LOCUS       NM_006370               5142 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens vesicle transport through interaction with t-SNAREs 1B
            (VTI1B), mRNA.
ACCESSION   NM_006370
VERSION     NM_006370.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5142)
  AUTHORS   Chevalier,B., Baatallah,N., Najm,M., Castanier,S., Jung,V.,
            Pranke,I., Golec,A., Stoven,V., Marullo,S., Antigny,F.,
            Guerrera,I.C., Sermet-Gaudelus,I., Edelman,A. and Hinzpeter,A.
  TITLE     Differential CFTR-Interactome Proximity Labeling Procedures
            Identify Enrichment in Multiple SLC Transporters
  JOURNAL   Int J Mol Sci 23 (16), 8937 (2022)
   PUBMED   36012204
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5142)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 5142)
  AUTHORS   Lim,S.H., Snider,J., Birimberg-Schwartz,L., Ip,W., Serralha,J.C.,
            Botelho,H.M., Lopes-Pacheco,M., Pinto,M.C., Moutaoufik,M.T.,
            Zilocchi,M., Laselva,O., Esmaeili,M., Kotlyar,M., Lyakisheva,A.,
            Tang,P., Lopez Vazquez,L., Akula,I., Aboualizadeh,F., Wong,V.,
            Grozavu,I., Opacak-Bernardi,T., Yao,Z., Mendoza,M., Babu,M.,
            Jurisica,I., Gonska,T., Bear,C.E., Amaral,M.D. and Stagljar,I.
  TITLE     CFTR interactome mapping using the mammalian membrane two-hybrid
            high-throughput screening system
  JOURNAL   Mol Syst Biol 18 (2), e10629 (2022)
   PUBMED   35156780
REFERENCE   4  (bases 1 to 5142)
  AUTHORS   Chou,H.Y., Lee,Y.T., Lin,Y.J., Wen,J.K., Peng,W.H., Hsieh,P.L.,
            Lin,S.Y., Hung,C.C. and Chen,G.C.
  TITLE     PTPN9-mediated dephosphorylation of VTI1B promotes ATG16L1
            precursor fusion and autophagosome formation
  JOURNAL   Autophagy 17 (10), 2750-2765 (2021)
   PUBMED   33112705
  REMARK    GeneRIF: PTPN9-mediated dephosphorylation of VTI1B promotes ATG16L1
            precursor fusion and autophagosome formation.
REFERENCE   5  (bases 1 to 5142)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 5142)
  AUTHORS   Antonin,W., Holroyd,C., Fasshauer,D., Pabst,S., Von Mollard,G.F.
            and Jahn,R.
  TITLE     A SNARE complex mediating fusion of late endosomes defines
            conserved properties of SNARE structure and function
  JOURNAL   EMBO J 19 (23), 6453-6464 (2000)
   PUBMED   11101518
REFERENCE   7  (bases 1 to 5142)
  AUTHORS   Kirchhausen,T.
  TITLE     Three ways to make a vesicle
  JOURNAL   Nat Rev Mol Cell Biol 1 (3), 187-198 (2000)
   PUBMED   11252894
  REMARK    Review article
            Erratum:[Nat Rev Mol Cell Biol 2001 Mar;2(3):216]
REFERENCE   8  (bases 1 to 5142)
  AUTHORS   Subramaniam,V.N., Loh,E., Horstmann,H., Habermann,A., Xu,Y.,
            Coe,J., Griffiths,G. and Hong,W.
  TITLE     Preferential association of syntaxin 8 with the early endosome
  JOURNAL   J Cell Sci 113 (Pt 6), 997-1008 (2000)
   PUBMED   10683148
REFERENCE   9  (bases 1 to 5142)
  AUTHORS   Li,H.C., Tahara,H., Tsuyama,N. and Ide,T.
