LOCUS       NM_024626               2605 bp    mRNA    linear   PRI 24-JUN-2024
DEFINITION  Homo sapiens V-set domain containing T cell activation inhibitor 1
            (VTCN1), transcript variant 1, mRNA.
ACCESSION   NM_024626
VERSION     NM_024626.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2605)
  AUTHORS   Chen,L., Zhou,B., Tang,M., Yao,Y., Zhao,Y., Hu,Y., Lin,Y., Ji,J.
            and Jiao,Q.
  TITLE     Aberrant expression of B7-H4 and B7-H5 contributes to the
            development of cutaneous squamous cell carcinoma
  JOURNAL   Arch Dermatol Res 316 (7), 382 (2024)
   PUBMED   38850312
  REMARK    GeneRIF: Aberrant expression of B7-H4 and B7-H5 contributes to the
            development of cutaneous squamous cell carcinoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2605)
  AUTHORS   Su,H., Lin,X., Huo,J. and Zhang,F.
  TITLE     Diagnostic, clinicopathological features and prognostic value of
            B7x expression in Chinese women with breast cancer: A meta-analysis
  JOURNAL   Asian J Surg 46 (11), 5210-5216 (2023)
   PUBMED   37481357
  REMARK    GeneRIF: Diagnostic, clinicopathological features and prognostic
            value of B7x expression in Chinese women with breast cancer: A
            meta-analysis.
REFERENCE   3  (bases 1 to 2605)
  AUTHORS   Jin,Y.C., Dong,L.J., Yang,Q.Y., Xiong,W.N., Wang,W.Y., Feng,X.H.,
            Yu,W., Huang,W. and Chen,B.F.
  TITLE     An Investigation of the Effects of B7-H4 Gene rs10754339 and
            miR-125a Gene rs12976445 on Cancer Susceptibility
  JOURNAL   Biomed Environ Sci 36 (9), 814-825 (2023)
   PUBMED   37803894
  REMARK    GeneRIF: An Investigation of the Effects of B7-H4 Gene rs10754339
            and miR-125a Gene rs12976445 on Cancer Susceptibility.
REFERENCE   4  (bases 1 to 2605)
  AUTHORS   Ozaki,H., Inoue,N., Iwatani,Y., Watanabe,A., Yamamoto,M.,
            Kitahara,N., Tanikawa,S., Noguchi,Y., Hidaka,Y. and Watanabe,M.
  TITLE     Association of B7H3 and B7H4 gene polymorphisms and protein
            expression with the development and prognosis of autoimmune thyroid
            diseases
  JOURNAL   Clin Endocrinol (Oxf) 99 (1), 103-112 (2023)
   PUBMED   37066992
  REMARK    GeneRIF: Association of B7H3 and B7H4 gene polymorphisms and
            protein expression with the development and prognosis of autoimmune
            thyroid diseases.
REFERENCE   5  (bases 1 to 2605)
  AUTHORS   Mortezaee,K.
  TITLE     B7x in cancer immunity and immunotherapy
  JOURNAL   Int Immunopharmacol 118, 110133 (2023)
   PUBMED   37028278
  REMARK    GeneRIF: B7x in cancer immunity and immunotherapy.
            Review article
REFERENCE   6  (bases 1 to 2605)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   7  (bases 1 to 2605)
  AUTHORS   Zang,X., Loke,P., Kim,J., Murphy,K., Waitz,R. and Allison,J.P.
  TITLE     B7x: a widely expressed B7 family member that inhibits T cell
            activation
  JOURNAL   Proc Natl Acad Sci U S A 100 (18), 10388-10392 (2003)
   PUBMED   12920180
REFERENCE   8  (bases 1 to 2605)
  AUTHORS   Watanabe,N., Gavrieli,M., Sedy,J.R., Yang,J., Fallarino,F.,
            Loftin,S.K., Hurchla,M.A., Zimmerman,N., Sim,J., Zang,X.,
            Murphy,T.L., Russell,J.H., Allison,J.P. and Murphy,K.M.
  TITLE     BTLA is a lymphocyte inhibitory receptor with similarities to
            CTLA-4 and PD-1
  JOURNAL   Nat Immunol 4 (7), 670-679 (2003)
   PUBMED   12796776
REFERENCE   9  (bases 1 to 2605)
  AUTHORS   Prasad,D.V., Richards,S., Mai,X.M. and Dong,C.
  TITLE     B7S1, a novel B7 family member that negatively regulates T cell
            activation
  JOURNAL   Immunity 18 (6), 863-873 (2003)
   PUBMED   12818166
  REMARK    GeneRIF: Negative regulator of T cell activation.  (B7S1)
REFERENCE   10 (bases 1 to 2605)
  AUTHORS   Sica,G.L., Choi,I.H., Zhu,G., Tamada,K., Wang,S.D., Tamura,H.,
            Chapoval,A.I., Flies,D.B., Bajorath,J. and Chen,L.
