LOCUS       NM_001080500            4638 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens von Willebrand factor C domain containing 2 like
            (VWC2L), transcript variant 1, mRNA.
ACCESSION   NM_001080500 XM_377783
VERSION     NM_001080500.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4638)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 4638)
  AUTHORS   Jeff,J.M., Ritchie,M.D., Denny,J.C., Kho,A.N., Ramirez,A.H.,
            Crosslin,D., Armstrong,L., Basford,M.A., Wolf,W.A., Pacheco,J.A.,
            Chisholm,R.L., Roden,D.M., Hayes,M.G. and Crawford,D.C.
  TITLE     Generalization of variants identified by genome-wide association
            studies for electrocardiographic traits in African Americans
  JOURNAL   Ann Hum Genet 77 (4), 321-332 (2013)
   PUBMED   23534349
REFERENCE   3  (bases 1 to 4638)
  AUTHORS   Ohyama,Y., Katafuchi,M., Almehmadi,A., Venkitapathi,S., Jaha,H.,
            Ehrenman,J., Morcos,J., Aljamaan,R. and Mochida,Y.
  TITLE     Modulation of matrix mineralization by Vwc2-like protein and its
            novel splicing isoforms
  JOURNAL   Biochem Biophys Res Commun 418 (1), 12-16 (2012)
   PUBMED   22209847
  REMARK    GeneRIF: Vwc2l is a novel secreted protein that promotes matrix
            mineralization by modulating Osterix expression likely through
            TGF-beta superfamily growth factor signaling pathway.
REFERENCE   4  (bases 1 to 4638)
  AUTHORS   Dick,D.M., Meyers,J., Aliev,F., Nurnberger,J. Jr., Kramer,J.,
            Kuperman,S., Porjesz,B., Tischfield,J., Edenberg,H.J., Foroud,T.,
            Schuckit,M., Goate,A., Hesselbrock,V. and Bierut,L.
  TITLE     Evidence for genes on chromosome 2 contributing to alcohol
            dependence with conduct disorder and suicide attempts
  JOURNAL   Am J Med Genet B Neuropsychiatr Genet 153B (6), 1179-1188 (2010)
   PUBMED   20468071
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC107218.4, BC146903.1 and AC068051.7.
            
            On Nov 21, 2018 this sequence version replaced NM_001080500.3.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.110678.1,
                                           SRR1803611.257421.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743, SAMEA2157437
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000312504.10/ ENSP00000308976.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-683               AC107218.4         2398-3080
            684-1591            BC146903.1         1-908
            1592-4638           AC068051.7         4654-7700
FEATURES             Location/Qualifiers
     source          1..4638
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q34-q35"
     gene            1..4638
                     /gene="VWC2L"
                     /note="von Willebrand factor C domain containing 2 like"
                     /db_xref="GeneID:402117"
                     /db_xref="HGNC:HGNC:37203"
                     /db_xref="MIM:619794"
     exon            1..733
                     /gene="VWC2L"
                     /inference="alignment:Splign:2.1.0"
     exon            734..1203
                     /gene="VWC2L"
                     /inference="alignment:Splign:2.1.0"
     CDS             814..1482
                     /gene="VWC2L"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; brorin-like; von Willebrand factor C domain
                     containing protein 2 like; VWC2-like protein"
                     /codon_start=1
                     /product="von Willebrand factor C domain-containing
