LOCUS       NM_001272046            5846 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens von Willebrand factor A domain containing 2 (VWA2),
            transcript variant 1, mRNA.
ACCESSION   NM_001272046
VERSION     NM_001272046.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5846)
  AUTHORS   Hoogmartens,J., Hens,E., Engelborghs,S., Vandenberghe,R., De
            Deyn,P.P., Cacace,R. and Van Broeckhoven,C.
  CONSRTM   BELNEU Consortium
  TITLE     Contribution of homozygous and compound heterozygous missense
            mutations in VWA2 to Alzheimer's disease
  JOURNAL   Neurobiol Aging 99, 100 (2021)
   PUBMED   33023779
  REMARK    GeneRIF: Contribution of homozygous and compound heterozygous
            missense mutations in VWA2 to Alzheimer's disease.
REFERENCE   2  (bases 1 to 5846)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 5846)
  AUTHORS   Gonzalez,B., Fece de la Cruz,F., Samuelsson,J.K., Alibes,A. and
            Alonso,S.
  TITLE     Epigenetic and transcriptional dysregulation of VWA2 associated
            with a MYC-driven oncogenic program in colorectal cancer
  JOURNAL   Sci Rep 8 (1), 11097 (2018)
   PUBMED   30038405
  REMARK    GeneRIF: VWA2 might be a constituent of a larger oncogenic
            transcriptional program regulated by c-Myc.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5846)
  AUTHORS   Jakobi,A.J. and Huizinga,E.G.
  TITLE     A rapid cloning method employing orthogonal end protection
  JOURNAL   PLoS One 7 (6), e37617 (2012)
   PUBMED   22685543
REFERENCE   5  (bases 1 to 5846)
  AUTHORS   Gonzalez-Begne,M., Lu,B., Han,X., Hagen,F.K., Hand,A.R.,
            Melvin,J.E. and Yates,J.R.
  TITLE     Proteomic analysis of human parotid gland exosomes by
            multidimensional protein identification technology (MudPIT)
  JOURNAL   J Proteome Res 8 (3), 1304-1314 (2009)
   PUBMED   19199708
REFERENCE   6  (bases 1 to 5846)
  AUTHORS   Gebauer,J.M., Muller,S., Hanisch,F.G., Paulsson,M. and Wagener,R.
  TITLE     O-glucosylation and O-fucosylation occur together in close
            proximity on the first epidermal growth factor repeat of AMACO
            (VWA2 protein)
  JOURNAL   J Biol Chem 283 (26), 17846-17854 (2008)
   PUBMED   18434322
  REMARK    GeneRIF: O-glucosylation and O-fucosylation occur together in close
            proximity on the first epidermal growth factor repeat of AMACO
REFERENCE   7  (bases 1 to 5846)
  AUTHORS   Grupe,A., Li,Y., Rowland,C., Nowotny,P., Hinrichs,A.L., Smemo,S.,
            Kauwe,J.S., Maxwell,T.J., Cherny,S., Doil,L., Tacey,K., van
            Luchene,R., Myers,A., Wavrant-De Vrieze,F., Kaleem,M.,
            Hollingworth,P., Jehu,L., Foy,C., Archer,N., Hamilton,G.,
            Holmans,P., Morris,C.M., Catanese,J., Sninsky,J., White,T.J.,
            Powell,J., Hardy,J., O'Donovan,M., Lovestone,S., Jones,L.,
            Morris,J.C., Thal,L., Owen,M., Williams,J. and Goate,A.
  TITLE     A scan of chromosome 10 identifies a novel locus showing strong
            association with late-onset Alzheimer disease
  JOURNAL   Am J Hum Genet 78 (1), 78-88 (2006)
   PUBMED   16385451
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 5846)
  AUTHORS   Xin,B., Platzer,P., Fink,S.P., Reese,L., Nosrati,A., Willson,J.K.,
            Wilson,K. and Markowitz,S.
