LOCUS       NM_016312               4581 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens WW domain binding protein 11 (WBP11), mRNA.
ACCESSION   NM_016312
VERSION     NM_016312.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4581)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 4581)
  AUTHORS   Martin,E.M.M.A., Enriquez,A., Sparrow,D.B., Humphreys,D.T.,
            McInerney-Leo,A.M., Leo,P.J., Duncan,E.L., Iyer,K.R., Greasby,J.A.,
            Ip,E., Giannoulatou,E., Sheng,D., Wohler,E., Dimartino,C.,
            Amiel,J., Capri,Y., Lehalle,D., Mory,A., Wilnai,Y., Lebenthal,Y.,
            Gharavi,A.G., Krzemien,G.G., Miklaszewska,M., Steiner,R.D.,
            Raggio,C., Blank,R., Baris Feldman,H., Milo Rasouly,H.,
            Sobreira,N.L.M., Jobling,R., Gordon,C.T., Giampietro,P.F.,
            Dunwoodie,S.L. and Chapman,G.
  TITLE     Heterozygous loss of WBP11 function causes multiple congenital
            defects in humans and mice
  JOURNAL   Hum Mol Genet 29 (22), 3662-3678 (2020)
   PUBMED   33276377
  REMARK    GeneRIF: Heterozygous loss of WBP11 function causes multiple
            congenital defects in humans and mice.
REFERENCE   3  (bases 1 to 4581)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 4581)
  AUTHORS   Henning,L.M., Santos,K.F., Sticht,J., Jehle,S., Lee,C.T.,
            Wittwer,M., Urlaub,H., Stelzl,U., Wahl,M.C. and Freund,C.
  TITLE     A new role for FBP21 as regulator of Brr2 helicase activity
  JOURNAL   Nucleic Acids Res 45 (13), 7922-7937 (2017)
   PUBMED   28838205
REFERENCE   5  (bases 1 to 4581)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   6  (bases 1 to 4581)
  AUTHORS   Andersen,J.S., Lam,Y.W., Leung,A.K., Ong,S.E., Lyon,C.E.,
            Lamond,A.I. and Mann,M.
  TITLE     Nucleolar proteome dynamics
  JOURNAL   Nature 433 (7021), 77-83 (2005)
   PUBMED   15635413
REFERENCE   7  (bases 1 to 4581)
  AUTHORS   Llorian,M., Beullens,M., Andres,I., Ortiz,J.M. and Bollen,M.
  TITLE     SIPP1, a novel pre-mRNA splicing factor and interactor of protein
            phosphatase-1
  JOURNAL   Biochem J 378 (Pt 1), 229-238 (2004)
   PUBMED   14640981
REFERENCE   8  (bases 1 to 4581)
  AUTHORS   Craggs,G., Finan,P.M., Lawson,D., Wingfield,J., Perera,T.,
            Gadher,S., Totty,N.F. and Kellie,S.
  TITLE     A nuclear SH3 domain-binding protein that colocalizes with mRNA
            splicing factors and intermediate filament-containing perinuclear
            networks
  JOURNAL   J Biol Chem 276 (32), 30552-30560 (2001)
   PUBMED   11375989
REFERENCE   9  (bases 1 to 4581)
  AUTHORS   Bedford,M.T., Sarbassova,D., Xu,J., Leder,P. and Yaffe,M.B.
  TITLE     A novel pro-Arg motif recognized by WW domains
  JOURNAL   J Biol Chem 275 (14), 10359-10369 (2000)
   PUBMED   10744724
REFERENCE   10 (bases 1 to 4581)
  AUTHORS   Komuro,A., Saeki,M. and Kato,S.
  TITLE     Association of two nuclear proteins, Npw38 and NpwBP, via the
            interaction between the WW domain and a novel proline-rich motif
            containing glycine and arginine
  JOURNAL   J Biol Chem 274 (51), 36513-36519 (1999)
   PUBMED   10593949
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC007655.1 and AC010168.6.
            
            On Nov 25, 2018 this sequence version replaced NM_016312.2.