  TITLE     A hVti1 homologue: its expression depends on population doubling
            levels in both normal and SV40-transformed human fibroblasts
  JOURNAL   Biochem Biophys Res Commun 247 (1), 70-74 (1998)
   PUBMED   9636656
REFERENCE   10 (bases 1 to 5142)
  AUTHORS   Fischer von Mollard,G. and Stevens,T.H.
  TITLE     A human homolog can functionally replace the yeast
            vesicle-associated SNARE Vti1p in two vesicle transport pathways
  JOURNAL   J Biol Chem 273 (5), 2624-2630 (1998)
   PUBMED   9446565
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC003142.1 and AL049779.6.
            
            On Nov 23, 2018 this sequence version replaced NM_006370.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.144867.1,
                                           SRR1803617.30613.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000554659.6/ ENSP00000450731.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1078              BC003142.1         70-1147
            1079-5142           AL049779.6         20589-24652         c
FEATURES             Location/Qualifiers
     source          1..5142
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q24.1"
     gene            1..5142
                     /gene="VTI1B"
                     /gene_synonym="v-SNARE; VTI1; VTI1-LIKE; vti1-rp1; VTI1L;
                     VTI2"
                     /note="vesicle transport through interaction with t-SNAREs
                     1B"
                     /db_xref="GeneID:10490"
                     /db_xref="HGNC:HGNC:17793"
                     /db_xref="MIM:603207"
     exon            1..258
                     /gene="VTI1B"
                     /gene_synonym="v-SNARE; VTI1; VTI1-LIKE; vti1-rp1; VTI1L;
                     VTI2"
                     /inference="alignment:Splign:2.1.0"
     CDS             144..842
                     /gene="VTI1B"
                     /gene_synonym="v-SNARE; VTI1; VTI1-LIKE; vti1-rp1; VTI1L;
                     VTI2"
                     /note="vesicle-associated soluble NSF attachment protein
                     receptor; vesicle transport v-SNARE protein Vti1-like 1"
                     /codon_start=1
                     /product="vesicle transport through interaction with
                     t-SNAREs homolog 1B"
                     /protein_id="NP_006361.1"
                     /db_xref="CCDS:CCDS9786.1"
                     /db_xref="GeneID:10490"
                     /db_xref="HGNC:HGNC:17793"
                     /db_xref="MIM:603207"
                     /translation="MASSAASSEHFEKLHEIFRGLHEDLQGVPERLLGTAGTEEKKKL
                     IRDFDEKQQEANETLAEMEEELRYAPLSFRNPMMSKLRNYRKDLAKLHREVRSTPLTA
                     TPGGRGDMKYGIYAVENEHMNRLQSQRAMLLQGTESLNRATQSIERSHRIATETDQIG
                     SEIIEELGEQRDQLERTKSRLVNTSENLSKSRKILRSMSRKVTTNKLLLSIIILLELA
                     ILGGLVYYKFFRSH"
     exon            259..317
                     /gene="VTI1B"
                     /gene_synonym="v-SNARE; VTI1; VTI1-LIKE; vti1-rp1; VTI1L;
                     VTI2"
                     /inference="alignment:Splign:2.1.0"
