LOCUS       NM_198570              11322 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens von Willebrand factor C domain containing 2 (VWC2),
            transcript variant 1, mRNA.
ACCESSION   NM_198570 XM_351703
VERSION     NM_198570.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 11322)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 11322)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 11322)
  AUTHORS   Zhang,J.L., Huang,Y., Qiu,L.Y., Nickel,J. and Sebald,W.
  TITLE     von Willebrand factor type C domain-containing proteins regulate
            bone morphogenetic protein signaling through different recognition
            mechanisms
  JOURNAL   J Biol Chem 282 (27), 20002-20014 (2007)
   PUBMED   17483092
REFERENCE   4  (bases 1 to 11322)
  AUTHORS   Koike,N., Kassai,Y., Kouta,Y., Miwa,H., Konishi,M. and Itoh,N.
  TITLE     Brorin, a novel secreted bone morphogenetic protein antagonist,
            promotes neurogenesis in mouse neural precursor cells
  JOURNAL   J Biol Chem 282 (21), 15843-15850 (2007)
   PUBMED   17400546
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC093775.2, AY358393.2,
            BC110857.1 and AC034145.5.
            
            On Nov 22, 2018 this sequence version replaced NM_198570.4.
            
            Summary: This gene encodes a secreted bone morphogenic protein
            antagonist. The encoded protein is possibly involved in neural
            function and development and may have a role in cell
            adhesion.[provided by RefSeq, Oct 2009].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY358393.2, BC110857.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968540,
                                           SAMEA1968968 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000340652.5/ ENSP00000341819.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-23                AC093775.2         101602-101624
            24-477              AY358393.2         1-454
            478-733             BC110857.1         398-653
            734-1914            AY358393.2         711-1891
            1915-11322          AC034145.5         137615-147022
FEATURES             Location/Qualifiers
     source          1..11322
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p12.2"
     gene            1..11322
                     /gene="VWC2"
                     /gene_synonym="PSST739; UNQ739"
                     /note="von Willebrand factor C domain containing 2"
                     /db_xref="GeneID:375567"
                     /db_xref="HGNC:HGNC:30200"
                     /db_xref="MIM:611108"
     exon            1..476
                     /gene="VWC2"
                     /gene_synonym="PSST739; UNQ739"
                     /inference="alignment:Splign:2.1.0"
     exon            477..1275
                     /gene="VWC2"
                     /gene_synonym="PSST739; UNQ739"
                     /inference="alignment:Splign:2.1.0"
     CDS             580..1557
                     /gene="VWC2"
                     /gene_synonym="PSST739; UNQ739"
                     /note="brain-specific chordin-like protein; brorin; von
                     Willebrand factor C domain-containing protein 2"
                     /codon_start=1
                     /product="brorin precursor"
                     /protein_id="NP_940972.2"
