LOCUS       NM_025258               2915 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens von Willebrand factor A domain containing 7 (VWA7),
            mRNA.
ACCESSION   NM_025258
VERSION     NM_025258.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2915)
  AUTHORS   McElroy,J.P., Cree,B.A., Caillier,S.J., Gregersen,P.K., Herbert,J.,
            Khan,O.A., Freudenberg,J., Lee,A., Bridges,S.L. Jr., Hauser,S.L.,
            Oksenberg,J.R. and Gourraud,P.A.
  TITLE     Refining the association of MHC with multiple sclerosis in African
            Americans
  JOURNAL   Hum Mol Genet 19 (15), 3080-3088 (2010)
   PUBMED   20466734
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   2  (bases 1 to 2915)
  AUTHORS   Chapuis,J., Hot,D., Hansmannel,F., Kerdraon,O., Ferreira,S.,
            Hubans,C., Maurage,C.A., Huot,L., Bensemain,F., Laumet,G.,
            Ayral,A.M., Fievet,N., Hauw,J.J., DeKosky,S.T., Lemoine,Y.,
            Iwatsubo,T., Wavrant-Devrieze,F., Dartigues,J.F., Tzourio,C.,
            Buee,L., Pasquier,F., Berr,C., Mann,D., Lendon,C., Alperovitch,A.,
            Kamboh,M.I., Amouyel,P. and Lambert,J.C.
  TITLE     Transcriptomic and genetic studies identify IL-33 as a candidate
            gene for Alzheimer's disease
  JOURNAL   Mol Psychiatry 14 (11), 1004-1016 (2009)
   PUBMED   19204726
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   3  (bases 1 to 2915)
  AUTHORS   Barcellos,L.F., May,S.L., Ramsay,P.P., Quach,H.L., Lane,J.A.,
            Nititham,J., Noble,J.A., Taylor,K.E., Quach,D.L., Chung,S.A.,
            Kelly,J.A., Moser,K.L., Behrens,T.W., Seldin,M.F., Thomson,G.,
            Harley,J.B., Gaffney,P.M. and Criswell,L.A.
  TITLE     High-density SNP screening of the major histocompatibility complex
            in systemic lupus erythematosus demonstrates strong evidence for
            independent susceptibility regions
  JOURNAL   PLoS Genet 5 (10), e1000696 (2009)
   PUBMED   19851445
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   4  (bases 1 to 2915)
  AUTHORS   Valdes,A.M. and Thomson,G.
  CONSRTM   Type 1 Diabetes Genetics Consortium
  TITLE     Several loci in the HLA class III region are associated with T1D
            risk after adjusting for DRB1-DQB1
  JOURNAL   Diabetes Obes Metab 11 Suppl 1 (Suppl 1), 46-52 (2009)
   PUBMED   19143814
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   5  (bases 1 to 2915)
  AUTHORS   Xie,T., Rowen,L., Aguado,B., Ahearn,M.E., Madan,A., Qin,S.,
            Campbell,R.D. and Hood,L.