            
            Summary: This gene encodes a nuclear protein, which colocalizes
            with mRNA splicing factors and intermediate filament-containing
            perinuclear networks. This protein has 95% amino acid sequence
            identity to the mouse Wbp11 protein. It contains two proline-rich
            regions that bind to the WW domain of Npw38, a nuclear protein, and
            thus this protein is also called Npw38-binding protein NpwBP. The
            Npw38-NpwBP complex may function as a component of an mRNA factory
            in the nucleus. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.155094.1,
                                           SRR1803616.79110.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000261167.7/ ENSP00000261167.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-127               AC007655.1         14077-14203         c
            128-236             AC007655.1         12045-12153         c
            237-268             AC007655.1         11477-11508         c
            269-362             AC007655.1         10360-10453         c
            363-559             AC007655.1         7532-7728           c
            560-693             AC007655.1         5696-5829           c
            694-893             AC007655.1         5262-5461           c
            894-1085            AC007655.1         4456-4647           c
            1086-1182           AC007655.1         1899-1995           c
            1183-1187           AC010168.6         1-5
            1188-1481           AC010168.6         425-718
            1482-1664           AC010168.6         2041-2223
            1665-4581           AC010168.6         3676-6592
FEATURES             Location/Qualifiers
     source          1..4581
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p12.3"
     gene            1..4581
                     /gene="WBP11"
                     /gene_synonym="BUG13; CFAP90; FAP90; NPWBP; PPP1R165;
                     SIPP1; VCTERL; VCTRL; WBP-11"
                     /note="WW domain binding protein 11"
                     /db_xref="GeneID:51729"
                     /db_xref="HGNC:HGNC:16461"
                     /db_xref="MIM:618083"
     exon            1..127
                     /gene="WBP11"
                     /gene_synonym="BUG13; CFAP90; FAP90; NPWBP; PPP1R165;
                     SIPP1; VCTERL; VCTRL; WBP-11"
                     /inference="alignment:Splign:2.1.0"
     exon            128..236
                     /gene="WBP11"
                     /gene_synonym="BUG13; CFAP90; FAP90; NPWBP; PPP1R165;
                     SIPP1; VCTERL; VCTRL; WBP-11"
                     /inference="alignment:Splign:2.1.0"
     CDS             173..2098
                     /gene="WBP11"
                     /gene_synonym="BUG13; CFAP90; FAP90; NPWBP; PPP1R165;
                     SIPP1; VCTERL; VCTRL; WBP-11"
                     /note="Npw38-binding protein NpwBP; splicing factor, PQBP1
                     and PP1 interacting; SH3 domain-binding protein SNP70;
                     splicing factor that interacts with PQBP-1 and PP1;
                     protein phosphatase 1, regulatory subunit 165"
                     /codon_start=1
                     /product="WW domain-binding protein 11"
                     /protein_id="NP_057396.1"
                     /db_xref="CCDS:CCDS8666.1"
                     /db_xref="GeneID:51729"
                     /db_xref="HGNC:HGNC:16461"
                     /db_xref="MIM:618083"
                     /translation="MGRRSTSSTKSGKFMNPTDQARKEARKRELKKNKKQRMMVRAAV
