagca gcggcaacat gaaatcaacc tgatcgctta
      421 ccgagaagcc cacaattact cagcgctgcc attttatttc aggtttttgc caaactattt
      481 actacctcct tatgaggaag tggtgaaccg acctccaact cctcccccac catacagtgc
      541 cttccagcta cagcagcagc agctgctgcc tccacagtgt ggccctgcag gtggcagtcc
      601 cccgggcatc gatcccacca ggggatccca gggggcacag agcagcccct tgtctgagcc
      661 cagcagaagc agcacaagac ccccaagcat cgctgaccct gatccctctg acctaccagt
      721 tgaccgagca gccaccaaag ccccagggat ggagcccagt ggctctgtgg ctggcctggg
      781 ggagctggac ccgggggcct tcctggacaa agatgcagaa tgtagggagg agctgctgaa
      841 agatgacagc tctgaacacg gcgcacccga cagcaaagag aagacgcctg ggagacatcg
      901 ccgcttcaca ggtgactcgg gcattgaagt gtgtgtgtgc aaccggggcc accatgacga
      961 tgacctcaaa gagttcaaca cactcatcga tgatgctctg gatgggcccc tggacttctg
     1021 cgacagctgc catgtgcggc cccctggtga tgaggaggaa ggcctctgtc agtcctctga
     1081 ggagcaggct cgagagcctg ggcacccgca cctgccacgg ccgcccgcat gcctgctgct
     1141 gaacaccatc aacgagcagg actctcccaa ctcccagagc agcagctccc ccagctagag
     1201 caggtcctgc cagcacccag caacttggca aagcaaccag ggtaggggag aaccacgaga
     1261 gaagcattaa gtgactttca aagactttca gagtacagcc acttggttcc tttttgtttg
     1321 ttttccttct cctctcctgc attttcctcc atctccaggt acagttcggg gtgtggatgc
     1381 ctcttcctcc acaagggcac agtgttgtgg agggctaagt tggttctgtg actcattcct
     1441 cataccctaa ctccatctcc tttctttaaa gtcaaatctc acctacctgt ttgggtcaga
     1501 gagatgtgtt ttaaaagccc ccaaggaagg aggctgggac tgtgccctga catgattctt
     1561 ggtgatggaa taggtttgtg ctctgattct agtttaagag aacgttgctg tatctcagtc
     1621 caggagaggc agcccatctt ggccctggat gaagaaggaa acccacagag gcccagggct
     1681 tgtcattggg ctgccagtgt ctgccaagcc agcattgagc taatcctgtg ggaggatgag
     1741 agctactggg ccgttgtatg ataggttggt aggggcttgt tgatctgtca aattccaggt
     1801 gacaagatct atgcacccca tgcgtccttg aggggcctct tccccgcagg ctctggctgg
     1861 ccgcaggctg gttctggtgt gaaaggttat actgcctttt ctttgtttgt ttgttttttt
     1921 ctctaaaaac aaacagcaaa agacagctga aaacaagaac ttcaccggtg ggcaggcaag
     1981 aattctcttc tggaaaatga cgtttgtggc tctttcccaa gttggccttc aaagagcctg
     2041 cctgctgttg agccagaaga tgtctcgtgt gaaggctggg gtggcggctg tcttggaacc
     2101 tctgtgagca ggaggcccta agccgcagca gtggatagag gtgcagctct ctgcctctct
     2161 gccctttggt ctgtgttcac aggtgacccg tgtcagcctg catcgcaagc acacaccctg
     2221 cgggccttca agtctcactg ttccgtatga ggaaacagac agcggactga ggaagcgatg
     2281 gccccagaga aagggcccct gtagcctggc tctcacacag tattttatct ttgattctga
     2341 ataaatattt tttgtggggt tttttttttt tttttggtgg cagttgtttg ttttaaactg
     2401 accacttgga agaaacacct tggttatctg tggttttcat gccttgtccc tgcctctacc
     2461 cccacccctt ttgagtcggg tgactcattt ttctgtgtag agactcggtg gcccaggcag
     2521 gaggtgaaag cagccatccg gaaggccctg gggacccttg tgcctgttgc tcgccttcag
     2581 gtcaccagct gagctgcgat aggaaaatct gaatggaggc agcaaacagc caaaacaaac
     2641 attccccacc cggccctgtg catatgaagt ctttcttccc ccaactcttg aacgatgatg
     2701 atattcagac gaagcattga tgttatggaa gaaagaaaga aacaaacaaa atatatatat
     2761 atatgtccaa aaacagacaa atccaagggt gtgaggtaaa cgagtgtctg catttagatt
     2821 ccacaaaacc aaaatccatg ttgaacaaag ttaagtccgt acacagtgac tttttgggtg
     2881 agccgtgtgt gtctgtctgt tgtgtgtgtg cctcaagccc tgttttcctg tgaagatact
     2941 ttgagtggca gccattctct ccacgtgaac cacacgtctg gagcacagac aggcctctca
     3001 aggtcattga tcttacgcat ttactgttta ccgaacaaat gtctgactgt gtactcgggt
     3061 gtactccgca gcattgtcga ctgcagtccc ctgtgtttgc cagagatact gtgctcgaag
     3121 tagaggtttt actctactca tcactgcgat ttgcacattg ctccgtggac actcggaggc
     3181 ctgcgttctg ttccctataa atggaagcgt gctctgagcc tgtctgcctc cctcggctgc
     3241 tgctggtcct cagtaccagc gcccgggggt gtccacaacc acttgggaca gaagaaggtg
     3301 gaatttcaga cagaagcttg actgggtctt caatgacagg cttggactag ctgtggccca
     3361 gacatcggcc ctgcccagaa ttgccaggag gaggctttgc aggctctaga ggagccgcag
     3421 ggcctgcctg cctctggtga gtccaacagg cacaagcaag ctggcgtgtg gccagaggta
     3481 gccggagtgt gtcacagccc ctcagatgcc tttccttcca ccttttttta ttttttaaga
     3541 atcccaaata actcactgaa gtgtctcaaa ggcgaacaag ttttaccaaa atgaatcctt
     3601 tttcagttaa cagatcaaat ggatgagttc tgagcctctc aagttccttt ccccagttag
     3661 agtggggaac tgggcaagtg ttaactgtgg gactcactgc agcgtcctat cctaaaggca
     3721 cgagaagacg gaaatgcaac ctgcggagct gggcttggtt cccaggtcac agtttggccc
     3781 ccgctacagg atgctgccct gctcagagag agatttaata gggagctgaa ggaatcgtta
     3841 gggggccagg gagatgtgac tgaggctggc tttccacgtg aatgagacgg ggtcggtgga
     3901 gggtttggtg ctacagccag tcagaagatt tgcaaatgcg aacacattcc tgtgtgaggc
     3961 acgttaccct ttgtcagtta ttgtgaatat gtgtatttta agcaataaga ttcagctggt
     4021 cagacttttc tgggcagtct cagtgacgca tttcctgtgc tgtgattgtt ctgaagacag
     4081 agtggctcta accactgtga gaagcccaaa taaaaattga tcccaaaaa
//