     exon            318..509
                     /gene="VTI1B"
                     /gene_synonym="v-SNARE; VTI1; VTI1-LIKE; vti1-rp1; VTI1L;
                     VTI2"
                     /inference="alignment:Splign:2.1.0"
     exon            510..683
                     /gene="VTI1B"
                     /gene_synonym="v-SNARE; VTI1; VTI1-LIKE; vti1-rp1; VTI1L;
                     VTI2"
                     /inference="alignment:Splign:2.1.0"
     exon            684..745
                     /gene="VTI1B"
                     /gene_synonym="v-SNARE; VTI1; VTI1-LIKE; vti1-rp1; VTI1L;
                     VTI2"
                     /inference="alignment:Splign:2.1.0"
     exon            746..5142
                     /gene="VTI1B"
                     /gene_synonym="v-SNARE; VTI1; VTI1-LIKE; vti1-rp1; VTI1L;
                     VTI2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1024..1029
                     /regulatory_class="polyA_signal_sequence"
                     /gene="VTI1B"
                     /gene_synonym="v-SNARE; VTI1; VTI1-LIKE; vti1-rp1; VTI1L;
                     VTI2"
                     /note="hexamer: AACAAG"
     regulatory      1051..1056
                     /regulatory_class="polyA_signal_sequence"
                     /gene="VTI1B"
                     /gene_synonym="v-SNARE; VTI1; VTI1-LIKE; vti1-rp1; VTI1L;
                     VTI2"
                     /note="hexamer: AATAAA"
     polyA_site      1052
                     /gene="VTI1B"
                     /gene_synonym="v-SNARE; VTI1; VTI1-LIKE; vti1-rp1; VTI1L;
                     VTI2"
                     /note="major polyA site"
     polyA_site      1082
                     /gene="VTI1B"
                     /gene_synonym="v-SNARE; VTI1; VTI1-LIKE; vti1-rp1; VTI1L;
                     VTI2"
                     /note="major polyA site"
     regulatory      1740..1745
                     /regulatory_class="polyA_signal_sequence"
                     /gene="VTI1B"
                     /gene_synonym="v-SNARE; VTI1; VTI1-LIKE; vti1-rp1; VTI1L;
                     VTI2"
                     /note="hexamer: AATAAA"
     polyA_site      1763
                     /gene="VTI1B"
                     /gene_synonym="v-SNARE; VTI1; VTI1-LIKE; vti1-rp1; VTI1L;
                     VTI2"
     regulatory      5119..5124
                     /regulatory_class="polyA_signal_sequence"
                     /gene="VTI1B"
                     /gene_synonym="v-SNARE; VTI1; VTI1-LIKE; vti1-rp1; VTI1L;
                     VTI2"
                     /note="hexamer: AGTAAA"
     polyA_site      5142
                     /gene="VTI1B"
                     /gene_synonym="v-SNARE; VTI1; VTI1-LIKE; vti1-rp1; VTI1L;
                     VTI2"
                     /note="major polyA site"
ORIGIN      
        1 gcggctccgg aagagcctcg tcctgggcgg cggtggtgcg gcggtcgccg ttatggccac
       61 tgggctgggc ggctgaccgc cgggctagga aagggcccag ggccccgaat ctcggtggcc
      121 gctgctccag cgcggcctgc gccatggcct cctccgccgc ctcctcggag catttcgaga
      181 agctgcacga gatcttccgc ggcctccatg aagacctaca aggggtgccc gagcggctgc