                     protein 2-like isoform 1 precursor"
                     /protein_id="NP_001073969.1"
                     /db_xref="CCDS:CCDS46509.1"
                     /db_xref="GeneID:402117"
                     /db_xref="HGNC:HGNC:37203"
                     /db_xref="MIM:619794"
                     /translation="MALHIHEACILLLVIPGLVTSAAISHEDYPADEGDQISSNDNLI
                     FDDYRGKGCVDDSGFVYKLGERFFPGHSNCPCVCALDGPVCDQPECPKIHPKCTKVEH
                     NGCCPECKEVKNFCEYHGKNYKILEEFKPSPCEWCRCEPSNEVHCVVADCAVPECVNP
                     VYEPEQCCPVCKNGPNCFAGTTIIPAGIEVKVDECNICHCHNGDWWKPAQCSKRECQG
                     KQTV"
     exon            1204..1333
                     /gene="VWC2L"
                     /inference="alignment:Splign:2.1.0"
     exon            1334..4638
                     /gene="VWC2L"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4616..4621
                     /regulatory_class="polyA_signal_sequence"
                     /gene="VWC2L"
                     /note="hexamer: TATAAA"
     polyA_site      4638
                     /gene="VWC2L"
                     /note="major polyA site"
ORIGIN      
        1 agcctcgtct aaagcagctc tgggatttcg acagagctgg gctcagaagc cagttgttgg
       61 cgctgtccgt ggtgctgagg aattcccggc tgccggcaga atgagctcca aatcagcaat
      121 ctgcaaactg ctcttactga tgcagaaacc cagctaaagt tgctcctttc cttcacatcc
      181 acagttagta ttttccggtg tgtaagaggg gattcaagca acacactgtg gacgatggtg
      241 atggtattgc cagcggagtg ggctttaagc tacagcatgc tgttgctgtt tgtgatcctc
      301 agagcctagc caaatcacct ctactgccgt agcaaacact gtgtaagtga actcatgtgt
      361 ggaggaggcg taatcagccg ggaaatttca tagaaggatc taagaaaatg ctaaaaataa
      421 gttcaacatg attctgctac tggggtctgg atttctacag gaccagcttt gcttcttgct
      481 ttgaattctg aagacaggtc caaagcaaat ttcttatatg tgtctgctgt gtttctttct
      541 ggaagggcgg gagactgctt ctttactgtg ttttgaaatg ggaggtagag agaatggatt
      601 gcctttaatt catgcctaaa aaatgtattc tttgggtaat taaagaggaa ctgctttctt
      661 aaaacatacc tgacctttta gttcattttg ggctgtgacc cctaccacca ccattaacct
      721 ccagagtgat tagcctaccc ctcttgtatt cccatggaag gagctgagta tatttaatat
      781 taggagcaca tccagaagtc tttgaagagg gggatggctc ttcatattca tgaagcttgc
      841 atacttctgt tggtcatccc tggattggtc acctctgctg ctatcagtca tgaagactat
      901 cctgctgatg aaggtgacca gatctccagt aatgacaatc tgatctttga tgactatcga
      961 gggaaagggt gtgtcgatga cagcggcttt gtatacaagt tgggagaacg atttttccct
     1021 gggcattcca actgtccatg tgtctgtgct ctagatggac ctgtttgcga ccaaccagaa
     1081 tgccctaaaa ttcacccaaa gtgtactaaa gtggaacaca atggatgctg tcctgagtgc
     1141 aaagaagtaa aaaacttctg tgaatatcac gggaaaaatt acaaaatctt ggaggaattt
     1201 aagccctctc catgtgaatg gtgtcgctgt gagcccagca atgaagttca ctgtgttgta
     1261 gcagactgcg cagttcctga gtgtgtcaac ccagtctatg aaccagaaca atgttgtcct
     1321 gtctgcaaaa atggtccaaa ctgctttgca ggaacgacga taattccagc tggcattgaa
     1381 gtgaaagtgg acgaatgtaa catctgtcat tgtcacaacg gggactggtg gaagcctgct
     1441 cagtgttcga aacgtgaatg ccaaggcaag cagactgtgt aggacaaact tccacccaat
     1501 gatgagttct taggaaagga tgctatggct tcaacactgc acatgtttaa cacaaaacaa
     1561 aacaaacaaa ctcctgccag ctacaacagg gtcaccagca aaactttcta gggttgacaa
     1621 aagtgaatat tttcctaaga ggaaatttct ttctctcttg ctatataaaa tatatatagt
     1681 atatagctat ctaaatcgct tttgtattta ccaatgcttg atggtgactt gacgactgga
     1741 ttgctggaac aaaaagaaag aaatagcctt gcacaggctc cttccctggt aatgcctctg
     1801 acctaccagc tcactgtccc ctggtttact tcatttttac tcttctgtac attgtacatg
