LOCUS       NM_015058               7174 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens von Willebrand factor A domain containing 8 (VWA8),
            transcript variant 1, mRNA.
ACCESSION   NM_015058 XM_038664
VERSION     NM_015058.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7174)
  AUTHORS   Kong,L., Chu,G., Ma,W., Liang,J., Liu,D., Liu,Q., Wei,X., Jia,S.,
            Gu,H., He,Y., Luo,W., Cao,S., Zhou,X., He,R. and Yuan,Z.
  TITLE     Mutations in VWA8 cause autosomal-dominant retinitis pigmentosa via
            aberrant mitophagy activation
  JOURNAL   J Med Genet 60 (10), 939-950 (2023)
   PUBMED   37012052
  REMARK    GeneRIF: Mutations in VWA8 cause autosomal-dominant retinitis
            pigmentosa via aberrant mitophagy activation.
REFERENCE   2  (bases 1 to 7174)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   3  (bases 1 to 7174)
  AUTHORS   Umair,M., Farooq Khan,M., Aldrees,M., Nashabat,M., Alhamoudi,K.M.,
            Bilal,M., Alyafee,Y., Al Tuwaijri,A., Aldarwish,M., Al-Rumayyan,A.,
            Alkhalaf,H., Wadaan,M.A.M. and Alfadhel,M.
  TITLE     Mutated VWA8 Is Associated With Developmental Delay, Microcephaly,
            and Scoliosis and Plays a Novel Role in Early Development and
            Skeletal Morphogenesis in Zebrafish
  JOURNAL   Front Cell Dev Biol 9, 736960 (2021)
   PUBMED   34660594
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7174)
  AUTHORS   Imanaka,T. and Kawaguchi,K.
  TITLE     A novel dynein-type AAA+ protein with peroxisomal targeting signal
            type 2
  JOURNAL   J Biochem 167 (5), 429-432 (2020)
   PUBMED   32027355
  REMARK    GeneRIF: A novel dynein-type AAA+ protein with peroxisomal
            targeting signal type 2.
REFERENCE   5  (bases 1 to 7174)
  AUTHORS   Niwa,H., Miyauchi-Nanri,Y., Okumoto,K., Mukai,S., Noi,K., Ogura,T.
            and Fujiki,Y.
  TITLE     A newly isolated Pex7-binding, atypical PTS2 protein P7BP2 is a
            novel dynein-type AAA+ protein
  JOURNAL   J Biochem 164 (6), 437-447 (2018)
   PUBMED   30204880
  REMARK    GeneRIF: Data suggest that P7BP2 is localized to peroxisomes by
            binding to PEX5 via PEX7 in manner dependent on apparent PTS2 (type
            2 peroxisomal targeting signal peptide) in N-terminal region of
            P7BP2; the PTS2 is subsequently cleaved off in peroxisomes. (P7BP2
            = PEX7-binding protein-2; PEX5 = peroxisomal biogenesis factor-5;
            PEX7 = peroxisomal biogenesis factor-7)
REFERENCE   6  (bases 1 to 7174)
  AUTHORS   Castaldi,P.J., Cho,M.H., San Jose Estepar,R., McDonald,M.L.,
            Laird,N., Beaty,T.H., Washko,G., Crapo,J.D. and Silverman,E.K.
  CONSRTM   COPDGene Investigators
  TITLE     Genome-wide association identifies regulatory Loci associated with
            distinct local histogram emphysema patterns
  JOURNAL   Am J Respir Crit Care Med 190 (4), 399-409 (2014)
   PUBMED   25006744
REFERENCE   7  (bases 1 to 7174)
  AUTHORS   Chimusa,E.R., Zaitlen,N., Daya,M., Moller,M., van Helden,P.D.,
            Mulder,N.J., Price,A.L. and Hoal,E.G.