  TITLE     Colon cancer secreted protein-2 (CCSP-2), a novel candidate
            serological marker of colon neoplasia
  JOURNAL   Oncogene 24 (4), 724-731 (2005)
   PUBMED   15580307
  REMARK    GeneRIF: CCSP-2 is a novel candidate for development as a
            diagnostic serum marker of early stage colon cancer
REFERENCE   9  (bases 1 to 5846)
  AUTHORS   Eller,E., Vardi,P., Daly,M.J., Babu,S., Roberts,C., Yang,F.,
            Eisenbarth,G.S. and Fain,P.R.
  TITLE     IDDM17: polymorphisms in the AMACO gene are associated with
            dominant protection against type 1A diabetes in a Bedouin Arab
            family
  JOURNAL   Ann N Y Acad Sci 1037, 145-149 (2004)
   PUBMED   15699509
  REMARK    GeneRIF: Single nucleotide polymorphisms in the AMACO gene are
            associated with dominant protection against Type 1A diabetes in an
            Arab family.
REFERENCE   10 (bases 1 to 5846)
  AUTHORS   Sengle,G., Kobbe,B., Morgelin,M., Paulsson,M. and Wagener,R.
  TITLE     Identification and characterization of AMACO, a new member of the
            von Willebrand factor A-like domain protein superfamily with a
            regulated expression in the kidney
  JOURNAL   J Biol Chem 278 (50), 50240-50249 (2003)
   PUBMED   14506275
  REMARK    GeneRIF: AMACO is a new member of the von Willebrand factor A-like
            domain protein superfamily with a regulated expression in the
            kidney
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB210781.1, DA170480.1,
            AJ536328.2, AK122716.1, AY572972.1, BF849816.1, AC005383.2,
            BF355787.1, CA487263.1, BF754676.1, BF802655.1, DB349964.1 and
            AI870708.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001272046.1.
            
            Summary: This gene encodes a member of the von Willebrand factor
            A-like domain protein superfamily. The encoded protein is localized
            to the extracellular matrix and may serve as a structural component
            in basement membranes or in anchoring structures on scaffolds of
            collagen VII or fibrillin. This gene has been linked to type 1A
            diabetes and is a candidate serological marker for colon cancer.
            [provided by RefSeq, Jan 2013].
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants 1 and 2 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY572972.1, SRR1660805.198373.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000392982.8/ ENSP00000376708.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 DB210781.1         1-5
            6-76                DA170480.1         6-76
            77-79               AJ536328.2         1-3
            80-166              AK122716.1         75-161
            167-294             AJ536328.2         91-218
            295-2448            AK122716.1         290-2443
            2449-2723           AJ536328.2         2373-2647
            2724-3233           AY572972.1         2486-2995
            3234-3374           BF849816.1         19-159              c
            3375-3774           AC005383.2         78954-79353
            3775-3788           BF355787.1         160-173
            3789-3959           CA487263.1         1-171
            3960-3988           AC005383.2         79539-79567