                     /db_xref="CCDS:CCDS5508.1"
                     /db_xref="GeneID:375567"
                     /db_xref="HGNC:HGNC:30200"
                     /db_xref="MIM:611108"
                     /translation="MPSSTAMAVGALSSSLLVTCCLMVALCSPSIPLEKLAQAPEQPG
                     QEKREHASRDGPGRVNELGRPARDEGGSGRDWKSKSGRGLAGREPWSKLKQAWVSQGG
                     GAKAGDLQVRPRGDTPQAEALAAAAQDAIGPELAPTPEPPEEYVYPDYRGKGCVDESG
                     FVYAIGEKFAPGPSACPCLCTEEGPLCAQPECPRLHPRCIHVDTSQCCPQCKERKNYC
                     EFRGKTYQTLEEFVVSPCERCRCEANGEVLCTVSACPQTECVDPVYEPDQCCPICKNG
                     PNCFAETAVIPAGREVKTDECTICHCTYEEGTWRIERQAMCTRHECRQM"
     exon            1276..1405
                     /gene="VWC2"
                     /gene_synonym="PSST739; UNQ739"
                     /inference="alignment:Splign:2.1.0"
     exon            1406..11322
                     /gene="VWC2"
                     /gene_synonym="PSST739; UNQ739"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1888..1893
                     /regulatory_class="polyA_signal_sequence"
                     /gene="VWC2"
                     /gene_synonym="PSST739; UNQ739"
                     /note="hexamer: ATTAAA"
     polyA_site      1914
                     /gene="VWC2"
                     /gene_synonym="PSST739; UNQ739"
                     /note="major polyA site"
     regulatory      6100..6105
                     /regulatory_class="polyA_signal_sequence"
                     /gene="VWC2"
                     /gene_synonym="PSST739; UNQ739"
                     /note="hexamer: ATTAAA"
     regulatory      6111..6116
                     /regulatory_class="polyA_signal_sequence"
                     /gene="VWC2"
                     /gene_synonym="PSST739; UNQ739"
                     /note="hexamer: ACTAAA"
     polyA_site      6124
                     /gene="VWC2"
                     /gene_synonym="PSST739; UNQ739"
                     /note="major polyA site"
     polyA_site      6138
                     /gene="VWC2"
                     /gene_synonym="PSST739; UNQ739"
                     /note="major polyA site"
     regulatory      11301..11306
                     /regulatory_class="polyA_signal_sequence"
                     /gene="VWC2"
                     /gene_synonym="PSST739; UNQ739"
                     /note="hexamer: AATAAA"
     polyA_site      11322
                     /gene="VWC2"
                     /gene_synonym="PSST739; UNQ739"
ORIGIN      
        1 gcgctagctc ccatgctggc ctcggtgcca ctcgcgcgcc ggccgcgctc cgggcttctc
       61 ttttccctcc gacgcgccac ggctgcccag acattccggc tgccgggtct ggagagctcc
      121 ccgaacccct ccgcggagag gagcgaggcg gcgccagggt ggcccccggg gcgcgcttgg
      181 tctcggagaa gcggggacga ggccggagga tgagcgactg agggcgacgc gggcactgac
      241 gcgagttggg gccgcgacta ccggcagctg acagcgcgat gagcgactcc ccagagacgc
      301 cctagcccgg tgtgcgcgcc aggcggagcg cgcaggtggg gctgggctgt tagtggtccg
      361 ccccacgcgg gtcgccggcc ggcccaggat gggcgctggc aacccgggcc cgcgcccgcc
      421 gctgctaccc ctgcgcccgc tgcgagcccg gcgtccggcc cgcgccctgc gctcatggac
      481 ggcggctccc ggctggcggc ggcgcgcccc cgggctgtga atgcgactcg cccctcggcc
      541 gcgctccccg cccgcccgcc cgccgggacg tggtagggga tgcccagctc cactgcgatg
      601 gcagttggcg cgctctccag ttccctcctg gtcacctgct gcctgatggt ggctctgtgc