  TITLE     B7-H4, a molecule of the B7 family, negatively regulates T cell
            immunity
  JOURNAL   Immunity 18 (6), 849-861 (2003)
   PUBMED   12818165
  REMARK    GeneRIF: May participate in negative regulation of cell-mediated
            immunity in peripheral tissues
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB198367.1, AY280972.1, CN259811.1, AL391476.20 and AI686571.1.
            
            On Nov 22, 2018 this sequence version replaced NM_024626.3.
            
            Summary: This gene encodes a protein belonging to the B7
            costimulatory protein family. Proteins in this family are present
            on the surface of antigen-presenting cells and interact with ligand
            bound to receptors on the surface of T cells. Studies have shown
            that high levels of the encoded protein has been correlated with
            tumor progression. A pseudogene of this gene is located on
            chromosome 20. Multiple transcript variants encoding different
            isoforms have been found for this gene. [provided by RefSeq, Dec
            2011].
            
            Transcript Variant: This variant (1) encodes the longest protein
            (isoform 1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY358352.1, AK026071.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000369458.8/ ENSP00000358470.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-72                DB198367.1         1-72
            73-921              AY280972.1         1-849
            922-1054            CN259811.1         523-655
            1055-2172           AL391476.20        81082-82199         c
            2173-2605           AI686571.1         15-447              c
FEATURES             Location/Qualifiers
     source          1..2605
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p13.1-p12"
     gene            1..2605
                     /gene="VTCN1"
                     /gene_synonym="B7-H4; B7h.5; B7H4; B7S1; B7X; PRO1291;
                     VCTN1"
                     /note="V-set domain containing T cell activation inhibitor
                     1"
                     /db_xref="GeneID:79679"
                     /db_xref="HGNC:HGNC:28873"
                     /db_xref="MIM:608162"
     exon            1..104
                     /gene="VTCN1"
                     /gene_synonym="B7-H4; B7h.5; B7H4; B7S1; B7X; PRO1291;
                     VCTN1"
                     /inference="alignment:Splign:2.1.0"
     CDS             73..921
                     /gene="VTCN1"
                     /gene_synonym="B7-H4; B7h.5; B7H4; B7S1; B7X; PRO1291;
                     VCTN1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; B7 family member, H4; immune costimulatory
                     protein B7-H4; T cell costimulatory molecule B7x; B7
                     superfamily member 1; B7 homolog 4"
                     /codon_start=1
                     /product="V-set domain-containing T-cell activation
                     inhibitor 1 isoform 1 precursor"
                     /protein_id="NP_078902.2"
                     /db_xref="CCDS:CCDS894.1"
                     /db_xref="GeneID:79679"
                     /db_xref="HGNC:HGNC:28873"
                     /db_xref="MIM:608162"
                     /translation="MASLGQILFWSIISIIIILAGAIALIIGFGISGRHSITVTTVAS
                     AGNIGEDGILSCTFEPDIKLSDIVIQWLKEGVLGLVHEFKEGKDELSEQDEMFRGRTA
                     VFADQVIVGNASLRLKNVQLTDAGTYKCYIITSKGKGNANLEYKTGAFSMPEVNVDYN
                     ASSETLRCEAPRWFPQPTVVWASQVDQGANFSEVSNTSFELNSENVTMKVVSVLYNVT
                     INNTYSCMIENDIAKATGDIKVTESEIKRRSHLQLLNSKASLCVSSFFAISWALLPLS
                     PYLMLK"
     exon            105..169
                     /gene="VTCN1"
                     /gene_synonym="B7-H4; B7h.5; B7H4; B7S1; B7X; PRO1291;
                     VCTN1"
                     /inference="alignment:Splign:2.1.0"
     exon            170..517
                     /gene="VTCN1"
                     /gene_synonym="B7-H4; B7h.5; B7H4; B7S1; B7X; PRO1291;
                     VCTN1"
                     /inference="alignment:Splign:2.1.0"
     exon            518..796
                     /gene="VTCN1"
                     /gene_synonym="B7-H4; B7h.5; B7H4; B7S1; B7X; PRO1291;