            3989-4236           CA487263.1         201-448
            4237-4299           AC005383.2         79816-79878
            4300-4504           CA487263.1         512-716
            4505-4740           AC005383.2         80084-80319
            4741-4914           BF754676.1         28-201
            4915-5286           BF802655.1         61-432
            5287-5300           AC005383.2         80866-80879
            5301-5722           DB349964.1         138-559             c
            5723-5846           AI870708.1         3-126               c
FEATURES             Location/Qualifiers
     source          1..5846
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q25.3"
     gene            1..5846
                     /gene="VWA2"
                     /gene_synonym="AMACO; CCSP-2; CCSP2; NET42"
                     /note="von Willebrand factor A domain containing 2"
                     /db_xref="GeneID:340706"
                     /db_xref="HGNC:HGNC:24709"
                     /db_xref="MIM:618281"
     exon            1..316
                     /gene="VWA2"
                     /gene_synonym="AMACO; CCSP-2; CCSP2; NET42"
                     /inference="alignment:Splign:2.1.0"
     exon            317..378
                     /gene="VWA2"
                     /gene_synonym="AMACO; CCSP-2; CCSP2; NET42"
                     /inference="alignment:Splign:2.1.0"
     CDS             327..2594
                     /gene="VWA2"
                     /gene_synonym="AMACO; CCSP-2; CCSP2; NET42"
                     /note="von Willebrand factor A domain-containing protein
                     2; colon cancer diagnostic marker; colon cancer secreted
                     protein 2; a domain-containing protein similar to matrilin
                     and collagen"
                     /codon_start=1
                     /product="von Willebrand factor A domain-containing
                     protein 2 precursor"
                     /protein_id="NP_001258975.1"
                     /db_xref="CCDS:CCDS7589.2"
                     /db_xref="GeneID:340706"
                     /db_xref="HGNC:HGNC:24709"
                     /db_xref="MIM:618281"
                     /translation="MPPFLLLEAVCVFLFSRVPPSLPLQEVHVSKETIGKISAASKMM
                     WCSAAVDIMFLLDGSNSVGKGSFERSKHFAITVCDGLDISPERVRVGAFQFSSTPHLE
                     FPLDSFSTQQEVKARIKRMVFKGGRTETELALKYLLHRGLPGGRNASVPQILIIVTDG
                     KSQGDVALPSKQLKERGVTVFAVGVRFPRWEELHALASEPRGQHVLLAEQVEDATNGL
                     FSTLSSSAICSSATPDCRVEAHPCEHRTLEMVREFAGNAPCWRGSRRTLAVLAAHCPF
                     YSWKRVFLTHPATCYRTTCPGPCDSQPCQNGGTCVPEGLDGYQCLCPLAFGGEANCAL
                     KLSLECRVDLLFLLDSSAGTTLDGFLRAKVFVKRFVRAVLSEDSRARVGVATYSRELL
                     VAVPVGEYQDVPDLVWSLDGIPFRGGPTLTGSALRQAAERGFGSATRTGQDRPRRVVV
                     LLTESHSEDEVAGPARHARARELLLLGVGSEAVRAELEEITGSPKHVMVYSDPQDLFN
                     QIPELQGKLCSRQRPGCRTQALDLVFMLDTSASVGPENFAQMQSFVRSCALQFEVNPD
                     VTQVGLVVYGSQVQTAFGLDTKPTRAAMLRAISQAPYLGGVGSAGTALLHIYDKVMTV
                     QRGARPGVPKAVVVLTGGRGAEDAAVPAQKLRNNGISVLVVGVGPVLSEGLRRLAGPR
                     DSLIHVAAYADLRYHQDVLIEWLCGEAKQPVNLCKPSPCMNEGSCVLQNGSYRCKCRD
                     GWEGPHCENRFLRRP"
     exon            379..453
                     /gene="VWA2"
