LOCUS       NM_016628               5912 bp    mRNA    linear   PRI 10-OCT-2024
DEFINITION  Homo sapiens WW domain containing adaptor with coiled-coil (WAC),
            transcript variant 1, mRNA.
ACCESSION   NM_016628 NM_018604
VERSION     NM_016628.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5912)
  AUTHORS   Morales,J.A., Valenzuela,I., Cusco,I., Cogne,B., Isidor,B.,
            Matalon,D.R. and Gomez-Ospina,N.
  TITLE     Clinical and molecular characterization of five new individuals
            with WAC-related intellectual disability: Evidence of pathogenicity
            for a novel splicing variant
  JOURNAL   Am J Med Genet A 188 (5), 1396-1406 (2022)
   PUBMED   35018708
  REMARK    GeneRIF: Clinical and molecular characterization of five new
            individuals with WAC-related intellectual disability: Evidence of
            pathogenicity for a novel splicing variant.
REFERENCE   2  (bases 1 to 5912)
  AUTHORS   Wang,Y., Zhang,S., Sun,Q., Yuan,F., Zhao,L., Ye,Z., Li,Y., Wang,R.,
            Jiang,H., Hu,P., Tian,D. and Liu,B.
  TITLE     WAC, a novel GBM tumor suppressor, induces GBM cell apoptosis and
            promotes autophagy
  JOURNAL   Med Oncol 38 (11), 132 (2021)
   PUBMED   34581882
  REMARK    GeneRIF: WAC, a novel GBM tumor suppressor, induces GBM cell
            apoptosis and promotes autophagy.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5912)
  AUTHORS   Wahlster,L., Verboon,J.M., Ludwig,L.S., Black,S.C., Luo,W.,
            Garg,K., Voit,R.A., Collins,R.L., Garimella,K., Costello,M.,
            Chao,K.R., Goodrich,J.K., DiTroia,S.P., O'Donnell-Luria,A.,
            Talkowski,M.E., Michelson,A.D., Cantor,A.B. and Sankaran,V.G.
  TITLE     Familial thrombocytopenia due to a complex structural variant
            resulting in a WAC-ANKRD26 fusion transcript
  JOURNAL   J Exp Med 218 (6) (2021)
   PUBMED   33857290
  REMARK    GeneRIF: Familial thrombocytopenia due to a complex structural
            variant resulting in a WAC-ANKRD26 fusion transcript.
REFERENCE   4  (bases 1 to 5912)
  AUTHORS   Alawadhi,A., Morgan,A.T., Mucha,B.E., Scheffer,I.E. and Myers,K.A.
  TITLE     Self-limited focal epilepsy and childhood apraxia of speech with
            WAC pathogenic variants
  JOURNAL   Eur J Paediatr Neurol 30, 25-28 (2021)
   PUBMED   33387902
  REMARK    GeneRIF: Self-limited focal epilepsy and childhood apraxia of
            speech with WAC pathogenic variants.
REFERENCE   5  (bases 1 to 5912)
  AUTHORS   McKnight,N.C., Jefferies,H.B., Alemu,E.A., Saunders,R.E.,
            Howell,M., Johansen,T. and Tooze,S.A.
  TITLE     Genome-wide siRNA screen reveals amino acid starvation-induced
            autophagy requires SCOC and WAC
  JOURNAL   EMBO J 31 (8), 1931-1946 (2012)
   PUBMED   22354037
  REMARK    GeneRIF: The identification of SCOC and WAC as novel regulatory
            proteins with diverse functions in autophagy contributes towards a
            fuller understanding of autophagosome formation.
REFERENCE   6  (bases 1 to 5912)
  AUTHORS   Zhang,F. and Yu,X.