                     LKMKDPKQIIRDMEKLDEMEFNPVQQPQLNEKVLKDKRKKLRETFERILRLYEKENPD
                     IYKELRKLEVEYEQKRAQLSQYFDAVKNAQHVEVESIPLPDMPHAPSNILIQDIPLPG
                     AQPPSILKKTSAYGPPTRAVSILPLLGHGVPRLPPGRKPPGPPPGPPPPQVVQMYGRK
                     VGFALDLPPRRRDEDMLYSPELAQRGHDDDVSSTSEDDGYPEDMDQDKHDDSTDDSDT
                     DKSDGESDGDEFVHRDNGERDNNEEKKSGLSVRFADMPGKSRKKKKNMKELTPLQAMM
                     LRMAGQEIPEEGREVEEFSEDDDEDDSDDSEAEKQSQKQHKEESHSDGTSTASSQQQA
                     PPQSVPPSQIQAPPMPGPPPLGPPPAPPLRPPGPPTGLPPGPPPGAPPFLRPPGMPGL
                     RGPLPRLLPPGPPPGRPPGPPPGPPPGLPPGPPPRGPPPRLPPPAPPGIPPPRPGMMR
                     PPLVPPLGPAPPGLFPPAPLPNPGVLSAPPNLIQRPKADDTSAATIEKKATATISAKP
                     QITNPKAEITRFVPTALRVRRENKGATAAPQRKSEDDSAVPLAKAAPKSGPSVPVSVQ
                     TKDDVYEAFMKEMEGLL"
     exon            237..268
                     /gene="WBP11"
                     /gene_synonym="BUG13; CFAP90; FAP90; NPWBP; PPP1R165;
                     SIPP1; VCTERL; VCTRL; WBP-11"
                     /inference="alignment:Splign:2.1.0"
     exon            269..362
                     /gene="WBP11"
                     /gene_synonym="BUG13; CFAP90; FAP90; NPWBP; PPP1R165;
                     SIPP1; VCTERL; VCTRL; WBP-11"
                     /inference="alignment:Splign:2.1.0"
     exon            363..559
                     /gene="WBP11"
                     /gene_synonym="BUG13; CFAP90; FAP90; NPWBP; PPP1R165;
                     SIPP1; VCTERL; VCTRL; WBP-11"
                     /inference="alignment:Splign:2.1.0"
     exon            560..693
                     /gene="WBP11"
                     /gene_synonym="BUG13; CFAP90; FAP90; NPWBP; PPP1R165;
                     SIPP1; VCTERL; VCTRL; WBP-11"
                     /inference="alignment:Splign:2.1.0"
     exon            694..893
                     /gene="WBP11"
                     /gene_synonym="BUG13; CFAP90; FAP90; NPWBP; PPP1R165;
                     SIPP1; VCTERL; VCTRL; WBP-11"
                     /inference="alignment:Splign:2.1.0"
     exon            894..1085
                     /gene="WBP11"
                     /gene_synonym="BUG13; CFAP90; FAP90; NPWBP; PPP1R165;
                     SIPP1; VCTERL; VCTRL; WBP-11"
                     /inference="alignment:Splign:2.1.0"
     exon            1086..1187
                     /gene="WBP11"
                     /gene_synonym="BUG13; CFAP90; FAP90; NPWBP; PPP1R165;
                     SIPP1; VCTERL; VCTRL; WBP-11"
                     /inference="alignment:Splign:2.1.0"
     exon            1188..1481
                     /gene="WBP11"
                     /gene_synonym="BUG13; CFAP90; FAP90; NPWBP; PPP1R165;
                     SIPP1; VCTERL; VCTRL; WBP-11"
                     /inference="alignment:Splign:2.1.0"
     exon            1482..1664
                     /gene="WBP11"
                     /gene_synonym="BUG13; CFAP90; FAP90; NPWBP; PPP1R165;
                     SIPP1; VCTERL; VCTRL; WBP-11"
                     /inference="alignment:Splign:2.1.0"
     exon            1665..4581
                     /gene="WBP11"
                     /gene_synonym="BUG13; CFAP90; FAP90; NPWBP; PPP1R165;
                     SIPP1; VCTERL; VCTRL; WBP-11"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2667..2672
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WBP11"
                     /gene_synonym="BUG13; CFAP90; FAP90; NPWBP; PPP1R165;
                     SIPP1; VCTERL; VCTRL; WBP-11"
                     /note="hexamer: AATAAA"
     polyA_site      2687
                     /gene="WBP11"
                     /gene_synonym="BUG13; CFAP90; FAP90; NPWBP; PPP1R165;
