LOCUS       NM_015045               6310 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens WAPL cohesin release factor (WAPL), transcript variant
            1, mRNA.
ACCESSION   NM_015045 XM_290471
VERSION     NM_015045.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6310)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 6310)
  AUTHORS   Haarhuis,J.H.I., van der Weide,R.H., Blomen,V.A., Flach,K.D.,
            Teunissen,H., Willems,L., Brummelkamp,T.R., Rowland,B.D. and de
            Wit,E.
  TITLE     A Mediator-cohesin axis controls heterochromatin domain formation
  JOURNAL   Nat Commun 13 (1), 754 (2022)
   PUBMED   35136067
  REMARK    GeneRIF: A Mediator-cohesin axis controls heterochromatin domain
            formation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6310)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 6310)
  AUTHORS   Kumagai,K., Takanashi,M., Ohno,S.I., Harada,Y., Fujita,K.,
            Oikawa,K., Sudo,K., Ikeda,S.I., Nishi,H., Oikawa,K. and Kuroda,M.
  TITLE     WAPL induces cervical intraepithelial neoplasia modulated with
            estrogen signaling without HPV E6/E7
  JOURNAL   Oncogene 40 (21), 3695-3706 (2021)
   PUBMED   33947962
  REMARK    GeneRIF: WAPL induces cervical intraepithelial neoplasia modulated
            with estrogen signaling without HPV E6/E7.
REFERENCE   5  (bases 1 to 6310)
  AUTHORS   Benedict,B., van Schie,J.J.M., Oostra,A.B., Balk,J.A.,
            Wolthuis,R.M.F., Riele,H.T. and de Lange,J.
  TITLE     WAPL-Dependent Repair of Damaged DNA Replication Forks Underlies
            Oncogene-Induced Loss of Sister Chromatid Cohesion
  JOURNAL   Dev Cell 52 (6), 683-698 (2020)
   PUBMED   32084359
  REMARK    GeneRIF: WAPL-Dependent Repair of Damaged DNA Replication Forks
            Underlies Oncogene-Induced Loss of Sister Chromatid Cohesion.
REFERENCE   6  (bases 1 to 6310)
  AUTHORS   Kuroda,M., Oikawa,K., Ohbayashi,T., Yoshida,K., Yamada,K.,
            Mimura,J., Matsuda,Y., Fujii-Kuriyama,Y. and Mukai,K.
  TITLE     A dioxin sensitive gene, mammalian WAPL, is implicated in
            spermatogenesis
  JOURNAL   FEBS Lett 579 (1), 167-172 (2005)
   PUBMED   15620708
REFERENCE   7  (bases 1 to 6310)
  AUTHORS   Ballif,B.A., Villen,J., Beausoleil,S.A., Schwartz,D. and Gygi,S.P.
  TITLE     Phosphoproteomic analysis of the developing mouse brain
  JOURNAL   Mol Cell Proteomics 3 (11), 1093-1101 (2004)
   PUBMED   15345747
REFERENCE   8  (bases 1 to 6310)
  AUTHORS   Kwiatkowski,B.A., Ragoczy,T., Ehly,J. and Schubach,W.H.
  TITLE     Identification and cloning of a novel chromatin-associated protein
            partner of Epstein-Barr nuclear protein 2
  JOURNAL   Exp Cell Res 300 (1), 223-233 (2004)
   PUBMED   15383329
  REMARK    GeneRIF: FOE encodes a protein of 1227 amino acids with a
            functional bipartite nuclear localization signal, an arginine-rich
            motif, a putative nuclear export signal as well as with three
            highly acidic regions and a predicted coiled-coil domain.
REFERENCE   9  (bases 1 to 6310)
  AUTHORS   Lehner,B. and Sanderson,C.M.
  TITLE     A protein interaction framework for human mRNA degradation
  JOURNAL   Genome Res 14 (7), 1315-1323 (2004)
   PUBMED   15231747
REFERENCE   10 (bases 1 to 6310)
  AUTHORS   Fallone,C.A.
  TITLE     Epidemiology of the antibiotic resistance of Helicobacter pylori in
            Canada
  JOURNAL   Can J Gastroenterol 14 (10), 879-882 (2000)
   PUBMED   11111111
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL731569.18 and AL844892.5.