  TITLE     WAC, a functional partner of RNF20/40, regulates histone H2B
            ubiquitination and gene transcription
  JOURNAL   Mol Cell 41 (4), 384-397 (2011)
   PUBMED   21329877
REFERENCE   7  (bases 1 to 5912)
  AUTHORS   Kaltenbach,L.S., Romero,E., Becklin,R.R., Chettier,R., Bell,R.,
            Phansalkar,A., Strand,A., Torcassi,C., Savage,J., Hurlburt,A.,
            Cha,G.H., Ukani,L., Chepanoske,C.L., Zhen,Y., Sahasrabudhe,S.,
            Olson,J., Kurschner,C., Ellerby,L.M., Peltier,J.M., Botas,J. and
            Hughes,R.E.
  TITLE     Huntingtin interacting proteins are genetic modifiers of
            neurodegeneration
  JOURNAL   PLoS Genet 3 (5), e82 (2007)
   PUBMED   17500595
REFERENCE   8  (bases 1 to 5912)
  AUTHORS   Xu,G.M. and Arnaout,M.A.
  TITLE     WAC, a novel WW domain-containing adapter with a coiled-coil
            region, is colocalized with splicing factor SC35
  JOURNAL   Genomics 79 (1), 87-94 (2002)
   PUBMED   11827461
REFERENCE   9  (bases 1 to 5912)
  AUTHORS   Sudol,M., Sliwa,K. and Russo,T.
  TITLE     Functions of WW domains in the nucleus
  JOURNAL   FEBS Lett 490 (3), 190-195 (2001)
   PUBMED   11223034
  REMARK    Review article
REFERENCE   10 (bases 1 to 5912)
  AUTHORS   Varvagiannis,K., de Vries,B.B.A. and Vissers,L.E.L.M.
  TITLE     WAC-Related Intellectual Disability
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   29190062
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL358234.14, CB143386.1,
            AK290174.1 and AL161936.15.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_016628.4.
            
            Summary: The protein encoded by this gene contains a WW domain,
            which is a protein module found in a wide range of signaling
            proteins. This domain mediates protein-protein interactions and
            binds proteins containing short linear peptide motifs that are
            proline-rich or contain at least one proline. This gene product
            shares 94% sequence identity with the WAC protein in mouse,
            however, its exact function is not known. Alternative splicing
            results in multiple transcript variants. [provided by RefSeq, Dec
            2008].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.223900.1,
                                           SRR1660805.173887.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000354911.9/ ENSP00000346986.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-374               AL358234.14        89372-89745
            375-382             CB143386.1         180-187
            383-2550            AK290174.1         14-2181
            2551-5912           AL161936.15        74075-77436
FEATURES             Location/Qualifiers
     source          1..5912
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10p12.1"
     gene            1..5912
                     /gene="WAC"
                     /gene_synonym="BM-016; DESSH; PRO1741; Wwp4"
                     /note="WW domain containing adaptor with coiled-coil"
                     /db_xref="GeneID:51322"
                     /db_xref="HGNC:HGNC:17327"
                     /db_xref="MIM:615049"
     exon            1..503
                     /gene="WAC"
                     /gene_synonym="BM-016; DESSH; PRO1741; Wwp4"
