LOCUS       NM_012477               1175 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens WW domain binding protein 1 (WBP1), mRNA.
ACCESSION   NM_012477
VERSION     NM_012477.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1175)
  AUTHORS   Benz,C., Ali,M., Krystkowiak,I., Simonetti,L., Sayadi,A.,
            Mihalic,F., Kliche,J., Andersson,E., Jemth,P., Davey,N.E. and
            Ivarsson,Y.
  TITLE     Proteome-scale mapping of binding sites in the unstructured regions
            of the human proteome
  JOURNAL   Mol Syst Biol 18 (1), e10584 (2022)
   PUBMED   35044719
REFERENCE   2  (bases 1 to 1175)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 1175)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1175)
  AUTHORS   Tao,H., Zhang,M., Yang,J.J. and Shi,K.H.
  TITLE     MicroRNA-21 via Dysregulation of WW Domain-Containing Protein 1
            Regulate Atrial Fibrosis in Atrial Fibrillation
  JOURNAL   Heart Lung Circ 27 (1), 104-113 (2018)
   PUBMED   28495464
  REMARK    GeneRIF: miR-21 inhibits cardiac fibroblasts proliferation by
            inactivating the TGF-beta1/Smad2 signaling pathway via
            up-regulation of WWP-1.
REFERENCE   5  (bases 1 to 1175)
  AUTHORS   Schuchardt,B.J., Mikles,D.C., Hoang,L.M., Bhat,V., McDonald,C.B.,
            Sudol,M. and Farooq,A.
  TITLE     Ligand binding to WW tandem domains of YAP2 transcriptional
            regulator is under negative cooperativity
  JOURNAL   FEBS J 281 (24), 5532-5551 (2014)
   PUBMED   25283809
REFERENCE   6  (bases 1 to 1175)
  AUTHORS   Morishima,N., Nakanishi,K. and Nakano,A.
  TITLE     Activating transcription factor-6 (ATF6) mediates apoptosis with
            reduction of myeloid cell leukemia sequence 1 (Mcl-1) protein via
            induction of WW domain binding protein 1
  JOURNAL   J Biol Chem 286 (40), 35227-35235 (2011)
   PUBMED   21841196
  REMARK    GeneRIF: Mcl-1 is a determinant of cell fate, and ATF6 mediates
            apoptosis via specific suppression of Mcl-1 through up-regulation
            of WBP1
REFERENCE   7  (bases 1 to 1175)
  AUTHORS   Ludes-Meyers,J.H., Kil,H., Bednarek,A.K., Drake,J., Bedford,M.T.
            and Aldaz,C.M.
  TITLE     WWOX binds the specific proline-rich ligand PPXY: identification of
            candidate interacting proteins
  JOURNAL   Oncogene 23 (29), 5049-5055 (2004)
   PUBMED   15064722
REFERENCE   8  (bases 1 to 1175)
  AUTHORS   Chen,H.I., Einbond,A., Kwak,S.J., Linn,H., Koepf,E., Peterson,S.,
            Kelly,J.W. and Sudol,M.
  TITLE     Characterization of the WW domain of human yes-associated protein
            and its polyproline-containing ligands
  JOURNAL   J Biol Chem 272 (27), 17070-17077 (1997)
   PUBMED   9202023
REFERENCE   9  (bases 1 to 1175)
  AUTHORS   Pirozzi,G., McConnell,S.J., Uveges,A.J., Carter,J.M., Sparks,A.B.,
            Kay,B.K. and Fowlkes,D.M.
  TITLE     Identification of novel human WW domain-containing proteins by
            cloning of ligand targets
  JOURNAL   J Biol Chem 272 (23), 14611-14616 (1997)
   PUBMED   9169421
REFERENCE   10 (bases 1 to 1175)
  AUTHORS   Chen,H.I. and Sudol,M.
  TITLE     The WW domain of Yes-associated protein binds a proline-rich ligand
            that differs from the consensus established for Src homology
            3-binding modules
  JOURNAL   Proc Natl Acad Sci U S A 92 (17), 7819-7823 (1995)
   PUBMED   7644498
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CN403791.1 and BC010012.2.
            
            On Nov 23, 2018 this sequence version replaced NM_012477.3.