      661 agtccgagca tcccgctgga gaagctggcc caggcaccag agcagccggg ccaggagaag
      721 cgtgagcacg cctctcggga cggcccgggg cgggtgaacg agctcgggcg cccggcgagg
      781 gacgagggcg gcagcggccg ggactggaag agcaagagcg gccgtgggct cgccggccgt
      841 gagccgtgga gcaagctgaa gcaggcctgg gtctcccagg gcgggggcgc caaggccggg
      901 gatctgcagg tccggccccg cggggacacc ccgcaggcgg aagccctggc cgcagccgcc
      961 caggacgcga ttggcccgga actcgcgccc acgcccgagc cacccgagga gtacgtgtac
     1021 ccggactacc gtggcaaggg ctgcgtggac gagagcggct tcgtgtacgc gatcggggag
     1081 aagttcgcgc cgggcccctc ggcctgcccg tgcctgtgca ccgaggaggg gccgctgtgc
     1141 gcgcagcccg agtgcccgag gctgcacccg cgctgcatcc acgtcgacac gagccagtgc
     1201 tgcccgcagt gcaaggagag gaagaactac tgcgagttcc ggggcaagac ctatcagact
     1261 ttggaggagt tcgtggtgtc tccatgcgag aggtgtcgct gtgaagccaa cggtgaggtg
     1321 ctatgcacag tgtcagcgtg tccccagacg gagtgtgtgg accctgtgta cgagcctgat
     1381 cagtgctgtc ccatctgcaa aaatggtcca aactgctttg cagaaaccgc ggtgatccct
     1441 gctggcagag aagtgaagac tgacgagtgc accatatgcc actgtactta tgaggaaggc
     1501 acatggagaa tcgagcggca ggccatgtgc acgagacatg aatgcaggca aatgtagacg
     1561 cttcccagaa cacaaactct gactttttct agaacatttt actgatgtga acattctaga
     1621 tgactctggg aactatcagt caaagaagac ttttgatgag gaataatgga aaattgttgg
     1681 tacttttcct tttcttgata acagttacta caacagaagg aaatggatat atttcaaaac
     1741 atcaacaaga actttgggca taaaatcctt ctctaaataa atgtgctatt ttcacagtaa
     1801 gtacacaaaa gtacactatt atatatcaaa tgtatttcta taatccctcc attagagagc
     1861 ttatataagt gttttctata gatgcagatt aaaaatgctg tgttgtcaac cgtcctcacc
     1921 gtgtacctgc atatcttttt cagttctgat tccatcaccc aggaatgttc cccctgcaca
     1981 ttttcacagg gcagagtcac gcatgaatgg atcataagat attaggacca atttccactg
     2041 aaaccctgtt taaattctat ttaattacag acatatctct aatgttgatg tctacttcac
     2101 ataaatatat ttccttttta taataatata tggcttttat ctgcttcatt ctcagtcact
     2161 tgtgaaatgc aggtgtaaag atcactaact cacactttct cagttctttc ccctaagctc
     2221 ctgtattgta caccataggt aagcacatac atatatttca ttcttattta cattattttc
     2281 tcttctaagg ataactttaa ttcattccct aaactgagga ataaagtagg ctggaaaatt
     2341 tgcattactg ttccatcaag ctgaagcaga caacaaaata ggggaggagt ccttcgattc
     2401 tcctaggata gttaaggaaa atcaaactcc taaacaagtt tatatacctg aaatctaaat
     2461 gtgctacaga taactcagct gtcagttcag tggaatcata tttgtcatca gacttgagtc
     2521 atctatcctc cataaactac acagtaaaat cttgactgat aaccttgaat tagccaccct
     2581 tcacaagcag agtgaggaag cagttatttt gttaaaacaa agctgaagac caagtgcact
     2641 ccacaacttt cctatagtta taattccaaa ccaacttctt ttctcttcat ttgaacagag
     2701 aacataaaaa gccactgcaa agtcctgcta atctaattaa tgcataatag aaaatagttc
     2761 tacctttatc aatcatatca gcatgcggtg tgttgatgaa agaggtaatt ggagtcttaa
     2821 taggtgtagg ataaaaaaag caaaactata atcactatta atgtctttaa aggattaaaa
     2881 tatatataat cattatttga agcctctaaa ggtatttttc atatttttgt ttattctgaa
     2941 attttgcatt aagaacctat taagtacaaa gcattgacaa caagggaata aggcttgatt
     3001 tcttgccttc ttggactttc ggtctctggc ataagaagta tatgaaatca taatgtattg
     3061 tattaggagc caaactagag accagcaaat ggagattaga aagccttcct aatgagaaga
     3121 tggagaacat gaaaaaatca ttatataaaa aataattcaa tcattaaaga ctgaataaca
     3181 ttcaagaaaa atggatacat ctatcataat tgaaaaatta aactattgtg aaccttagta
     3241 agtataaaga tgccactgac tgagtcatca aaacactaca tatagtcatt taatttttgt
     3301 cttgttcata aagaacacct tgagccaaag gaactaccag tacatagatt tcatgaaaat