  TITLE     Genome-wide association study of ancestry-specific TB risk in the
            South African Coloured population
  JOURNAL   Hum Mol Genet 23 (3), 796-809 (2014)
   PUBMED   24057671
REFERENCE   8  (bases 1 to 7174)
  AUTHORS   Anney,R., Klei,L., Pinto,D., Regan,R., Conroy,J., Magalhaes,T.R.,
            Correia,C., Abrahams,B.S., Sykes,N., Pagnamenta,A.T., Almeida,J.,
            Bacchelli,E., Bailey,A.J., Baird,G., Battaglia,A., Berney,T.,
            Bolshakova,N., Bolte,S., Bolton,P.F., Bourgeron,T., Brennan,S.,
            Brian,J., Carson,A.R., Casallo,G., Casey,J., Chu,S.H., Cochrane,L.,
            Corsello,C., Crawford,E.L., Crossett,A., Dawson,G., de Jonge,M.,
            Delorme,R., Drmic,I., Duketis,E., Duque,F., Estes,A., Farrar,P.,
            Fernandez,B.A., Folstein,S.E., Fombonne,E., Freitag,C.M.,
            Gilbert,J., Gillberg,C., Glessner,J.T., Goldberg,J., Green,J.,
            Guter,S.J., Hakonarson,H., Heron,E.A., Hill,M., Holt,R., Howe,J.L.,
            Hughes,G., Hus,V., Igliozzi,R., Kim,C., Klauck,S.M., Kolevzon,A.,
            Korvatska,O., Kustanovich,V., Lajonchere,C.M., Lamb,J.A.,
            Laskawiec,M., Leboyer,M., Le Couteur,A., Leventhal,B.L.,
            Lionel,A.C., Liu,X.Q., Lord,C., Lotspeich,L., Lund,S.C.,
            Maestrini,E., Mahoney,W., Mantoulan,C., Marshall,C.R.,
            McConachie,H., McDougle,C.J., McGrath,J., McMahon,W.M.,
            Melhem,N.M., Merikangas,A., Migita,O., Minshew,N.J., Mirza,G.K.,
            Munson,J., Nelson,S.F., Noakes,C., Noor,A., Nygren,G., Oliveira,G.,
            Papanikolaou,K., Parr,J.R., Parrini,B., Paton,T., Pickles,A.,
            Piven,J., Posey,D.J., Poustka,A., Poustka,F., Prasad,A.,
            Ragoussis,J., Renshaw,K., Rickaby,J., Roberts,W., Roeder,K.,
            Roge,B., Rutter,M.L., Bierut,L.J., Rice,J.P., Salt,J., Sansom,K.,
            Sato,D., Segurado,R., Senman,L., Shah,N., Sheffield,V.C.,
            Soorya,L., Sousa,I., Stoppioni,V., Strawbridge,C., Tancredi,R.,
            Tansey,K., Thiruvahindrapduram,B., Thompson,A.P., Thomson,S.,
            Tryfon,A., Tsiantis,J., Van Engeland,H., Vincent,J.B., Volkmar,F.,
            Wallace,S., Wang,K., Wang,Z., Wassink,T.H., Wing,K., Wittemeyer,K.,
            Wood,S., Yaspan,B.L., Zurawiecki,D., Zwaigenbaum,L., Betancur,C.,
            Buxbaum,J.D., Cantor,R.M., Cook,E.H., Coon,H., Cuccaro,M.L.,
            Gallagher,L., Geschwind,D.H., Gill,M., Haines,J.L., Miller,J.,
            Monaco,A.P., Nurnberger,J.I. Jr., Paterson,A.D.,
            Pericak-Vance,M.A., Schellenberg,G.D., Scherer,S.W.,
            Sutcliffe,J.S., Szatmari,P., Vicente,A.M., Vieland,V.J.,
            Wijsman,E.M., Devlin,B., Ennis,S. and Hallmayer,J.
  TITLE     A genome-wide scan for common alleles affecting risk for autism
  JOURNAL   Hum Mol Genet 19 (20), 4072-4082 (2010)
   PUBMED   20663923
  REMARK    GeneRIF: Observational study and genome-wide association study of
            gene-disease association. (HuGE Navigator)
REFERENCE   9  (bases 1 to 7174)
  AUTHORS   Oedegaard,K.J., Greenwood,T.A., Johansson,S., Jacobsen,K.K.,
            Halmoy,A., Fasmer,O.B., Akiskal,H.S., Haavik,J. and Kelsoe,J.R.
  CONSRTM   Bipolar Genome Study (BiGS)
  TITLE     A genome-wide association study of bipolar disorder and comorbid
            migraine
  JOURNAL   Genes Brain Behav 9 (7), 673-680 (2010)
   PUBMED   20528957
  REMARK    GeneRIF: Observational study and genome-wide association study of
            gene-disease association. (HuGE Navigator)
REFERENCE   10 (bases 1 to 7174)
  AUTHORS   Nakayama,M., Kikuno,R. and Ohara,O.
  TITLE     Protein-protein interactions between large proteins: two-hybrid
            screening using a functionally classified library composed of long
            cDNAs
  JOURNAL   Genome Res 12 (11), 1773-1784 (2002)
   PUBMED   12421765
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL442203.12, AL163544.24, AL161417.17, AL160252.20 and AL354833.9.
