LOCUS       NP_078902                282 aa            linear   PRI 24-JUN-2024
DEFINITION  V-set domain-containing T-cell activation inhibitor 1 isoform 1
            precursor [Homo sapiens].
ACCESSION   NP_078902
VERSION     NP_078902.2
DBSOURCE    REFSEQ: accession NM_024626.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 282)
  AUTHORS   Chen,L., Zhou,B., Tang,M., Yao,Y., Zhao,Y., Hu,Y., Lin,Y., Ji,J.
            and Jiao,Q.
  TITLE     Aberrant expression of B7-H4 and B7-H5 contributes to the
            development of cutaneous squamous cell carcinoma
  JOURNAL   Arch Dermatol Res 316 (7), 382 (2024)
   PUBMED   38850312
  REMARK    GeneRIF: Aberrant expression of B7-H4 and B7-H5 contributes to the
            development of cutaneous squamous cell carcinoma.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 282)
  AUTHORS   Su,H., Lin,X., Huo,J. and Zhang,F.
  TITLE     Diagnostic, clinicopathological features and prognostic value of
            B7x expression in Chinese women with breast cancer: A meta-analysis
  JOURNAL   Asian J Surg 46 (11), 5210-5216 (2023)
   PUBMED   37481357
  REMARK    GeneRIF: Diagnostic, clinicopathological features and prognostic
            value of B7x expression in Chinese women with breast cancer: A
            meta-analysis.
REFERENCE   3  (residues 1 to 282)
  AUTHORS   Jin,Y.C., Dong,L.J., Yang,Q.Y., Xiong,W.N., Wang,W.Y., Feng,X.H.,
            Yu,W., Huang,W. and Chen,B.F.
  TITLE     An Investigation of the Effects of B7-H4 Gene rs10754339 and
            miR-125a Gene rs12976445 on Cancer Susceptibility
  JOURNAL   Biomed Environ Sci 36 (9), 814-825 (2023)
   PUBMED   37803894
  REMARK    GeneRIF: An Investigation of the Effects of B7-H4 Gene rs10754339
            and miR-125a Gene rs12976445 on Cancer Susceptibility.
REFERENCE   4  (residues 1 to 282)
  AUTHORS   Ozaki,H., Inoue,N., Iwatani,Y., Watanabe,A., Yamamoto,M.,
            Kitahara,N., Tanikawa,S., Noguchi,Y., Hidaka,Y. and Watanabe,M.
  TITLE     Association of B7H3 and B7H4 gene polymorphisms and protein
            expression with the development and prognosis of autoimmune thyroid
            diseases
  JOURNAL   Clin Endocrinol (Oxf) 99 (1), 103-112 (2023)
   PUBMED   37066992
  REMARK    GeneRIF: Association of B7H3 and B7H4 gene polymorphisms and
            protein expression with the development and prognosis of autoimmune
            thyroid diseases.
REFERENCE   5  (residues 1 to 282)
  AUTHORS   Mortezaee,K.
  TITLE     B7x in cancer immunity and immunotherapy
  JOURNAL   Int Immunopharmacol 118, 110133 (2023)
   PUBMED   37028278
  REMARK    GeneRIF: B7x in cancer immunity and immunotherapy.
            Review article
REFERENCE   6  (residues 1 to 282)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   7  (residues 1 to 282)
  AUTHORS   Zang,X., Loke,P., Kim,J., Murphy,K., Waitz,R. and Allison,J.P.
  TITLE     B7x: a widely expressed B7 family member that inhibits T cell
            activation
  JOURNAL   Proc Natl Acad Sci U S A 100 (18), 10388-10392 (2003)
   PUBMED   12920180
REFERENCE   8  (residues 1 to 282)
  AUTHORS   Watanabe,N., Gavrieli,M., Sedy,J.R., Yang,J., Fallarino,F.,
            Loftin,S.K., Hurchla,M.A., Zimmerman,N., Sim,J., Zang,X.,
            Murphy,T.L., Russell,J.H., Allison,J.P. and Murphy,K.M.
  TITLE     BTLA is a lymphocyte inhibitory receptor with similarities to
            CTLA-4 and PD-1
  JOURNAL   Nat Immunol 4 (7), 670-679 (2003)
   PUBMED   12796776
REFERENCE   9  (residues 1 to 282)
  AUTHORS   Prasad,D.V., Richards,S., Mai,X.M. and Dong,C.
  TITLE     B7S1, a novel B7 family member that negatively regulates T cell
            activation
  JOURNAL   Immunity 18 (6), 863-873 (2003)
   PUBMED   12818166
  REMARK    GeneRIF: Negative regulator of T cell activation.  (B7S1)
REFERENCE   10 (residues 1 to 282)
  AUTHORS   Sica,G.L., Choi,I.H., Zhu,G., Tamada,K., Wang,S.D., Tamura,H.,
            Chapoval,A.I., Flies,D.B., Bajorath,J. and Chen,L.
  TITLE     B7-H4, a molecule of the B7 family, negatively regulates T cell
            immunity
  JOURNAL   Immunity 18 (6), 849-861 (2003)
   PUBMED   12818165
  REMARK    GeneRIF: May participate in negative regulation of cell-mediated
            immunity in peripheral tissues
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB198367.1, AY280972.1, CN259811.1, AL391476.20 and AI686571.1.
            
