LOCUS       NM_000552               8830 bp    mRNA    linear   PRI 10-DEC-2024
DEFINITION  Homo sapiens von Willebrand factor (VWF), mRNA.
ACCESSION   NM_000552
VERSION     NM_000552.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8830)
  AUTHORS   Otmani,H.E., Vanhoorelbeke,K. and Tersteeg,C.
  TITLE     Improving our understanding on the clinical role of
            plasmin-mediated von Willebrand factor degradation
  JOURNAL   Curr Opin Hematol 31 (5), 245-250 (2024)
   PUBMED   38723202
  REMARK    GeneRIF: Improving our understanding on the clinical role of
            plasmin-mediated von Willebrand factor degradation.
            Review article
REFERENCE   2  (bases 1 to 8830)
  AUTHORS   Karampini,E., Doherty,D., Burgisser,P.E., Garre,M., Schoen,I.,
            Elliott,S., Bierings,R. and O'Donnell,J.S.
  TITLE     O-glycan determinants regulate VWF trafficking to Weibel-Palade
            bodies
  JOURNAL   Blood Adv 8 (12), 3254-3266 (2024)
   PUBMED   38640438
  REMARK    GeneRIF: O-glycan determinants regulate VWF trafficking to
            Weibel-Palade bodies.
REFERENCE   3  (bases 1 to 8830)
  AUTHORS   de Vries,P.S., Reventun,P., Brown,M.R., Heath,A.S., Huffman,J.E.,
            Le,N.Q., Bebo,A., Brody,J.A., Temprano-Sagrera,G., Raffield,L.M.,
            Ozel,A.B., Thibord,F., Jain,D., Lewis,J.P., Rodriguez,B.A.T.,
            Pankratz,N., Taylor,K.D., Polasek,O., Chen,M.H., Yanek,L.R.,
            Carrasquilla,G.D., Marioni,R.E., Kleber,M.E., Tregouet,D.A.,
            Yao,J., Li-Gao,R., Joshi,P.K., Trompet,S., Martinez-Perez,A.,
            Ghanbari,M., Howard,T.E., Reiner,A.P., Arvanitis,M., Ryan,K.A.,
            Bartz,T.M., Rudan,I., Faraday,N., Linneberg,A., Ekunwe,L.,
            Davies,G., Delgado,G.E., Suchon,P., Guo,X., Rosendaal,F.R.,
            Klaric,L., Noordam,R., van Rooij,F., Curran,J.E., Wheeler,M.M.,
            Osburn,W.O., O'Connell,J.R., Boerwinkle,E., Beswick,A., Psaty,B.M.,
            Kolcic,I., Souto,J.C., Becker,L.C., Hansen,T., Doyle,M.F.,
            Harris,S.E., Moissl,A.P., Deleuze,J.F., Rich,S.S., van Hylckama
            Vlieg,A., Campbell,H., Stott,D.J., Soria,J.M., de Maat,M.P.M.,
            Almasy,L., Brody,L.C., Auer,P.L., Mitchell,B.D., Ben-Shlomo,Y.,
            Fornage,M., Hayward,C., Mathias,R.A., Kilpelainen,T.O., Lange,L.A.,
            Cox,S.R., Marz,W., Morange,P.E., Rotter,J.I., Mook-Kanamori,D.O.,
            Wilson,J.F., van der Harst,P., Jukema,J.W., Ikram,M.A.,
            Blangero,J., Kooperberg,C., Desch,K.C., Johnson,A.D.,
            Sabater-Lleal,M., Lowenstein,C.J., Smith,N.L. and Morrison,A.C.
  TITLE     A genetic association study of circulating coagulation factor VIII
            and von Willebrand factor levels
  JOURNAL   Blood 143 (18), 1845-1855 (2024)
   PUBMED   38320121
  REMARK    GeneRIF: A genetic association study of circulating coagulation
            factor VIII and von Willebrand factor levels.
REFERENCE   4  (bases 1 to 8830)
  AUTHORS   Schulz,K., Donat,C., Punjabi,M., Glatz,K., Kaufmann,B. and
            Trendelenburg,M.
  TITLE     Complement C1q and von Willebrand factor interaction in
            atherosclerosis of human carotid artery
  JOURNAL   Front Immunol 14, 1265387 (2023)
   PUBMED   38155969
  REMARK    GeneRIF: Complement C1q and von Willebrand factor interaction in
            atherosclerosis of human carotid artery.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 8830)
  AUTHORS   Lenting,P.J., Christophe,O.D. and Denis,C.V.
  TITLE     von Willebrand factor biosynthesis, secretion, and clearance:
            connecting the far ends
  JOURNAL   Blood 125 (13), 2019-2028 (2015)
   PUBMED   25712991
  REMARK    Review article
REFERENCE   6  (bases 1 to 8830)
  AUTHORS   Johnsen,J.
  TITLE     Von Willebrand Disease
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301765
REFERENCE   7  (bases 1 to 8830)
  AUTHORS   Rabinowitz,I., Tuley,E.A., Mancuso,D.J., Randi,A.M., Firkin,B.G.,
            Howard,M.A. and Sadler,J.E.