            
            On May 17, 2019 this sequence version replaced NM_015058.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.24681.1,
                                           SRR1803616.274809.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000379310.8/ ENSP00000368612.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-257               AL442203.12        113702-113958       c
            258-335             AL442203.12        102785-102862       c
            336-466             AL442203.12        64887-65017         c
            467-577             AL442203.12        60435-60545         c
            578-745             AL442203.12        44269-44436         c
            746-910             AL442203.12        40046-40210         c
            911-960             AL442203.12        39630-39679         c
            961-1069            AL442203.12        38769-38877         c
            1070-1174           AL442203.12        36236-36340         c
            1175-1306           AL442203.12        21195-21326         c
            1307-1441           AL442203.12        18751-18885         c
            1442-1519           AL442203.12        18585-18662         c
            1520-1680           AL163544.24        44506-44666         c
            1681-1794           AL163544.24        41664-41777         c
            1795-1963           AL163544.24        30353-30521         c
            1964-2041           AL163544.24        27833-27910         c
            2042-2157           AL163544.24        22360-22475         c
            2158-2264           AL161417.17        153878-153984       c
            2265-2371           AL161417.17        150236-150342       c
            2372-2443           AL161417.17        144426-144497       c
            2444-2520           AL161417.17        127569-127645       c
            2521-2596           AL161417.17        98521-98596         c
            2597-2732           AL161417.17        95983-96118         c
            2733-2852           AL161417.17        93635-93754         c
            2853-3058           AL161417.17        87811-88016         c
            3059-3210           AL161417.17        86032-86183         c
            3211-3319           AL161417.17        69744-69852         c
            3320-3458           AL161417.17        67833-67971         c
            3459-3658           AL161417.17        65512-65711         c
            3659-3769           AL161417.17        59303-59413         c
            3770-3834           AL161417.17        58315-58379         c
            3835-3960           AL161417.17        57761-57886         c
            3961-4070           AL161417.17        56607-56716         c
            4071-4225           AL161417.17        55795-55949         c
            4226-4421           AL161417.17        51488-51683         c
            4422-4503           AL161417.17        41656-41737         c
            4504-4705           AL161417.17        37387-37588         c
            4706-4814           AL160252.20        17336-17444         c
            4815-4971           AL160252.20        13936-14092         c
            4972-5080           AL160252.20        7528-7636           c
            5081-5206           AL354833.9         149871-149996       c
            5207-5365           AL354833.9         146743-146901       c
            5366-5464           AL354833.9         134971-135069       c
            5465-5703           AL354833.9         129699-129937       c
            5704-7174           AL354833.9         126066-127536       c
FEATURES             Location/Qualifiers
     source          1..7174
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q14.11"
     gene            1..7174
                     /gene="VWA8"
                     /gene_synonym="KIAA0564; P7BP2; RP97"
                     /note="von Willebrand factor A domain containing 8"
                     /db_xref="GeneID:23078"
                     /db_xref="HGNC:HGNC:29071"
                     /db_xref="MIM:617509"
     exon            1..257
                     /gene="VWA8"
                     /gene_synonym="KIAA0564; P7BP2; RP97"
