LOCUS       NM_152765               3155 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens vexin (VXN), mRNA.
ACCESSION   NM_152765
VERSION     NM_152765.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3155)
  AUTHORS   Koshimizu,H., Suzuki,S., Kawai,A., Miura,R., Ohta,K.I., Miki,T.,
            Adachi,N. and Matsuoka,H.
  TITLE     Vexin is upregulated in cerebral cortical neurons by brain-derived
            neurotrophic factor
  JOURNAL   Neuropsychopharmacol Rep 40 (3), 275-280 (2020)
   PUBMED   32558188
  REMARK    GeneRIF: Vexin is upregulated in cerebral cortical neurons by
            brain-derived neurotrophic factor.
REFERENCE   2  (bases 1 to 3155)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 3155)
  AUTHORS   Moore,K.B., Logan,M.A., Aldiri,I., Roberts,J.M., Steele,M. and
            Vetter,M.L.
  TITLE     C8orf46 homolog encodes a novel protein Vexin that is required for
            neurogenesis in Xenopus laevis
  JOURNAL   Dev Biol 437 (1), 27-40 (2018)
   PUBMED   29518376
REFERENCE   4  (bases 1 to 3155)
  AUTHORS   Pandey,A.K., Lu,L., Wang,X., Homayouni,R. and Williams,R.W.
  TITLE     Functionally enigmatic genes: a case study of the brain ignorome
  JOURNAL   PLoS One 9 (2), e88889 (2014)
   PUBMED   24523945
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC028400.2, AK055047.1 and H17010.1.
            
            On Nov 23, 2018 this sequence version replaced NM_152765.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.255526.1,
                                           SRR1803615.221105.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2145743
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000305454.8/ ENSP00000302260.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1710              BC028400.2         35-1744
            1711-2670           AK055047.1         1355-2314
            2671-3136           BC028400.2         2706-3171
            3137-3155           H17010.1           7-25                c
FEATURES             Location/Qualifiers
     source          1..3155
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q13.1"
     gene            1..3155
                     /gene="VXN"
                     /gene_synonym="C8orf46"
                     /note="vexin"
                     /db_xref="GeneID:254778"
                     /db_xref="HGNC:HGNC:28498"
     exon            1..153
                     /gene="VXN"
                     /gene_synonym="C8orf46"
                     /inference="alignment:Splign:2.1.0"
     CDS             84..707
                     /gene="VXN"
                     /gene_synonym="C8orf46"
                     /note="uncharacterized protein C8orf46"
                     /codon_start=1
                     /product="vexin"
                     /protein_id="NP_689978.2"
                     /db_xref="CCDS:CCDS6191.2"
                     /db_xref="GeneID:254778"
                     /db_xref="HGNC:HGNC:28498"
                     /translation="MMHQIYSCSDENIEVFTTVIPSKVSSPARRRAKSSQHLLTKNVV
                     IESDLYTHQPLELLPHRGDRRDPGDRRRFGRLQTARPPTAHPAKASARPVGISEPKTS
                     NLCGNRAYGKSLIPPVPRISVKTSASASLEATAMGTEKGAVLMRGSRHLKKMTEEYPA
                     LPQGAEASLPLTGSASCGVPGILRKMWTRHKKKSEYVGATNSAFEAD"
     exon            154..209
                     /gene="VXN"
                     /gene_synonym="C8orf46"
                     /inference="alignment:Splign:2.1.0"
     exon            210..363
                     /gene="VXN"
                     /gene_synonym="C8orf46"
                     /inference="alignment:Splign:2.1.0"
     exon            364..425
                     /gene="VXN"
                     /gene_synonym="C8orf46"
                     /inference="alignment:Splign:2.1.0"
     exon            426..523
                     /gene="VXN"
                     /gene_synonym="C8orf46"
                     /inference="alignment:Splign:2.1.0"
     exon            524..3155
                     /gene="VXN"
                     /gene_synonym="C8orf46"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3108..3113
                     /regulatory_class="polyA_signal_sequence"
                     /gene="VXN"
                     /gene_synonym="C8orf46"
                     /note="hexamer: AATAAA"
     regulatory      3114..3119
                     /regulatory_class="polyA_signal_sequence"