  TITLE     von Willebrand disease type B: a missense mutation selectively
            abolishes ristocetin-induced von Willebrand factor binding to
            platelet glycoprotein Ib
  JOURNAL   Proc Natl Acad Sci U S A 89 (20), 9846-9849 (1992)
   PUBMED   1409710
REFERENCE   8  (bases 1 to 8830)
  AUTHORS   Lavergne,J.M., De Paillette,L., Bahnak,B.R., Ribba,A.S.,
            Fressinaud,E., Meyer,D. and Pietu,G.
  TITLE     Defects in type IIA von Willebrand disease: a cysteine 509 to
            arginine substitution in the mature von Willebrand factor disrupts
            a disulphide loop involved in the interaction with platelet
            glycoprotein Ib-IX
  JOURNAL   Br J Haematol 82 (1), 66-72 (1992)
   PUBMED   1419804
REFERENCE   9  (bases 1 to 8830)
  AUTHORS   Donner,M., Kristoffersson,A.C., Lenk,H., Scheibel,E., Dahlback,B.,
            Nilsson,I.M. and Holmberg,L.
  TITLE     Type IIB von Willebrand's disease: gene mutations and clinical
            presentation in nine families from Denmark, Germany and Sweden
  JOURNAL   Br J Haematol 82 (1), 58-65 (1992)
   PUBMED   1419803
REFERENCE   10 (bases 1 to 8830)
  AUTHORS   Sadler,J.E., Shelton-Inloes,B.B., Sorace,J.M., Harlan,J.M.,
            Titani,K. and Davie,E.W.
  TITLE     Cloning and characterization of two cDNAs coding for human von
            Willebrand factor
  JOURNAL   Proc Natl Acad Sci U S A 82 (19), 6394-6398 (1985)
   PUBMED   2864688
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CD690980.1, X04385.1,
            AC005846.1, DB293903.1, M10321.1, BQ898017.1 and AW015780.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Feb 27, 2020 this sequence version replaced NM_000552.4.
            
            Summary: This gene encodes a glycoprotein involved in hemostasis.
            The encoded preproprotein is proteolytically processed following
            assembly into large multimeric complexes. These complexes function
            in the adhesion of platelets to sites of vascular injury and the
            transport of various proteins in the blood. Mutations in this gene
            result in von Willebrand disease, an inherited bleeding disorder.
            An unprocessed pseudogene has been found on chromosome 22.
            [provided by RefSeq, Oct 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X04385.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000261405.10/ ENSP00000261405.5
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-151               CD690980.1         33-183
            152-2804            X04385.1           1-2653
            2805-2805           AC005846.1         85827-85827
            2806-4390           X04385.1           2655-4239
            4391-4860           DB293903.1         70-539
            4861-4890           X04385.1           4710-4739
            4891-4933           DB293903.1         569-611
            4934-5990           X04385.1           4783-5839
            5991-6609           M10321.1           3525-4143
            6610-7488           X04385.1           6459-7337
            7489-7798           BQ898017.1         421-730
            7799-8726           X04385.1           7648-8575
            8727-8826           M10321.1           6261-6360
            8827-8830           AW015780.1         21-24               c
FEATURES             Location/Qualifiers
     source          1..8830
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p13.31"
     gene            1..8830
                     /gene="VWF"
                     /gene_synonym="F8VWF; VWD"
                     /note="von Willebrand factor"
                     /db_xref="GeneID:7450"
                     /db_xref="HGNC:HGNC:12726"
                     /db_xref="MIM:613160"
     exon            1..250
                     /gene="VWF"
                     /gene_synonym="F8VWF; VWD"
                     /inference="alignment:Splign:2.1.0"
     CDS             251..8692
                     /gene="VWF"
                     /gene_synonym="F8VWF; VWD"
                     /note="coagulation factor VIII VWF; Factor VIII related
