LOCUS       NM_152718               3536 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens von Willebrand factor C and EGF domains (VWCE), mRNA.
ACCESSION   NM_152718
VERSION     NM_152718.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3536)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 3536)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 3536)
  AUTHORS   Sun,C., Zhang,G., Cheng,S., Qian,H., Li,D. and Liu,M.
  TITLE     URG11 promotes proliferation and induced apoptosis of LNCaP cells
  JOURNAL   Int J Mol Med 43 (5), 2075-2085 (2019)
   PUBMED   30864678
  REMARK    GeneRIF: URG11 served an oncogenic role in the development of
            prostate cancer cells.
REFERENCE   4  (bases 1 to 3536)
  AUTHORS   Zhang,G., Zhu,F., Han,G., Li,Z., Yu,Q., Li,Z. and Li,J.
  TITLE     Silencing of URG11 expression inhibits the proliferation and
            epithelial-mesenchymal transition in benign prostatic hyperplasia
            cells via the RhoA/ROCK1 pathway
  JOURNAL   Mol Med Rep 18 (1), 391-398 (2018)
   PUBMED   29749520
  REMARK    GeneRIF: silencing of URG11 altered the expression levels of cell
            cycleassociated genes, epithelialmesenchymal transitionassociated
            genes, and RhoA and ROCK1 protein levels. Thus, the results of the
            present study suggest that URG11 may be a potential therapeutic
            target, which may be important to inhibit the development and
            progression of prostatic hyperplasia.
REFERENCE   5  (bases 1 to 3536)
  AUTHORS   Pan,B., Ye,Y., Liu,H., Zhen,J., Zhou,H., Li,Y., Qu,L., Wu,Y.,
            Zeng,C. and Zhong,W.
  TITLE     URG11 Regulates Prostate Cancer Cell Proliferation, Migration, and
            Invasion
  JOURNAL   Biomed Res Int 2018, 4060728 (2018)
   PUBMED   29955600
  REMARK    GeneRIF: URG11 is critical for the proliferation, migration, and
            invasion in prostate cancer cells
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3536)
  AUTHORS   Du,R., Xia,L., Sun,S., Lian,Z., Zou,X., Gao,J., Xie,H., Fan,R.,
            Song,J., Li,X., Liu,J. and Fan,D.
  TITLE     URG11 promotes gastric cancer growth and invasion by activation of
            beta-catenin signalling pathway
  JOURNAL   J Cell Mol Med 14 (3), 621-635 (2010)
   PUBMED   19413886
  REMARK    GeneRIF: Data suggest that URG11 contributes to gastric cancer
            growth and metastasis at least partially through activation of
            beta-catenin signalling pathway.
REFERENCE   7  (bases 1 to 3536)
  AUTHORS   Du,R., Huang,C., Bi,Q., Zhai,Y., Xia,L., Liu,J., Sun,S. and Fan,D.
  TITLE     URG11 mediates hypoxia-induced epithelial-to-mesenchymal transition
            by modulation of E-cadherin and beta-catenin
  JOURNAL   Biochem Biophys Res Commun 391 (1), 135-141 (2010)
   PUBMED   19900406
  REMARK    GeneRIF: URG11 mediates hypoxia-induced epithelial-to-mesenchymal
            transition through the suppression of E-cadherin and the activation
            of the beta-catenin/T-cell factor pathway.
REFERENCE   8  (bases 1 to 3536)
  AUTHORS   Lian,Z., Liu,J., Li,L., Li,X., Clayton,M., Wu,M.C., Wang,H.Y.,
            Arbuthnot,P., Kew,M., Fan,D. and Feitelson,M.A.
  TITLE     Enhanced cell survival of Hep3B cells by the hepatitis B x antigen
            effector, URG11, is associated with upregulation of beta-catenin
  JOURNAL   Hepatology 43 (3), 415-424 (2006)
   PUBMED   16496348
  REMARK    GeneRIF: beta-catenin is activated by HBxAg, in part, through the
            upregulated expression of the HBxAg effector URG11; URG11
            stimulates the beta-catenin promoter and hepatocellular growth and
            survival
REFERENCE   9  (bases 1 to 3536)
  AUTHORS   Lian,Z., Liu,J., Li,L., Li,X., Tufan,N.L., Clayton,M., Wu,M.C.,
            Wang,H.Y., Arbuthnot,P., Kew,M. and Feitelson,M.A.
