LOCUS       NM_001031746            6414 bp    mRNA    linear   PRI 17-APR-2022
DEFINITION  Homo sapiens V-set and transmembrane domain containing 4 (VSTM4),
            transcript variant 1, mRNA.
ACCESSION   NM_001031746
VERSION     NM_001031746.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6414)
  AUTHORS   Luck K, Kim DK, Lambourne L, Spirohn K, Begg BE, Bian W, Brignall
            R, Cafarelli T, Campos-Laborie FJ, Charloteaux B, Choi D, Cote AG,
            Daley M, Deimling S, Desbuleux A, Dricot A, Gebbia M, Hardy MF,
            Kishore N, Knapp JJ, Kovacs IA, Lemmens I, Mee MW, Mellor JC,
            Pollis C, Pons C, Richardson AD, Schlabach S, Teeking B, Yadav A,
            Babor M, Balcha D, Basha O, Bowman-Colin C, Chin SF, Choi SG,
            Colabella C, Coppin G, D'Amata C, De Ridder D, De Rouck S,
            Duran-Frigola M, Ennajdaoui H, Goebels F, Goehring L, Gopal A,
            Haddad G, Hatchi E, Helmy M, Jacob Y, Kassa Y, Landini S, Li R, van
            Lieshout N, MacWilliams A, Markey D, Paulson JN, Rangarajan S,
            Rasla J, Rayhan A, Rolland T, San-Miguel A, Shen Y, Sheykhkarimli
            D, Sheynkman GM, Simonovsky E, Tasan M, Tejeda A, Tropepe V,
            Twizere JC, Wang Y, Weatheritt RJ, Weile J, Xia Y, Yang X,
            Yeger-Lotem E, Zhong Q, Aloy P, Bader GD, De Las Rivas J, Gaudet S,
            Hao T, Rak J, Tavernier J, Hill DE, Vidal M, Roth FP and Calderwood
            MA.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 6414)
  AUTHORS   Anttila V, Winsvold BS, Gormley P, Kurth T, Bettella F, McMahon G,
            Kallela M, Malik R, de Vries B, Terwindt G, Medland SE, Todt U,
            McArdle WL, Quaye L, Koiranen M, Ikram MA, Lehtimaki T, Stam AH,
            Ligthart L, Wedenoja J, Dunham I, Neale BM, Palta P, Hamalainen E,
            Schurks M, Rose LM, Buring JE, Ridker PM, Steinberg S, Stefansson
            H, Jakobsson F, Lawlor DA, Evans DM, Ring SM, Farkkila M, Artto V,
            Kaunisto MA, Freilinger T, Schoenen J, Frants RR, Pelzer N, Weller
            CM, Zielman R, Heath AC, Madden PAF, Montgomery GW, Martin NG,
            Borck G, Gobel H, Heinze A, Heinze-Kuhn K, Williams FMK,
            Hartikainen AL, Pouta A, van den Ende J, Uitterlinden AG, Hofman A,
            Amin N, Hottenga JJ, Vink JM, Heikkila K, Alexander M,
            Muller-Myhsok B, Schreiber S, Meitinger T, Wichmann HE, Aromaa A,
            Eriksson JG, Traynor B, Trabzuni D, Rossin E, Lage K, Jacobs SBR,
            Gibbs JR, Birney E, Kaprio J, Penninx BW, Boomsma DI, van Duijn C,
            Raitakari O, Jarvelin MR, Zwart JA, Cherkas L, Strachan DP, Kubisch
            C, Ferrari MD, van den Maagdenberg AMJM, Dichgans M, Wessman M,
            Smith GD, Stefansson K, Daly MJ, Nyholt DR, Chasman D and Palotie
            A.
  CONSRTM   North American Brain Expression Consortium; UK Brain Expression
            Consortium
  TITLE     Genome-wide meta-analysis identifies new susceptibility loci for
            migraine
  JOURNAL   Nat. Genet. 45 (8), 912-917 (2013)
   PUBMED   23793025
REFERENCE   3  (bases 1 to 6414)
  AUTHORS   Charles BA, Shriner D, Doumatey A, Chen G, Zhou J, Huang H, Herbert
            A, Gerry NP, Christman MF, Adeyemo A and Rotimi CN.
  TITLE     A genome-wide association study of serum uric acid in African
            Americans
  JOURNAL   BMC Med Genomics 4, 17 (2011)
   PUBMED   21294900
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6414)
  AUTHORS   Grupe A, Li Y, Rowland C, Nowotny P, Hinrichs AL, Smemo S, Kauwe
            JS, Maxwell TJ, Cherny S, Doil L, Tacey K, van Luchene R, Myers A,
            Wavrant-De Vrieze F, Kaleem M, Hollingworth P, Jehu L, Foy C,
            Archer N, Hamilton G, Holmans P, Morris CM, Catanese J, Sninsky J,
            White TJ, Powell J, Hardy J, O'Donovan M, Lovestone S, Jones L,
            Morris JC, Thal L, Owen M, Williams J and Goate A.