                     antigen"
                     /codon_start=1
                     /product="von Willebrand factor preproprotein"
                     /protein_id="NP_000543.3"
                     /db_xref="CCDS:CCDS8539.1"
                     /db_xref="GeneID:7450"
                     /db_xref="HGNC:HGNC:12726"
                     /db_xref="MIM:613160"
                     /translation="MIPARFAGVLLALALILPGTLCAEGTRGRSSTARCSLFGSDFVN
                     TFDGSMYSFAGYCSYLLAGGCQKRSFSIIGDFQNGKRVSLSVYLGEFFDIHLFVNGTV
                     TQGDQRVSMPYASKGLYLETEAGYYKLSGEAYGFVARIDGSGNFQVLLSDRYFNKTCG
                     LCGNFNIFAEDDFMTQEGTLTSDPYDFANSWALSSGEQWCERASPPSSSCNISSGEMQ
                     KGLWEQCQLLKSTSVFARCHPLVDPEPFVALCEKTLCECAGGLECACPALLEYARTCA
                     QEGMVLYGWTDHSACSPVCPAGMEYRQCVSPCARTCQSLHINEMCQERCVDGCSCPEG
                     QLLDEGLCVESTECPCVHSGKRYPPGTSLSRDCNTCICRNSQWICSNEECPGECLVTG
                     QSHFKSFDNRYFTFSGICQYLLARDCQDHSFSIVIETVQCADDRDAVCTRSVTVRLPG
                     LHNSLVKLKHGAGVAMDGQDVQLPLLKGDLRIQHTVTASVRLSYGEDLQMDWDGRGRL
                     LVKLSPVYAGKTCGLCGNYNGNQGDDFLTPSGLAEPRVEDFGNAWKLHGDCQDLQKQH
                     SDPCALNPRMTRFSEEACAVLTSPTFEACHRAVSPLPYLRNCRYDVCSCSDGRECLCG
                     ALASYAAACAGRGVRVAWREPGRCELNCPKGQVYLQCGTPCNLTCRSLSYPDEECNEA
                     CLEGCFCPPGLYMDERGDCVPKAQCPCYYDGEIFQPEDIFSDHHTMCYCEDGFMHCTM
                     SGVPGSLLPDAVLSSPLSHRSKRSLSCRPPMVKLVCPADNLRAEGLECTKTCQNYDLE
                     CMSMGCVSGCLCPPGMVRHENRCVALERCPCFHQGKEYAPGETVKIGCNTCVCQDRKW
                     NCTDHVCDATCSTIGMAHYLTFDGLKYLFPGECQYVLVQDYCGSNPGTFRILVGNKGC
                     SHPSVKCKKRVTILVEGGEIELFDGEVNVKRPMKDETHFEVVESGRYIILLLGKALSV
                     VWDRHLSISVVLKQTYQEKVCGLCGNFDGIQNNDLTSSNLQVEEDPVDFGNSWKVSSQ
                     CADTRKVPLDSSPATCHNNIMKQTMVDSSCRILTSDVFQDCNKLVDPEPYLDVCIYDT
                     CSCESIGDCACFCDTIAAYAHVCAQHGKVVTWRTATLCPQSCEERNLRENGYECEWRY
                     NSCAPACQVTCQHPEPLACPVQCVEGCHAHCPPGKILDELLQTCVDPEDCPVCEVAGR
                     RFASGKKVTLNPSDPEHCQICHCDVVNLTCEACQEPGGLVVPPTDAPVSPTTLYVEDI
                     SEPPLHDFYCSRLLDLVFLLDGSSRLSEAEFEVLKAFVVDMMERLRISQKWVRVAVVE
                     YHDGSHAYIGLKDRKRPSELRRIASQVKYAGSQVASTSEVLKYTLFQIFSKIDRPEAS
                     RITLLLMASQEPQRMSRNFVRYVQGLKKKKVIVIPVGIGPHANLKQIRLIEKQAPENK
                     AFVLSSVDELEQQRDEIVSYLCDLAPEAPPPTLPPDMAQVTVGPGLLGVSTLGPKRNS
                     MVLDVAFVLEGSDKIGEADFNRSKEFMEEVIQRMDVGQDSIHVTVLQYSYMVTVEYPF
                     SEAQSKGDILQRVREIRYQGGNRTNTGLALRYLSDHSFLVSQGDREQAPNLVYMVTGN
                     PASDEIKRLPGDIQVVPIGVGPNANVQELERIGWPNAPILIQDFETLPREAPDLVLQR
                     CCSGEGLQIPTLSPAPDCSQPLDVILLLDGSSSFPASYFDEMKSFAKAFISKANIGPR
                     LTQVSVLQYGSITTIDVPWNVVPEKAHLLSLVDVMQREGGPSQIGDALGFAVRYLTSE
                     MHGARPGASKAVVILVTDVSVDSVDAAADAARSNRVTVFPIGIGDRYDAAQLRILAGP
                     AGDSNVVKLQRIEDLPTMVTLGNSFLHKLCSGFVRICMDEDGNEKRPGDVWTLPDQCH
                     TVTCQPDGQTLLKSHRVNCDRGLRPSCPNSQSPVKVEETCGCRWTCPCVCTGSSTRHI
                     VTFDGQNFKLTGSCSYVLFQNKEQDLEVILHNGACSPGARQGCMKSIEVKHSALSVEL
                     HSDMEVTVNGRLVSVPYVGGNMEVNVYGAIMHEVRFNHLGHIFTFTPQNNEFQLQLSP
                     KTFASKTYGLCGICDENGANDFMLRDGTVTTDWKTLVQEWTVQRPGQTCQPILEEQCL
                     VPDSSHCQVLLLPLFAECHKVLAPATFYAICQQDSCHQEQVCEVIASYAHLCRTNGVC
                     VDWRTPDFCAMSCPPSLVYNHCEHGCPRHCDGNVSSCGDHPSEGCFCPPDKVMLEGSC
                     VPEEACTQCIGEDGVQHQFLEAWVPDHQPCQICTCLSGRKVNCTTQPCPTAKAPTCGL
                     CEVARLRQNADQCCPEYECVCDPVSCDLPPVPHCERGLQPTLTNPGECRPNFTCACRK
                     EECKRVSPPSCPPHRLPTLRKTQCCDEYECACNCVNSTVSCPLGYLASTATNDCGCTT
                     TTCLPDKVCVHRSTIYPVGQFWEEGCDVCTCTDMEDAVMGLRVAQCSQKPCEDSCRSG
                     FTYVLHEGECCGRCLPSACEVVTGSPRGDSQSSWKSVGSQWASPENPCLINECVRVKE
                     EVFIQQRNVSCPQLEVPVCPSGFQLSCKTSACCPSCRCERMEACMLNGTVIGPGKTVM
                     IDVCTTCRCMVQVGVISGFKLECRKTTCNPCPLGYKEENNTGECCGRCLPTACTIQLR