     3361 actcagggga attattagct aattgttctc aggtgtaatc agctttccaa aatttaacct
     3421 ttgtattaaa gactggtaga cattggccat ccctccttta ttcaaggatg gattgtttga
     3481 gacacagtta tttaaagttg tcgttttgct aataaatggc cctagccccc atgggtaggt
     3541 gggccattag taacctcttc tctctccatc aggcatgatg cagttagaga ctcagtccat
     3601 gcagctcaaa gtcttcctgt ttcccttaat aataattcct accagaatgg atgatgagct
     3661 ctgaaataat tgcaatggtg ttttcaatgc tgtgagaatt tcagaaaacc tagtattttg
     3721 ttgcatatag agagaatgaa cccagtatca tcttgggaag ttaactgact cacttgctct
     3781 aaacttagtt tgacctgcag ggtcaccagc acacactcct aagagctaaa gctcaatggc
     3841 tgttattaca ccaaagtaac tcccctcccc atctctgatt tcaaccccct cattcctctc
     3901 tcctcataga aataatgcat aaaccaaaca catggaagaa cttggatttt tgacactgta
     3961 tatactcatt aataataatg gcattatttg catttttgtc caagatcaac ttcttcttgc
     4021 agttagactt tcacaaatac atagctatct cagattgaca ttctattttc ctcccctctg
     4081 ttgtcagaga actctttgct gagattgtca acaacaaact gttctattca ataaataacc
     4141 tgaataactg cccaataaaa aaggaaagta taagttactc aatttcaaaa taatatggtt
     4201 tggagatagc acagaaaagg gggcctcaga attcaagtat agaagttctg gaaaagccat
     4261 aatcactaaa attcaaatag gcctgctcta taagtaccta ataattgtta aatgatttgt
     4321 tcaagttaat aaactaaatc gtgcttacaa atgtattaat gaatttattt caaattttca
     4381 acccatattt agatctgaaa gtataaagct acttatgtaa gcaatagaat ggttctggaa
     4441 attatctgat gtcttagagg ttttcaagtt aaattcattc tttcagtgat aggatattta
     4501 cttgttgggt ggattaacaa tactttttat tgacatttcc cagaagtctt gagaaaagtc
     4561 atttcaaaaa cttgtatttc atccctgcat gcaagaagta ttagatgcac tccagtccag
     4621 gcaagtcctg ctataatgtt gcagctagtg cagatggaga ggcacagtgt ccttgacatc
     4681 aaggggtctg taagccttga aactaattta ggtttgatta taatactttt aatcttttga
     4741 tacttagaat ttcatcacct gctttgtgca gtaaaacatg ctaagaagaa ttatcatgca
     4801 gttttaagtt cataacatca ataatatgtt taataaactt tcttccctcg ttctccaaca
     4861 taaatgttgc atttatataa ggttaaaagt cctaaaaaat cataaaattc agatgtttaa
     4921 tttttgtttt taagcagtga aatgggtttt taaatgtata cattatctga aacttacaaa
     4981 atatacactg tttcaaacaa gcattgttgg aaactaaatc cattatttta aatgtggact
     5041 atttaaacat gtagaaaaca aaattataga cataaactat gattttaaaa atattaacaa
     5101 tttgctaaat ttgcttcaat gggcaagaga tcaatcctac ttttcattgt tatttttaat
     5161 atcatatttt tccccaacat aatgttatta tgaagagtat cagatgtaca aataagcatc
     5221 attggtaaaa acatacatgc ttctttggcc aacataattt gtaactgtct tactgaacct
     5281 acttacctac tatatttttt ttcctcacta gtagcatctg atggttgata cagtcagtaa
     5341 ctattctgaa gaatcagatt aagagagaac aatttactta ttcaggaata agtgcatttt
     5401 tacagtacat atttttcaca tttcagctgc aacttccaaa gatcaggttc tcattgctcc
     5461 gtagcacaga ttaaacagcc tacttatgtc atatcctcac ttcacaccaa cttcttcagt
     5521 ctattatttt agttttctaa atgtagatct agttttcaac tgaattcttt gaggatcgca
     5581 atcacacaca aaataacatc caaactcctc aacatggaag actggtgtct tcacaattag
     5641 atcatggaca acaccatgac ccaggcccct gtggctggtg agacttctgg gccctgggta
     5701 ccacagacta tactctaaac atggtcttta ctatctcaga tcctgccctg agtgtccttt
     5761 gcagcatgtt gagtattagc cattttcaat gtccagttca agtgccattg ctggtaaggc
     5821 ttctgtagtt cttattggaa gaattgtcac tctatgtccc agtaatagta ctaatttggt
     5881 ttcttatttt aacatatcat ttaggaatca taccatagtt tgcataatgg ttaattttat
     5941 gcctgcttct tctattattt acaaatccct ttagtttggg ctgtgaaata ttcaattccc