                     /inference="alignment:Splign:2.1.0"
     CDS             95..5812
                     /gene="VWA8"
                     /gene_synonym="KIAA0564; P7BP2; RP97"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; von Willebrand factor A domain-containing
                     protein 8; PEX7-binding protein 2; Pex7p-binding protein
                     2"
                     /codon_start=1
                     /product="von Willebrand factor A domain-containing
                     protein 8 isoform a precursor"
                     /protein_id="NP_055873.1"
                     /db_xref="CCDS:CCDS41881.1"
                     /db_xref="GeneID:23078"
                     /db_xref="HGNC:HGNC:29071"
                     /db_xref="MIM:617509"
                     /translation="MQSRLLLLGAPGGHGGPASRRMRLLLRQVVQRRPGGDRQRPEVR
                     LLHAGSGADTGDTVNIGDVSYKLKIPKNPELVPQNYISDSLAQSVVQHLRWIMQKDLL
                     GQDVFLIGPPGPLRRSIAMQYLELTKREVEYIALSRDTTETDLKQRREIRAGTAFYID
                     QCAVRAATEGRTLILEGLEKAERNVLPVLNNLLENREMQLEDGRFLMSAERYDKLLRD
                     HTKKELDSWKIVRVSENFRVIALGLPVPRYSGNPLDPPLRSRFQARDIYYLPFKDQLK
                     LLYSIGANVSAEKVSQLLSFATTLCSQESSTLGLPDFPLDSLAAAVQILDSFPMMPIK
                     HAIQWLYPYSILLGHEGKMAVEGVLKRFELQDSGSSLLPKEIVKVEKMMENHVSQASV
                     TIRIADKEVTIKVPAGTRLLSQPCASDRFIQTLSHKQLQAEMMQSHMVKDICLIGGKG
                     CGKTVIAKNFADTLGYNIEPIMLYQDMTARDLLQQRYTLPNGDTAWRSSPLVNAALEG
                     KLVLLDGIHRVNAGTLAVLQRLIHDRELSLYDGSRLLREDRYMRLKEELQLSDEQLQK
                     RSIFPIHPSFRIIALAEPPVIGSTAHQWLGPEFLTMFFFHYMKPLVKSEEIQVIKEKV
                     PNVPQEALDKLLSFTHKLRETQDPTAQSLAASLSTRQLLRISRRLSQYPNENLHSAVT
                     KACLSRFLPSLARSALEKNLADATIEINTDDNLEPELKDYKCEVTSGTLRIGAVSAPI
                     YNAHEKMKVPDVLFYDNIQHVIVMEDMLKDFLLGEHLLLVGNQGVGKNKIVDRFLHLL
                     NRPREYIQLHRDTTVQTLTLQPSVKDGLIVYEDSPLVKAVKLGHILVVDEADKAPTNV
                     TCILKTLVENGEMILADGRRIVANSANVNGRENVVVIHPDFRMIVLANRPGFPFLGND
                     FFGTLGDIFSCHAVDNPKPHSELEMLRQYGPNVPEPILQKLVAAFGELRSLADQGIIN
                     YPYSTREVVNIVKHLQKFPTEGLSSVVRNVFDFDSYNNDMREILINTLHKYGIPIGAK
                     PTSVQLAKELTLPEQTFMGYWTIGQARSGMQKLLCPVETHHIDIKGPALINIQEYPIE
                     RHEERSLNFTEECASWRIPLDEINIICDIATSHENEQNTLYVVTCNPASLYFMNMTGK
                     SGFFVDFFDIFPRTANGVWHPFVTVAPLGSPLKGQVVLHEQQSNVILLLDTTGRALHR
                     LILPSEKFTSKKPFWWNKEEAETYKMCKEFSHKNWLVFYKEKGNSLTVLDVLEGRTHT
                     ISLPINLKTVFLVAEDKWLLVESKTNQKYLLTKPAHIESEGSGVCQLYVLKEEPPSTG
                     FGVTQETEFSIPHKISSDQLSSEHLSSAVEQKIASPNRILSDEKNYATIVVGFPDLMS
                     PSEVYSWKRPSSLHKRSGTDTSFYRGKKKRGTPKQSNCVTLLDTNQVVRILPPGEVPL
                     KDIYPKDVTPPQTSGYIEVTDLQSKKLRYIPIPRSESLSPYTTWLSTISDTDALLAEW
                     DKSGVVTVDMGGHIRLWETGLERLQRSLMEWRNMIGQDDRNMQITINRDSGEDVSSPK
                     HGKEDPDNMPHVGGNTWAGGTGGRDTAGLGGKGGPYRLDAGHTVYQVSQAEKDAVPEE
                     VKRAAREMGQRAFQQRLKEIQMSEYDAATYERFSGAVRRQVHSLRIILDNLQAKGKER
                     QWLRHQATGELDDAKIIDGLTGEKAIYKRRGELEPQLGSPQQKPKRLRLVVDVSGSMY
                     RFNRMDGRLERTMEAVCMVMEAFENYEEKFQYDIVGHSGDGYNIGLVPMNKIPKDNKQ
                     RLEILKTMHAHSQFCMSGDHTLEGTEHAIKEIVKEEADEYFVIVLSDANLSRYGIHPA
                     KFAQILTRDPQVNAFAIFIGSLGDQATRLQRTLPAGRSFVAMDTKDIPQILQQIFTST
                     MLSSV"
     exon            258..335
                     /gene="VWA8"
                     /gene_synonym="KIAA0564; P7BP2; RP97"
                     /inference="alignment:Splign:2.1.0"
     exon            336..466
                     /gene="VWA8"
                     /gene_synonym="KIAA0564; P7BP2; RP97"
                     /inference="alignment:Splign:2.1.0"
     exon            467..577
                     /gene="VWA8"
                     /gene_synonym="KIAA0564; P7BP2; RP97"
                     /inference="alignment:Splign:2.1.0"
     exon            578..745
                     /gene="VWA8"
                     /gene_synonym="KIAA0564; P7BP2; RP97"
                     /inference="alignment:Splign:2.1.0"