                     GGQIMTLKRDETLQDGCDTHFCKVNERGEYFWEKRVTGCPPFDEHKCLAEGGKIMKIP
                     GTCCDTCEEPECNDITARLQYVKVGSCKSEVEVDIHYCQGKCASKAMYSIDINDVQDQ
                     CSCCSPTRTEPMQVALHCTNGSVVYHEVLNAMECKCSPRKCSK"
     exon            251..305
                     /gene="VWF"
                     /gene_synonym="F8VWF; VWD"
                     /inference="alignment:Splign:2.1.0"
     exon            306..470
                     /gene="VWF"
                     /gene_synonym="F8VWF; VWD"
                     /inference="alignment:Splign:2.1.0"
     exon            471..573
                     /gene="VWF"
                     /gene_synonym="F8VWF; VWD"
                     /inference="alignment:Splign:2.1.0"
     exon            574..782
                     /gene="VWF"
                     /gene_synonym="F8VWF; VWD"
                     /inference="alignment:Splign:2.1.0"
     exon            783..907
                     /gene="VWF"
                     /gene_synonym="F8VWF; VWD"
                     /inference="alignment:Splign:2.1.0"
     exon            908..1124
                     /gene="VWF"
                     /gene_synonym="F8VWF; VWD"
                     /inference="alignment:Splign:2.1.0"
     exon            1125..1247
                     /gene="VWF"
                     /gene_synonym="F8VWF; VWD"
                     /inference="alignment:Splign:2.1.0"
     exon            1248..1359
                     /gene="VWF"
                     /gene_synonym="F8VWF; VWD"
                     /inference="alignment:Splign:2.1.0"
     exon            1360..1406
                     /gene="VWF"
                     /gene_synonym="F8VWF; VWD"
                     /inference="alignment:Splign:2.1.0"
     exon            1407..1543
                     /gene="VWF"
                     /gene_synonym="F8VWF; VWD"
                     /inference="alignment:Splign:2.1.0"
     exon            1544..1682
                     /gene="VWF"
                     /gene_synonym="F8VWF; VWD"
                     /inference="alignment:Splign:2.1.0"
     exon            1683..1783
                     /gene="VWF"
                     /gene_synonym="F8VWF; VWD"
                     /inference="alignment:Splign:2.1.0"
     exon            1784..1979
                     /gene="VWF"
                     /gene_synonym="F8VWF; VWD"
                     /inference="alignment:Splign:2.1.0"
     exon            1980..2195
                     /gene="VWF"
                     /gene_synonym="F8VWF; VWD"
                     /inference="alignment:Splign:2.1.0"
     exon            2196..2436
                     /gene="VWF"
                     /gene_synonym="F8VWF; VWD"
                     /inference="alignment:Splign:2.1.0"
     exon            2437..2531
                     /gene="VWF"
                     /gene_synonym="F8VWF; VWD"
                     /inference="alignment:Splign:2.1.0"
     exon            2532..2692
                     /gene="VWF"
                     /gene_synonym="F8VWF; VWD"
                     /inference="alignment:Splign:2.1.0"
     exon            2693..2796
                     /gene="VWF"
                     /gene_synonym="F8VWF; VWD"
                     /inference="alignment:Splign:2.1.0"
     exon            2797..2935
                     /gene="VWF"
                     /gene_synonym="F8VWF; VWD"
                     /inference="alignment:Splign:2.1.0"
     exon            2936..3070
                     /gene="VWF"
                     /gene_synonym="F8VWF; VWD"
                     /inference="alignment:Splign:2.1.0"
     exon            3071..3217
                     /gene="VWF"
                     /gene_synonym="F8VWF; VWD"
                     /inference="alignment:Splign:2.1.0"
     exon            3218..3358
                     /gene="VWF"
                     /gene_synonym="F8VWF; VWD"
                     /inference="alignment:Splign:2.1.0"
     exon            3359..3472
                     /gene="VWF"
                     /gene_synonym="F8VWF; VWD"
                     /inference="alignment:Splign:2.1.0"