                     VCTN1"
                     /inference="alignment:Splign:2.1.0"
     exon            797..966
                     /gene="VTCN1"
                     /gene_synonym="B7-H4; B7h.5; B7H4; B7S1; B7X; PRO1291;
                     VCTN1"
                     /inference="alignment:Splign:2.1.0"
     exon            967..2605
                     /gene="VTCN1"
                     /gene_synonym="B7-H4; B7h.5; B7H4; B7S1; B7X; PRO1291;
                     VCTN1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2582..2587
                     /regulatory_class="polyA_signal_sequence"
                     /gene="VTCN1"
                     /gene_synonym="B7-H4; B7h.5; B7H4; B7S1; B7X; PRO1291;
                     VCTN1"
                     /note="hexamer: ATTAAA"
     polyA_site      2605
                     /gene="VTCN1"
                     /gene_synonym="B7-H4; B7h.5; B7H4; B7S1; B7X; PRO1291;
                     VCTN1"
                     /note="major polyA site"
ORIGIN      
        1 gtgagtcacc aaggaaggca gcggcagctc cactcagcca gtacccagat acgctgggaa
       61 ccttccccag ccatggcttc cctggggcag atcctcttct ggagcataat tagcatcatc
      121 attattctgg ctggagcaat tgcactcatc attggctttg gtatttcagg gagacactcc
      181 atcacagtca ctactgtcgc ctcagctggg aacattgggg aggatggaat cctgagctgc
      241 acttttgaac ctgacatcaa actttctgat atcgtgatac aatggctgaa ggaaggtgtt
      301 ttaggcttgg tccatgagtt caaagaaggc aaagatgagc tgtcggagca ggatgaaatg
      361 ttcagaggcc ggacagcagt gtttgctgat caagtgatag ttggcaatgc ctctttgcgg
      421 ctgaaaaacg tgcaactcac agatgctggc acctacaaat gttatatcat cacttctaaa
      481 ggcaagggga atgctaacct tgagtataaa actggagcct tcagcatgcc ggaagtgaat
      541 gtggactata atgccagctc agagaccttg cggtgtgagg ctccccgatg gttcccccag
      601 cccacagtgg tctgggcatc ccaagttgac cagggagcca acttctcgga agtctccaat
      661 accagctttg agctgaactc tgagaatgtg accatgaagg ttgtgtctgt gctctacaat
      721 gttacgatca acaacacata ctcctgtatg attgaaaatg acattgccaa agcaacaggg
      781 gatatcaaag tgacagaatc ggagatcaaa aggcggagtc acctacagct gctaaactca
      841 aaggcttctc tgtgtgtctc ttctttcttt gccatcagct gggcacttct gcctctcagc
      901 ccttacctga tgctaaaata atgtgcctcg gccacaaaaa agcatgcaaa gtcattgtta
      961 caacagggat ctacagaact atttcaccac cagatatgac ctagttttat atttctggga
     1021 ggaaatgaat tcatatctag aagtctggag tgagcaaaca agagcaagaa acaaaaagaa
     1081 gccaaaagca gaaggctcca atatgaacaa gataaatcta tcttcaaaga catattagaa
     1141 gttgggaaaa taattcatgt gaactagaca agtgtgttaa gagtgataag taaaatgcac
     1201 gtggagacaa gtgcatcccc agatctcagg gacctccccc tgcctgtcac ctggggagtg
     1261 agaggacagg atagtgcatg ttctttgtct ctgaattttt agttatatgt gctgtaatgt
     1321 tgctctgagg aagcccctgg aaagtctatc ccaacatatc cacatcttat attccacaaa
     1381 ttaagctgta gtatgtaccc taagacgctg ctaattgact gccacttcgc aactcagggg
     1441 cggctgcatt ttagtaatgg gtcaaatgat tcacttttta tgatgcttcc aaaggtgcct
     1501 tggcttctct tcccaactga caaatgccaa agttgagaaa aatgatcata attttagcat
     1561 aaacagagca gtcggcgaca ccgattttat aaataaactg agcaccttct ttttaaacaa
     1621 acaaatgcgg gtttatttct cagatgatgt tcatccgtga atggtccagg gaaggacctt
     1681 tcaccttgtc tatatggcat tatgtcatca caagctctga ggcttctcct ttccatcctg
     1741 cgtggacagc taagacctca gttttcaata gcatctagag cagtgggact cagctggggt
     1801 gatttcgccc cccatctccg ggggaatgtc tgaagacaat tttggttacc tcaatgaggg
     1861 agtggaggag gatacagtgc tactaccaac tagtggatag aggccaggga tgctgctcaa
     1921 cctcctacca tgtacaggac gtctccccat tacaactacc caatccgaag tgtcaactgt
     1981 gtcagggcta agaaaccctg gttttgagta gaaaagggcc tggaaagagg ggagccaaca
     2041 aatctgtctg cttcctcaca ttagtcattg gcaaataagc attctgtctc tttggctgct
     2101 gcctcagcac agagagccag aactctatcg ggcaccagga taacatctct cagtgaacag
     2161 agttgacaag gcctatggga aatgcctgat gggattatct tcagcttgtt gagcttctaa
     2221 gtttctttcc cttcattcta ccctgcaagc caagttctgt aagagaaatg cctgagttct
     2281 agctcaggtt ttcttactct gaatttagat ctccagaccc tgcctggcca caattcaaat
     2341 taaggcaaca aacatatacc ttccatgaag cacacacaga cttttgaaag caaggacaat
     2401 gactgcttga attgaggcct tgaggaatga agctttgaag gaaaagaata ctttgtttcc
     2461 agcccccttc ccacactctt catgtgttaa ccactgcctt cctggacctt ggagccacgg
     2521 tgactgtatt acatgttgtt atagaaaact gattttagag ttctgatcgt tcaagagaat
     2581 gattaaatat acatttccta cacca
//
