LOCUS       NM_000638               1626 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens vitronectin (VTN), mRNA.
ACCESSION   NM_000638
VERSION     NM_000638.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1626)
  AUTHORS   Zhang,Y., Zhang,W., Zhang,R. and Xia,Y.
  TITLE     Knockdown of FBLN2 suppresses TGF-beta1-induced MRC-5 cell
            migration and fibrosis by downregulating VTN
  JOURNAL   Tissue Cell 81, 102005 (2023)
   PUBMED   36608640
  REMARK    GeneRIF: Knockdown of FBLN2 suppresses TGF-beta1-induced MRC-5 cell
            migration and fibrosis by downregulating VTN.
REFERENCE   2  (bases 1 to 1626)
  AUTHORS   Biasella,F., Strunz,T., Kiel,C., On Behalf Of The International Amd
            Genomics Consortium,Iamdgc., Weber,B.H.F. and Friedrich,U.
  TITLE     Vitronectin and Its Interaction with PAI-1 Suggests a Functional
            Link to Vascular Changes in AMD Pathobiology
  JOURNAL   Cells 11 (11), 1766 (2022)
   PUBMED   35681461
  REMARK    GeneRIF: Vitronectin and Its Interaction with PAI-1 Suggests a
            Functional Link to Vascular Changes in AMD Pathobiology.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1626)
  AUTHORS   Zhang,S., Pan,W., Wang,H., Zhi,C., Lin,Y., Wu,P., Ren,Q., Wei,P.,
            Chen,R., Li,F., Xie,Y., Wong,C.K., Tang,H., Cai,Z., Xu,W. and
            Zeng,H.
  TITLE     Vitronectin, a Novel Urinary Proteomic Biomarker, Promotes Cell
            Pyroptosis in Juvenile Systemic Lupus Erythematosus
  JOURNAL   Mediators Inflamm 2022, 8447675 (2022)
   PUBMED   35462789
  REMARK    GeneRIF: Vitronectin, a Novel Urinary Proteomic Biomarker, Promotes
            Cell Pyroptosis in Juvenile Systemic Lupus Erythematosus.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1626)
  AUTHORS   Fox,C.R. and Parks,G.D.
  TITLE     Complement Inhibitors Vitronectin and Clusterin Are Recruited from
            Human Serum to the Surface of Coronavirus OC43-Infected Lung Cells
            through Antibody-Dependent Mechanisms
  JOURNAL   Viruses 14 (1), 29 (2021)
   PUBMED   35062233
  REMARK    GeneRIF: Complement Inhibitors Vitronectin and Clusterin Are
            Recruited from Human Serum to the Surface of Coronavirus
            OC43-Infected Lung Cells through Antibody-Dependent Mechanisms.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1626)
  AUTHORS   Ghasempour,G., Shaikhnia,F., Soleimani,A.A., Rahimi,B. and
            Najafi,M.
  TITLE     Correlations between vitronectin, miR-520, and miR-34 in patients
            with stenosis of coronary arteries
  JOURNAL   Mol Biol Rep 48 (12), 7913-7920 (2021)
   PUBMED   34652615
  REMARK    GeneRIF: Correlations between vitronectin, miR-520, and miR-34 in
            patients with stenosis of coronary arteries.
REFERENCE   6  (bases 1 to 1626)
  AUTHORS   Noris,M., Bresin,E., Mele,C. and Remuzzi,G.
  TITLE     Genetic Atypical Hemolytic-Uremic Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301541
REFERENCE   7  (bases 1 to 1626)
  AUTHORS   Liakka,K.A. and Autio-Harmainen,H.I.
  TITLE     Distribution of the extracellular matrix proteins tenascin,
            fibronectin, and vitronectin in fetal, infant, and adult human
            spleens
  JOURNAL   J Histochem Cytochem 40 (8), 1203-1210 (1992)
   PUBMED   1377736
REFERENCE   8  (bases 1 to 1626)
  AUTHORS   Hagege,J., Peraldi,M.N., Rondeau,E., Adida,C., Delarue,F.,
            Medcalf,R., Schleuning,W.D. and Sraer,J.D.
  TITLE     Plasminogen activator inhibitor-1 deposition in the extracellular
            matrix of cultured human mesangial cells
  JOURNAL   Am J Pathol 141 (1), 117-128 (1992)
   PUBMED   1632457
REFERENCE   9  (bases 1 to 1626)
  AUTHORS   Fink,T.M., Jenne,D.E. and Lichter,P.
