LOCUS       NM_016485               6991 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens vesicle trafficking 1 (VTA1), transcript variant 1,
            mRNA.
ACCESSION   NM_016485
VERSION     NM_016485.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6991)
  AUTHORS   Dvilansky,I., Altaras,Y., Kamenetsky,N., Nachmias,D. and Elia,N.
  TITLE     The human AAA-ATPase VPS4A isoform and its co-factor VTA1 have a
            unique function in regulating mammalian cytokinesis abscission
  JOURNAL   PLoS Biol 22 (4), e3002327 (2024)
   PUBMED   38687820
  REMARK    GeneRIF: The human AAA-ATPase VPS4A isoform and its co-factor VTA1
            have a unique function in regulating mammalian cytokinesis
            abscission.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6991)
  AUTHORS   Sun,X., Wu,R., Guan,X., Dong,C., Qiu,D., Xia,G., Feng,S., Duan,J.
            and Zhang,L.
  TITLE     High expression of VTA1 is an adverse prognostic factor in lung
            adenocarcinoma
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 70 (1), 46-55 (2024)
   PUBMED   38372114
  REMARK    GeneRIF: High expression of VTA1 is an adverse prognostic factor in
            lung adenocarcinoma.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6991)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 6991)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 6991)
  AUTHORS   Roche,J.V., Nesverova,V., Olsson,C., Deen,P.M. and
            Tornroth-Horsefield,S.
  TITLE     Structural Insights into AQP2 Targeting to Multivesicular Bodies
  JOURNAL   Int J Mol Sci 20 (21), 5351 (2019)
   PUBMED   31661793
  REMARK    GeneRIF: A structural model of the AQP2-LIP5 complex, giving the
            very first structural insight into how membrane proteins are
            recruited to multivesicular bodies inner vesicles.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6991)
  AUTHORS   Scott,A., Chung,H.Y., Gonciarz-Swiatek,M., Hill,G.C., Whitby,F.G.,
            Gaspar,J., Holton,J.M., Viswanathan,R., Ghaffarian,S., Hill,C.P.
            and Sundquist,W.I.
  TITLE     Structural and mechanistic studies of VPS4 proteins
  JOURNAL   EMBO J 24 (20), 3658-3669 (2005)
   PUBMED   16193069
REFERENCE   7  (bases 1 to 6991)
  AUTHORS   Ward,D.M., Vaughn,M.B., Shiflett,S.L., White,P.L., Pollock,A.L.,
            Hill,J., Schnegelberger,R., Sundquist,W.I. and Kaplan,J.
  TITLE     The role of LIP5 and CHMP5 in multivesicular body formation and
            HIV-1 budding in mammalian cells
  JOURNAL   J Biol Chem 280 (11), 10548-10555 (2005)
   PUBMED   15644320
REFERENCE   8  (bases 1 to 6991)
  AUTHORS   Fujita,H., Umezuki,Y., Imamura,K., Ishikawa,D., Uchimura,S.,
            Nara,A., Yoshimori,T., Hayashizaki,Y., Kawai,J., Ishidoh,K.,
            Tanaka,Y. and Himeno,M.
  TITLE     Mammalian class E Vps proteins, SBP1 and mVps2/CHMP2A, interact
            with and regulate the function of an AAA-ATPase SKD1/Vps4B
  JOURNAL   J Cell Sci 117 (Pt 14), 2997-3009 (2004)
   PUBMED   15173323
REFERENCE   9  (bases 1 to 6991)
  AUTHORS   Tchernev,V.T., Mansfield,T.A., Giot,L., Kumar,A.M., Nandabalan,K.,
            Li,Y., Mishra,V.S., Detter,J.C., Rothberg,J.M., Wallace,M.R.,
            Southwick,F.S. and Kingsmore,S.F.
  TITLE     The Chediak-Higashi protein interacts with SNARE complex and signal
            transduction proteins
  JOURNAL   Mol Med 8 (1), 56-64 (2002)
   PUBMED   11984006
REFERENCE   10 (bases 1 to 6991)
  AUTHORS   Shi,J., Cai,W., Chen,X., Ying,K., Zhang,K. and Xie,Y.