            
            On Aug 31, 2019 this sequence version replaced NM_015045.4.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038192.2491898.1, AB065003.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000298767.10/ ENSP00000298767.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-428               AL731569.18        50440-50867         c
            429-949             AL731569.18        46646-47166         c
            950-1975            AL731569.18        28793-29818         c
            1976-2094           AL731569.18        26276-26394         c
            2095-2190           AL731569.18        2953-3048           c
            2191-2343           AL844892.5         167467-167619       c
            2344-2480           AL844892.5         167063-167199       c
            2481-2592           AL844892.5         165847-165958       c
            2593-2820           AL844892.5         162134-162361       c
            2821-2932           AL844892.5         156031-156142       c
            2933-3030           AL844892.5         155254-155351       c
            3031-3107           AL844892.5         153844-153920       c
            3108-3283           AL844892.5         148511-148686       c
            3284-3399           AL844892.5         148075-148190       c
            3400-3564           AL844892.5         146822-146986       c
            3565-3772           AL844892.5         141097-141304       c
            3773-3861           AL844892.5         138130-138218       c
            3862-3957           AL844892.5         132775-132870       c
            3958-6310           AL844892.5         130111-132463       c
FEATURES             Location/Qualifiers
     source          1..6310
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q23.2"
     gene            1..6310
                     /gene="WAPL"
                     /gene_synonym="FOE; KIAA0261; WAPAL"
                     /note="WAPL cohesin release factor"
                     /db_xref="GeneID:23063"
                     /db_xref="HGNC:HGNC:23293"
                     /db_xref="MIM:610754"
     exon            1..428
                     /gene="WAPL"
                     /gene_synonym="FOE; KIAA0261; WAPAL"
                     /inference="alignment:Splign:2.1.0"
     exon            429..949
                     /gene="WAPL"
                     /gene_synonym="FOE; KIAA0261; WAPAL"
                     /inference="alignment:Splign:2.1.0"
     CDS             451..4023
                     /gene="WAPL"
                     /gene_synonym="FOE; KIAA0261; WAPAL"
                     /note="isoform 1 is encoded by transcript variant 1;
                     friend of EBNA2 (Epstein-Barr virus nuclear protein 2);
                     wings apart-like protein homolog; friend of EBNA2 protein"
                     /codon_start=1
                     /product="wings apart-like protein homolog isoform 1"
                     /protein_id="NP_055860.1"
                     /db_xref="CCDS:CCDS7375.1"
                     /db_xref="GeneID:23063"
                     /db_xref="HGNC:HGNC:23293"
                     /db_xref="MIM:610754"
                     /translation="MTSRFGKTYSRKGGNGSSKFDEVFSNKRTTLSTKWGETTFMAKL
                     GQKRPNFKPDIQEIPKKPKVEEESTGDPFGFDSDDESLPVSSKNLAQVKCSSYSESSE