  TITLE     Analysis of the gene-dense major histocompatibility complex class
            III region and its comparison to mouse
  JOURNAL   Genome Res 13 (12), 2621-2636 (2003)
   PUBMED   14656967
REFERENCE   6  (bases 1 to 2915)
  AUTHORS   Mungall,A.J., Palmer,S.A., Sims,S.K., Edwards,C.A., Ashurst,J.L.,
            Wilming,L., Jones,M.C., Horton,R., Hunt,S.E., Scott,C.E.,
            Gilbert,J.G., Clamp,M.E., Bethel,G., Milne,S., Ainscough,R.,
            Almeida,J.P., Ambrose,K.D., Andrews,T.D., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Barker,D.J.,
            Barlow,K.F., Bates,K., Beare,D.M., Beasley,H., Beasley,O.,
            Bird,C.P., Blakey,S., Bray-Allen,S., Brook,J., Brown,A.J.,
            Brown,J.Y., Burford,D.C., Burrill,W., Burton,J., Carder,C.,
            Carter,N.P., Chapman,J.C., Clark,S.Y., Clark,G., Clee,C.M.,
            Clegg,S., Cobley,V., Collier,R.E., Collins,J.E., Colman,L.K.,
            Corby,N.R., Coville,G.J., Culley,K.M., Dhami,P., Davies,J.,
            Dunn,M., Earthrowl,M.E., Ellington,A.E., Evans,K.A., Faulkner,L.,
            Francis,M.D., Frankish,A., Frankland,J., French,L., Garner,P.,
            Garnett,J., Ghori,M.J., Gilby,L.M., Gillson,C.J., Glithero,R.J.,
            Grafham,D.V., Grant,M., Gribble,S., Griffiths,C., Griffiths,M.,
            Hall,R., Halls,K.S., Hammond,S., Harley,J.L., Hart,E.A.,
            Heath,P.D., Heathcott,R., Holmes,S.J., Howden,P.J., Howe,K.L.,
            Howell,G.R., Huckle,E., Humphray,S.J., Humphries,M.D., Hunt,A.R.,
            Johnson,C.M., Joy,A.A., Kay,M., Keenan,S.J., Kimberley,A.M.,
            King,A., Laird,G.K., Langford,C., Lawlor,S., Leongamornlert,D.A.,
            Leversha,M., Lloyd,C.R., Lloyd,D.M., Loveland,J.E., Lovell,J.,
            Martin,S., Mashreghi-Mohammadi,M., Maslen,G.L., Matthews,L.,
            McCann,O.T., McLaren,S.J., McLay,K., McMurray,A., Moore,M.J.,
            Mullikin,J.C., Niblett,D., Nickerson,T., Novik,K.L., Oliver,K.,
            Overton-Larty,E.K., Parker,A., Patel,R., Pearce,A.V., Peck,A.I.,
            Phillimore,B., Phillips,S., Plumb,R.W., Porter,K.M., Ramsey,Y.,
            Ranby,S.A., Rice,C.M., Ross,M.T., Searle,S.M., Sehra,H.K.,
            Sheridan,E., Skuce,C.D., Smith,S., Smith,M., Spraggon,L.,
            Squares,S.L., Steward,C.A., Sycamore,N., Tamlyn-Hall,G., Tester,J.,
            Theaker,A.J., Thomas,D.W., Thorpe,A., Tracey,A., Tromans,A.,
            Tubby,B., Wall,M., Wallis,J.M., West,A.P., White,S.S.,
            Whitehead,S.L., Whittaker,H., Wild,A., Willey,D.J., Wilmer,T.E.,
            Wood,J.M., Wray,P.W., Wyatt,J.C., Young,L., Younger,R.M.,
            Bentley,D.R., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E.,
            Dunham,I., Rogers,J. and Beck,S.
  TITLE     The DNA sequence and analysis of human chromosome 6
  JOURNAL   Nature 425 (6960), 805-811 (2003)
   PUBMED   14574404
REFERENCE   7  (bases 1 to 2915)
  AUTHORS   Kumanovics,A. and Lindahl,K.F.
  TITLE     G7c in the lung tumor susceptibility (Lts) region of the Mhc class
            III region encodes a von Willebrand factor type A domain protein
  JOURNAL   Immunogenetics 53 (1), 64-68 (2001)
   PUBMED   11261934
REFERENCE   8  (bases 1 to 2915)
  AUTHORS   Snoek,M., Albertella,M.R., van Kooij,M., Wixon,J., van Vugt,H., de
            Groot,K. and Campbell,R.D.
  TITLE     G7c, a novel gene in the mouse and human major histocompatibility
            complex class III region, possibly controlling lung tumor
            susceptibility
  JOURNAL   Immunogenetics 51 (4-5), 383-386 (2000)
   PUBMED   10803853
REFERENCE   9  (bases 1 to 2915)
  AUTHORS   Albertella,M.R., Jones,H., Thomson,W., Olavesen,M.G. and
            Campbell,R.D.