  TITLE     Identification of dopamine responsive mRNAs in glial cells by
            suppression subtractive hybridization
  JOURNAL   Brain Res 910 (1-2), 29-37 (2001)
   PUBMED   11489251
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC022536.1, AF271994.1 and AL033522.1.
            
            On Nov 22, 2018 this sequence version replaced NM_016485.4.
            
            Summary: C6ORF55 encodes a protein involved in trafficking of the
            multivesicular body, an endosomal compartment involved in sorting
            membrane proteins for degradation in lysosomes (Ward et al., 2005
            [PubMed 15644320]).[supplied by OMIM, Mar 2008].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC022536.1, SRR1660805.178443.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000367630.9/ ENSP00000356602.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2670              BC022536.1         1-2670
            2671-3254           AF271994.1         2661-3244
            3255-6991           AL033522.1         111763-115499
FEATURES             Location/Qualifiers
     source          1..6991
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q24.1-q24.2"
     gene            1..6991
                     /gene="VTA1"
                     /gene_synonym="6orf55; C6orf55; DRG-1; DRG1; HSPC228;
                     LIP5; My012; SBP1"
                     /note="vesicle trafficking 1"
                     /db_xref="GeneID:51534"
                     /db_xref="HGNC:HGNC:20954"
                     /db_xref="MIM:610902"
     exon            1..137
                     /gene="VTA1"
                     /gene_synonym="6orf55; C6orf55; DRG-1; DRG1; HSPC228;
                     LIP5; My012; SBP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             26..949
                     /gene="VTA1"
                     /gene_synonym="6orf55; C6orf55; DRG-1; DRG1; HSPC228;
                     LIP5; My012; SBP1"
                     /note="isoform a is encoded by transcript variant 1;
                     homolog of mouse SKD1-binding protein 1; LYST-interacting
                     protein 5; vacuolar protein sorting-associated protein
                     VTA1 homolog; vesicle (multivesicular body) trafficking 1;
                     dopamine-responsive gene 1 protein; Vps20-associated 1
                     homolog"
                     /codon_start=1
                     /product="vacuolar protein sorting-associated protein VTA1
                     homolog isoform a"
                     /protein_id="NP_057569.2"
                     /db_xref="CCDS:CCDS5197.1"
                     /db_xref="GeneID:51534"
                     /db_xref="HGNC:HGNC:20954"
                     /db_xref="MIM:610902"
                     /translation="MAALAPLPPLPAQFKSIQHHLRTAQEHDKRDPVVAYYCRLYAMQ
                     TGMKIDSKTPECRKFLSKLMDQLEALKKQLGDNEAITQEIVGCAHLENYALKMFLYAD
                     NEDRAGRFHKNMIKSFYTASLLIDVITVFGELTDENVKHRKYARWKATYIHNCLKNGE
                     TPQAGPVGIEEDNDIEENEDAGAASLPTQPTQPSSSSTYDPSNMPSGNYTGIQIPPGA
                     HAPANTPAEVPHSTGVASNTIQPTPQTIPAIDPALFNTISQGDVRLTPEDFARAQKYC
                     KYAGSALQYEDVSTAVQNLQKALKLLTTGRE"