                     /gene_synonym="AMACO; CCSP-2; CCSP2; NET42"
                     /inference="alignment:Splign:2.1.0"
     exon            454..587
                     /gene="VWA2"
                     /gene_synonym="AMACO; CCSP-2; CCSP2; NET42"
                     /inference="alignment:Splign:2.1.0"
     exon            588..697
                     /gene="VWA2"
                     /gene_synonym="AMACO; CCSP-2; CCSP2; NET42"
                     /inference="alignment:Splign:2.1.0"
     exon            698..892
                     /gene="VWA2"
                     /gene_synonym="AMACO; CCSP-2; CCSP2; NET42"
                     /inference="alignment:Splign:2.1.0"
     exon            893..1026
                     /gene="VWA2"
                     /gene_synonym="AMACO; CCSP-2; CCSP2; NET42"
                     /inference="alignment:Splign:2.1.0"
     exon            1027..1159
                     /gene="VWA2"
                     /gene_synonym="AMACO; CCSP-2; CCSP2; NET42"
                     /inference="alignment:Splign:2.1.0"
     exon            1160..1215
                     /gene="VWA2"
                     /gene_synonym="AMACO; CCSP-2; CCSP2; NET42"
                     /inference="alignment:Splign:2.1.0"
     exon            1216..1323
                     /gene="VWA2"
                     /gene_synonym="AMACO; CCSP-2; CCSP2; NET42"
                     /inference="alignment:Splign:2.1.0"
     exon            1324..1896
                     /gene="VWA2"
                     /gene_synonym="AMACO; CCSP-2; CCSP2; NET42"
                     /inference="alignment:Splign:2.1.0"
     exon            1897..2448
                     /gene="VWA2"
                     /gene_synonym="AMACO; CCSP-2; CCSP2; NET42"
                     /inference="alignment:Splign:2.1.0"
     exon            2449..2574
                     /gene="VWA2"
                     /gene_synonym="AMACO; CCSP-2; CCSP2; NET42"
                     /inference="alignment:Splign:2.1.0"
     exon            2575..5846
                     /gene="VWA2"
                     /gene_synonym="AMACO; CCSP-2; CCSP2; NET42"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5824..5829
                     /regulatory_class="polyA_signal_sequence"
                     /gene="VWA2"
                     /gene_synonym="AMACO; CCSP-2; CCSP2; NET42"
                     /note="hexamer: AATAAA"
     polyA_site      5846
                     /gene="VWA2"
                     /gene_synonym="AMACO; CCSP-2; CCSP2; NET42"
                     /note="major polyA site"
ORIGIN      
        1 acagtgttcg cggctgcacc gctcggaggc tgggtgaccc gcgtagaagt gaagtacttt
       61 tttatttgca gacctgggcc gatgccgctt taaaaaacgc gaggggctct atgcacctcc
      121 ctggcggtag ttcctccgac ctcagccggg tcgggtcgtg ccgccctctc ccaggagaga
      181 caaacaggtg tcccacgtgg cagccgcgcc ccgggcgccc ctcctgtgat cccgtagcgc
      241 cccctggccc gagccgcgcc cgggtctgtg agtagagccg cccgggcacc gagcgctggt
      301 cgccgctctc cttccgttat atcaacatgc cccctttcct gttgctggaa gccgtctgtg
      361 ttttcctgtt ttccagagtg cccccatctc tccctctcca ggaagtccat gtaagcaaag
      421 aaaccatcgg gaagatttca gctgccagca aaatgatgtg gtgctcggct gcagtggaca
      481 tcatgtttct gttagatggg tctaacagcg tcgggaaagg gagctttgaa aggtccaagc
      541 actttgccat cacagtctgt gacggtctgg acatcagccc cgagagggtc agagtgggag