  TITLE     Localization of eight additional genes in the human major
            histocompatibility complex, including the gene encoding the casein
            kinase II beta subunit (CSNK2B)
  JOURNAL   Genomics 36 (2), 240-251 (1996)
   PUBMED   8812450
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DC323829.1, BC114625.1 and AL662899.5.
            
            On May 17, 2019 this sequence version replaced NM_025258.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.260206.1,
                                           SRR1803612.93110.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2153733 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000375688.5/ ENSP00000364840.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-238               DC323829.1         5-242
            239-2766            BC114625.1         1-2528
            2767-2911           AL662899.5         107935-108079       c
            2912-2915           AL662899.5         107931-107934       c
FEATURES             Location/Qualifiers
     source          1..2915
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.33"
     gene            1..2915
                     /gene="VWA7"
                     /gene_synonym="C6orf27; G7c; NG37"
                     /note="von Willebrand factor A domain containing 7"
                     /db_xref="GeneID:80737"
                     /db_xref="HGNC:HGNC:13939"
                     /db_xref="MIM:609693"
     exon            1..220
                     /gene="VWA7"
                     /gene_synonym="C6orf27; G7c; NG37"
                     /inference="alignment:Splign:2.1.0"
     exon            221..469
                     /gene="VWA7"
                     /gene_synonym="C6orf27; G7c; NG37"
                     /inference="alignment:Splign:2.1.0"
     CDS             236..2911
                     /gene="VWA7"
                     /gene_synonym="C6orf27; G7c; NG37"
                     /note="protein G7c; von Willebrand factor A
                     domain-containing protein 7"
                     /codon_start=1
                     /product="von Willebrand factor A domain-containing
                     protein 7 precursor"
                     /protein_id="NP_079534.2"
                     /db_xref="CCDS:CCDS4721.2"
                     /db_xref="GeneID:80737"
                     /db_xref="HGNC:HGNC:13939"
                     /db_xref="MIM:609693"
                     /translation="MLPTEVPQSHPGPSALLLLQLLLPPTSAFFPNIWSLLAAPGSIT
                     HQDLTEEAALNVTLQLFLEQPPPGRPPLRLEDFLGRTLLADDLFAAYFGPGSSRRFRA
                     ALGEVSRANAAQDFLPTSRNDPDLHFDAERLGQGRARLVGALRETVVAARALDHTLAR
                     QRLGAALHALQDFYSHSNWVELGEQQPHPHLLWPRQELQNLAQVADPTCSDCEELSCP
                     RNWLGFTLLTSGYFGTHPPKPPGKCSHGGHFDRSSSQPPRGGINKDSTSPGFSPHHML
                     HLQAAKLALLASIQAFSLLRSRLGDRDFSRLLDITPASSLSFVLDTTGSMGEEINAAK
                     IQARHLVEQRRGSPMEPVHYVLVPFHDPGFGPVFTTSDPDSFWQQLNEIHALGGGDEP
                     EMCLSALQLALLHTPPLSDIFVFTDASPKDAFLTNQVESLTQERRCRVTFLVTEDTSR
                     VQGRARREILSPLRFEPYKAVALASGGEVIFTKDQHIRDVAAIVGESMAALVTLPLDP
                     PVVVPGQPLVFSVDGLLQKITVRIHGDISSFWIKNPAGVSQGQEEGGGPLGHTRRFGQ
                     FWMVTMDDPPQTGTWEIQVTAEDTPGVRVQAQTSLDFLFHFGIPMEDGPHPGLYPLTQ
                     PVAGLQTQLLVEVTGLGSRANPGDPQPHFSHVILRGVPEGAELGQVPLEPVGPPERGL