     exon            138..232
                     /gene="VTA1"
                     /gene_synonym="6orf55; C6orf55; DRG-1; DRG1; HSPC228;
                     LIP5; My012; SBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            233..360
                     /gene="VTA1"
                     /gene_synonym="6orf55; C6orf55; DRG-1; DRG1; HSPC228;
                     LIP5; My012; SBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            361..436
                     /gene="VTA1"
                     /gene_synonym="6orf55; C6orf55; DRG-1; DRG1; HSPC228;
                     LIP5; My012; SBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            437..545
                     /gene="VTA1"
                     /gene_synonym="6orf55; C6orf55; DRG-1; DRG1; HSPC228;
                     LIP5; My012; SBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            546..722
                     /gene="VTA1"
                     /gene_synonym="6orf55; C6orf55; DRG-1; DRG1; HSPC228;
                     LIP5; My012; SBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            723..803
                     /gene="VTA1"
                     /gene_synonym="6orf55; C6orf55; DRG-1; DRG1; HSPC228;
                     LIP5; My012; SBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            804..6991
                     /gene="VTA1"
                     /gene_synonym="6orf55; C6orf55; DRG-1; DRG1; HSPC228;
                     LIP5; My012; SBP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1878..1883
                     /regulatory_class="polyA_signal_sequence"
                     /gene="VTA1"
                     /gene_synonym="6orf55; C6orf55; DRG-1; DRG1; HSPC228;
                     LIP5; My012; SBP1"
                     /note="hexamer: AATACA"
     polyA_site      1909
                     /gene="VTA1"
                     /gene_synonym="6orf55; C6orf55; DRG-1; DRG1; HSPC228;
                     LIP5; My012; SBP1"
                     /note="major polyA site"
     regulatory      2155..2160
                     /regulatory_class="polyA_signal_sequence"
                     /gene="VTA1"
                     /gene_synonym="6orf55; C6orf55; DRG-1; DRG1; HSPC228;
                     LIP5; My012; SBP1"
                     /note="hexamer: AATAAA"
     polyA_site      2175
                     /gene="VTA1"
                     /gene_synonym="6orf55; C6orf55; DRG-1; DRG1; HSPC228;
                     LIP5; My012; SBP1"
                     /note="major polyA site"
     regulatory      3054..3059
                     /regulatory_class="polyA_signal_sequence"
                     /gene="VTA1"
                     /gene_synonym="6orf55; C6orf55; DRG-1; DRG1; HSPC228;
                     LIP5; My012; SBP1"
                     /note="hexamer: AATAAA"
     polyA_site      3083
                     /gene="VTA1"
                     /gene_synonym="6orf55; C6orf55; DRG-1; DRG1; HSPC228;
                     LIP5; My012; SBP1"
     regulatory      3237..3242
                     /regulatory_class="polyA_signal_sequence"
                     /gene="VTA1"
                     /gene_synonym="6orf55; C6orf55; DRG-1; DRG1; HSPC228;