                     AAQLEEVTSVLEANSKISHVVVEDTVVSDKCFPLEDTLLGKEKSTNRIVEDDASISSC
                     NKLITSDKVENFHEEHEKNSHHIHKNADDSTKKPNAETTVASEIKETNDTWNSQFGKR
                     PESPSEISPIKGSVRTGLFEWDNDFEDIRSEDCILSLDSDPLLEMKDDDFKNRLENLN
                     EAIEEDIVQSVLRPTNCRTYCRANKTKSSQGASNFDKLMDGTSQALAKANSESSKDGL
                     NQAKKGGVSCGTSFRGTVGRTRDYTVLHPSCLSVCNVTIQDTMERSMDEFTASTPADL
                     GEAGRLRKKADIATSKTTTRFRPSNTKSKKDVKLEFFGFEDHETGGDEGGSGSSNYKI
                     KYFGFDDLSESEDDEDDDCQVERKTSKKRTKTAPSPSLQPPPESNDNSQDSQSGTNNA
                     ENLDFTEDLPGVPESVKKPINKQGDKSKENTRKIFSGPKRSPTKAVYNARHWNHPDSE
                     ELPGPPVVKPQSVTVRLSSKEPNQKDDGVFKAPAPPSKVIKTVTIPTQPYQDIVTALK
                     CRREDKELYTVVQHVKHFNDVVEFGENQEFTDDIEYLLSGLKSTQPLNTRCLSVISLA
                     TKCAMPSFRMHLRAHGMVAMVFKTLDDSQHHQNLSLCTAALMYILSRDRLNMDLDRAS
                     LDLMIRLLELEQDASSAKLLNEKDMNKIKEKIRRLCETVHNKHLDLENITTGHLAMET
                     LLSLTSKRAGDWFKEELRLLGGLDHIVDKVKECVDHLSRDEDEEKLVASLWGAERCLR
                     VLESVTVHNPENQSYLIAYKDSQLIVSSAKALQHCEELIQQYNRAEDSICLADSKPLP
                     HQNVTNHVGKAVEDCMRAIIGVLLNLTNDNEWGSTKTGEQDGLIGTALNCVLQVPKYL
                     PQEQRFDIRVLGLGLLINLVEYSARNRHCLVNMETSCSFDSSICSGEGDDSLRIGGQV
                     HAVQALVQLFLERERAAQLAESKTDELIKDAPTTQHDKSGEWQETSGEIQWVSTEKTD
                     GTEEKHKKEEEDEELDLNKALQHAGKHMEDCIVASYTALLLGCLCQESPINVTTVREY
                     LPEGDFSIMTEMLKKFLSFMNLTCAVGTTGQKSISRVIEYLEHC"
     exon            950..1975
                     /gene="WAPL"
                     /gene_synonym="FOE; KIAA0261; WAPAL"
                     /inference="alignment:Splign:2.1.0"
     exon            1976..2094
                     /gene="WAPL"
                     /gene_synonym="FOE; KIAA0261; WAPAL"
                     /inference="alignment:Splign:2.1.0"
     exon            2095..2190
                     /gene="WAPL"
                     /gene_synonym="FOE; KIAA0261; WAPAL"
                     /inference="alignment:Splign:2.1.0"
     exon            2191..2343
                     /gene="WAPL"
                     /gene_synonym="FOE; KIAA0261; WAPAL"
                     /inference="alignment:Splign:2.1.0"
     exon            2344..2480
                     /gene="WAPL"
                     /gene_synonym="FOE; KIAA0261; WAPAL"
                     /inference="alignment:Splign:2.1.0"
     exon            2481..2592
                     /gene="WAPL"
                     /gene_synonym="FOE; KIAA0261; WAPAL"
                     /inference="alignment:Splign:2.1.0"
     exon            2593..2820
                     /gene="WAPL"
                     /gene_synonym="FOE; KIAA0261; WAPAL"
                     /inference="alignment:Splign:2.1.0"
     exon            2821..2932
                     /gene="WAPL"
                     /gene_synonym="FOE; KIAA0261; WAPAL"
                     /inference="alignment:Splign:2.1.0"
     exon            2933..3030
                     /gene="WAPL"
                     /gene_synonym="FOE; KIAA0261; WAPAL"
                     /inference="alignment:Splign:2.1.0"
     exon            3031..3107
                     /gene="WAPL"
                     /gene_synonym="FOE; KIAA0261; WAPAL"
                     /inference="alignment:Splign:2.1.0"