  TITLE     The human vitronectin (complement S-protein) gene maps to the
            centromeric region of 17q
  JOURNAL   Hum Genet 88 (5), 569-572 (1992)
   PUBMED   1372588
REFERENCE   10 (bases 1 to 1626)
  AUTHORS   Fryklund,L. and Sievertsson,H.
  TITLE     Primary structure of somatomedin B: a growth hormone-dependent
            serum factor with protease inhibiting activity
  JOURNAL   FEBS Lett 87 (1), 55-60 (1978)
   PUBMED   631332
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BG470977.1, BC005046.1 and
            AI352496.1.
            
            On Nov 23, 2018 this sequence version replaced NM_000638.3.
            
            Summary: The protein encoded by this gene functions in part as an
            adhesive glycoprotein. Differential expression of this protein can
            promote either cell adhesion or migration as it links cells to the
            extracellular matrix through a variety of ligands. These ligands
            include integrins, plasminogen activator inhibitor-1, and urokinase
            plasminogen activator receptor. This secreted protein can be
            present in the plasma as a monomer or dimer and forms a multimer in
            the extracellular matrix of several tissues. This protein also
            inhibits the membrane-damaging effect of the terminal cytolytic
            complement pathway and binds to several serpin serine protease
            inhibitors. This protein can also promote extracellular matrix
            degradation and thus plays a role in tumorigenesis. It is involved
            in a variety of other biological processes such as the regulation
            of the coagulation pathway, wound healing, and tissue remodeling.
            The heparin-binding domain of this protein give it anti-microbial
            properties. It is also a lipid binding protein that forms a
            principal component of high density lipoprotein. [provided by
            RefSeq, Aug 2020].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189655.110316.1,
                                           SRR5189664.122025.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145122, SAMEA2155590
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000226218.9/ ENSP00000226218.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-548               BG470977.1         46-593
            549-1302            BC005046.1         525-1278
            1303-1626           AI352496.1         8-331               c
FEATURES             Location/Qualifiers
     source          1..1626
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q11.2"
     gene            1..1626
                     /gene="VTN"
                     /gene_synonym="V75; VN; VNT"
                     /note="vitronectin"
                     /db_xref="GeneID:7448"
                     /db_xref="HGNC:HGNC:12724"
                     /db_xref="MIM:193190"
     exon            1..168
                     /gene="VTN"
                     /gene_synonym="V75; VN; VNT"
                     /inference="alignment:Splign:2.1.0"
     CDS             105..1541
                     /gene="VTN"
                     /gene_synonym="V75; VN; VNT"
                     /note="serum spreading factor; somatomedin B; complement
                     S-protein; epibolin"
                     /codon_start=1
                     /product="vitronectin precursor"
                     /protein_id="NP_000629.3"
                     /db_xref="CCDS:CCDS11229.1"
                     /db_xref="GeneID:7448"
                     /db_xref="HGNC:HGNC:12724"
                     /db_xref="MIM:193190"
                     /translation="MAPLRPLLILALLAWVALADQESCKGRCTEGFNVDKKCQCDELC
                     SYYQSCCTDYTAECKPQVTRGDVFTMPEDEYTVYDDGEEKNNATVHEQVGGPSLTSDL
                     QAQSKGNPEQTPVLKPEEEAPAPEVGASKPEGIDSRPETLHPGRPQPPAEEELCSGKP
                     FDAFTDLKNGSLFAFRGQYCYELDEKAVRPGYPKLIRDVWGIEGPIDAAFTRINCQGK