                     LIP5; My012; SBP1"
                     /note="hexamer: AATATA"
     polyA_site      3254
                     /gene="VTA1"
                     /gene_synonym="6orf55; C6orf55; DRG-1; DRG1; HSPC228;
                     LIP5; My012; SBP1"
     regulatory      6971..6976
                     /regulatory_class="polyA_signal_sequence"
                     /gene="VTA1"
                     /gene_synonym="6orf55; C6orf55; DRG-1; DRG1; HSPC228;
                     LIP5; My012; SBP1"
                     /note="hexamer: AATAAA"
     polyA_site      6991
                     /gene="VTA1"
                     /gene_synonym="6orf55; C6orf55; DRG-1; DRG1; HSPC228;
                     LIP5; My012; SBP1"
ORIGIN      
        1 aggaagtggt gagttcggag tagagatggc cgcgcttgca ccgctgcccc cgctccccgc
       61 acagttcaag agcatacagc atcatctgag gacggctcag gagcatgaca agcgagaccc
      121 tgtggtggct tattactgtc gtttatacgc aatgcagact ggaatgaaga tcgatagtaa
      181 aactcctgaa tgtcgcaaat ttttatcaaa gttaatggat cagttagaag ctctaaagaa
      241 gcagttgggt gataatgaag ctattactca agaaatagtg ggctgtgccc atttggagaa
      301 ttatgctttg aaaatgtttt tgtatgcaga caatgaagat cgtgctggac gatttcacaa
      361 aaacatgatc aagtccttct atactgcaag tcttttgata gatgtcataa cagtatttgg
      421 agaactcact gatgaaaatg tgaaacacag gaagtatgcc agatggaagg caacatacat
      481 ccataattgt ttaaagaatg gggagactcc tcaagcaggc cctgttggaa ttgaagaaga
      541 taatgatatt gaagaaaatg aagatgctgg agcagcctct ctgcccactc agccaactca
      601 gccatcatca tcttcaactt atgacccaag caacatgcca tcaggcaact atactggaat
      661 acagattcct ccgggtgcac acgctccagc taatacacca gcagaagtgc ctcacagcac
      721 aggtgtagca agtaatacta tccaacctac tccacagact atacctgcca ttgatcccgc
      781 acttttcaat acaatttccc agggggatgt tcgtctaacc ccagaagact ttgctagagc
      841 tcagaagtac tgcaaatatg ctggcagtgc tttgcagtat gaagatgtaa gcactgctgt
      901 ccagaatcta caaaaggctc tcaagttact gacgacaggc agagaatgaa gcctttgtat
      961 gacagaccca tgtatttttg gcatgaggaa ctaacagtcc attactctat cttcagccta
     1021 tcaggatcac agttttaagg aagacttggt tttgttgaat atgacaatga aatctgtgtg
     1081 tatcagattt ttattgaagc attcatcagc agcctcaacc agttttcatt gtccatttac
     1141 tagattcaat cgtctctgag tatatagggc tgatgttagc aagaccctaa aaatgtccat
     1201 tgaaccctgc ttcaaaaaat gaaaacacac ctctataaaa tgtgtactgg gaataagctt
     1261 tgtatttaca tacattaggg gaatttttta aaatctgtaa tgtttggaca aacagatgat
     1321 attactttgc tataaaatta taaatgtaac ttttaataaa gatagccaga atattctaaa
     1381 ttagaaatta cgtttttgtt tccctcaaga cataaaacaa atataaacat tctaaactgc
     1441 tggatgaatc tgaaaagaca ttaagttcaa attttaattt attctcatat taaatataac
     1501 tccattaaaa gtttaaaatt tcatgggaga aaatataata aggtaaagag gtagaatcac
     1561 tttcagactt aagaataatg ttgatttccc aagtgcttta ccttatctgt taaagcgtaa
     1621 gatgaattgg tatttgcttc ataggcagtt tgactgcatg tattagagaa tgaaaagaag
     1681 atatttgtag taatgcctgg aaacttggtg ctttaaatta aggtactcct ctgctgctgt
     1741 agaatggatt ccacacagtg gatagctatg ggtgattcag aatattatgt ttagattccc
     1801 atttgttaag tttataagtt ttgtggggaa ttatgaactt actgtgtact acctgcattt
     1861 gtgctgtgtg aaaaataaat acaaggattc gtttagctaa ttcaacttac tacaaagaca