                     /inference="alignment:Splign:2.1.0"
     CDS             463..2406
                     /gene="WAC"
                     /gene_synonym="BM-016; DESSH; PRO1741; Wwp4"
                     /note="isoform 1 is encoded by transcript variant 1; WW
                     domain-containing adapter protein with coiled-coil"
                     /codon_start=1
                     /product="WW domain-containing adapter protein with
                     coiled-coil isoform 1"
                     /protein_id="NP_057712.2"
                     /db_xref="CCDS:CCDS7159.1"
                     /db_xref="GeneID:51322"
                     /db_xref="HGNC:HGNC:17327"
                     /db_xref="MIM:615049"
                     /translation="MVMYARKQQRLSDGCHDRRGDSQPYQALKYSSKSHPSSGDHRHE
                     KMRDAGDPSPPNKMLRRSDSPENKYSDSTGHSKAKNVHTHRVRERDGGTSYSPQENSH
                     NHSALHSSNSHSSNPSNNPSKTSDAPYDSADDWSEHISSSGKKYYYNCRTEVSQWEKP
                     KEWLEREQRQKEANKMAVNSFPKDRDYRREVMQATATSGFASGMEDKHSSDASSLLPQ
                     NILSQTSRHNDRDYRLPRAETHSSSTPVQHPIKPVVHPTATPSTVPSSPFTLQSDHQP
                     KKSFDANGASTLSKLPTPTSSVPAQKTERKESTSGDKPVSHSCTTPSTSSASGLNPTS
                     APPTSASAVPVSPVPQSPIPPLLQDPNLLRQLLPALQATLQLNNSNVDISKINEVLTA
                     AVTQASLQSIIHKFLTAGPSAFNITSLISQAAQLSTQAQPSNQSPMSLTSDASSPRSY
                     VSPRISTPQTNTVPIKPLISTPPVSSQPKVSTPVVKQGPVSQSATQQPVTADKQQGHE
                     PVSPRSLQRSSSQRSPSPGPNHTSNSSNASNATVVPQNSSARSTCSLTPALAAHFSEN
                     LIKHVQGWPADHAEKQASRLREEAHNMGTIHMSEICTELKNLRSLVRVCEIQATLREQ
                     RILFLRQQIKELEKLKNQNSFMV"
     exon            504..540
                     /gene="WAC"
                     /gene_synonym="BM-016; DESSH; PRO1741; Wwp4"
                     /inference="alignment:Splign:2.1.0"
     exon            541..736
                     /gene="WAC"
                     /gene_synonym="BM-016; DESSH; PRO1741; Wwp4"
                     /inference="alignment:Splign:2.1.0"
     exon            737..843
                     /gene="WAC"
                     /gene_synonym="BM-016; DESSH; PRO1741; Wwp4"
                     /inference="alignment:Splign:2.1.0"
     exon            844..959
                     /gene="WAC"
                     /gene_synonym="BM-016; DESSH; PRO1741; Wwp4"
                     /inference="alignment:Splign:2.1.0"
     exon            960..1072
                     /gene="WAC"
                     /gene_synonym="BM-016; DESSH; PRO1741; Wwp4"
                     /inference="alignment:Splign:2.1.0"
     exon            1073..1381
                     /gene="WAC"
                     /gene_synonym="BM-016; DESSH; PRO1741; Wwp4"
                     /inference="alignment:Splign:2.1.0"
     exon            1382..1627
                     /gene="WAC"
                     /gene_synonym="BM-016; DESSH; PRO1741; Wwp4"
                     /inference="alignment:Splign:2.1.0"
     exon            1628..1750
                     /gene="WAC"
                     /gene_synonym="BM-016; DESSH; PRO1741; Wwp4"
                     /inference="alignment:Splign:2.1.0"
     exon            1751..1899
                     /gene="WAC"
                     /gene_synonym="BM-016; DESSH; PRO1741; Wwp4"