     exon            3473..3629
                     /gene="VWF"
                     /gene_synonym="F8VWF; VWD"
                     /inference="alignment:Splign:2.1.0"
     exon            3630..3788
                     /gene="VWF"
                     /gene_synonym="F8VWF; VWD"
                     /inference="alignment:Splign:2.1.0"
     exon            3789..3924
                     /gene="VWF"
                     /gene_synonym="F8VWF; VWD"
                     /inference="alignment:Splign:2.1.0"
     exon            3925..5303
                     /gene="VWF"
                     /gene_synonym="F8VWF; VWD"
                     /inference="alignment:Splign:2.1.0"
     exon            5304..5420
                     /gene="VWF"
                     /gene_synonym="F8VWF; VWD"
                     /inference="alignment:Splign:2.1.0"
     exon            5421..5561
                     /gene="VWF"
                     /gene_synonym="F8VWF; VWD"
                     /inference="alignment:Splign:2.1.0"
     exon            5562..5705
                     /gene="VWF"
                     /gene_synonym="F8VWF; VWD"
                     /inference="alignment:Splign:2.1.0"
     exon            5706..5870
                     /gene="VWF"
                     /gene_synonym="F8VWF; VWD"
                     /inference="alignment:Splign:2.1.0"
     exon            5871..5914
                     /gene="VWF"
                     /gene_synonym="F8VWF; VWD"
                     /inference="alignment:Splign:2.1.0"
     exon            5915..6092
                     /gene="VWF"
                     /gene_synonym="F8VWF; VWD"
                     /inference="alignment:Splign:2.1.0"
     exon            6093..6313
                     /gene="VWF"
                     /gene_synonym="F8VWF; VWD"
                     /inference="alignment:Splign:2.1.0"
     exon            6314..6506
                     /gene="VWF"
                     /gene_synonym="F8VWF; VWD"
                     /inference="alignment:Splign:2.1.0"
     exon            6507..6848
                     /gene="VWF"
                     /gene_synonym="F8VWF; VWD"
                     /inference="alignment:Splign:2.1.0"
     exon            6849..7048
                     /gene="VWF"
                     /gene_synonym="F8VWF; VWD"
                     /inference="alignment:Splign:2.1.0"
     exon            7049..7151
                     /gene="VWF"
                     /gene_synonym="F8VWF; VWD"
                     /inference="alignment:Splign:2.1.0"
     exon            7152..7226
                     /gene="VWF"
                     /gene_synonym="F8VWF; VWD"
                     /inference="alignment:Splign:2.1.0"
     exon            7227..7331
                     /gene="VWF"
                     /gene_synonym="F8VWF; VWD"
                     /inference="alignment:Splign:2.1.0"
     exon            7332..7537
                     /gene="VWF"
                     /gene_synonym="F8VWF; VWD"
                     /inference="alignment:Splign:2.1.0"
     exon            7538..7687
                     /gene="VWF"
                     /gene_synonym="F8VWF; VWD"
                     /inference="alignment:Splign:2.1.0"
     exon            7688..7798
                     /gene="VWF"
                     /gene_synonym="F8VWF; VWD"
                     /inference="alignment:Splign:2.1.0"
     exon            7799..7979
                     /gene="VWF"
                     /gene_synonym="F8VWF; VWD"
                     /inference="alignment:Splign:2.1.0"
     exon            7980..8020
                     /gene="VWF"
                     /gene_synonym="F8VWF; VWD"
                     /inference="alignment:Splign:2.1.0"
     exon            8021..8137
                     /gene="VWF"
                     /gene_synonym="F8VWF; VWD"
                     /inference="alignment:Splign:2.1.0"
     exon            8138..8236
                     /gene="VWF"
                     /gene_synonym="F8VWF; VWD"
                     /inference="alignment:Splign:2.1.0"