     1921 aatgtctgtt tttatttgcc tgctaggatt gtctttttta aaagtcattt ttatttatag
     1981 gaatatgggt gtttctatag gaagaaacag gttttttgtt ttttgttttt taagataaat
     2041 ttgacaaagt taactgaaat ttatctggtc cattttattc atgctactaa gatgggaatc
     2101 tttaaacaca agggtcagca agctttggcc catggattgg ccacctgtta cgtaaataaa
     2161 gtttctttga aacaagccta cactcattca tttatgtttt gtctgtggtt gctttccaca
     2221 actgcagagt tgtatggctt gcaagtctaa aaacatttac tatttggccc tctaagaaaa
     2281 agttaagaca cctagtctaa tggccttttg ggaaaaaaca aatcactaac tcataatcat
     2341 ttatatccat tattttctgc ataaatgtaa tgctattgta cagggtttgg tagaataaat
     2401 attcagactg actaaactgt tctaaatcct cacaaaaaag tccccaaaca acatgcctcc
     2461 taaaaaacat tttcctatct tttacaagag gtatgaacat ttgtagggtt ccacatttgc
     2521 atctagaaat ccaatgctct ttagaatgtt attacgaata gaaagatggc caggatgacc
     2581 tttagtgtta catgatgttc agcaaatttt aattcaaacc ttgatatgcc tggacactga
     2641 aaagtaaacg catcacctcc tattttatac cctaccttct ggttcccaat tgggagagca
     2701 catagaggga aggagacaat atagaaacta cggagtccgc tggtagtggg ctgcatggtg
     2761 tgacagagcc cttctctgta aaatggaaat gacaccacta gccatctcaa tagttacaag
     2821 aattaaaaga gatacagtac ctgaagtgct tagcgcatgg tagcatttca taaatgttta
     2881 gtgtcaatac taatgctcta ataatgtaaa ttgttaataa tttatttccc taatatcagg
     2941 aaatcccagt tgtctatgtg gcccagtgct taaaaacgcc ttcttgcatg aggggattga
     3001 actatacaat gtttgttaac tttgtatttg tattttttcc tataaaatct taaaataaaa
     3061 ttaggagatg tgttctgatg taacagtagg attagcaatt ttcatttatt ccttccatat
     3121 atatttactg aatggctact atatgcctgg tattgttctt tgaaagcaga aacagcagga
     3181 aaaaaagtcc ctccctcata gagtttacat tctaaaaggg aggaaataga taataaaata
     3241 tacattacat ttaatcagtg gctctccgag tgtgattaga aatacaaatt ttgggcccca
     3301 cctgtcctac ccaatcagaa actctaggga tgggtcccag ccttctgagt tttaagagac
     3361 acttaaggtg gtccctaaag ttcgagtggt ttagctctac ccaaatcaga aatattgcaa
     3421 gtctgagaaa agagattctc ctcaaaccgg ttctcaaagg tgtctctgga cgaccggcat
     3481 cagcatcacc tgcgaacttg ctagaaagtt ctggggacca cactatggga acttctgtat
     3541 taaatagtga taaatgctat ggaggaaaca ttgaggacag gataggagat gcttaggtgt
     3601 gtacagacat atgcatattt caatagaata gccaggatag acctccctga ggtaacattt
     3661 gagcaaagaa ggaaaagagt aactagtatg cagatacata catggaggaa gagcattccc
     3721 aacaggtaga cagaaatcag gtcagagggt aaaagcagga gaaaggctgg tgagggagct
     3781 aaaagcttag gatcataaag cttttttgta agacacttga ctgggagcta tatggaaagg
     3841 ttttcagaag aaacgtagcc tgatgtgact taacttttga aataatcata ttggctccta
     3901 tgttgagaat agaccgtaag gtgggtggta agtaagggag gaagctggga gaccagttaa
     3961 aaagagtatt aacaataggc cgggggcggt ggttcgcacc tgcaatccca gcactttggg
     4021 agccaaggca ggcggatcat ctgaggtcag gagtatatat ttattaatat ataaatatgt
     4081 atttatatat aaatcataaa tatattaata aatatataat atatatatta gcctggcatg
     4141 gtggcacata cctctaatct cagctactga agaggctgag gcaggagaat cgcttgaacc
     4201 caggaggcgg aggttgcagt gagccgagat cgtgccactg cactccagcc tgggcgacag
     4261 agcgagactc cttctcaaaa aaaaaaaaag tattacaata atcaaggtga gatattatga
     4321 tgtcttagtc caggagtagc cttggaggta ataaaacggg attggtttct ggcggctttt
     4381 ttttaggtag agccacagga tttctgtaaa ctggatgtga ggtacgaaca taagagaagg