     6001 aaaacatcac ccaatatcta tatgttaaag gcttgttgaa ttgtattcca tctattagtt
     6061 cagagttatt tgctattctt gtttaaggac aatgtatgta ttaaagagca actaaaaact
     6121 cccattactg tttgccaacc cagttgtctt ttgatttctc tgtcaactta caagtatcaa
     6181 atatctaagt cacagaaccc agagacacat caaatacccc aaatacccca tggtagtttt
     6241 cggatgaact ctgacagcta ttggccattt ctggtgcaag tcagaaaaaa attgctttta
     6301 gtgtgaaatt tttgatgctg aagaaagttg attgtattga agagacactg gccctttatg
     6361 ataaaggaag tcaagtttac agttttgata tttgtttact ttcttatttc taatttttgg
     6421 aaaacaattt tcttagactt tcatttgtga tattgatcat ttctgtgtgt tttaatcttt
     6481 ctacataaca taattaaaca cctcagtagg tatctagtga actgatacaa taatgagctg
     6541 agtcatttgt acagaaatat agtagcttcc ataatctgaa tgataaccat ttaaaagtga
     6601 tggttgttga aattttactg tagtgtcaaa tttcacttta aattttgcaa agcacctgct
     6661 attctagcct taacacaaag atttggctaa tttttaaatg aacaaatccc attgaatatt
     6721 aagtgacact gacaatcacc ctgaaaagta ttcagccaaa gtttcaatag aattaggaaa
     6781 cttaaatgaa aatgtgctct cagtgcttgg cccatgagca gtttatgatt taagacgtgc
     6841 atactgttta actctttcct ttaaagttca gaaaagtaca taaaacctct ggctgaccta
     6901 ttatataggc acagaattat caaaagcaat caaagtatgt acctaaagtc aatttagtat
     6961 attatgaata cagcctgatg actaaacaca attgcaaata ttgcgacttt agtttttaat
     7021 tcaattttca gcaagtagaa atatttctca attttatttg gtatctaatt atattaagac
     7081 caacatatac attaaagtgt atttagatga ttaatattta atgatcatta ttttatttaa
     7141 tgattaatat tttctattat ttgaatttct gtaatttatg ttttagaaag aactgtttcc
     7201 aaacacattt tatggaaaga tttcattttt ccattccctt tacttttata tttacattgt
     7261 caaataaata caattctatt ttcatttcta ttagttttca gggtttattc ttttcctaag
     7321 catataattc ttataatgga aaaaagtgaa aagtatccag taagtaatat acacctatga
     7381 aactattaat gttctttata ctaccaagta gtttcatagt tttaaaaagc cattcttaag
     7441 cagtcggtga atgtatatca tcggccaaaa gttatgctag gtttccttca cttattatca
     7501 catttaacct cacagttctc ccaaattgtg ggtaatgcta tcccctttgt tgcagaaaag
     7561 taaatatagg ctcagggaaa tttaaaaact gccttaagat tcagtctagt gaatgagagg
     7621 ctgagttaag aatccaaatc tgctttatat cagagcccgt gatttgaagt cttatcattt
     7681 gtgtttaggt cagggacctc tagaaaatag acagaaattt ccaaaatggt cttttacccc
     7741 actccccata aataagataa tgaatagcaa cactgatccc taattctaga atatcaatct
     7801 tgatacttgt caaagtaaat agtagctcgt cacaaaaatg ttgtagcctc cctagtctaa
     7861 atgcttatgc tatattttgt ttcctaaatc tagagatctc tttttaaaaa tagtattgaa
     7921 gcatcaggtt gttcaggtat gattctcata ttgaaattta caaaatataa ccaaatattg
     7981 tgacccagtt tttctggagc caagagaagt aaactgccat ttattaggtg atgattatag
     8041 ggcaaacact acaatttcaa atttcatatt cttttatctg atttattcat tttatcaact
     8101 ctgctatatt gatgaagaag tcaacatatg gtgggtaact tatccaaatt tcagtgatgg
     8161 gctgggcgtg gtggctcacg cctataatcc cagcactttg ggaggctgag gcaggtggat
     8221 caggagtttg aggccaacct gaccaacatg tgaaacccca tctctactaa aaatacaaaa
     8281 aaattacctg ggcatggtgg cacatgcctg taatctactc gggaggctga ggcaggagaa
     8341 tcccttaaac cgagggggtg gaggttgctt gagccgagat cgcgtcactg cactccagcc
     8401 tgggtaacag agcaagactc tgtttaaaaa aaaaaaaaaa atcagtgatg gaactgaggc
     8461 caaatctgtc tggttccaaa gctatcctac atggggcaca gtcaggactg gaatggatag
     8521 ctctacctgc ttccaaatat tcttccctgg ggagcagctg tgagtcttac tgaatcgatt
     8581 tattcattgc attctatgtg tcaactgcaa tttagacctg ggtgatagag tcatatatgg