                     /inference="alignment:Splign:2.1.0"
     exon            1900..2018
                     /gene="WAC"
                     /gene_synonym="BM-016; DESSH; PRO1741; Wwp4"
                     /inference="alignment:Splign:2.1.0"
     exon            2019..2208
                     /gene="WAC"
                     /gene_synonym="BM-016; DESSH; PRO1741; Wwp4"
                     /inference="alignment:Splign:2.1.0"
     exon            2209..2336
                     /gene="WAC"
                     /gene_synonym="BM-016; DESSH; PRO1741; Wwp4"
                     /inference="alignment:Splign:2.1.0"
     exon            2337..5912
                     /gene="WAC"
                     /gene_synonym="BM-016; DESSH; PRO1741; Wwp4"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2749
                     /gene="WAC"
                     /gene_synonym="BM-016; DESSH; PRO1741; Wwp4"
                     /note="major polyA site"
     regulatory      3766..3771
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WAC"
                     /gene_synonym="BM-016; DESSH; PRO1741; Wwp4"
                     /note="hexamer: AATAAA"
     regulatory      3774..3779
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WAC"
                     /gene_synonym="BM-016; DESSH; PRO1741; Wwp4"
                     /note="hexamer: AAGAAA"
     polyA_site      3791
                     /gene="WAC"
                     /gene_synonym="BM-016; DESSH; PRO1741; Wwp4"
                     /note="major polyA site"
     polyA_site      3796
                     /gene="WAC"
                     /gene_synonym="BM-016; DESSH; PRO1741; Wwp4"
                     /note="major polyA site"
     regulatory      5793..5798
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WAC"
                     /gene_synonym="BM-016; DESSH; PRO1741; Wwp4"
                     /note="hexamer: AATAAA"
     polyA_site      5813
                     /gene="WAC"
                     /gene_synonym="BM-016; DESSH; PRO1741; Wwp4"
     regulatory      5887..5892
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WAC"
                     /gene_synonym="BM-016; DESSH; PRO1741; Wwp4"
                     /note="hexamer: AATACA"
     polyA_site      5912
                     /gene="WAC"
                     /gene_synonym="BM-016; DESSH; PRO1741; Wwp4"
ORIGIN      
        1 gagttgcccg gatgtagttg gtggagcggc agcggcggca ccagcggcgg cggcggcggc
       61 gggaggagga ggaggagaag aaggaccagg cggcggcagc agcggcggcg gcggggggag
      121 gaggggagga ggcggcggag caggaggagg agaaggcgga ggaggcagtc gctctccgcg
      181 gggctgagcc ggacgcgtcg tcttgccccc ctccccccgg ttcgcggtgc cgccgtgtag
      241 ttggcgccgc tgccccggct gagagtgagc gtggtgtcga cggagggaga tggcccggga
      301 gcgccggcgc cagtaactgg gagctgatga gagtcgccga gggcgcgccg ggcccaggtg
      361 ccggggctgc ccgccgcccg ccgccgccgc cgcctgcgcg cccgcccgcc tttcgcggcc
      421 gctctccccc ctccccgaca cacactcaca ggccgggcat tgatggtaat gtatgcgagg
      481 aaacagcaga gactcagtga tggctgtcac gaccggaggg gggactcgca gccttaccag
      541 gcacttaagt attcatcgaa gagtcacccc agtagcggtg atcacagaca tgaaaagatg
      601 cgagacgccg gagatccttc accaccaaat aaaatgttgc ggagatctga tagtcctgaa
      661 aacaaataca gtgacagcac aggtcacagt aaggccaaaa atgtgcatac tcacagagtt