     exon            3108..3283
                     /gene="WAPL"
                     /gene_synonym="FOE; KIAA0261; WAPAL"
                     /inference="alignment:Splign:2.1.0"
     exon            3284..3399
                     /gene="WAPL"
                     /gene_synonym="FOE; KIAA0261; WAPAL"
                     /inference="alignment:Splign:2.1.0"
     exon            3400..3564
                     /gene="WAPL"
                     /gene_synonym="FOE; KIAA0261; WAPAL"
                     /inference="alignment:Splign:2.1.0"
     exon            3565..3772
                     /gene="WAPL"
                     /gene_synonym="FOE; KIAA0261; WAPAL"
                     /inference="alignment:Splign:2.1.0"
     exon            3773..3861
                     /gene="WAPL"
                     /gene_synonym="FOE; KIAA0261; WAPAL"
                     /inference="alignment:Splign:2.1.0"
     exon            3862..3957
                     /gene="WAPL"
                     /gene_synonym="FOE; KIAA0261; WAPAL"
                     /inference="alignment:Splign:2.1.0"
     exon            3958..6310
                     /gene="WAPL"
                     /gene_synonym="FOE; KIAA0261; WAPAL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4531..4536
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WAPL"
                     /gene_synonym="FOE; KIAA0261; WAPAL"
                     /note="hexamer: AATAAA"
     polyA_site      4556
                     /gene="WAPL"
                     /gene_synonym="FOE; KIAA0261; WAPAL"
     regulatory      6287..6292
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WAPL"
                     /gene_synonym="FOE; KIAA0261; WAPAL"
                     /note="hexamer: AATAAA"
     polyA_site      6310
                     /gene="WAPL"
                     /gene_synonym="FOE; KIAA0261; WAPAL"
                     /note="major polyA site"
ORIGIN      
        1 gtgacggagc gagcggctgt tggaggaagg aggtgggggc cgggagcgca aatggcgttg
       61 agatggttca gggccctgtt caaactccag cactgaccat tcaccggcgg aagcggcggc
      121 gcaggaggcg gcggcggccc agcgggggca cacagcaggc tctgttacca gctccagcag
      181 tggcggccag cgagagctag gcctgggccc ggccggcggc gctcgaggcg gggagggaag
      241 ttgcggggcc gccgctcctg cccccccaac cgggcttcct atttaccgaa agcagagtcc
      301 ctcgcctctc tcggctctca cctgccggcc ctgctctccc gcgcgagggt tccgcgcccg
      361 cccgcgggcc gtagggagcg ggagaggcgg aggcggcccg tggccaaagc acccgccagg
      421 ctccgaggag aatatgaaac tggtgtcaaa atgacatcca gatttgggaa aacatacagt
      481 aggaaaggtg gaaatggcag ttcaaaattc gatgaagtct tttccaacaa acggactacc
      541 cttagcacaa aatggggaga gaccacattt atggctaaat tagggcagaa gaggcccaat
      601 ttcaaaccag atatccaaga aattccgaag aaacctaaag tggaagaaga aagtactgga
      661 gatccttttg gatttgatag tgatgatgag tctctaccag tttcttcaaa gaatttagcc
      721 caggttaagt gttcctctta ttcagaatct agtgaagctg ctcagttgga agaggtcact
      781 tcagtacttg aagctaatag caaaattagt catgtggtcg ttgaagacac tgtcgtttct
      841 gataaatgct tccctttgga ggacacttta cttgggaaag aaaagagcac aaaccgaatt
      901 gtagaagatg atgcaagcat aagtagctgt aataaattaa taacttcaga taaagtggag
      961 aattttcatg aagaacatga aaagaatagt caccatattc acaaaaatgc tgatgacagt
     1021 actaagaaac ccaatgcaga aactacagtg gcttctgaaa tcaaggaaac aaatgatact