     8641 tctttggacc catgaagctc tgagtcaagg ataccagcag atatccttaa actaataaaa
     8701 aaagcgatgg catcacatgc cattttgaac ttttgcatta aagtcataaa cttacatcag
     8761 tattatgatt tatactttta agcaaaattt tgccattttc tgatacatag tagctagcta
     8821 gtgataaaat tatgaagtta ccattgtatg ttccaatgac ataaaaaact aagtgcctgc
     8881 ttgggctagt tatactctgc agtataccct ggtttattgt gaggattaaa taaaaaatcc
     8941 tcacaaaccc caatttaatt taatatagat taattataaa aataatctac ccatgttaca
     9001 taatgttaaa tctgtagttt caaggtgtat gctatttctt aaaacaaaaa caaagattgt
     9061 ccccactcca aacaataaca gcaatggtga aggttgtggg tggacagagg tagtcccact
     9121 catccccagg gggctcagct gccaccggcc aggtctatct attgctccca cctgctctga
     9181 ctgttttctc tcaagaaaaa gattttcatt ttaagatagg catcagtgca ataaaggagc
     9241 ttgatacaaa aatcattatg ttctatatat gtttttgtag gttttagatt aattatggcc
     9301 aactgatacc ttaaaatatt tgttacaaat aacactgaag tgagattcaa aattgtgcct
     9361 tctattgaag ccaagaaagt aaatgtcttt aaaataaaca taatggtgtt tttttttggt
     9421 acaataaaca gcatacctac atttcagagg acaaatcatg ttattataat aaccaggaga
     9481 gaaaataaaa ggagacatta atttggatat ggaagcaaaa tggaacagag caatatagag
     9541 caaaacagag gtttgtctga aacatttaaa atattaagaa gtatgactaa aaaactcaaa
     9601 cattttaata cacgatgaat ccttttctta aggaaaaaat gaaaataata aaagtggtat
     9661 ttggatgaga taattttcct ttaaatttat tcctcagaat gatgtaaatt ttccagctgg
     9721 aaggtcatct ttctatacat gcatgcatct atacaaatgg ttaaacagtt actctctcaa
     9781 tttgctgtga taggaaaggt ggatataaat ataagcaagg gtctgattaa aacaaaacaa
     9841 aacaaacaaa agacaagaga agcactgcat tgttggcaag aaattccttt taagtcagac
     9901 ttaagtccac ggaaagctgg acctaagcag tgaaggatgt aagggaacag agagagactc
     9961 tgcttggccg agtttgctat tctcatttgt ctatgtcaat acggctacat aaagttcaca
    10021 actatttgca catagctata aatatagcat gaataaaaca catatgtatt taattgtgtt
    10081 atttactatt tataatttga attgtttaaa ataattttaa atacttattc cataaactca
    10141 gtatttgaaa acttaaaaaa aaagtcattt taaataacat catttaccaa gtctgtgtga
    10201 tgctttacaa ggtacctgat gaatgtaaaa ttatagcttt ttgtcttcat ttctaataga
    10261 ctgttatagg ggaaatgtac taaaatgttg tacttattac atttatgaat ttctgacagt
    10321 ttctatagac tgagaataat gatatgcttt tataaattat ttggtgaaag ttttccagta
    10381 agtgttcatg tcctgtacaa atttattaaa caacatcaat tttacctaac aactgtaacc
    10441 actaataaat catcagtcac cacctttcct gcatatctga cagatggaga acactgtgct
    10501 tagtgttgaa gataccaaag ggaattcaag tgaggggaaa agaggagagc aaactgatca
    10561 aaagggaatg cccatgatgc tttcaggaaa ccagggtgag aacatgctgg ctggaggatg
    10621 ggtctggttt ccagcagaga tgataggagt taaaaggcat aggtgagttg ttcccatccc
    10681 tggcctgagc cttactccat agctatagag acatagtctc tagaaacaaa ggccagagca
    10741 tccttttaac atttatatca taagtattct caataaacgt ttgcaattta tttgctttaa
    10801 tgtaacttgg cagtaaagac tttggccttt ggaggtctga ttctaatccc agttctacca
    10861 cttactggtt atttatcagg tacacgttac ctacctctct gtaactcaga ttgctcatca
    10921 gtaacatggg gagagtggta tcaaccacta agaggattaa atgagtgaat atttgtaaaa
    10981 cacgtagcct agaatagata tttataaagc acaagatcta tgtaaagtgt ttataacata
    11041 atacattgga atatgagact tgaacatttt gaagattcta ataaatgaat aatttaattt
    11101 agtgctcatt tgaaaaatat tttatcctca tgtttacatt taacacatat aatttatatc
    11161 ttagttttta tcccatttat atatatattt accagaaaaa tgttttgtaa taccttaatt
    11221 ttatgtggag ttgaatttaa ataattaggc cgaatttgta tgtattgttg gatgggtatg
    11281 tgtattgacc tgatttataa aataaagtat ttattaaact ga
//