     1861 gcattgttct cctgtaatat ttgttttttc acttttagag tctaaggggc taaatttgac
     1921 tgcacagtaa agttttgagt tgtgtaaaaa aaaaagtttg gtaaaggaat gtcaggggaa
     1981 atatctttcc cgagctggga aacacaagag catccagtca attgctcccc tagggtgaat
     2041 catgccctgt agactaagga aagaggggtg ggcacataga cgggcctatt gctggacagg
     2101 gttgggaaca agtactttgt ccattacgtg ggggctcaca atttaattct tacaaaccac
     2161 acatttcata tggaaaacct cgaaactgcc aatcaaaatc tattacgtaa agaacaccat
     2221 aagctcaact aaagaatcca aagagagaca gatctttaaa attgtagcat taatcatcag
     2281 actttttcat gatgtgaaat ttgagtttgg tttgtagcta aacacactct aaactcactg
     2341 tcatcaggca atataaatac cagaaccagg gtgagaaaac ccactgtgaa tccaaatcct
     2401 tatgaacatc tctggctttt gagttcagat ttggctaaaa gtcagtagta cacactggca
     2461 gtttttgtgg ttcgggactg tgtttgccat gttgtagtaa caaccactca gccctatgtc
     2521 tgaaacacag attcaggaca ccctttccac ctcaagtgct gatttaaatt aaagattagg
     2581 gtagagtgag tcttgcacaa tacaattcca tttgttgaac attttttaaa atgtatatat
     2641 tagatactga aaaattaaag tgaacctttg aagagtctct aggttgccct ggtaatgctg
     2701 ctagtatagt aacagaaaaa acaaaacaca cagggtatct gatgccacct cgattcaagt
     2761 gcaaaattaa caattctgaa accacatggc atagttagtc gcttattcca tgctcctgcc
     2821 ctaaaaaccc tggcacagat ctgatagggt ccttgaagag actttacagt tgtctttatt
     2881 atcaatgttc tttctttttc tgctccccca acctgggctt tgccatagct cctgtggaga
     2941 gccatattct agagcaaggt gtctcaatct tagtaggatt gacatttggg gccagatcat
     3001 tattcgttgg tgggggctgt cctgtgtgct tttaggatgt ttagcaccat cactggcctc
     3061 tatccactag caacatccca gcaactggtg acaaccaaat ttctccagac attgcctaat
     3121 gtccctaagg agtgggagtg aggggcctaa tttcacctcg ttgagaacca gtggtctaga
     3181 ataatcagta tagagtggtt tctggcaggg gacacagtag gcaagctcta gcagcacctg
     3241 tggcttttgt gagcttctga tccctatggg acatacacag tcagcatttc caaggggtca
     3301 gtcttctcca tagagagtga ggcttctaat gctataggcc caccctcagg aaacatattt
     3361 ttttgagtct tgtcaactgg tttttcattt aaaattgtca gcctctcctc cctggaagca
     3421 tctgctgtca tcaagaaaga gttgtcattt ccaaaattaa cgtgctgacg agtcagacct
     3481 gacattctta tgcacactgt gcttgcgtta tgatacaaat agccatgccg gcaccatccc
     3541 gaggaagagc atcaagccac cttcccttag aacaccaatt tgcagcaagg ttggtgcctt
     3601 tcatttgcca ccatggatac atcatataga cagtcatgaa tcattcatga gcaatgctgc
     3661 atgatttatg tctgcactca aaagtaaagg aattccacac tttagcttat gtctagacag
     3721 agatgtatta tagagctttc tttgccccga ggttgcctgt tgccaacttc aaaaatccac
     3781 actcttggaa agaaataata ataataaatg acaggaataa ggtttgaaac tcagaaaata
     3841 tcattaatag agccatgcag catagtacct tatctattat taaggagtta ctatgtcctt
     3901 ttttagaaaa cagaaagaga gtacaactgg gaagctgaag tgcagaaatt ttgcatcaaa
     3961 gcattggcac agcgagagtc acagcaagaa tttactagaa ttgaatggga catccattaa
     4021 ggatctctct tcagagagtt tgcagaaagc aggctgttct gtggcctctg ataaccagct
     4081 agagagaggg atttttatgg ttggttttgt tgttgttgga ttttcttttt ctcaaagttt
     4141 cactgcaggc tgtttccttt aagattttgt agcactgaca tttttccccc tttagggaga
     4201 gatgaaccta tactgtgaca atttctcata aactgataaa cattttacaa cttccttcta
     4261 cccaggtcat tgagaaattc tttccagact ctgaacaaca gagctctggt ctcatctgtt
     4321 gtttgtttct tgtgaagtct ttgtttgcag ccacactgtc atctctgtac tcctatttct
     4381 cctccgcctt tggttctcgg ctttaacaac agctatgtta aaataaggga tcaacatctt
     4441 gtttgtcagc tgatgcctat taaaaacgat tcagtttcta aaatctttga aaaatggcgt
     4501 gcctgaaaac tagtgagaaa aaaaaaaaac ctaaacacta aactgtaaaa aggggattct
     4561 agcaacaata tttgatgtgt aaaagaatat attattaaaa aattattttg ttaaatataa
     4621 agtgtgttaa ccagcaaa
//