     1081 tggaactccc agtttgggaa aaggccagaa tcaccatcag aaatatctcc aatcaaggga
     1141 tctgttagaa ctggtttgtt tgaatgggat aatgattttg aagatatcag atcagaagac
     1201 tgtattttaa gtttggatag tgatcccctt ttggagatga aggatgacga ttttaaaaat
     1261 cgattggaaa atctgaatga agccattgag gaagatattg tacaaagtgt tcttaggcca
     1321 accaactgta ggacgtactg tagggccaat aaaacgaaat cctcccaagg agcatcaaat
     1381 tttgataagc tgatggacgg caccagtcag gccttagcca aagcaaacag tgaatcgagt
     1441 aaagatggcc tgaatcaggc aaagaaaggg ggtgtaagtt gtgggaccag ttttagaggg
     1501 acagttggac ggactagaga ttacactgtt ttacatccat cttgcttgtc agtttgtaat
     1561 gttaccatac aggatactat ggaacgcagc atggatgagt tcactgcatc cactcctgca
     1621 gatttgggag aagctggtcg tctcagaaaa aaggcagata ttgcaacttc taagactact
     1681 actagatttc gacctagtaa tactaaatcc aaaaaggatg ttaaacttga attttttggt
     1741 tttgaagatc atgagacagg aggtgatgaa ggaggttctg gaagttctaa ttacaaaatt
     1801 aagtattttg gctttgatga tctcagtgaa agcgaagatg atgaagatga tgactgtcaa
     1861 gtagaaagaa agacaagcaa aaaaagaact aaaacagctc catcaccctc cttgcagcct
     1921 cccccagaaa gcaatgataa ttcccaggac agtcagtctg gtactaacaa tgcagaaaac
     1981 ttggatttta cagaggactt gcctggtgtg cctgaaagtg tgaagaagcc cataaataaa
     2041 caaggagata aatcaaagga aaataccaga aagattttta gtggccccaa acggtcaccc
     2101 acaaaagctg tatataatgc cagacattgg aatcatccag attcagaaga actgcctggg
     2161 ccaccagtag taaaacctca gagtgtcaca gtgaggctgt cttcaaagga accaaatcaa
     2221 aaagatgatg gagtttttaa ggctcctgca ccaccatcca aagtgataaa aactgtgaca
     2281 atacctactc agccctacca agatatagtt actgcactga aatgcagacg agaagacaaa
     2341 gaattatata ctgttgttca gcacgtgaag cacttcaacg atgttgtaga atttggtgaa
     2401 aatcaagagt tcactgatga cattgagtac ttgttaagtg gcttaaagag cactcagcct
     2461 ctaaacacac gttgccttag tgttattagc ttggctacta aatgtgccat gcccagtttt
     2521 cgaatgcacc tgagagcaca tgggatggta gcaatggtct ttaaaacctt ggatgattcc
     2581 cagcaccatc agaatctgtc cctctgtaca gctgccctca tgtatatact gagtagagat
     2641 cgtttgaaca tggatcttga tagagctagc ttagatctaa tgattcgact tttggaactg
     2701 gaacaagatg cttcatcagc caagctactg aatgaaaaag acatgaacaa aattaaagaa
     2761 aaaatccgaa ggctctgtga aactgtacac aacaagcatc ttgatctaga aaatataacg
     2821 actgggcatt tagctatgga gacattatta tcccttactt ctaaacgagc aggagactgg
     2881 tttaaagaag aactccggct tttgggtggt ctggatcata ttgtagataa agtaaaagaa
     2941 tgtgtggatc atttaagtag agatgaggat gaagagaaac tggtagcctc actatgggga
     3001 gcagagagat gtttacgagt tttagaaagt gtaactgtgc ataatcccga aaatcaaagc
     3061 tacttgatag catataaaga ttcccaactt attgtttcat cagctaaagc attacagcat
     3121 tgtgaagaac tgattcagca gtacaaccgt gctgaggaca gcatatgctt agctgacagt
     3181 aagcctctgc ctcaccagaa tgtaactaac catgtaggca aagcagtgga ggactgcatg
     3241 agggccatca tcggggtgtt gcttaattta actaatgata atgagtgggg cagcaccaaa
     3301 acaggagagc aggacggtct cataggcaca gcgctgaact gtgtgcttca ggttccaaag
     3361 tacctacctc aggagcagag atttgatatt cgagtgctgg gcttaggtct gctgataaat
     3421 ctagtggagt atagtgctcg gaatcggcac tgtcttgtca acatggaaac atcgtgctct
     3481 tttgattctt ccatctgtag tggagaaggg gatgatagtt taaggatagg tggacaagtt
     3541 catgctgtcc aggctttagt gcagctattc cttgagcgag agcgggcagc ccagctagca
     3601 gaaagtaaaa cagatgagtt gatcaaagat gctcccacca ctcagcatga taagagtgga
     3661 gagtggcaag aaacaagtgg agaaatacag tgggtgtcaa ctgaaaagac tgatggtaca