                     TYLFKGSQYWRFEDGVLDPDYPRNISDGFDGIPDNVDAALALPAHSYSGRERVYFFKG
                     KQYWEYQFQHQPSQEECEGSSLSAVFEHFAMMQRDSWEDIFELLFWGRTSAGTRQPQF
                     ISRDWHGVPGQVDAAMAGRIYISGMAPRPSLAKKQRFRHRNRKGYRSQRGHSRGRNQN
                     SRRPSRATWLSLFSSEESNLGANNYDDYRMDWLVPATCEPIQSVFFFSGDKYYRVNLR
                     TRRVDTVDPPYPRSIAQYWLGCPAPGHL"
     exon            169..288
                     /gene="VTN"
                     /gene_synonym="V75; VN; VNT"
                     /inference="alignment:Splign:2.1.0"
     exon            289..633
                     /gene="VTN"
                     /gene_synonym="V75; VN; VNT"
                     /inference="alignment:Splign:2.1.0"
     exon            634..773
                     /gene="VTN"
                     /gene_synonym="V75; VN; VNT"
                     /inference="alignment:Splign:2.1.0"
     exon            774..930
                     /gene="VTN"
                     /gene_synonym="V75; VN; VNT"
                     /inference="alignment:Splign:2.1.0"
     exon            931..1083
                     /gene="VTN"
                     /gene_synonym="V75; VN; VNT"
                     /inference="alignment:Splign:2.1.0"
     exon            1084..1428
                     /gene="VTN"
                     /gene_synonym="V75; VN; VNT"
                     /inference="alignment:Splign:2.1.0"
     exon            1429..1626
                     /gene="VTN"
                     /gene_synonym="V75; VN; VNT"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1605..1610
                     /regulatory_class="polyA_signal_sequence"
                     /gene="VTN"
                     /gene_synonym="V75; VN; VNT"
                     /note="hexamer: AATAAA"
     polyA_site      1626
                     /gene="VTN"
                     /gene_synonym="V75; VN; VNT"
                     /note="major polyA site"
ORIGIN      
        1 ctccttccct gtctctgcct ctccctccct tcctcaggca tcagagcgga gacttcaggg
       61 agaccagagc ccagcttgcc aggcactgag ctagaagccc tgccatggca cccctgagac
      121 cccttctcat actggccctg ctggcatggg ttgctctggc tgaccaagag tcatgcaagg
      181 gccgctgcac tgagggcttc aacgtggaca agaagtgcca gtgtgacgag ctctgctctt
      241 actaccagag ctgctgcaca gactatacgg ctgagtgcaa gccccaagtg actcgcgggg
      301 atgtgttcac tatgccggag gatgagtaca cggtctatga cgatggcgag gagaaaaaca
      361 atgccactgt ccatgaacag gtggggggcc cctccctgac ctctgacctc caggcccagt
      421 ccaaagggaa tcctgagcag acacctgttc tgaaacctga ggaagaggcc cctgcgcctg
      481 aggtgggcgc ctctaagcct gaggggatag actcaaggcc tgagaccctt catccaggga
      541 gacctcagcc cccagcagag gaggagctgt gcagtgggaa gcccttcgac gccttcaccg
      601 acctcaagaa cggttccctc tttgccttcc gagggcagta ctgctatgaa ctggacgaaa
      661 aggcagtgag gcctgggtac cccaagctca tccgagatgt ctggggcatc gagggcccca
      721 tcgatgccgc cttcacccgc atcaactgtc aggggaagac ctacctcttc aagggtagtc
      781 agtactggcg ctttgaggat ggtgtcctgg accctgatta cccccgaaat atctctgacg
      841 gcttcgatgg catcccggac aacgtggatg cagccttggc cctccctgcc catagctaca
      901 gtggccggga gcgggtctac ttcttcaagg ggaaacagta ctgggagtac cagttccagc
      961 accagcccag tcaggaggag tgtgaaggca gctccctgtc ggctgtgttt gaacactttg
     1021 ccatgatgca gcgggacagc tgggaggaca tcttcgagct tctcttctgg ggcagaacct
     1081 ctgctggtac cagacagccc cagttcatta gccgggactg gcacggtgtg ccagggcaag
     1141 tggacgcagc catggctggc cgcatctaca tctcaggcat ggcaccccgc ccctccttgg
     1201 ccaagaaaca aaggtttagg catcgcaacc gcaaaggcta ccgttcacaa cgaggccaca
     1261 gccgtggccg caaccagaac tcccgccggc catcccgcgc cacgtggctg tccttgttct
     1321 ccagtgagga gagcaacttg ggagccaaca actatgatga ctacaggatg gactggcttg
     1381 tgcctgccac ctgtgaaccc atccagagtg tcttcttctt ctctggagac aagtactacc
     1441 gagtcaatct tcgcacacgg cgagtggaca ctgtggaccc tccctaccca cgctccatcg
     1501 ctcagtactg gctgggctgc ccagctcctg gccatctgta ggagtcagag cccacatggc
     1561 cgggccctct gtagctccct cctcccatct ccttccccca gcccaataaa ggtcccttag
     1621 ccccga
//