                     LAASLSPTLLSTPRPFSLELIGQDAAGRRLHRAAPQPSTVVPVLLELSGPSGFLAPGS
                     KVPLSLRIASFSGPQDLDLRTFVNPSFSLTSNLSRAHLELNESAWGRLWLEVPDSAAP
                     DSVVMVTVTAGGREANPVPPTHAFLRLLVSAPAPQDRHTTPTGSSDPILTTATPAFSP
                     FTLVTQGRAGAGLAAGSPWWGTVGGVLLLLGLASW"
     exon            470..748
                     /gene="VWA7"
                     /gene_synonym="C6orf27; G7c; NG37"
                     /inference="alignment:Splign:2.1.0"
     exon            749..845
                     /gene="VWA7"
                     /gene_synonym="C6orf27; G7c; NG37"
                     /inference="alignment:Splign:2.1.0"
     exon            846..956
                     /gene="VWA7"
                     /gene_synonym="C6orf27; G7c; NG37"
                     /inference="alignment:Splign:2.1.0"
     exon            957..1152
                     /gene="VWA7"
                     /gene_synonym="C6orf27; G7c; NG37"
                     /inference="alignment:Splign:2.1.0"
     exon            1153..1322
                     /gene="VWA7"
                     /gene_synonym="C6orf27; G7c; NG37"
                     /inference="alignment:Splign:2.1.0"
     exon            1323..1435
                     /gene="VWA7"
                     /gene_synonym="C6orf27; G7c; NG37"
                     /inference="alignment:Splign:2.1.0"
     exon            1436..1552
                     /gene="VWA7"
                     /gene_synonym="C6orf27; G7c; NG37"
                     /inference="alignment:Splign:2.1.0"
     exon            1553..1738
                     /gene="VWA7"
                     /gene_synonym="C6orf27; G7c; NG37"
                     /inference="alignment:Splign:2.1.0"
     exon            1739..1871
                     /gene="VWA7"
                     /gene_synonym="C6orf27; G7c; NG37"
                     /inference="alignment:Splign:2.1.0"
     exon            1872..2024
                     /gene="VWA7"
                     /gene_synonym="C6orf27; G7c; NG37"
                     /inference="alignment:Splign:2.1.0"
     exon            2025..2117
                     /gene="VWA7"
                     /gene_synonym="C6orf27; G7c; NG37"
                     /inference="alignment:Splign:2.1.0"
     exon            2118..2419
                     /gene="VWA7"
                     /gene_synonym="C6orf27; G7c; NG37"
                     /inference="alignment:Splign:2.1.0"
     exon            2420..2559
                     /gene="VWA7"
                     /gene_synonym="C6orf27; G7c; NG37"
                     /inference="alignment:Splign:2.1.0"
     exon            2560..2734
                     /gene="VWA7"
                     /gene_synonym="C6orf27; G7c; NG37"
                     /inference="alignment:Splign:2.1.0"
     exon            2735..2915
                     /gene="VWA7"
                     /gene_synonym="C6orf27; G7c; NG37"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 actcacctcc gcactgcagc caagggaggc ccgccctggc gtgggctgct gcctgtggct
       61 ttgggcaggc aggagcgaaa gggccagggg ttgcctgtcc tcccccaccc tgttgaggcc
      121 ttcctccccc tctgctgagc ctcggttaat tataactctg acctaagtgc cctgtgacgt
      181 caagcccggg ccagccctgc ccaggagacc cagcaaccag gtccatgtct cagccatgct
      241 ccccacggag gtcccccaat cccacccggg cccctcagcg ttgcttctgc tgcagctgtt