      601 cattccagtt cagttccact cctcatctgg aattcccctt ggattcattt tcaacccaac
      661 aggaagtgaa ggcaagaatc aagaggatgg ttttcaaagg agggcgcacg gagacggaac
      721 ttgctctgaa ataccttctg cacagagggt tgcctggagg cagaaatgct tctgtgcccc
      781 agatcctcat catcgtcact gatgggaagt cccaggggga tgtggcactg ccatccaagc
      841 agctgaagga aaggggtgtc actgtgtttg ctgtgggggt caggtttccc aggtgggagg
      901 agctgcatgc actggccagc gagcctagag ggcagcacgt gctgttggct gagcaggtgg
      961 aggatgccac caacggcctc ttcagcaccc tcagcagctc ggccatctgc tccagcgcca
     1021 cgccagactg cagggtcgag gctcacccct gtgagcacag gacgctggag atggtccggg
     1081 agttcgctgg caatgcccca tgctggagag gatcgcggcg gacccttgcg gtgctggctg
     1141 cacactgtcc cttctacagc tggaagagag tgttcctaac ccaccctgcc acctgctaca
     1201 ggaccacctg cccaggcccc tgtgactcgc agccctgcca gaatggaggc acatgtgttc
     1261 cagaaggact ggacggctac cagtgcctct gcccgctggc ctttggaggg gaggctaact
     1321 gtgccctgaa gctgagcctg gaatgcaggg tcgacctcct cttcctgctg gacagctctg
     1381 cgggcaccac tctggacggc ttcctgcggg ccaaagtctt cgtgaagcgg tttgtgcggg
     1441 ccgtgctgag cgaggactct cgggcccgag tgggtgtggc cacatacagc agggagctgc
     1501 tggtggcggt gcctgtgggg gagtaccagg atgtgcctga cctggtctgg agcctcgatg
     1561 gcattccctt ccgtggtggc cccaccctga cgggcagtgc cttgcggcag gcggcagagc
     1621 gtggcttcgg gagcgccacc aggacaggcc aggaccggcc acgtagagtg gtggttttgc
     1681 tcactgagtc acactccgag gatgaggttg cgggcccagc gcgtcacgca agggcgcgag
     1741 agctgctcct gctgggtgta ggcagtgagg ccgtgcgggc agagctggag gagatcacag
     1801 gcagcccaaa gcatgtgatg gtctactcgg atcctcagga tctgttcaac caaatccctg
     1861 agctgcaggg gaagctgtgc agccggcagc ggccagggtg ccggacacaa gccctggacc
     1921 tcgtcttcat gttggacacc tctgcctcag tagggcccga gaattttgct cagatgcaga
     1981 gctttgtgag aagctgtgcc ctccagtttg aggtgaaccc tgacgtgaca caggtcggcc
     2041 tggtggtgta tggcagccag gtgcagactg ccttcgggct ggacaccaaa cccacccggg
     2101 ctgcgatgct gcgggccatt agccaggccc cctacctagg tggggtgggc tcagccggca
     2161 ccgccctgct gcacatctat gacaaagtga tgaccgtcca gaggggtgcc cggcctggtg
     2221 tccccaaagc tgtggtggtg ctcacaggcg ggagaggcgc agaggatgca gccgttcctg
     2281 cccagaagct gaggaacaat ggcatctctg tcttggtcgt gggcgtgggg cctgtcctaa
     2341 gtgagggtct gcggaggctt gcaggtcccc gggattccct gatccacgtg gcagcttacg
     2401 ccgacctgcg gtaccaccag gacgtgctca ttgagtggct gtgtggagaa gccaagcagc
     2461 cagtcaacct ctgcaaaccc agcccgtgca tgaatgaggg cagctgcgtc ctgcagaatg
     2521 ggagctaccg ctgcaagtgt cgggatggct gggagggccc ccactgcgag aaccgattct
     2581 tgagacgccc ctgaggcaca tggctcccgt gcaggagggc agcagccgta cccctcccag
     2641 caactacaga gaaggcctgg gcactgaaat ggtgcctacc ttctggaatg tctgtgcccc
     2701 aggtccttag aatgtctgct tcccgccgtg gccaggacca ctattctcac tgagggagga
     2761 ggatgtccca actgcagcca tgctgcttag agacaagaaa gcagctgatg tcacccacaa
     2821 acgatgttgt tgaaaagttt tgatgtgtaa gtaaataccc actttctgta cctgctgtgc
     2881 cttgttgagg ctatgtcatc tgccaccttt cccttgagga taaacaaggg gtcctgaaga
     2941 cttaaattta gcggcctgac gttcctttgc acacaatcaa tgctcgccag aatgttgttg
     3001 acacagtaat gcccagcaga ggcctttact agagcatcct ttggacggcg aaggccacgg
     3061 cctttcaaga tggaaagcag cagcttttcc acttccccag agacattctg gatgcatttg
     3121 cattgagtct gaaagggggc ttgagggacg tttgtgactt ctggcgactg ccttttgtgt
     3181 gtggaagaga cttggaaagg tctcagactg aaatgtgacc aattaaccag cttgtttgat