     exon            8237..8365
                     /gene="VWF"
                     /gene_synonym="F8VWF; VWD"
                     /inference="alignment:Splign:2.1.0"
     exon            8366..8405
                     /gene="VWF"
                     /gene_synonym="F8VWF; VWD"
                     /inference="alignment:Splign:2.1.0"
     exon            8406..8503
                     /gene="VWF"
                     /gene_synonym="F8VWF; VWD"
                     /inference="alignment:Splign:2.1.0"
     exon            8504..8830
                     /gene="VWF"
                     /gene_synonym="F8VWF; VWD"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8802..8807
                     /regulatory_class="polyA_signal_sequence"
                     /gene="VWF"
                     /gene_synonym="F8VWF; VWD"
                     /note="hexamer: AATAAA"
     polyA_site      8830
                     /gene="VWF"
                     /gene_synonym="F8VWF; VWD"
                     /note="major polyA site"
ORIGIN      
        1 agctcacagc tattgtggtg ggaaagggag ggtggttggt ggatgtcaca gcttgggctt
       61 tatctccccc agcagtgggg actccacagc ccctgggcta cataacagca agacagtccg
      121 gagctgtagc agacctgatt gagcctttgc agcagctgag agcatggcct agggtgggcg
      181 gcaccattgt ccagcagctg agtttcccag ggaccttgga gatagccgca gccctcattt
      241 gcaggggaag atgattcctg ccagatttgc cggggtgctg cttgctctgg ccctcatttt
      301 gccagggacc ctttgtgcag aaggaactcg cggcaggtca tccacggccc gatgcagcct
      361 tttcggaagt gacttcgtca acacctttga tgggagcatg tacagctttg cgggatactg
      421 cagttacctc ctggcagggg gctgccagaa acgctccttc tcgattattg gggacttcca
      481 gaatggcaag agagtgagcc tctccgtgta tcttggggaa ttttttgaca tccatttgtt
      541 tgtcaatggt accgtgacac agggggacca aagagtctcc atgccctatg cctccaaagg
      601 gctgtatcta gaaactgagg ctgggtacta caagctgtcc ggtgaggcct atggctttgt
      661 ggccaggatc gatggcagcg gcaactttca agtcctgctg tcagacagat acttcaacaa
      721 gacctgcggg ctgtgtggca actttaacat ctttgctgaa gatgacttta tgacccaaga
      781 agggaccttg acctcggacc cttatgactt tgccaactca tgggctctga gcagtggaga
      841 acagtggtgt gaacgggcat ctcctcccag cagctcatgc aacatctcct ctggggaaat
      901 gcagaagggc ctgtgggagc agtgccagct tctgaagagc acctcggtgt ttgcccgctg
      961 ccaccctctg gtggaccccg agccttttgt ggccctgtgt gagaagactt tgtgtgagtg
     1021 tgctgggggg ctggagtgcg cctgccctgc cctcctggag tacgcccgga cctgtgccca
     1081 ggagggaatg gtgctgtacg gctggaccga ccacagcgcg tgcagcccag tgtgccctgc
     1141 tggtatggag tataggcagt gtgtgtcccc ttgcgccagg acctgccaga gcctgcacat
     1201 caatgaaatg tgtcaggagc gatgcgtgga tggctgcagc tgccctgagg gacagctcct
     1261 ggatgaaggc ctctgcgtgg agagcaccga gtgtccctgc gtgcattccg gaaagcgcta
     1321 ccctcccggc acctccctct ctcgagactg caacacctgc atttgccgaa acagccagtg
     1381 gatctgcagc aatgaagaat gtccagggga gtgccttgtc acaggtcaat cacacttcaa
     1441 gagctttgac aacagatact tcaccttcag tgggatctgc cagtacctgc tggcccggga
     1501 ttgccaggac cactccttct ccattgtcat tgagactgtc cagtgtgctg atgaccgcga
     1561 cgctgtgtgc acccgctccg tcaccgtccg gctgcctggc ctgcacaaca gccttgtgaa
     1621 actgaagcat ggggcaggag ttgccatgga tggccaggac gtccagctcc ccctcctgaa
     1681 aggtgacctc cgcatccagc atacagtgac ggcctccgtg cgcctcagct acggggagga
     1741 cctgcagatg gactgggatg gccgcgggag gctgctggtg aagctgtccc ccgtctatgc
     1801 cgggaagacc tgcggcctgt gtgggaatta caatggcaac cagggcgacg acttccttac
     1861 cccctctggg ctggcggagc cccgggtgga ggacttcggg aacgcctgga agctgcacgg
     1921 ggactgccag gacctgcaga agcagcacag cgatccctgc gccctcaacc cgcgcatgac
     1981 caggttctcc gaggaggcgt gcgcggtcct gacgtccccc acattcgagg cctgccatcg
     2041 tgccgtcagc ccgctgccct acctgcggaa ctgccgctac gacgtgtgct cctgctcgga
     2101 cggccgcgag tgcctgtgcg gcgccctggc cagctatgcc gcggcctgcg cggggagagg
     2161 cgtgcgcgtc gcgtggcgcg agccaggccg ctgtgagctg aactgcccga aaggccaggt
     2221 gtacctgcag tgcgggaccc cctgcaacct gacctgccgc tctctctctt acccggatga
     2281 ggaatgcaat gaggcctgcc tggagggctg cttctgcccc ccagggctct acatggatga
     2341 gaggggggac tgcgtgccca aggcccagtg cccctgttac tatgacggtg agatcttcca