     3721 gaagagaaac ataagaagga ggaggaggat gaagaacttg acctcaataa agcccttcag
     3781 catgccggca aacacatgga ggattgcatt gtggcctcct acacagcact acttcttggg
     3841 tgtctctgcc aggaaagtcc aatcaatgta accactgtgc gggaatatct gccagaagga
     3901 gacttttcaa taatgacaga gatgctcaaa aaatttttga gttttatgaa tctcacttgt
     3961 gctgttggaa caactggcca gaaatctatc tctagagtga ttgaatattt ggaacattgc
     4021 tagctgcttt acctttgctt caggtgctcg gtaatgctgg agctatcctt agacaaagaa
     4081 aagtcaagtc atgaaagaag tccttgaaga tataccaaga acattcatca gtatcattcg
     4141 tgtttggatt tttaaggcca cctgatttct tcgtcatgca ttcggcattt gctaaatgac
     4201 agttactaca tcaatctgca actatcaaaa atgaggggaa aaggttcagg ctgttaacaa
     4261 ttccatgcag tatttaaata catttacttt ggcagagttt ataccctccc cttgttttct
     4321 tgctttattc tgggcaagtt tgaaggggaa aatttgtgct gctgttagtg caactgctgt
     4381 gtatgttgag ccactgttgt catgccagcc aggtgcaaag gcagcttagc tactgaggta
     4441 gcgaatgttc tgaggacatt ctagacaaca gcttagttcc tttttcaggc tcatttgctt
     4501 ttgctttttt gttgaatgat tccaatcgta aataaagctt ttaataattt tgtgaatttt
     4561 ttggttgttg ttccctgaac tactgtctat atttaaaatt agatggaatc caaagataca
     4621 cgggattaat agtatatttt tttattcttg attaggtttg ggttattgaa ctatttttta
     4681 cttttgagac cacaaccata ttcaatatca taccataatg tgtcatagct ataggcacaa
     4741 gaaaaacaac agtttgagag aatattatat aagatgatgt gccctgttaa aaggaggagg
     4801 caaaatagtc aaacccaggg tagtttacac ttaatgctag ggaggctctt aaaacattat
     4861 tagattttga ggaaagactc tctagatata ttttctaatg ttcagtacaa taaatataag
     4921 gaagctaaaa caccaatgtg gaattcctgt ttccagataa catgtatatt cttctataga
     4981 gtgacaggat caattgcata agcgcaaagc cttaaattgc tggtttagag aagacccttt
     5041 tttcattcag attctttgtt cgtagagcag ttatttgaaa aacagttatg gaacacaaaa
     5101 cattttatag atttaatatc ataacattgc aaatttttct tgtattattc acaccactgg
     5161 ttatactttt ttttttcctt ttttattgat tgggcctgaa tacaggcttt ctagagatct
     5221 ttttcattaa tacttttaaa tacctttcag gtagttacat catgtttctt cattggattt
     5281 gtaaaacttg aagccataaa aatattagtt tggtgtgtat tggggaaaat agctaaaagt
     5341 ctaattttta cccatttaga ctttgttatt tccttgtata aagtgacaaa tcggggctct
     5401 tgtatcagtg ccagctgtaa tgtttttaaa tgcagtggct gccttctatt gtcttcctat
     5461 ttttgataat gcagattgtt gggaaatctg taaggaagta actgattcca ggcaaattgt
     5521 tttcttcctt ctacccaccc caacccctac ccatcacctt ttaagaacat agtacgccag
     5581 tgtaacgtgg gaaccattga gattgtattt gccctgagta ttaaagctag cttagcaaaa
     5641 tacttttaaa aacatattgg taaatgatac ccgtaaaatt aaattagtta tattttattt
     5701 taaaatgcaa aatacattga tatttattaa tcattggatt tagggaaagg gacagatttt
     5761 tggtgaacct gacttgtggc agatggtaag gaatattata aaacatttgg atgagaacaa
     5821 tcagggcgaa ctgcattttt ctgttacact ggtaatcatt tgaaaattga tttacctcag
     5881 tgtttaacag ttttttgttt tgttttgttt tttaaataat aactaattgt cgagcactga
     5941 tagagatgca gattttggtg gggggaggtg gtgggggaga taatcacttc accaactgca
     6001 gtgcatttgt gtgtttttaa ccctcagaga actctgcatt ttagggtact tgaggctgac
     6061 ttaactaaaa gttttaaagt aacctttttt ccattgtaaa tatttctgta aatactacca
     6121 attggaaatt agaacagtag agtacttttc tgaatccaat cctattttta ttttatacag
     6181 tatttctcag ctgtgatctt tggagcaaaa gccaacggca ggaaaaaata gtttgtacca
     6241 gtttcatgaa gtatgtcttt gggtttttgt aaataatttt aactcaaata aaattgctac
     6301 tttcaataca
//