     4441 agtaaaggtt gactccagat ttttcacctg aatgcctgaa aggaatgagt aatcatgtac
     4501 tgcagtaggg aaagttgccg aattcctctc tcacttagac tgaagtacaa tgtttccaag
     4561 tttttgtgac cagcccaagt gaaactgata acggtgtttt gtcaatgcgg cagagggaga
     4621 agaagaaata aggttctgct gacaatgatt gccacagata tctcaccaaa tcactgctga
     4681 actggagctg caagccaaga atagttccca tggttagcat ggcctaggaa gtttactgac
     4741 atcaggacta caccaagaaa aagactccag ttatgggtct tgaaaattaa tatcctcaga
     4801 tgtttttaga atttatatat gacttgtaat tctagaaatt tgagaattct atgtatgcat
     4861 tgaaagatta tatactgtct tttctaaaga aacaccctaa tagcagcatt gtacaaatat
     4921 tttcaactct aaaagaataa tagctaatgg agttgatggg ttttggtttt catatgagaa
     4981 gtatccttcc ctggttggtt gtaatctttg aagtctatgt ggaattctaa gactgcaggc
     5041 ttgttcattg gagtacactt aagtaggaca aattctaagt aagcaacact tcaataataa
     5101 tcataatagc taacatttca atgtttacta aatgtcagat actattctaa gtattttgca
     5161 tatattaatt catttaatct tcacagtggt cctgagaggt aggctttatt tctgttttaa
     5221 gatgaggaaa gggagccaca gagtaacaaa tttgcctaag gtaacacagc taatatttat
     5281 ttctaagctc agactgcctg tttcagatca taagaagtat catccatgtc agtaagtcac
     5341 ctgttacatt gtaagtacaa tgagatgtta tgagttccac attatcaagg tcattggaca
     5401 gttcctttta ttagtgaggt gttagcacct aaatttttct attatctggg ccatatgttc
     5461 caattgacag tgctaggcag tgaacacagg gtatgaactt gaaaatctga ttgcaccctc
     5521 aatatctgga atatacactg atctatgacc tgaaattgta tggactgcag caatccaagg
     5581 ggacactaag cagggtttga gtaatgctac aatggattta taggtcattt tggagaaggt
     5641 gttccacatc attagggagt ctgggtttcc cagatgtgcc tgttttatcc tttttatttt
     5701 aaataacatc actgtctttc ctaactaaaa attcttcatc ttcaggaaat aagattgaga
     5761 tacggactga aaatataaaa ttagcaataa tgtttattat tagatacttc ctcaattaaa
     5821 tttctccctg aaagtcttag gcaaaagccc ctgtctctta cttcatatat caagtttgga
     5881 gggaaagaca taattgcata gcagtattcc atgaatataa cttaatgggg aactggcttc
     5941 agagttcagc aatattggga agtcttgtca aatattaagt cattcatatg ttcaaaaata
     6001 ttaatatgta ttgagcatct accatcaaat atttaatatg ataatgccat actggatatt
     6061 atatacgagt tacaataatt cttcctaaag tcagggaaag cttcacagat aaggttgagc
     6121 tgaaggtttg gcaggcaggg aagcaaggag aagttagcag agagaaaagc acaagcaaca
     6181 ccatggagga acaaatgtgg gcaattcagg taactcgagt aatttagtgt tactatgcat
     6241 atggcctatg gaggccagga gtgtaaatgt attatggctg gggcgggggg ctagggaatg
     6301 tgttatgact aaattgtatc ccttcagaat tcatattttg aagcactgat ctccagtgtg
     6361 tctgtgttca gaggcaggtc ccatagggag gcaattaagg ttacatgaga tcataaaggt
     6421 gaggccctaa tcctataggt ctgctgtcat tacaagaaga ggaagagcca ccggagctgg
     6481 ctcattctgc acgtgtacag agaagaggcc atgtgaggac acgcagaggc tcgaatatgc
     6541 tctcaaccct atcagttgcc tgctttaatt catcccatgg aattgttttg tcttttcgac
     6601 ccctcggcta tgttatttgt attgtgatat aggggatatt cggagtcctc tgagacggga
     6661 caaggacact ggacggtcta ttgtgccatg cttatatatt ttctgtatac aatgctttct
     6721 gtataaaacc agtaatacct gagaaacaac agtaacttga caaaattact attgatcact
     6781 taactttatg tatcacgtaa gttaaacttt atttatttac atgtgtctcc ctcattagat
     6841 gctaagttcc ttgatatttt atacatttgt gaattcctgg taattcacat gaagcttgat
     6901 gcattgtaag tattctgacc tggtgaaata aatatacgaa tgggcaaaaa aatatatact
     6961 aaaatgatca aataaaggtt gtgttcagaa a
//