     2401 gccagaagac atcttctcag accatcacac catgtgctac tgtgaggatg gcttcatgca
     2461 ctgtaccatg agtggagtcc ccggaagctt gctgcctgac gctgtcctca gcagtcccct
     2521 gtctcatcgc agcaaaagga gcctatcctg tcggcccccc atggtcaagc tggtgtgtcc
     2581 cgctgacaac ctgcgggctg aagggctcga gtgtaccaaa acgtgccaga actatgacct
     2641 ggagtgcatg agcatgggct gtgtctctgg ctgcctctgc cccccgggca tggtccggca
     2701 tgagaacaga tgtgtggccc tggaaaggtg tccctgcttc catcagggca aggagtatgc
     2761 ccctggagaa acagtgaaga ttggctgcaa cacttgtgtc tgtcaggacc ggaagtggaa
     2821 ctgcacagac catgtgtgtg atgccacgtg ctccacgatc ggcatggccc actacctcac
     2881 cttcgacggg ctcaaatacc tgttccccgg ggagtgccag tacgttctgg tgcaggatta
     2941 ctgcggcagt aaccctggga cctttcggat cctagtgggg aataagggat gcagccaccc
     3001 ctcagtgaaa tgcaagaaac gggtcaccat cctggtggag ggaggagaga ttgagctgtt
     3061 tgacggggag gtgaatgtga agaggcccat gaaggatgag actcactttg aggtggtgga
     3121 gtctggccgg tacatcattc tgctgctggg caaagccctc tccgtggtct gggaccgcca
     3181 cctgagcatc tccgtggtcc tgaagcagac ataccaggag aaagtgtgtg gcctgtgtgg
     3241 gaattttgat ggcatccaga acaatgacct caccagcagc aacctccaag tggaggaaga
     3301 ccctgtggac tttgggaact cctggaaagt gagctcgcag tgtgctgaca ccagaaaagt
     3361 gcctctggac tcatcccctg ccacctgcca taacaacatc atgaagcaga cgatggtgga
     3421 ttcctcctgt agaatcctta ccagtgacgt cttccaggac tgcaacaagc tggtggaccc
     3481 cgagccatat ctggatgtct gcatttacga cacctgctcc tgtgagtcca ttggggactg
     3541 cgcctgcttc tgcgacacca ttgctgccta tgcccacgtg tgtgcccagc atggcaaggt
     3601 ggtgacctgg aggacggcca cattgtgccc ccagagctgc gaggagagga atctccggga
     3661 gaacgggtat gagtgtgagt ggcgctataa cagctgtgca cctgcctgtc aagtcacgtg
     3721 tcagcaccct gagccactgg cctgccctgt gcagtgtgtg gagggctgcc atgcccactg
     3781 ccctccaggg aaaatcctgg atgagctttt gcagacctgc gttgaccctg aagactgtcc
     3841 agtgtgtgag gtggctggcc ggcgttttgc ctcaggaaag aaagtcacct tgaatcccag
     3901 tgaccctgag cactgccaga tttgccactg tgatgttgtc aacctcacct gtgaagcctg
     3961 ccaggagccg ggaggcctgg tggtgcctcc cacagatgcc ccggtgagcc ccaccactct
     4021 gtatgtggag gacatctcgg aaccgccgtt gcacgatttc tactgcagca ggctactgga
     4081 cctggtcttc ctgctggatg gctcctccag gctgtccgag gctgagtttg aagtgctgaa
     4141 ggcctttgtg gtggacatga tggagcggct gcgcatctcc cagaagtggg tccgcgtggc
     4201 cgtggtggag taccacgacg gctcccacgc ctacatcggg ctcaaggacc ggaagcgacc
     4261 gtcagagctg cggcgcattg ccagccaggt gaagtatgcg ggcagccagg tggcctccac
     4321 cagcgaggtc ttgaaataca cactgttcca aatcttcagc aagatcgacc gccctgaagc
     4381 ctcccgcatc accctgctcc tgatggccag ccaggagccc caacggatgt cccggaactt
     4441 tgtccgctac gtccagggcc tgaagaagaa gaaggtcatt gtgatcccgg tgggcattgg
     4501 gccccatgcc aacctcaagc agatccgcct catcgagaag caggcccctg agaacaaggc
     4561 cttcgtgctg agcagtgtgg atgagctgga gcagcaaagg gacgagatcg ttagctacct
     4621 ctgtgacctt gcccctgaag cccctcctcc tactctgccc cccgacatgg cacaagtcac
     4681 tgtgggcccg gggctcttgg gggtttcgac cctggggccc aagaggaact ccatggttct
     4741 ggatgtggcg ttcgtcctgg aaggatcgga caaaattggt gaagccgact tcaacaggag
     4801 caaggagttc atggaggagg tgattcagcg gatggatgtg ggccaggaca gcatccacgt
     4861 cacggtgctg cagtactcct acatggtgac tgtggagtac cccttcagcg aggcacagtc
     4921 caaaggggac atcctgcagc gggtgcgaga gatccgctac cagggcggca acaggaccaa
     4981 cactgggctg gccctgcggt acctctctga ccacagcttc ttggtcagcc agggtgaccg
     5041 ggagcaggcg cccaacctgg tctacatggt caccggaaat cctgcctctg atgagatcaa
     5101 gaggctgcct ggagacatcc aggtggtgcc cattggagtg ggccctaatg ccaacgtgca
     5161 ggagctggag aggattggct ggcccaatgc ccctatcctc atccaggact ttgagacgct
     5221 cccccgagag gctcctgacc tggtgctgca gaggtgctgc tccggagagg ggctgcagat
     5281 ccccaccctc tcccctgcac ctgactgcag ccagcccctg gacgtgatcc ttctcctgga
     5341 tggctcctcc agtttcccag cttcttattt tgatgaaatg aagagtttcg ccaaggcttt
     5401 catttcaaaa gccaatatag ggcctcgtct cactcaggtg tcagtgctgc agtatggaag
     5461 catcaccacc attgacgtgc catggaacgt ggtcccggag aaagcccatt tgctgagcct
     5521 tgtggacgtc atgcagcggg agggaggccc cagccaaatc ggggatgcct tgggctttgc
     5581 tgtgcgatac ttgacttcag aaatgcatgg tgccaggccg ggagcctcaa aggcggtggt