     exon            746..910
                     /gene="VWA8"
                     /gene_synonym="KIAA0564; P7BP2; RP97"
                     /inference="alignment:Splign:2.1.0"
     exon            911..960
                     /gene="VWA8"
                     /gene_synonym="KIAA0564; P7BP2; RP97"
                     /inference="alignment:Splign:2.1.0"
     exon            961..1069
                     /gene="VWA8"
                     /gene_synonym="KIAA0564; P7BP2; RP97"
                     /inference="alignment:Splign:2.1.0"
     exon            1070..1174
                     /gene="VWA8"
                     /gene_synonym="KIAA0564; P7BP2; RP97"
                     /inference="alignment:Splign:2.1.0"
     exon            1175..1306
                     /gene="VWA8"
                     /gene_synonym="KIAA0564; P7BP2; RP97"
                     /inference="alignment:Splign:2.1.0"
     exon            1307..1441
                     /gene="VWA8"
                     /gene_synonym="KIAA0564; P7BP2; RP97"
                     /inference="alignment:Splign:2.1.0"
     exon            1442..1519
                     /gene="VWA8"
                     /gene_synonym="KIAA0564; P7BP2; RP97"
                     /inference="alignment:Splign:2.1.0"
     exon            1520..1680
                     /gene="VWA8"
                     /gene_synonym="KIAA0564; P7BP2; RP97"
                     /inference="alignment:Splign:2.1.0"
     exon            1681..1794
                     /gene="VWA8"
                     /gene_synonym="KIAA0564; P7BP2; RP97"
                     /inference="alignment:Splign:2.1.0"
     exon            1795..1963
                     /gene="VWA8"
                     /gene_synonym="KIAA0564; P7BP2; RP97"
                     /inference="alignment:Splign:2.1.0"
     exon            1964..2041
                     /gene="VWA8"
                     /gene_synonym="KIAA0564; P7BP2; RP97"
                     /inference="alignment:Splign:2.1.0"
     exon            2042..2157
                     /gene="VWA8"
                     /gene_synonym="KIAA0564; P7BP2; RP97"
                     /inference="alignment:Splign:2.1.0"
     exon            2158..2264
                     /gene="VWA8"
                     /gene_synonym="KIAA0564; P7BP2; RP97"
                     /inference="alignment:Splign:2.1.0"
     exon            2265..2371
                     /gene="VWA8"
                     /gene_synonym="KIAA0564; P7BP2; RP97"
                     /inference="alignment:Splign:2.1.0"
     exon            2372..2443
                     /gene="VWA8"
                     /gene_synonym="KIAA0564; P7BP2; RP97"
                     /inference="alignment:Splign:2.1.0"
     exon            2444..2520
                     /gene="VWA8"
                     /gene_synonym="KIAA0564; P7BP2; RP97"
                     /inference="alignment:Splign:2.1.0"
     exon            2521..2596
                     /gene="VWA8"
                     /gene_synonym="KIAA0564; P7BP2; RP97"
                     /inference="alignment:Splign:2.1.0"
     exon            2597..2732
                     /gene="VWA8"
                     /gene_synonym="KIAA0564; P7BP2; RP97"
                     /inference="alignment:Splign:2.1.0"
     exon            2733..2852
                     /gene="VWA8"
                     /gene_synonym="KIAA0564; P7BP2; RP97"
                     /inference="alignment:Splign:2.1.0"
     exon            2853..3058
                     /gene="VWA8"
                     /gene_synonym="KIAA0564; P7BP2; RP97"
                     /inference="alignment:Splign:2.1.0"
     exon            3059..3210
                     /gene="VWA8"
                     /gene_synonym="KIAA0564; P7BP2; RP97"
                     /inference="alignment:Splign:2.1.0"
     exon            3211..3319
                     /gene="VWA8"
                     /gene_synonym="KIAA0564; P7BP2; RP97"
                     /inference="alignment:Splign:2.1.0"
     exon            3320..3458
                     /gene="VWA8"
                     /gene_synonym="KIAA0564; P7BP2; RP97"
                     /inference="alignment:Splign:2.1.0"
     exon            3459..3658