            
            Summary: The globular WW domain, named for the conserved tryptophan
            residues in the protein motif present in various structural and
            regulatory proteins, is known to play a role in the mediation of
            protein-protein interactions. This gene encodes a ligand of the WW
            domain of the Yes kinase-associated protein. Readthrough
            transcription of the neighboring upstream gene, which encodes INO80
            complex subunit B, into this gene generates a non-coding
            transcript. [provided by RefSeq, Feb 2011].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC071626.1, BC010012.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000233615.7/ ENSP00000233615.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                CN403791.1         41-52
            13-1175             BC010012.2         1-1163
FEATURES             Location/Qualifiers
     source          1..1175
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p13.1"
     gene            1..1175
                     /gene="WBP1"
                     /gene_synonym="WBP-1"
                     /note="WW domain binding protein 1"
                     /db_xref="GeneID:23559"
                     /db_xref="HGNC:HGNC:12737"
                     /db_xref="MIM:606961"
     exon            1..234
                     /gene="WBP1"
                     /gene_synonym="WBP-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             166..975
                     /gene="WBP1"
                     /gene_synonym="WBP-1"
                     /note="epididymis secretory sperm binding protein"
                     /codon_start=1
                     /product="WW domain-binding protein 1"
                     /protein_id="NP_036609.1"
                     /db_xref="CCDS:CCDS1943.1"
                     /db_xref="GeneID:23559"
                     /db_xref="HGNC:HGNC:12737"
                     /db_xref="MIM:606961"
                     /translation="MARASSGNGSEEAWGALRAPQQQLRELCPGVNNQPYLCESGHCC
                     GETGCCTYYYELWWFWLLWTVLILFSCCCAFRHRRAKLRLQQQQRQREINLLAYHGAC
                     HGAGPFPTGSLLDLRFLSTFKPPAYEDVVHRPGTPPPPYTVAPGRPLTASSEQTCCSS
                     SSSCPAHFEGTNVEGVSSHQSAPPHQEGEPGAGVTPASTPPSCRYRRLTGDSGIELCP
                     CPASGEGEPVKEVRVSATLPDLEDYSPCALPPESVPQIFPMGLSSSEGDIP"
     exon            235..337
                     /gene="WBP1"
                     /gene_synonym="WBP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            338..514
                     /gene="WBP1"
                     /gene_synonym="WBP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            515..1175
                     /gene="WBP1"
                     /gene_synonym="WBP-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1157..1162
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WBP1"
                     /gene_synonym="WBP-1"
                     /note="hexamer: ATTAAA"
     polyA_site      1175
                     /gene="WBP1"
                     /gene_synonym="WBP-1"
                     /note="major polyA site"
ORIGIN      
        1 ctagttggtg gagttctgcc cggatggaag ctccggccgc ggagtgatgg tggcctcagc
       61 gaagatgggc cgggcaggga ccatggcggt ggcagcagag gtggcagggg cggggcggct
      121 ggcggtagag gaggctgtgg tcctcagggg gctgtaggtg gaggtatggc tcgggccagc
      181 agcgggaacg gcagcgagga ggcctggggg gcacttcggg cgccgcaaca gcagcttcga
      241 gagctgtgcc caggagtgaa caaccagccc tacctctgtg agagtggtca ctgctgcggg
      301 gagactggct gctgcaccta ctactatgag ctctggtggt tctggctgct ctggactgtc
      361 ctcatcctct ttagctgctg ttgcgccttc cgccaccgac gagctaaact caggctgcaa
      421 caacagcagc ggcagcgtga aatcaacttg ttggcctatc atggggcatg ccatggggct
      481 ggtcctttcc ctaccggttc actgcttgac cttcgcttcc tcagcacctt caagccccca
      541 gcctacgagg atgtggttca ccgcccaggc acaccacccc ccccttatac tgtggcccca
      601 ggccgcccct tgactgcttc cagtgaacaa acctgctgtt cctcctcatc cagctgccct
      661 gcccactttg aaggaacaaa tgtggaaggt gtttcctccc accagagtgc cccccctcat
      721 caggagggtg agcccggggc aggggtgacc cctgcctcca cacccccctc ctgccgctat
      781 cgccgtttaa ctggcgactc cggtattgag ctctgccctt gtcctgcctc cggtgagggt
      841 gagccagtca aggaggtgag ggttagtgcc accctgccag atctggagga ctactccccg
      901 tgtgcactac ccccagagtc tgtaccgcag atctttccca tggggctgtc ttccagtgaa
      961 ggggacatcc cataagtagt tttgagaggg tggatgggtt acttgcccac cagaaacagc
     1021 cctagtccca actccttgcg ttcctttggc ccctccctgc ctacctagaa tctgcctgaa
     1081 agggctggag aggggcagta ttgggggact gtgctagctt tacccccgca ggacatacac
     1141 aggagccttt gatctcatta aagagatgtg aacca
//