  TITLE     Upregulated expression of a unique gene by hepatitis B x antigen
            promotes hepatocellular growth and tumorigenesis
  JOURNAL   Neoplasia 5 (3), 229-244 (2003)
   PUBMED   12869306
REFERENCE   10 (bases 1 to 3536)
  AUTHORS   Adams,M.D., Kerlavage,A.R., Fleischmann,R.D., Fuldner,R.A.,
            Bult,C.J., Lee,N.H., Kirkness,E.F., Weinstock,K.G., Gocayne,J.D.,
            White,O. et al.
  TITLE     Initial assessment of human gene diversity and expression patterns
            based upon 83 million nucleotides of cDNA sequence
  JOURNAL   Nature 377 (6547 Suppl), 3-174 (1995)
   PUBMED   7566098
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB126089.1, AK056571.1, AP003037.2 and AA328361.1.
            
            On Sep 15, 2006 this sequence version replaced NM_152718.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK056571.1, BC142624.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000335613.10/ ENSP00000334186.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-242               DB126089.1         1-242
            243-678             AK056571.1         1-436
            679-703             AP003037.2         70784-70808         c
            704-820             AP003037.2         66299-66415         c
            821-933             AP003037.2         62778-62890         c
            934-3534            AK056571.1         692-3292
            3535-3536           AA328361.1         8-9
FEATURES             Location/Qualifiers
     source          1..3536
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q12.2"
     gene            1..3536
                     /gene="VWCE"
                     /gene_synonym="URG11; VWC1"
                     /note="von Willebrand factor C and EGF domains"
                     /db_xref="GeneID:220001"
                     /db_xref="HGNC:HGNC:26487"
                     /db_xref="MIM:611115"
     exon            1..389
                     /gene="VWCE"
                     /gene_synonym="URG11; VWC1"
                     /inference="alignment:Splign:2.1.0"
     CDS             280..3147
                     /gene="VWCE"
                     /gene_synonym="URG11; VWC1"
                     /note="von Willebrand factor C and EGF domain-containing
                     protein; HBxAg up-regulated gene 11 protein; HBV X protein
                     up-regulated gene 11 protein"
                     /codon_start=1
                     /product="von Willebrand factor C and EGF
                     domain-containing protein precursor"
                     /protein_id="NP_689931.2"
                     /db_xref="CCDS:CCDS8002.1"
                     /db_xref="GeneID:220001"
                     /db_xref="HGNC:HGNC:26487"
                     /db_xref="MIM:611115"
                     /translation="MWAGLLLRAACVALLLPGAPARGYTGRKPPGHFAAERRRLGPHV
                     CLSGFGSGCCPGWAPSMGGGHCTLPLCSFGCGSGICIAPNVCSCQDGEQGATCPETHG
                     PCGEYGCDLTCNHGGCQEVARVCPVGFSMTETAVGIRCTDIDECVTSSCEGHCVNTEG
                     GFVCECGPGMQLSADRHSCQDTDECLGTPCQQRCKNSIGSYKCSCRTGFHLHGNRHSC
                     VDVNECRRPLERRVCHHSCHNTVGSFLCTCRPGFRLRADRVSCEAFPKAVLAPSAILQ
                     PRQHPSKMLLLLPEAGRPALSPGHSPPSGAPGPPAGVRTTRLPSPTPRLPTSSPSAPV
                     WLLSTLLATPVPTASLLGNLRPPSLLQGEVMGTPSSPRGPESPRLAAGPSPCWHLGAM
                     HESRSRWTEPGCSQCWCEDGKVTCEKVRCEAACSHPIPSRDGGCCPSCTGCFHSGVVR
                     AEGDVFSPPNENCTVCVCLAGNVSCISPECPSGPCQTPPQTDCCTCVPVRCYFHGRWY
                     ADGAVFSGGGDECTTCVCQNGEVECSFMPCPELACPREEWRLGPGQCCFTCQEPTPST
                     GCSLDDNGVEFPIGQIWSPGDPCELCICQADGSVSCKRTDCVDSCPHPIRIPGQCCPD
                     CSAGCTYTGRIFYNNETFPSVLDPCLSCICLLGSVACSPVDCPITCTYPFHPDGECCP
                     VCRDCNYEGRKVANGQVFTLDDEPCTRCTCQLGEVSCEKVPCQRACADPALLPGDCCS
                     SCPDSLSPLEEKQGLSPHGNVAFSKAGRSLHGDTEAPVNCSSCPGPPTASPSRPVLHL
                     LQLLLRTNLMKTQTLPTSPAGAHGPHSLALGLTATFPGEPGASPRLSPGPSTPPGAPT