      721 agagagaggg atggtgggac cagttactct ccacaagaaa attcacacaa ccacagtgct
      781 cttcatagtt caaattcaca ttcttctaat ccaagcaata acccaagcaa aacttcagat
      841 gcaccttatg attctgcaga tgactggtct gagcatatta gctcttctgg gaaaaagtac
      901 tactacaatt gtcgaacaga agtttcacaa tgggaaaaac caaaagagtg gcttgaaaga
      961 gaacagagac aaaaagaagc aaacaagatg gcagtcaaca gcttcccaaa agatagggat
     1021 tacagaagag aggtgatgca agcaacagcc actagtgggt ttgccagtgg aatggaagac
     1081 aagcattcca gtgatgccag tagtttgctc ccacagaata ttttgtctca aacaagcaga
     1141 cacaatgaca gagactacag actgccaaga gcagagactc acagtagttc tacgccagta
     1201 cagcacccca tcaaaccagt ggttcatcca actgctaccc caagcactgt tccttctagt
     1261 ccatttacgc tacagtctga tcaccagcca aagaaatcat ttgatgctaa tggagcatct
     1321 actttatcaa aactgcctac acccacatct tctgtccctg cacagaaaac agaaagaaaa
     1381 gaatctacat caggagacaa acccgtatca cattcttgca caactccttc cacgtcttct
     1441 gcctctggac tgaaccccac atctgcacct ccaacatctg cttcagcggt ccctgtttct
     1501 cctgttccac agtcgccaat acctccctta cttcaggacc caaatcttct tagacaattg
     1561 cttcctgctt tgcaagccac gctgcagctt aataattcta atgtggacat atctaaaata
     1621 aatgaagttc ttacagcagc tgtgacacaa gcctcactgc agtctataat tcataagttt
     1681 cttactgctg gaccatctgc tttcaacata acgtctctga tttctcaagc tgctcagctc
     1741 tctacacaag cccagccatc taatcagtct ccgatgtctt taacatctga tgcgtcatcc
     1801 ccaagatcat atgtttctcc aagaataagc acacctcaaa ctaacacagt ccctatcaaa
     1861 cctttgatca gtactcctcc tgtttcatca cagccaaagg ttagtactcc agtagttaag
     1921 caaggaccag tgtcacagtc agccacacag cagcctgtaa ctgctgacaa gcagcaaggt
     1981 catgaacctg tctctcctcg aagtcttcag cgctcaagta gccagagaag tccatcacct
     2041 ggtcccaatc atacttctaa tagtagtaat gcatcaaatg caacagttgt accacagaat
     2101 tcttctgccc gatccacgtg ttcattaacg cctgcactag cagcacactt cagtgaaaat
     2161 ctcataaaac acgttcaagg atggcctgca gatcatgcag agaagcaggc atcaagatta
     2221 cgcgaagaag cgcataacat gggaactatt cacatgtccg aaatttgtac tgaattaaaa
     2281 aatttaagat ctttagtccg agtatgtgaa attcaagcaa ctttgcgaga gcaaaggata
     2341 ctatttttga gacaacaaat taaggaactt gaaaagctaa aaaatcagaa ttccttcatg
     2401 gtgtgaagat gtgaataatt gcacatggtt ttgagaacag gaactgtaaa tctgttgccc
     2461 aatcttaaca tttttgagct gcatttaagt agactttgga ccgttaagct gggcaaagga
     2521 aatgacaagg ggacggggtc tgtgagagtc aattcagggg aaagatacaa gattgatttg
     2581 taaaaccctt gaaatgtaga tttcttgtag atgtatcctt cacgttgtaa atatgttttg
     2641 tagagtgaag ccatgggaag ccatgtgtaa cagagcttag acatccaaaa ctaatcaatg
     2701 ctgaggtggc taaataccta gccttttaca tgtaaacctg tctgcaaaat tagctttttt
     2761 aaaaaaaaaa aaaaaaaaat tgggggggtt aatttatcat tcagaaatct tgcattttca
     2821 aaaattcagt gcaagcgcca ggcgatttgt gtctaaggat acgattttga accatatggg
     2881 cagtgtacaa aatatgaaac aactgtttcc acacttgcac ctgatcaaga gcagtgcttc
     2941 tccatttgtt ttgcagagaa atgtttttca tttcccgtgt gtttccattt ccttctgaaa
     3001 ttctgatttt atccattttt ttaaggctcc tctttatctc ctttcttaag gcactgttgc
     3061 tatggcactt ttctataacc ttttcattcc tgtgtacagt agcttaaaat tgcagtgatt
     3121 gagcataacc tacttgtttg tataaattat tgaaatccat ttgcaccctg ttaagaatgg
     3181 acttaaaagt actgctggac aggcatgtgt gctcaaagta cattgattgc tcaaatataa
     3241 ggaaatggcc caatgaacgt ggttgtggga ggggaaagag gaaacagagc tagtcagatg