                     SIPP1; VCTERL; VCTRL; WBP-11"
                     /note="major polyA site"
     regulatory      3116..3121
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WBP11"
                     /gene_synonym="BUG13; CFAP90; FAP90; NPWBP; PPP1R165;
                     SIPP1; VCTERL; VCTRL; WBP-11"
                     /note="hexamer: AATAAG"
     polyA_site      3136
                     /gene="WBP11"
                     /gene_synonym="BUG13; CFAP90; FAP90; NPWBP; PPP1R165;
                     SIPP1; VCTERL; VCTRL; WBP-11"
     regulatory      3590..3595
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WBP11"
                     /gene_synonym="BUG13; CFAP90; FAP90; NPWBP; PPP1R165;
                     SIPP1; VCTERL; VCTRL; WBP-11"
                     /note="hexamer: ATTAAA"
     polyA_site      3618
                     /gene="WBP11"
                     /gene_synonym="BUG13; CFAP90; FAP90; NPWBP; PPP1R165;
                     SIPP1; VCTERL; VCTRL; WBP-11"
     regulatory      4559..4564
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WBP11"
                     /gene_synonym="BUG13; CFAP90; FAP90; NPWBP; PPP1R165;
                     SIPP1; VCTERL; VCTRL; WBP-11"
                     /note="hexamer: ATTAAA"
     polyA_site      4581
                     /gene="WBP11"
                     /gene_synonym="BUG13; CFAP90; FAP90; NPWBP; PPP1R165;
                     SIPP1; VCTERL; VCTRL; WBP-11"
ORIGIN      
        1 gcgaggtttc aagatggcgg tagctgaggg gttgaccgag agacccagtt gaaggccttt
       61 acgaagtgaa agaggccggg agtcgccccc tacccgcttc tcgtagtcct gggagcacag
      121 cagaagtgtt tttctttttt taatgaacaa gtaaaccata caaattgtca acatgggacg
      181 gagatctaca tcatccacca agagtggaaa atttatgaac cccacagacc aagcccgaaa
      241 ggaagcccgg aagagagaat taaagaagaa caaaaaacag cgcatgatgg ttcgagctgc
      301 agttttaaag atgaaggatc caaaacagat aatccgagac atggagaaat tggatgaaat
      361 ggagtttaac ccagtgcaac agccacaatt aaatgagaaa gtactgaaag acaagcgtaa
      421 aaagctgcgt gaaacctttg aacgtattct acgactctat gaaaaagaga atccagatat
      481 ttacaaagaa ttgagaaagc tagaagtaga atatgaacag aagagggctc aacttagcca
      541 atattttgat gctgtcaaga atgctcagca tgtggaagtg gagagtattc ctttgccaga
      601 tatgccacat gctccttcca acattttgat ccaggacatt ccacttcctg gtgcccagcc
      661 accctctatc ctaaagaaaa cctcagccta tggacctcca actcgggcag tttctatcct
      721 tcctcttctt ggacatggtg ttccacgttt gccccctggc agaaaacctc ctggccctcc
      781 ccctggtcca cctcctcctc aagtcgtgca gatgtatggc cgtaaagtgg gttttgccct
      841 agatcttccc cctcgtaggc gagatgaaga catgttatat agtcctgaac ttgcccagcg
      901 aggtcatgat gatgatgttt ctagcaccag tgaagatgat ggctatcctg aggacatgga
      961 tcaagataag catgatgaca gtactgatga cagtgacacc gacaaatcag atggagaaag
     1021 tgacggggat gaatttgtgc accgtgataa tggtgagaga gacaacaatg aagaaaagaa
     1081 gtcaggtctg agtgtacggt ttgcagatat gcctggaaaa tcaaggaaga aaaagaagaa
     1141 catgaaggaa ctgactcctc ttcaagccat gatgcttcgt atggcaggtc aagaaatccc
     1201 tgaggaggga cgggaagtag aggaattttc agaggacgat gatgaagatg attctgatga
     1261 ctctgaagca gaaaagcaat cacaaaagca gcataaagag gaatcccatt ctgatggcac
     1321 atccactgct tcttcacagc agcaggctcc gccgcagtct gttcctcctt ctcagataca
     1381 agcacctccc atgccaggac caccacctct tggaccacca cctgctccac cattacggcc
     1441 tcctgggcca cctacaggcc ttcctcctgg tccacctcca ggagctcctc cattcctgag
     1501 accacctgga atgccaggac tccgagggcc cttaccccga cttttacctc caggaccacc
     1561 accaggccga ccccctggcc ctcccccagg tccacctcca ggtctgcctc ctggtccccc
     1621 tcctcgtgga cccccaccaa ggctacctcc ccctgcacct ccaggtattc ctccacctcg