                     /gene="VXN"
                     /gene_synonym="C8orf46"
                     /note="hexamer: AATAAA"
     polyA_site      3125
                     /gene="VXN"
                     /gene_synonym="C8orf46"
                     /note="major polyA site"
     polyA_site      3155
                     /gene="VXN"
                     /gene_synonym="C8orf46"
ORIGIN      
        1 agactggatt aggatgcctc gcgactaggg gtccagagac agaggcctcc agttcccagg
       61 cacttcggga agaggaggct gaaatgatgc atcagattta cagctgcagt gacgagaaca
      121 tagaagtttt caccaccgtg attccttcca aggtatccag tccagccaga agaagagcca
      181 aaagctctca gcacctcttg accaagaatg tggtgatcga gtcggacctg tacacgcacc
      241 agcccctgga gctgctgccc caccgcggag accgcaggga ccctggcgac cgccgcaggt
      301 ttgggcggct ccagaccgcg cggccgccca cagcccaccc ggccaaagcc tctgccagac
      361 ccgtggggat ttctgaaccc aaaacatcaa atctgtgtgg gaatcgagca tatggaaaat
      421 ctctgatacc gccagtgccc cggatctcag tgaaaacttc agcctctgcc tcattggagg
      481 cgacagccat gggcacagag aagggagctg ttctgatgag aggatccaga catctcaaga
      541 agatgactga agagtatcca gcccttcccc aaggagcaga agcctctcta ccactgacag
      601 gcagtgcttc ctgcggcgtc cccggcatcc tccggaaaat gtggacaagg cacaagaaga
      661 agtctgaata tgtgggagcc accaacagcg cctttgaggc cgactaaagg tgaccctctt
      721 caagtgccct gtgttggcca aggttccccg gacaagagga aaaaccttca ggattgaaac
      781 tgagccacac gcacctctgc tagtagctgg tccaaaccca ttatcctccc tcactcattg
      841 attaccctgg gatagggcac aggaaagaaa tgtccctcga aggcaatata aaactgcccc
      901 ttcttagaat tgctaaagcc attggtctga aagtgacttt gggaggtcat aaagtttgta
      961 tctctatctt taagcaaaaa attaaacttt cccagctcat tttaaagacc tccaaggaag
     1021 gaaaaaagca attcctctgt cttccttgtg agttgctcta aagtgtgtga ttttctagtg
     1081 taaatggact ttgaggcact tgtaaacaca atggttctta ctgtttccat tactgcattt
     1141 acttcacctt gacaaggtac aattttcaag gacaaagcac tatatataaa gttagtagtt
     1201 ctaatatcca cttgagagta tactcaagat tgattttcat ggccatttgg catgattgca
     1261 tgaattctct attcttttat gtgcagtttt tctatagaaa aacattaaaa gttaaatgtt
     1321 gactgctaat gttttctgaa gtggcatagt ctagtggaat caataatccc ttgctttggt
     1381 ataataattt gaacttttga aagtgctttc tcatccgtta tctcttatct tcacaaaacc
     1441 cctgtggaag aaagcacaat tattcccaat ctgcagaggg ggaaatggag gccttcagag
     1501 attacaggac cagataccag gtagtggaac cagacagcag gtccttaact tctctccagt
     1561 ggactccctg ctttgcctac tctctagcaa ctgacttggg gaagttttta aatggtgaga
     1621 gtgtgtctct gggggcaacc attgaaaaga agactctgat atgttggaac aagtaaggga
     1681 tttgaatgaa atacactatt atatcttata tgttagcttg aaccagaaaa agttgacatt
     1741 tttgtaggtc aaaaacaatt gagcatcaat ttcatatggt tcaacctcat atatgatact
     1801 atgcttttct tctatcagtg aaaatgtcat catcaattcc attgtcaaca ttagtagcct
     1861 taaaacaata acataataat aatgatgata atgatactta tagctatcat ctattaaatg
     1921 cctatgtttc aggcatgata ctaggcaatt tatatatatc atcctaatct ttctaaaaac
     1981 tctattaggt ggccctatcc acttaataga tgccaattca aagaggttaa atgattagac
     2041 taaggcacct aacttatgtg agtgtcaggc ttcaatgcct gtgttagagc tactccttca
     2101 cacaaaatag ttcagaacat agagaaggac caaggttaat aaatgatttt catcccaaac
     2161 actaaacatg attgatgggt agaggctgcc cgaagtactg tgtaaagatg gaatctgaga
     2221 tagaagaatg ctgtggtcaa ttagtaattc ttgcccatgg agggattagt gacacatgcc
     2281 ttgtatattt gtcatctgtg gcctaaactc tgcccctgaa ggtttgtttt ctaattcaga
     2341 ggtttaaatt aatctagccc acttaataaa accagagatc ctatgggaaa tttagcctaa
     2401 gacagtgctg gaaattgcca tatgttgata caaagaagtg tttggccaca ttacaggtct
     2461 cagactcaac tgctatgtgt gactgccgct ctgtgcctat gtcttgcttt tttgctgagt
     2521 tccctatttc catatctcca ggtgaatcca tgagaagcga gagggtggct gagaggcctg
     2581 ggcctctggg attccacctt gctatctctg ctcttcaacc attgttttag actctgaaca
     2641 ccagatcctc atatctgaaa gtgatttgga gacctgggca tcaagtgctc ttttaagaag
     2701 gggctatccc agaggactgt tcaaaagtct cattcaatag agatgttgga gtccagaaca
     2761 aagttaggga gcaaaccagt aacctatgct ggtcgtaaca gaggatccta caattacgtt
     2821 tgtttttaag acaggatttt gctgtgttgc ccagactggt ctcaaactcc tgggttcaag
     2881 agatccatcc tcccacctca gtctcctgaa agctgggatg acaggcacat gccaccacac
     2941 ctagctcctt acaaccattt attttaactt atttcattta taactggtat ctttcatttg
     3001 tatgtggcag ctagagattt atataggatg gaagtaattt atttttaatt taaatatttc
     3061 atgttgaact gtttgccttg tatggaacat tttacttggc caattcaaat aaaaataaag
     3121 tcagctttgt ttgtgacatt catgcaccac cataa
//