      241 tggggacggc ggggaccgaa gaaaagaaga aattgatcag ggattttgat gaaaagcaac
      301 aggaagcaaa tgaaacgctg gcagagatgg aggaggagct acgttatgca cccctgtctt
      361 tccgaaaccc catgatgtct aagcttcgaa actaccggaa ggaccttgct aaactccatc
      421 gggaggtgag aagcacacct ttgacagcca cacctggagg ccgaggagac atgaaatatg
      481 gcatatatgc tgtagagaat gagcatatga atcggctaca gtctcaaagg gcaatgcttc
      541 tgcagggcac tgaaagcctg aaccgggcca cccaaagtat tgaacgttct catcggattg
      601 ccacagagac tgaccagatt ggctcagaaa tcatagaaga gctgggggaa caacgagacc
      661 agttagaacg taccaagagt agactggtaa acacaagtga aaacttgagc aaaagtcgga
      721 agattctccg ttcaatgtcc agaaaagtga caaccaacaa gctgctgctt tccattatca
      781 tcttactgga gctcgccatc ctgggaggcc tggtttacta caaattcttt cgcagccatt
      841 gaacttctat agggaagggt ttgtggacca gaactttgac cttgtgaatg catgatgtta
      901 gggatgtgga tagaataagc atattgctgc tgtgggctga cagttcaagg atgcactgta
      961 tagccaggct gtgggaggag ggaggaaaga tgaaaaacca cttaaatgtg aaggaacaac
     1021 agcaacaaga ccagtatgat ataccaaggt aataaatgct gtttatgact tctttaaatt
     1081 tacatagtac tgtagcatat taataccctg tgaactgcaa aaaaccaaat acatttacag
     1141 tagtattggt caccaaaata gaggggaaac tttacaattg tgagaatgtg taaatgttct
     1201 cattaaggca gtattgaccc agacaaccat ttagtattca tctatcccct caatgcctca
     1261 taattctgga atgcctgttg tgaaacatgt cagtgcacag tgtctcctaa attctcacac
     1321 gtgcttgatt ttctgattca tctggtgaac tgggagtagg aagttggtca tagacaatat
     1381 gccctccttc tcttgtctga ccaaagcttg aagcaatcac atctactgcc aggttagctg
     1441 tagtcttcgc ctcttcctct gaggtggcca actgaggatt gacttcaaca agatccagtg
     1501 ctgatagcaa ccctggaaga acaaagtgtg acaaaacctc aggttccctt gctgctactc
     1561 tcagtgaggg tcatcccact gggacaggga gaacaagcca aagtaaaaac aagagtccat
     1621 tttatagtag aaaataccta tttttaggaa gccccttgca cctcatcctc ttggccatga
     1681 atttaagtta aaacactgtt gtgctatagt agattaaaag aaacctttta agataatgaa
     1741 ataaaccatc cctgttcaac taacataaca ggcataattg tcaggcgttc tggaaaagga
     1801 aaaggcttgg tgttgggtgg gggaggtttt catcctgctt gttggcaaaa tgtatgccac
     1861 ctccagtatg actaggaacc ttccagatgc ctgcctggaa atgaatcaag tatgaaggca
     1921 gaggaaatct gccacttgca ctagccaaac tgcattccca cttttgaact ctaatgtgtt
     1981 atctgtatct gttagagcac cacaccatat gccctgaaat gtagttatta ctgcaaactt
     2041 cattctcacc cctgcaggcc tgagctctgg aggcaggttc cacatctaac aacatctttt
     2101 tgtctcccag cagactgacc cagtgtcttg tacttgatca agagaaaatt cagccatatg
     2161 ttaattattt tatctggact tcagttacct tctgttaagg tttgagaact tgtgtcaaag
     2221 ttctcggtag tgttcctttg gcctggagca agtggaaggg aagcttaaac cagaagaacc
     2281 tatccagacc tgctactatg ctcacccctc taaatgcctc acttctctat agaatttaac
     2341 tttttagttg gttattctgg atgaagggtg atctgaacaa gctagtattc aggaatacaa
     2401 gtatctaaga atatttaggg tggccataaa gtctggaaac acaggcaaat gtacctaatg
     2461 gtttattgat attacactat agtacatgat gtgctgaatg ccatcatgtc cgttcagcat
     2521 cttcccttat tagcaatgca tagttgagtg tacagtgcca aactgcaacc aacaggtgta
     2581 ttactgtagc atttccatca tttcctgcac atggacctgt gttcctgatt tgtctctgat
     2641 ttccactgac taaacctgca cctttagcat atcccagaag tggtcatcaa agtttgcact