     3241 gatgggggag gggctgagtg tgcaatgggc ccaggtctgg aggggccacg taaaatcgtt
     3301 ctgagtcgtg agcagtgtcc acctgaaggg tcttcctttc aaaagaggct gcggccagag
     3361 actgtggctc atgcctgtaa tcccagcact ttggaggctg aggcaggtgg atcacccgag
     3421 gtcaggagtt tgagaccagc ctggccaacg tggtgaaagt ttgtctttac taaaaataca
     3481 aaaggtagcc gggggtggtg gtggatgcct ataatcccag ctactcggga ggctgagaca
     3541 ggagaatggc ttgaacctgg gaggcggaag ttacagtgag ccgagatctc accactgcac
     3601 tccagcctgg gcaacaagag taaaaatctg tctcaaaaag aaaaaaatgt acttaggagg
     3661 ggttaattgt ggcgtgttta tggaattctt tccttattct ccttttagtg gggcaaagag
     3721 aagtaagatt cttaaactca aaaatatagg ataaagaaac ttacagagat tttgcttttt
     3781 aaagcattga tcttacgctg tctaggtttt aattttgttt tgctttgctt ttctacacag
     3841 tttttaaaga aatatttcaa gaaatgttgg ttatttatta aacagggata tttgtaccta
     3901 tgtggcaaag aggcatattt ggaatattct ctggcaaact agatacttac ttccctatcg
     3961 ctgcagtatt taggaattac ttcttctcct tggttgtgtt gtttagagtt ggattttctg
     4021 tagaaatctt tctagagctc tgatgtgact ccagacactt tatcgttttt cttttttttg
     4081 agacggagtt ttgctcttgt tgcccaggct agagtgcagt ggtacaatct tggctcactg
     4141 caacctttgc ctcccaggtt gaagtgattc tcatgcctca gcctcttgag tagctgggat
     4201 tagaggcagg tgccaccatg cctagctaat ttttgtattt ttagttagag acagggtttc
     4261 accatgttgg ccaggctagt ctcgaacttc tgacctcagg tgatccccct gccttggcct
     4321 cccaaagttc tgggattaca ggggtgaacc actgtgcctg gcccattttt ctttataaat
     4381 attgtaacat aatgttttat agacaaacat tcaagggtac tttggcttta agaacttcag
     4441 gatttctggt gctagaaaag cgcttgaagc agtatcacca agattttaga tattaaaaag
     4501 tctggtgtac cagacattga gtcataatca tctatattca agggatactt tcattgataa
     4561 ctttgttatt atgctgccct tcacagaaga caacgtccgg ggcaggatca catgctccct
     4621 agcagatgct gatcagtgat gtcatagaaa ttacatgaat gcattgtctt taaatagcag
     4681 tttaaccatg ttataatgta ggctttttgt cttgttccgg gctggtattt gggtgccctg
     4741 attgaattac ttggatttaa acagcaaact gtgggctctc gacttacata gtaagggcct
     4801 ttactgtttc tttgtaggaa atgggtttct cgcctttgaa acattttttc cccttttgta
     4861 gtgacagtgc cactaaatag ttcagctttt gtcagtcccc caggaaagtg ctatcctatg
     4921 gcctaactag ccaagccttt tttctttcat ttaaaagaaa ttagctttaa tttttacctt
     4981 taattactta ttcaaataag acagaaatat attttccttg caataattaa aacattgcat
     5041 ataggccata aatttcctta ttttctctga acgatcctga ttccagtcat cttgttgaat
     5101 accctagttc taataattga ctcttgcttt tctagagaaa tatttccaaa tgatgctagt
     5161 tttgtctctt cctttcaaag ttgtatacca cttctttttc ttgtcatttt gcattgcctg
     5221 ggacctccag aataatgttt catgaagtag catgtatcca tatctggttc ttgacttttt
     5281 catcataata attgttttct atgggttact tatcagttta agaatgctta attcctagat
     5341 gaactaagag tgtttattac atgttgagat ttatggtatg ctttttcttc ctcaagataa
     5401 tgcatttttt gtattatctg ttaatgtgat aggttatcca tttgtgtatt ttcaatcatt
     5461 gaacaaccct tgattttttt ggataaactc tatttggtca ttatgcatca ttctataaac
     5521 cctgctgaat ttttcatttg ccaacatctt atttcagatt cttttaatct gtgtccaaca
     5581 atgagatttg ttttcttttg caatttgttt tgaatttttg gtatcagagc tatactaacc
     5641 ttataatgga aaatacatat ttctcaaact tttacactga tatattcata gtattttttt
     5701 ataatttgaa aaatcttgtc agtatctgta ttaaggcctc catttcagtt ctgctatttc
     5761 atattgcctt aggttgtcta tttgtctctt taatgaaccc gattttgatt ttgtcatttt
     5821 taaaataaac acatttatgc tataaa
//