     1681 tcctggcatg atgcgcccac ctttggtgcc tccccttgga cctgcccccc ctgggctgtt
     1741 cccaccagct cccttgccaa accctggggt tttaagtgcc ccacccaact tgattcagcg
     1801 acccaaggcg gatgatacaa gtgcagccac cattgagaag aaagccacag caaccatcag
     1861 tgccaagcca cagatcacta atcccaaggc agagattact cgatttgtgc ccactgcact
     1921 gagagtacgt cgggagaata aaggggctac tgctgctccc caaagaaagt cagaggatga
     1981 ttctgctgtg cctcttgcca aagcagcacc caaatctggt ccttctgttc ctgtctcagt
     2041 acaaactaag gatgatgtct atgaggcttt catgaaagag atggaagggc tactgtgaca
     2101 gcttttgatg ccagaaaagg cttctgttca caacagtggc ccatggagaa agaggctctt
     2161 attaaactta gatgaaagag ctgcttccat tgtcagggta ttttctaatt tcagttcaag
     2221 gaatatccta aaatttagcc ttgttcagaa tttactgcac ataaaaaagg gtatttcatc
     2281 cagaatagat cagttattga agcagtgctg ctaacatcca ttccctttca taccaccatt
     2341 ttcaccctgt ttcttcccct cctccagttc tttggaaatt tgtgatcggg ggatcttagt
     2401 tgcttatttg ttttgactct tgtgtgctgt gggcactgga gtagagattt ctggagaaaa
     2461 aaaaacagtt tatttcatct tgccttttgt gtttgagtta tttttaatat tttcctgtaa
     2521 atattttgta atattttact tgtaatgaaa tggatcacaa tgtcatttcc taatacaagg
     2581 caggatatgt gggaagaata tgtacaatta tttgattaaa attatttccc actgacctaa
     2641 actttcagtg atttgtggga aaaataaata aatgttctac accaagatac tctgtgttac
     2701 tgataatatg taaacataat acctatttta tggacagaaa aagttaaata tttaaaactt
     2761 gggtctttaa ggaactgcct ttctggtaca gaatgagaat cttactgaaa acatggtaaa
     2821 aactacattt taaattttaa gggataaaaa ggagtaatta tttccctttt ttaagattgt
     2881 catactggct ttagagaaac tgagaggtgt taagaatagt atggtttggc ttttattatt
     2941 taaaagatgt cttaccttca gtggttactt attccagagc ttcttgaact gatacgagtt
     3001 gaatggcaaa agtcatttta aaccattttt aagctataaa agaatcagaa gaggttagct
     3061 ttttttcctt tctgaattgg tgggtttggt gtgcttttat attaaaatat gaatgaataa
     3121 gagtgcttaa cattaatttg catttatacc attttcttta caaagtgctt taatgtaaac
     3181 tcatctacca atttagacta actcttagta agtttaatgt taatttaatg actaactcat
     3241 ctaccaatta accctataga taacttttct gggtattttc cccattttac attagagagt
     3301 attgaaactt aaaaaggact cgtgatttat ccagtgatcc aaagtgtgta tttcataaac
     3361 acatacacac agtgcgtgca ttgtttaggc atacgttact ttccacagta tctcaaatgc
     3421 cttttacatg aatcccatac tatcaaaaat tggtgataac ctaaaatgta gtgcaataat
     3481 acaataaggc atttattttc ttagagttga gttgatggat ttttagattt ttattcaaga
     3541 tcttttgttt gtttggcttt gcttggaaga tactgattta ttctttcata ttaaagcaaa
     3601 tcctgccaaa gcactaaata gaccgttttg ggttggtttt ttagtgtaat attaatacgg
     3661 gtccacaggt gaattgagtc tgttcagatg taaggattga accttatgtt atcaatcctt
     3721 gacaccatcc ttgataactt acggatatca aggatcaaac catatggtat caatattgtt
     3781 agttattcag cataaacaga attatttccc aatacttgat ctgaaatatt tttaatggtc
     3841 ttacttgaaa cttatattct ttctgggagt gatgttttta tcatttttcc atggagacag
     3901 gttctaactc tgttgcccag gctgcagtgc agtgatgtga tcatagctca ctgcagcctg
     3961 aaactcctgg gttcaagtga tctctggcct cagcctccca agtagttgga acttcagata
     4021 cgtgccacca caaccagcta atttattttt tagagatgag gtctcgctat gttgcccagt
     4081 ctggtctcct agcctcaagt gatcttccca tctcagcctt cagttggaga tttctgattt
     4141 atgttaatat aagaaagctg ttgatagttt atcataaagg catttcctta tattgctagt
     4201 ataattttct gaaaattagt ggtgtgacaa tacatcagct gcatccacag gaaaggggaa
     4261 ttaattagca gttctgattc tgggtacact tgttatgatc ataatttaca taatattttc
     4321 atgaaaatgg tcagctcaca gctatgaaat gtaaatgata gaaatcttta atcatgtata
     4381 tggatagact tgttactatt tccttatcaa agtgtcactt tagggacagc agttgcccct
     4441 ttaaattaag gatcaccaca ataatactct gccatgtcat ggaatcagca tgaagccctg
     4501 gatgctatcc aagattctgt ttcagttctc attttgtata ttcttgtttg tgctcttgat
     4561 taaaatatct ccttatatat a
//