     5641 catcctggtc acggacgtct ctgtggattc agtggatgca gcagctgatg ccgccaggtc
     5701 caacagagtg acagtgttcc ctattggaat tggagatcgc tacgatgcag cccagctacg
     5761 gatcttggca ggcccagcag gcgactccaa cgtggtgaag ctccagcgaa tcgaagacct
     5821 ccctaccatg gtcaccttgg gcaattcctt cctccacaaa ctgtgctctg gatttgttag
     5881 gatttgcatg gatgaggatg ggaatgagaa gaggcccggg gacgtctgga ccttgccaga
     5941 ccagtgccac accgtgactt gccagccaga tggccagacc ttgctgaaga gtcatcgggt
     6001 caactgtgac cgggggctga ggccttcgtg ccctaacagc cagtcccctg ttaaagtgga
     6061 agagacctgt ggctgccgct ggacctgccc ctgcgtgtgc acaggcagct ccactcggca
     6121 catcgtgacc tttgatgggc agaatttcaa gctgactggc agctgttctt atgtcctatt
     6181 tcaaaacaag gagcaggacc tggaggtgat tctccataat ggtgcctgca gccctggagc
     6241 aaggcagggc tgcatgaaat ccatcgaggt gaagcacagt gccctctccg tcgagctgca
     6301 cagtgacatg gaggtgacgg tgaatgggag actggtctct gttccttacg tgggtgggaa
     6361 catggaagtc aacgtttatg gtgccatcat gcatgaggtc agattcaatc accttggtca
     6421 catcttcaca ttcactccac aaaacaatga gttccaactg cagctcagcc ccaagacttt
     6481 tgcttcaaag acgtatggtc tgtgtgggat ctgtgatgag aacggagcca atgacttcat
     6541 gctgagggat ggcacagtca ccacagactg gaaaacactt gttcaggaat ggactgtgca
     6601 gcggccaggg cagacgtgcc agcccatcct ggaggagcag tgtcttgtcc ccgacagctc
     6661 ccactgccag gtcctcctct taccactgtt tgctgaatgc cacaaggtcc tggctccagc
     6721 cacattctat gccatctgcc agcaggacag ttgccaccag gagcaagtgt gtgaggtgat
     6781 cgcctcttat gcccacctct gtcggaccaa cggggtctgc gttgactgga ggacacctga
     6841 tttctgtgct atgtcatgcc caccatctct ggtctacaac cactgtgagc atggctgtcc
     6901 ccggcactgt gatggcaacg tgagctcctg tggggaccat ccctccgaag gctgtttctg
     6961 ccctccagat aaagtcatgt tggaaggcag ctgtgtccct gaagaggcct gcactcagtg
     7021 cattggtgag gatggagtcc agcaccagtt cctggaagcc tgggtcccgg accaccagcc
     7081 ctgtcagatc tgcacatgcc tcagcgggcg gaaggtcaac tgcacaacgc agccctgccc
     7141 cacggccaaa gctcccacgt gtggcctgtg tgaagtagcc cgcctccgcc agaatgcaga
     7201 ccagtgctgc cccgagtatg agtgtgtgtg tgacccagtg agctgtgacc tgcccccagt
     7261 gcctcactgt gaacgtggcc tccagcccac actgaccaac cctggcgagt gcagacccaa
     7321 cttcacctgc gcctgcagga aggaggagtg caaaagagtg tccccaccct cctgcccccc
     7381 gcaccgtttg cccacccttc ggaagaccca gtgctgtgat gagtatgagt gtgcctgcaa
     7441 ctgtgtcaac tccacagtga gctgtcccct tgggtacttg gcctcaactg ccaccaatga
     7501 ctgtggctgt accacaacca cctgccttcc cgacaaggtg tgtgtccacc gaagcaccat
     7561 ctaccctgtg ggccagttct gggaggaggg ctgcgatgtg tgcacctgca ccgacatgga
     7621 ggatgccgtg atgggcctcc gcgtggccca gtgctcccag aagccctgtg aggacagctg
     7681 tcggtcgggc ttcacttacg ttctgcatga aggcgagtgc tgtggaaggt gcctgccatc
     7741 tgcctgtgag gtggtgactg gctcaccgcg gggggactcc cagtcttcct ggaagagtgt
     7801 cggctcccag tgggcctccc cggagaaccc ctgcctcatc aatgagtgtg tccgagtgaa
     7861 ggaggaggtc tttatacaac aaaggaacgt ctcctgcccc cagctggagg tccctgtctg
     7921 cccctcgggc tttcagctga gctgtaagac ctcagcgtgc tgcccaagct gtcgctgtga
     7981 gcgcatggag gcctgcatgc tcaatggcac tgtcattggg cccgggaaga ctgtgatgat
     8041 cgatgtgtgc acgacctgcc gctgcatggt gcaggtgggg gtcatctctg gattcaagct
     8101 ggagtgcagg aagaccacct gcaacccctg ccccctgggt tacaaggaag aaaataacac
     8161 aggtgaatgt tgtgggagat gtttgcctac ggcttgcacc attcagctaa gaggaggaca
     8221 gatcatgaca ctgaagcgtg atgagacgct ccaggatggc tgtgatactc acttctgcaa
     8281 ggtcaatgag agaggagagt acttctggga gaagagggtc acaggctgcc caccctttga
     8341 tgaacacaag tgtctggctg agggaggtaa aattatgaaa attccaggca cctgctgtga
     8401 cacatgtgag gagcctgagt gcaacgacat cactgccagg ctgcagtatg tcaaggtggg
     8461 aagctgtaag tctgaagtag aggtggatat ccactactgc cagggcaaat gtgccagcaa
     8521 agccatgtac tccattgaca tcaacgatgt gcaggaccag tgctcctgct gctctccgac
     8581 acggacggag cccatgcagg tggccctgca ctgcaccaat ggctctgttg tgtaccatga
     8641 ggttctcaat gccatggagt gcaaatgctc ccccaggaag tgcagcaagt gaggctgctg
     8701 cagctgcatg ggtgcctgct gctgcctgcc ttggcctgat ggccaggcca gagtgctgcc
     8761 agtcctctgc atgttctgct cttgtgccct tctgagccca caataaaggc tgagctctta
     8821 tcttgcaaaa
//