                     /gene="VWA8"
                     /gene_synonym="KIAA0564; P7BP2; RP97"
                     /inference="alignment:Splign:2.1.0"
     exon            3659..3769
                     /gene="VWA8"
                     /gene_synonym="KIAA0564; P7BP2; RP97"
                     /inference="alignment:Splign:2.1.0"
     exon            3770..3834
                     /gene="VWA8"
                     /gene_synonym="KIAA0564; P7BP2; RP97"
                     /inference="alignment:Splign:2.1.0"
     exon            3835..3960
                     /gene="VWA8"
                     /gene_synonym="KIAA0564; P7BP2; RP97"
                     /inference="alignment:Splign:2.1.0"
     exon            3961..4070
                     /gene="VWA8"
                     /gene_synonym="KIAA0564; P7BP2; RP97"
                     /inference="alignment:Splign:2.1.0"
     exon            4071..4225
                     /gene="VWA8"
                     /gene_synonym="KIAA0564; P7BP2; RP97"
                     /inference="alignment:Splign:2.1.0"
     exon            4226..4421
                     /gene="VWA8"
                     /gene_synonym="KIAA0564; P7BP2; RP97"
                     /inference="alignment:Splign:2.1.0"
     exon            4422..4503
                     /gene="VWA8"
                     /gene_synonym="KIAA0564; P7BP2; RP97"
                     /inference="alignment:Splign:2.1.0"
     exon            4504..4705
                     /gene="VWA8"
                     /gene_synonym="KIAA0564; P7BP2; RP97"
                     /inference="alignment:Splign:2.1.0"
     exon            4706..4814
                     /gene="VWA8"
                     /gene_synonym="KIAA0564; P7BP2; RP97"
                     /inference="alignment:Splign:2.1.0"
     exon            4815..4971
                     /gene="VWA8"
                     /gene_synonym="KIAA0564; P7BP2; RP97"
                     /inference="alignment:Splign:2.1.0"
     exon            4972..5080
                     /gene="VWA8"
                     /gene_synonym="KIAA0564; P7BP2; RP97"
                     /inference="alignment:Splign:2.1.0"
     exon            5081..5206
                     /gene="VWA8"
                     /gene_synonym="KIAA0564; P7BP2; RP97"
                     /inference="alignment:Splign:2.1.0"
     exon            5207..5365
                     /gene="VWA8"
                     /gene_synonym="KIAA0564; P7BP2; RP97"
                     /inference="alignment:Splign:2.1.0"
     exon            5366..5464
                     /gene="VWA8"
                     /gene_synonym="KIAA0564; P7BP2; RP97"
                     /inference="alignment:Splign:2.1.0"
     exon            5465..5703
                     /gene="VWA8"
                     /gene_synonym="KIAA0564; P7BP2; RP97"
                     /inference="alignment:Splign:2.1.0"
     exon            5704..7174
                     /gene="VWA8"
                     /gene_synonym="KIAA0564; P7BP2; RP97"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7152..7157
                     /regulatory_class="polyA_signal_sequence"
                     /gene="VWA8"
                     /gene_synonym="KIAA0564; P7BP2; RP97"
                     /note="hexamer: AATAAA"
     polyA_site      7174
                     /gene="VWA8"
                     /gene_synonym="KIAA0564; P7BP2; RP97"
                     /note="major polyA site"
ORIGIN      
        1 cctgtcccct tctccgcgct gcctcacggt gcctgcacgg gacgccgctc gatccccgag
       61 ccccctcgcc gtccccgaca gcccccccgg cgccatgcaa tcccggcttc tactcctcgg
      121 ggcacccgga ggccacggcg gcccggcctc gcggcgcatg cggctgctcc tgcggcaggt
      181 ggtgcagcgc aggccgggtg gcgacaggca gcggccggag gtcagactgt tgcacgccgg
      241 ctcgggggcc gacacaggtg atacagttaa tattggagat gtatcctaca agttgaaaat
      301 tcctaagaat ccagaacttg tgccacagaa ctacatttca gactctctgg ctcaatctgt
      361 agttcagcat ctaagatgga taatgcagaa ggatcttttg gggcaagatg tttttctaat
      421 aggacctcct gggcctcttc gacgctctat tgctatgcag tacttggagc tgaccaaacg
      481 ggaggtcgaa tacattgccc tgtcaaggga caccactgaa actgatctca aacagcgacg
      541 agagatccgt gcaggcacag ccttttacat tgatcagtgt gcagttcgtg cagccacaga