            On May 20, 2006 this sequence version replaced NP_078902.1.
            
            Summary: This gene encodes a protein belonging to the B7
            costimulatory protein family. Proteins in this family are present
            on the surface of antigen-presenting cells and interact with ligand
            bound to receptors on the surface of T cells. Studies have shown
            that high levels of the encoded protein has been correlated with
            tumor progression. A pseudogene of this gene is located on
            chromosome 20. Multiple transcript variants encoding different
            isoforms have been found for this gene. [provided by RefSeq, Dec
            2011].
            
            Transcript Variant: This variant (1) encodes the longest protein
            (isoform 1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY358352.1, AK026071.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000369458.8/ ENSP00000358470.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..282
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p13.1-p12"
     Protein         1..282
                     /product="V-set domain-containing T-cell activation
                     inhibitor 1 isoform 1 precursor"
                     /note="B7 family member, H4; immune costimulatory protein
                     B7-H4; T cell costimulatory molecule B7x; B7 superfamily
                     member 1; B7 homolog 4"
                     /calculated_mol_wt=28381
     sig_peptide     1..24
                     /note="/evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q7Z7D3.1)"
                     /calculated_mol_wt=2515
     mat_peptide     25..282
                     /product="V-set domain-containing T-cell activation
                     inhibitor 1. /evidence=ECO:0000255. /id=PRO_0000339237"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7Z7D3.1)"
                     /calculated_mol_wt=28381
     Region          38..147
                     /region_name="IgV_B7-H4"
                     /note="Immunoglobulin Variable (IgV) domain of B7-H4;
                     cd20984"
                     /db_xref="CDD:409576"
     Region          38..57
                     /region_name="FR1"
                     /note="FR1 [structural motif]"
                     /db_xref="CDD:409576"
     Region          38..41
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409576"
     Region          43..46
                     /region_name="Ig strand A'"
                     /note="Ig strand A' [structural motif]"
                     /db_xref="CDD:409576"
     Region          49..57
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409576"
     Region          58..67
                     /region_name="CDR1"
                     /note="CDR1 [structural motif]"
                     /db_xref="CDD:409576"
     Region          67..73
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409576"
     Region          68..75
                     /region_name="FR2"
                     /note="FR2 [structural motif]"
                     /db_xref="CDD:409576"
     Region          76..90
                     /region_name="CDR2"
                     /note="CDR2 [structural motif]"
                     /db_xref="CDD:409576"
     Region          80..84
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409576"
     Region          87..90
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409576"
     Region          93..133
                     /region_name="FR3"
                     /note="FR3 [structural motif]"
                     /db_xref="CDD:409576"
     Region          100..104
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409576"
     Region          112..119
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409576"
     Region          126..134
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409576"
     Region          134..137
                     /region_name="CDR3"
                     /note="CDR3 [structural motif]"
                     /db_xref="CDD:409576"
     Region          137..147
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409576"
     Region          138..147
                     /region_name="FR4"
                     /note="FR4 [structural motif]"
                     /db_xref="CDD:409576"
     Site            216
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q7Z7D3.1)"
     Site            260..280
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7Z7D3.1)"
     CDS             1..282
                     /gene="VTCN1"
                     /gene_synonym="B7-H4; B7h.5; B7H4; B7S1; B7X; PRO1291;
                     VCTN1"
                     /coded_by="NM_024626.4:73..921"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1"
                     /db_xref="CCDS:CCDS894.1"
                     /db_xref="GeneID:79679"
                     /db_xref="HGNC:HGNC:28873"
                     /db_xref="MIM:608162"
ORIGIN      
        1 maslgqilfw siisiiiila gaialiigfg isgrhsitvt tvasagnige dgilsctfep
       61 diklsdiviq wlkegvlglv hefkegkdel seqdemfrgr tavfadqviv gnaslrlknv
      121 qltdagtykc yiitskgkgn anleyktgaf smpevnvdyn assetlrcea prwfpqptvv
      181 wasqvdqgan fsevsntsfe lnsenvtmkv vsvlynvtin ntyscmiend iakatgdikv
      241 teseikrrsh lqllnskasl cvssffaisw allplspylm lk
//