      301 gctgcccccc acatctgcct tcttccccaa catctggagc ctgctggctg cccctggctc
      361 catcacccac caagacctaa ctgaggaggc agcgctcaac gtcaccctgc agctcttcct
      421 ggagcagcca cccccaggcc gcccccctct tcgtcttgag gacttcctgg gtcgaacact
      481 ccttgctgat gacctctttg ccgcctactt tggacctggt tcttctcggc ggttccgagc
      541 agccttaggt gaggtgtctc gtgccaatgc agcccaggac ttcctgccaa cttccaggaa
      601 tgaccccgac ctgcactttg atgctgagcg actgggtcag ggacgcgcgc gcctggtagg
      661 ggctctgcgg gagaccgtgg tggcagccag ggcccttgac cacaccctgg ctcgccagcg
      721 cctcggggct gcacttcatg ccctgcagga tttctacagt catagcaact gggtggagct
      781 gggcgagcag cagccacacc ctcacctcct ctggccaagg caggagctcc agaacctggc
      841 acaagtggcc gatcctacct gctccgattg cgaggagttg agctgcccca ggaattggct
      901 gggcttcaca ctcctcacct ctggctactt tggaactcat cccccgaaac ctccagggaa
      961 atgtagccac gggggccatt ttgaccggag cagctcccag ccaccgaggg gaggcatcaa
     1021 caaggacagc acatccccag gcttctcccc tcaccacatg ctgcacctcc aggctgcaaa
     1081 actggccctt ctagcctcca tccaggcctt cagccttctg cgaagccgcc tgggagacag
     1141 ggatttctcc aggctgctgg acatcacccc agcctccagc ctgagctttg tcctggacac
     1201 cacgggcagc atgggtgagg agatcaacgc tgccaaaatc caggctcgcc accttgtgga
     1261 gcagcggaga ggcagcccca tggagcctgt ccactatgtc ctggtgcctt ttcatgaccc
     1321 agggttcggc cctgtcttta caaccagtga ccctgacagc ttctggcaac agcttaatga
     1381 gatccatgcc ttggggggtg gagacgagcc tgagatgtgc ctgtcagccc tgcagctggc
     1441 cctgctgcac acacctccac tctcagatat ctttgtcttc acggatgcct cccccaagga
     1501 tgcctttctc accaaccagg tggaatccct gactcaggag cggcgctgcc gggtaacatt
     1561 cctggtgact gaagatacat caagggttca gggtcgagct cggcgtgaga tcttgtcccc
     1621 tctgcgtttt gagccataca aagcagtggc cctggcctca ggaggagagg tgatcttcac
     1681 caaagaccag cacattcgag acgtggcagc cattgttggg gagagcatgg ctgccctggt
     1741 gactcttccc ctggaccctc ctgttgtggt gcctgggcag ccacttgtgt tcagcgtgga
     1801 tgggctgctc cagaagatca cagtccggat ccacggagac atcagcagct tctggatcaa
     1861 gaaccctgca ggggtctccc agggccagga ggaaggcggg ggtcctctag gtcacactcg
     1921 ccgctttggg cagttctgga tggtgaccat ggatgaccct ccacagacag gaacctggga
     1981 gatccaggtc acagctgagg acacccctgg ggtgagagtg caagcccaga cctccctgga
     2041 cttcctcttc cactttggga tccccatgga ggatggaccc caccctggcc tctaccccct
     2101 gactcagcca gttgcaggtc ttcagaccca gctgctggta gaagtgacag ggttgggttc
     2161 cagagccaat cctggggatc ctcagccgca tttctcccac gtcatccttc gaggggtccc
     2221 agagggtgcc gaactaggcc aggtgccctt ggagcccgtg ggacctccgg agcgaggtct
     2281 cctcgcagcc tcgctgtcgc ccacgctgct gtccacccct agacccttct ccctggagct
     2341 gattggccag gacgcagcgg ggcggcgcct gcacagggct gcccctcagc ctagcactgt
     2401 agtccctgtc cttctggagc ttagtggccc ctcgggtttc ttggccccgg gcagcaaagt
     2461 cccgctcagt ctccgcatcg ccagcttctc gggccctcag gatcttgacc ttaggacttt
     2521 cgtcaacccc agcttctccc tcacctccaa cctctccagg gctcacctgg aactgaatga
     2581 gtcggcctgg ggccgcctgt ggctggaggt cccagattca gcggccccgg attccgtggt
     2641 gatggtgact gtgactgcag ggggacgaga agccaaccca gtacccccga ctcatgcttt
     2701 cctccggctc ctggtatcgg ccccagcccc gcaggaccgg cacaccaccc ctaccggctc
     2761 atctgacccg atcctcacca cggccacccc tgccttttcc cccttcacat tggtgactca
     2821 aggcagggct ggggcagggc tggctgcggg cagcccctgg tggggcacag ttggaggggt
     2881 gctgcttctg ctaggcctgg cctcctggtg acaca
//