      601 aggcagaact ctcattttgg aaggtttgga aaaggcagag aggaatgttt tgcctgtttt
      661 gaacaacttg ctggaaaaca gagagatgca gcttgaagat ggacgcttcc tgatgtctgc
      721 tgagcgttac gacaaacttc tccgagatca taccaaaaaa gagttggatt cttggaaaat
      781 tgtccgagtt agtgaaaatt tccgagtgat tgccttgggc ttgccagtgc caaggtattc
      841 tgggaatcca ttagaccccc ctcttcgttc tcgatttcaa gccagggata tttattattt
      901 acccttcaag gaccaactta agttgttata ttcaattgga gccaatgttt ctgctgagaa
      961 agtttctcag ctcttgtcct ttgccacaac tctgtgttcc caagaatctt ctactcttgg
     1021 acttccagac tttcctttag atagtttagc agctgcggtt caaatcttgg attcctttcc
     1081 tatgatgcca atcaaacatg caatccagtg gctttatcca tatagtattt tactaggtca
     1141 tgaagggaag atggctgtgg aaggtgtttt aaagcgcttt gaacttcaag attcaggaag
     1201 ctctctactt cctaaagaga ttgtaaaagt agagaagatg atggaaaacc atgtgtccca
     1261 agcttctgtg accatccgga ttgcagataa agaggtgacc attaaggtgc cagccgggac
     1321 caggctatta agtcaacctt gtgcgtcaga ccgtttcata cagactttga gccataagca
     1381 gctacaggct gaaatgatgc agtctcacat ggttaaagat atatgtttaa ttggaggaaa
     1441 gggttgtgga aaaacagtga tcgctaagaa ctttgccgat accttaggat acaacataga
     1501 acctattatg ctctatcagg atatgacagc gcgtgatctg ctacagcaga gatacaccct
     1561 tccaaatgga gacactgcct ggcggtcctc accccttgtg aatgctgctc tggaaggcaa
     1621 gctggtcctg ctggatggca ttcaccgggt gaatgcgggc acgcttgctg tattgcaaag
     1681 gttaatccat gatcgagagc taagcctcta tgatggttct aggctgctga gagaagacag
     1741 gtatatgcgt ttaaaggagg agctgcaact gtctgatgaa cagctacaga agagatccat
     1801 ttttcctatc catccctcct tcagaatcat tgccttggca gaaccccctg ttattggaag
     1861 cacagcacac cagtggctgg gaccagaatt cttaaccatg ttctttttcc attacatgaa
     1921 accacttgtg aaaagtgaag aaatccaagt gattaaggaa aaggtcccaa atgtacctca
     1981 ggaagctctg gataagttat tatcatttac acacaaactc agagaaacac aggatccaac
     2041 ggcacaatca ttagcggcat cactttctac cagacaactg ttgcgaattt ctcgtcggct
     2101 gtcacagtat cctaatgaaa atcttcacag tgctgttact aaagcctgcc tttccaggtt
     2161 tttacccagt cttgctaggt cagcattaga aaaaaatctg gcagatgcta caatagaaat
     2221 aaatactgat gacaatttgg agccagaact gaaggattac aaatgtgaag taacatctgg
     2281 aactctgagg attggtgctg ttagtgcacc gatctataat gcacatgaga aaatgaaagt
     2341 gcctgatgtt cttttctatg acaacattca gcatgtgata gtgatggaag atatgctgaa
     2401 agactttctc cttggagaac acttattatt ggttggcaac cagggtgtag gaaaaaacaa
     2461 gattgttgac agattccttc acctgctcaa cagaccccga gaatatattc agctacacag
     2521 ggataccaca gtacaaactc ttacgcttca gccttcggtt aaagacggac ttattgtata
     2581 tgaagactca cctttggtta aagcagtaaa gttgggtcat attctggtag tagatgaggc
     2641 tgacaaagct ccaacaaatg tcacgtgtat tttaaaaact ctagtagaaa atggagaaat
     2701 gattctagca gatggaagac gcattgttgc aaattctgct aatgtgaatg gaagagaaaa
     2761 tgttgtagtg attcatcctg attttaggat gattgttctg gcaaatagac ctggatttcc
     2821 tttcctaggc aatgatttct tcggtacctt aggtgatatt tttagctgcc atgcagttga
     2881 taaccccaaa ccccactcgg agctcgagat gctcagacag tatggaccaa atgtgcctga
     2941 gcccatcctt cagaagcttg tggctgcctt tggagagctg aggagtttgg ctgaccaagg
     3001 gattattaac tatccttatt ctaccagaga agttgtcaac atagtcaaac atttacagaa
     3061 atttccgact gaaggtctct ccagtgtagt tcgaaatgtg tttgactttg attcctacaa
     3121 caatgacatg agggagatat tgattaacac tttacacaaa tacgggatac ctatcggagc
     3181 aaagcctacc agtgtgcagc tggcaaagga gttgactctg ccagaacaaa cgttcatggg
     3241 ctactggaca attggtcagg caagaagtgg gatgcaaaaa ctcttgtgtc cagtggaaac
     3301 tcatcatata gacataaagg gtccagcact tataaatata caggagtatc caatagaaag
     3361 acatgaagaa agatccctaa actttactga agaatgtgcc tcatggagaa taccattgga
     3421 tgaaattaat ataatctgtg acattgctac atcacatgaa aatgagcaaa atactctcta
     3481 tgtagttaca tgcaatcccg cttccctgta ctttatgaat atgactggga aaagtggctt
     3541 ctttgtggac ttttttgata tcttcccaag aacagccaat ggcgtttggc acccttttgt
     3601 gacagtggca ccgctgggaa gtcctctcaa aggtcaagtg gttctccatg agcagcagag
     3661 taatgttatc ctgttgttag atactactgg ccgggccctt catcgtctca tcctcccttc
     3721 cgagaagttt acatctaaga aacctttctg gtggaacaaa gaagaagctg aaacttataa
     3781 aatgtgtaaa gaattttcac acaaaaactg gctggtgttc tacaaagaaa aagggaacag
     3841 cctgactgtg ctggatgttc tagaagggcg aactcacacc atctcacttc ccatcaacct