                     LPLASPGAPQPPPVTPERSFSASGAQIVSRWPPLPGTLLTEASALSMMDPSPSKTPIT
                     LLGPRVLSPTTSRLSTALAATTHPGPQQPPVGASRGEESTM"
     exon            390..484
                     /gene="VWCE"
                     /gene_synonym="URG11; VWC1"
                     /inference="alignment:Splign:2.1.0"
     exon            485..574
                     /gene="VWCE"
                     /gene_synonym="URG11; VWC1"
                     /inference="alignment:Splign:2.1.0"
     exon            575..703
                     /gene="VWCE"
                     /gene_synonym="URG11; VWC1"
                     /inference="alignment:Splign:2.1.0"
     exon            704..820
                     /gene="VWCE"
                     /gene_synonym="URG11; VWC1"
                     /inference="alignment:Splign:2.1.0"
     exon            821..937
                     /gene="VWCE"
                     /gene_synonym="URG11; VWC1"
                     /inference="alignment:Splign:2.1.0"
     exon            938..1066
                     /gene="VWCE"
                     /gene_synonym="URG11; VWC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1067..1509
                     /gene="VWCE"
                     /gene_synonym="URG11; VWC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1510..1603
                     /gene="VWCE"
                     /gene_synonym="URG11; VWC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1604..1686
                     /gene="VWCE"
                     /gene_synonym="URG11; VWC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1687..1774
                     /gene="VWCE"
                     /gene_synonym="URG11; VWC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1775..1860
                     /gene="VWCE"
                     /gene_synonym="URG11; VWC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1861..1978
                     /gene="VWCE"
                     /gene_synonym="URG11; VWC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1979..2064
                     /gene="VWCE"
                     /gene_synonym="URG11; VWC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2065..2161
                     /gene="VWCE"
                     /gene_synonym="URG11; VWC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2162..2244
                     /gene="VWCE"
                     /gene_synonym="URG11; VWC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2245..2335
                     /gene="VWCE"
                     /gene_synonym="URG11; VWC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2336..2418
                     /gene="VWCE"
                     /gene_synonym="URG11; VWC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2419..2509
                     /gene="VWCE"
                     /gene_synonym="URG11; VWC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2510..3536
                     /gene="VWCE"
                     /gene_synonym="URG11; VWC1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3512..3517
                     /regulatory_class="polyA_signal_sequence"
                     /gene="VWCE"
                     /gene_synonym="URG11; VWC1"
                     /note="hexamer: ATTAAA"
     polyA_site      3536
                     /gene="VWCE"
                     /gene_synonym="URG11; VWC1"
                     /note="major polyA site"
ORIGIN      
        1 gcgcctctcg gagaggcatc agcaggcggg cggcgttgcc tttgtgtgtt tcgcttcgag
       61 gtgccagaga ccctccccac aatcgtccgc cgcgtcccct cgcggccctc ggcccctcct
      121 ctcggcgtcc caagcccccc tgctcagctc tgcgtgccat ttcggggatc gctggttcgc
      181 tccccacggc gccaggagga ggggcgaggg ccggcagccc cctctcccgc gcgcggcgca
      241 ggagccgagc ccagcccggg ggacccgccg ccgccggtca tgtgggccgg actgctcctt
      301 cgggccgcct gtgtcgcgct cctgctgccg ggggcaccag cccgaggcta caccgggagg
      361 aagccgcccg ggcacttcgc ggccgagaga cgccgactgg gcccccacgt ctgcctctct