     2701 attagaaata tatacatgac ttatgtttcc agactattgc caccctataa attaagcaaa
     2761 ctgctttatg tatctagttg acagcattat aacagtgcag tggcacaatc atggctcact
     2821 gcagcctcaa cctcccaagt agttgggaca cctggctaat tattttttgt agaaacgggg
     2881 tcacactatg ttgcccacgc tggtcttgaa cccctggggt caagtaatcc tcttgccttg
     2941 gcctcccaga gtactgggat tataggtatg aaccactgtg cctagcccca tgagtgtctt
     3001 ttggagtaaa atattgtagc ataggaacaa agagacaagc catgccatat ataagtgcta
     3061 gaggttatta acccctgctc taagtggtgt ttttaggaag caaagcagag aattgaaccc
     3121 ccaagttctc tggccaataa cctaaggacc actggcaaca tctaagattg cagatctgag
     3181 aattagacca gtactgcctg cctttttgta ctgcctaagg ttctggcagg ctgtggcgct
     3241 aaggagacca tttctcaatg tgagtttcta tcccagctag tcaagggttc tctatagccc
     3301 tgaacctttc aatctggggt ctctatctat accctagttc catcagatgg ttactgaagc
     3361 agtatgattt ggtagttctt taaattttgg aatgaaaggt catttgaagt agctttaaaa
     3421 ccagaagctt tctgacagaa atggaaactg tttgcaaaca agtatgagtt ttggaaaagt
     3481 agccagtctt gataacgtag aattcatctt agtactcttt ccatcagcca ttctcatcta
     3541 actgtatccc ccttattaga aatcctttca ggctctagta caagacctac cctacataaa
     3601 ggacccaaga tattgtccag tttgcagatt tcttcaagag atcagcttta gctccaaatt
     3661 cacaactccc aatgaaccaa tctcttagag tgcaaattac agccttgcac tcttatctta
     3721 tcttgccttc ttatcttaat ctgcctttag ataactcaaa gaactgcatc agtttgacaa
     3781 tttattcttg tatttaattg tttaaatata caatttttta ctcattatta ccttagtgta
     3841 atttggtaag agccatgtcc aagcatgact ctaaaggact atatcctttt tattagcatg
     3901 gccatataat ttttagctac aaaagtttaa gcaaaaacaa actctgcaat gatgtggaat
     3961 agcagaaaag atcctttgca ggcaagagac tctagcatat ttacctatgt agttaacagg
     4021 ctgcagacct ggttgctaca tacctgtatt gtgtatttcc tcagcaatat acatgccttc
     4081 tcgataggtt agtcccccga caacaggagt tcctgtggct ggagccagtg tagggtcaaa
     4141 tgcatcaata tcaaaactca aatggattgg tctttgtctc ctaaaaagga agaggataaa
     4201 ataatactta aaataatact taactggttg tccttggaca ctcatccttc ttatggttgc
     4261 aactccttga ttttgttgct attagtccta gtactttgtt aataaagctg ttaatacatt
     4321 tccaggcttc ctattcttgg aagttactga gattggcaat attaacttcc tacataccac
     4381 ttcatgatac tgccatttgt tctgcatacc tcagacagac taactccaat gtatatttct
     4441 gccttacact gggtattaga acctcttata ctaataactg tcaatagaga gatttcttca
     4501 cttctagatg agattgggct ctcatctaga gacaatttaa ttagacaatt taaattagtc
     4561 taatttaaat tggcttgatg taagttatgg ttgctcttat tctctgaacg taacagcagc
     4621 tgaagtgaac tctaatttta ggtctgcagt tttaacatct tccatttcta acttcattat
     4681 agccccagtg tccaaaggct gaagctaaca actaagtttc ttaacagctt atgaaatgac
     4741 atactaccag ataacaattc tgacattaat cacccagaag taaagacttg gtattgggaa
     4801 aatgctctta aaattaccat ttgattagta ttcatctgcc atctttctac actgccaaga
     4861 tttgcttaat ataaaactca gatgaaacaa tcgtgaggct gggaagaatg ggacagttga
     4921 aacaataaat gcttgtcatc tcagaagata agcattaaag atggagataa agaaaaattc
     4981 atgagacaga agatctaggc aatgatttag aggaaacctc ctcccaaaaa ccccagagga
     5041 agaatatgac ctgtgtttca aattttgcct ttctgaacta tttaaaatta tgtgtatgtt
     5101 tttgctttgt attttaaaag taaagctgct gtcctcaaga aa
//