     3901 caagacagtt ttccttgtag cagaggacaa atggcttctg gtggagagca aaacaaatca
     3961 gaaatatctt ttaactaagc ctgcacacat cgaatctgag ggtagtgggg tttgccagtt
     4021 gtatgtgctg aaagaggagc cgcccagcac agggtttgga gttacacaag aaacagagtt
     4081 cagcatacct cataaaattt ccagtgatca actatcatct gaacatctaa gttcagctgt
     4141 ggaacaaaag attgcctctc ccaacagaat tctctcagat gagaaaaatt atgctacaat
     4201 agttgttggt tttccagatc tcatgtcacc cagtgaagtt tattcttgga agagaccatc
     4261 atctttgcat aaacgaagtg gcactgatac atcattctat agaggaaaga agaaaagggg
     4321 gactccaaaa caaagcaatt gtgtgactct tttagatacg aatcaggtag tgaggatttt
     4381 acccccagga gaagtccctc taaaagatat ctacccaaaa gatgttactc ctccacaaac
     4441 atctggttat atagaagtca ctgatcttca atcaaagaaa ctccgatata tccctattcc
     4501 cagatcagaa tctctctcgc cgtataccac atggctgtcg accatttcag acacagatgc
     4561 actgctggct gagtgggaca aaagcggtgt tgttactgtt gatatgggag gtcacatcag
     4621 gctttgggaa actggacttg aacgtctgca gcgatcactc atggaatgga gaaacatgat
     4681 tggacaagat gacagaaata tgcagataac aatcaacaga gacagtggtg aagatgtaag
     4741 ctcccccaaa cacgggaagg aggacccaga caacatgcct cacgtgggcg gcaacacttg
     4801 ggctggcgga acagggggaa gagacacggc aggcctgggt ggcaaaggag gcccttaccg
     4861 gctggatgca ggccatacgg tgtaccaggt ctctcaggct gagaaagatg cagttcccga
     4921 agaggtcaag agagctgcta gagagatggg ccagagagca ttccagcaga ggctaaagga
     4981 gatccaaatg agtgaatacg atgctgcaac ctatgaaagg ttttcaggtg ctgttcggcg
     5041 acaggtgcac tccctccgaa tcatcctgga taatttacag gctaaaggta aagaaagaca
     5101 atggctaaga catcaagcta ctggagaatt agatgatgcc aagatcattg atgggctgac
     5161 tggagaaaaa gccatctaca aacgtcgggg tgagctggag ccacaacttg gcagcccaca
     5221 acagaaaccc aagcgtctgc gcctggtggt agatgtgtct ggtagcatgt accgtttcaa
     5281 caggatggat ggccggcttg agcgcacaat ggaggctgtg tgtatggtca tggaagcctt
     5341 cgagaactat gaggagaagt tccagtatga catcgttgga cactctggag atggctacaa
     5401 cattggtctg gttccaatga acaaaatccc caaggacaat aagcaaagac tagaaattct
     5461 gaagacaatg catgcccact ctcagttctg catgagtggg gaccacacgt tagaagggac
     5521 agaacatgcc atcaaggaaa ttgtcaaaga agaagctgat gagtactttg tcatagtctt
     5581 gagtgatgca aatctgtcac gatatggaat acatcctgct aagtttgctc aaatcctcac
     5641 aagagaccct caagtaaatg cttttgccat ttttattggc tctttaggtg atcaagcaac
     5701 caggcttcag agaactttac cagctggtcg gtctttcgtt gccatggata ccaaggatat
     5761 ccctcagatt ttacaacaga tcttcacctc caccatgttg tcgagtgtct aagaagtgcc
     5821 cttcatcacc ctgatgacac caggatttga aataagacag gaataaagag tattctgaaa
     5881 aaaagaagat atggatgaag tgaacccatg cagtgactgg atgattccgg cattcctggg
     5941 tcttcctaca cttgctccgt aatgagaatt cagagaagca gccagaagga gacttaaaca
     6001 tggaaagata ctccactgat gagtttagaa gtgattaggg caagctagtt gacctgcact
     6061 ttatcaaagg ttggggttaa aggaaggtgg ttttgagaac tatgtgtttg gtctatttcc
     6121 aaaaacctga gggggagaaa atactttgct tttgccttaa cacatcatct ggtcacgtta
     6181 gaaaagtgac cccatcaaac tgagcctttg atgtcacatt ctgacacaag atgcaagtct
     6241 gtgcaaaacc caccaaaatg ctcctatcca acaattattt ttattttctc cctgctctgt
     6301 attgaccaga aaacaatgat tttataatat ttaacccacc aaaaagtccc tccaacagca
     6361 atatcttatg aaagtctggc tgttctcaat aatttcattt tcttggccaa agccaaaagg
     6421 aatcaaaaaa tccttggagt gcttgccttt ccacgtgact tttaaaaggc tcttaaagag
     6481 caaatgtcct cttctccttg ctgctagagt gggaggagaa agatgtcttg ccttaaaagt
     6541 ttactgtttc ttctgttctt ctagcatctc tcaaaaaatt cacagtactc cattttgggg
     6601 tccaaactgt aatgctcaaa ataataaatg cttacacgaa aattatttat tgagaatatt
     6661 catataaaaa ttacctaaag caaagtaaaa aaagtaaaat caaggtggta tatttgaagt
     6721 gaatggtgat tggaaatttt tagctgtaac aaaaagaaag aaaacaactt tttttaaagc
     6781 ctcattctct tttctttcaa aatgtacctt attcccacac actcttgggc tgacctttat
     6841 tttatcaata agctcaatat tactttgttt aaaataagat gcttcagcaa aagtcattct
     6901 ctctttaacc atataattta aaaactcctc ttcacgattg atagcaaaat cagaaacgtt
     6961 agggcaccag tgagttgaaa aaactggtct taagttggaa aaactattat taataatatt
     7021 atcctatcca tccatatcta ttgaaattgt acaggtccat aatttcattt taattaatta
     7081 taggaaagaa gaaaagataa tacccatttg ttctatcacc cctctcccta tcattaacta
     7141 tcaaataaat aaataaaagc aatctgattt ccaa
//