      421 gggtttggga gtggctgctg ccctggctgg gcgccctcta tgggtggtgg gcactgcacc
      481 ctgcccctct gctccttcgg ctgtgggagt ggcatctgca tcgctcccaa tgtctgctcc
      541 tgccaggatg gagagcaagg ggccacctgc ccagaaaccc atggaccatg tggggagtac
      601 ggctgtgacc ttacctgcaa ccatggaggc tgtcaggagg tggcccgagt gtgccccgtg
      661 ggcttctcga tgacggagac agctgttggc atcaggtgta cagacattga cgaatgtgta
      721 acctcctcct gcgagggcca ctgtgtgaac acagaaggtg ggtttgtgtg cgagtgtggg
      781 ccgggcatgc agctgtctgc cgaccgccac agctgccaag acactgacga atgcctaggg
      841 actccctgtc agcagagatg taaaaacagc attggcagct acaagtgttc ctgtcgaact
      901 ggcttccacc ttcatggcaa ccggcactcc tgtgtagatg taaacgagtg tcggaggcca
      961 ttggagaggc gagtctgtca ccattcctgc cacaacaccg tgggcagctt cctatgcaca
     1021 tgccgacctg gcttcaggct ccgagctgac cgcgtgtcct gtgaagcttt cccgaaagcc
     1081 gtgctggccc catctgccat cctgcaaccc cggcaacacc cgtccaagat gcttctgttg
     1141 cttcctgagg ccggccggcc tgccctgtcc ccaggacata gccctccttc tggggctcca
     1201 gggcccccag ccggagtcag gaccacccgc ctgccatctc ccaccccacg actacccaca
     1261 tcctcccctt ctgcccctgt gtggctgctg tccaccctgc tggccacccc agtgcctact
     1321 gcctccctgc tggggaacct cagacccccc tcactccttc agggggaggt gatggggacc
     1381 ccttcctcac ccaggggccc tgagtccccc cgactggcag cagggccctc tccctgctgg
     1441 cacctgggag ccatgcatga atcaaggagt cgctggacag agcctgggtg ttcccagtgc
     1501 tggtgcgagg acgggaaggt gacctgtgaa aaggtgaggt gtgaagctgc ttgttcccac
     1561 ccaattccct ccagagatgg tgggtgctgc ccatcgtgca caggctgttt tcacagtggt
     1621 gtcgtccgag ctgaagggga tgtgttttca cctcccaatg agaactgcac cgtctgtgtc
     1681 tgtctggctg gaaacgtgtc ctgcatctct cctgagtgtc cttctggccc ctgtcagacc
     1741 cccccacaga cggattgctg tacttgtgtt ccagtgagat gctatttcca cggccggtgg
     1801 tacgcagacg gggctgtgtt cagtgggggt ggtgacgagt gtaccacctg tgtttgccag
     1861 aatggggagg tggagtgctc cttcatgccc tgccctgagc tggcctgccc ccgagaagag
     1921 tggcggctgg gccctgggca gtgttgcttc acctgccagg agcccacacc ctcgacaggc
     1981 tgctctcttg acgacaacgg ggttgagttt ccgattggac agatctggtc gcctggtgac
     2041 ccctgtgagt tatgcatctg ccaggcagat ggctcggtga gctgcaagag gacagactgt
     2101 gtggactcct gccctcaccc gatccggatc cctggacagt gctgcccaga ctgttcagca
     2161 ggctgcacct acacaggcag aatcttctat aacaacgaga ccttcccgtc tgtgctggac
     2221 ccatgtctga gctgcatctg cctgctgggc tcagtggcct gttcccccgt ggactgcccc
     2281 atcacctgta cctacccttt ccaccctgac ggggagtgct gccccgtgtg ccgagactgc
     2341 aactacgagg gaaggaaggt ggcgaatggc caggtgttca ccttggatga tgaaccctgc
     2401 acccggtgca cgtgccagct gggagaggtg agctgtgaga aggttccctg ccagcgggcc
     2461 tgtgccgacc ctgccctgct tcctggggac tgctgctctt cctgtccaga ttccctgtct
     2521 cctctggaag aaaagcaggg gctctcccct cacggaaatg tggcattcag caaagctggt
     2581 cggagcctgc atggagacac tgaggcccct gtcaactgta gctcctgtcc tgggcccccg
     2641 acagcatcac cctcgaggcc ggtgcttcat ctcctccagc tccttttaag aacgaacttg
     2701 atgaaaacac agactttacc tacaagcccg gcaggagctc atggtccaca ctcactcgct
     2761 ttggggctga cagccacttt cccaggggag cctggggcct cccctcgact ctcaccaggg
     2821 ccttcgaccc ctccaggagc ccccactcta cctctagctt ccccaggggc tcctcagcca
     2881 cctcctgtga ctccagagcg ctcgttctca gcctctgggg cccagatagt gtccaggtgg
     2941 cctcctctgc ctggcaccct cctgacggaa gcttcagcac tttccatgat ggaccccagc
     3001 ccctcgaaga cccccatcac cctcctcggg cctcgcgtgc tttctcccac cacctctaga
     3061 ctctccacag cccttgcagc caccacccac cctggccccc agcagccccc agtgggggct
     3121 tctcgggggg aagagtccac catgtaagga ggtcactgtg tccgggagac tctggagaga
     3181 ggacctctgc cagtggccca gggtgtgtgc agggcagctc caaggatgaa cctggtgggg
     3241 atgcctgggc tccctcctgc aggggccctg gtgaggatgg aagaccccca aggctggatg
     3301 taaccttgtt cccaagaagt gtttggaatg tgctgtaaga atggaggaag tcgtttccac
     3361 tgtcagcatc ctccctggac cgcgtggctg gctcatcttt tgagaagggt tgggactgcc
     3421 aagttctcct ggaggaagag ttgcgtccgg ctgggattcc actcactggg actgtaccgc
     3481 caggtgtcat gcgtctctct gaggtttcct gattaaaggt tgtctcggtt tcccca
//