     3301 tgaattgtat ctgttgtaat aaacatgtta aaacaaacaa aaattgttat ttttcttttc
     3361 cttcggtcag tgcacattag catttgaact acctggggat tctttatcag aactgttctt
     3421 gttgaatatt tatacttaat tgaaataatt ccttaaggga ggttttgttt aaaacgtatt
     3481 aacaggaaat tgtgtatgag atatttaatg aaataagaaa ttcaacaaga atgattaagt
     3541 cacttcccaa gtggttgtca tttgttaaac cctggtttac ctgtcttgct attatgacat
     3601 ttcatttgga aggatgtttg tgttgtagct aactgttcaa gtctggtgct gactgctgtt
     3661 cttagccatc acaaaacgct aaatttgtgt aattggagct tcctgctgtt atctggaaat
     3721 agcaggaaag cgcagctttg tatattgttt cctaaagtat attaaaataa aaaaagaaac
     3781 tattgctact ataaaattac cttgactttt tttttccttt gctgaaatat tagtcacata
     3841 gccttagctt cacactgcca gtaatgtatc aaatcacaag ggtttccgca tgaaaaaaat
     3901 cttttcttcc cccacaaaaa aacctttacc atcaaaatct tgccatctga tttagaaagg
     3961 tgtttcttct tcttcttctt ttttttcttt aaattggttt agggtttttt ggtgattttt
     4021 tttttttttt tttttctgtt ggggcagata agtgcttcca aaactggcag caccaagggc
     4081 ttatttttta tgttagacat caatgtcaat gttactacat tctcggatgc taacataaat
     4141 tttgaaattg ctcttgtgct ttaagcatat attgaaagta tggaagttaa atgttcaggc
     4201 ttttcagtaa gctcaaaaag ttaactgtaa gcgatagtgt tggtgttttc taaaatacaa
     4261 aaatgttcca gtgtaattaa aaggaattaa aatcttgaag atattttcct gtaatttaag
     4321 gatacttttt aaatgtaaga aaagacatgt cattaattta ttgtcatgtt tatacctctg
     4381 tgagattgtt aacatctgct gaatttaact agtgcatgta aatgaaaccc caaagagctg
     4441 tgtgttcagc tagaaacctt actgtatctt tcctggaaag aagtgagcaa tttgttgtaa
     4501 taggcaaatg tttcctgatc agatggcaat ttgtgattta ggtaaatttg aatttgattt
     4561 gcttatagtc tactggtctg tgtacctatg ttttgttttt caaaaaagtt tacatcccta
     4621 aatgaattag tcacatatat ttaggagaag atgcctaatt tggtatttct taatagtgaa
     4681 tttttttttt tcttgagaca gagtttcact cttgttgccc aggctggagt gcaatggcac
     4741 gatctcggct caccgcaacc tctgcctcct gggttcaagc gattctcctg cctcggcgtt
     4801 ccgagtagct gggattacag gcatgcacca ccacgcctgg ctaattttgt atttttagta
     4861 gagatggggt ttctccatgt tggtcaggct ggtcttgaac tgccaacttc aggtgatctg
     4921 cctgccttgg cctcccaaag tgctgggatt acaggcgtga gccaccgctc ctggccagta
     4981 gtgaattttt aaacacagaa aatctaaaat tttgtggaaa tattttaaat attgcacctt
     5041 aatacaaggt atccagctcc taaccttaac tagggaatat ctattaaaat aagcataatg
     5101 ttctggacta gagtattcct tatctagttg gttatggatt tgaacatgta ccttggttta
     5161 gatactttga aaatagaagt actgaatagc ctctagggaa cttgagtggc ctttccctcc
     5221 ccctgccccc cccccccccc ccccgtttta aaagatcagt agtctctatt caaactttta
     5281 aaatgtcgtg gtattgtaac aatatatttg atgaaagaag gttacagact cccctgaaga
     5341 accagctttc ctacgctttt tatttttcta acttgtctaa cctgatttta aaatgactgc
     5401 aattccagac taaaaacatg cttcagccct gtttcaagac attatgcttc ttttaacagt
     5461 ccaaattagt agttttattt ttcttctaaa tctttgtttc acacttgtaa aatcttggga
     5521 aggaggttct taaaactttg ccaggaattg ttacccattt ccaaaaacag tttattatgt
     5581 tcaaaaacca ccatatcttt gagggactgt ttgaaagggg agagggcaac gcgggaaata
     5641 attcactctg cgcaccggaa ctattgtagt tcaggacttc cagctactgt atttagatgt
     5701 tgggtttgaa tatacagatt tcttttcaat acctgtaaat atggctatat tcttgtattt
     5761 gtacgggagt gtacaaaatg acactgaaaa gtaataaata tgttttgact atattgtgca
     5821 gttatttcag aactgtgttt tgaaagtctt agaatgcata atttgcattt gagtaaggaa
     5881 atttaaaata cagattactg ctgagatttt aa
//