  TITLE     A scan of chromosome 10 identifies a novel locus showing strong
            association with late-onset Alzheimer disease
  JOURNAL   Am. J. Hum. Genet. 78 (1), 78-88 (2006)
   PUBMED   16385451
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            HY112498.1, AK297931.1, AK056299.1, BC041414.1, AC060234.11 and
            AW058485.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001031746.4.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.222611.1,
                                           SRR1803613.56143.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1966682,
                                           SAMEA1968189 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000332853.9/ ENSP00000331062.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                HY112498.1         12-26
            16-239              AK297931.1         1-224
            240-240             AK056299.1         227-227
            241-620             AK297931.1         226-605
            621-621             BC041414.1         613-613
            622-909             AK297931.1         607-894
            910-6382            AC060234.11        131759-137231       c
            6383-6405           AW058485.1         14-36               c
            6406-6414           AC060234.11        131727-131735       c
FEATURES             Location/Qualifiers
     source          1..6414
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q11.23"
     gene            1..6414
                     /gene="VSTM4"
                     /gene_synonym="C10orf72"
                     /note="V-set and transmembrane domain containing 4"
                     /db_xref="GeneID:196740"
                     /db_xref="HGNC:HGNC:26470"
     exon            1..92
                     /gene="VSTM4"
                     /gene_synonym="C10orf72"
                     /inference="alignment:Splign:2.1.0"
     CDS             38..1000
                     /gene="VSTM4"
                     /gene_synonym="C10orf72"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; V-set and transmembrane domain-containing
                     protein 4"
                     /codon_start=1
                     /product="V-set and transmembrane domain-containing
                     protein 4 isoform 1 precursor"
                     /protein_id="NP_001026916.2"
                     /db_xref="CCDS:CCDS31198.1"
                     /db_xref="GeneID:196740"
                     /db_xref="HGNC:HGNC:26470"
                     /translation="MRLLALAAAALLARAPAPEVCAALNVTVSPGPVVDYLEGENATL
                     LCHVSQKRRKDSLLAVRWFFAHSFDSQEALMVKMTKLRVVQYYGNFSRSAKRRRLRLL
                     EEQRGALYRLSVLTLQPSDQGHYVCRVQEISRHRNKWTAWSNGSSATEMRVISLKASE
                     ESSFEKTKETWAFFEDLYVYAVLVCCVGILSILLFMLVIVWQSVFNKRKSRVRHYLVK
                     CPQNSSGETVTSVTSLAPLQPKKGKRQKEKPDIPPAVPAKAPIAPTFHKPKLLKPQRK
                     VTLPKIAEENLTYAELELIKPHRAAKGAPTSTVYAQILFEENKL"
     exon            93..494
                     /gene="VSTM4"
                     /gene_synonym="C10orf72"
                     /inference="alignment:Splign:2.1.0"
     exon            495..563
                     /gene="VSTM4"
                     /gene_synonym="C10orf72"
                     /inference="alignment:Splign:2.1.0"
     exon            564..671
                     /gene="VSTM4"
                     /gene_synonym="C10orf72"
                     /inference="alignment:Splign:2.1.0"
     exon            672..705
                     /gene="VSTM4"
                     /gene_synonym="C10orf72"
                     /inference="alignment:Splign:2.1.0"
     exon            706..812
                     /gene="VSTM4"
                     /gene_synonym="C10orf72"
                     /inference="alignment:Splign:2.1.0"
     exon            813..874
                     /gene="VSTM4"
                     /gene_synonym="C10orf72"
                     /inference="alignment:Splign:2.1.0"
     exon            875..6414
                     /gene="VSTM4"
                     /gene_synonym="C10orf72"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6253..6258
                     /regulatory_class="polyA_signal_sequence"
                     /gene="VSTM4"
                     /gene_synonym="C10orf72"
                     /note="hexamer: AATAAA"
     polyA_site      6283
                     /gene="VSTM4"
                     /gene_synonym="C10orf72"
                     /note="major polyA site"
     regulatory      6332..6337
                     /regulatory_class="polyA_signal_sequence"
                     /gene="VSTM4"
                     /gene_synonym="C10orf72"
                     /note="hexamer: AATATA"
     polyA_site      6353
                     /gene="VSTM4"
                     /gene_synonym="C10orf72"
     regulatory      6394..6399
                     /regulatory_class="polyA_signal_sequence"
                     /gene="VSTM4"
                     /gene_synonym="C10orf72"
                     /note="hexamer: ATTACA"
     polyA_site      6414
                     /gene="VSTM4"
                     /gene_synonym="C10orf72"
ORIGIN      
        1 gctctcccgc gtcacagcgc cgggcggcgg cggggagatg cggctgctgg cactggcggc
       61 ggccgcgctg ctggcgcggg ctccggctcc ggaggtctgt gcggccctca atgtcactgt
      121 gtccccgggg cccgtggttg actacctgga gggggagaat gccactctcc tctgccacgt
      181 ctcccagaaa aggcggaagg acagcttgct ggccgtgcgc tggttctttg cacactcctt
      241 cgactcccag gaggccttga tggtgaagat gaccaagctc cgggtggtgc agtactatgg
      301 gaatttcagc cgcagcgcca aacggcggag gctgcgcctg ctggaggagc agcggggggc
      361 gctctacagg ctctccgtct tgacactgca gccctccgat caagggcatt acgtctgcag
      421 agtccaggaa atcagcaggc acaggaacaa gtggacggcc tggtccaatg gctcctcagc
      481 cacggaaatg agagtcattt ccctcaaagc ttctgaagag tcatcctttg agaaaacaaa
      541 agagacttgg gcattttttg aagatctcta tgtgtatgct gtcctcgtgt gctgcgtggg
      601 gatcctcagc attctgctct tcatgctggt catcgtctgg cagtctgtgt ttaacaagcg
      661 gaaatccaga gtgagacatt atttggtgaa atgccctcag aacagctcag gggagactgt
      721 cactagcgtg accagcttgg ccccactaca gcccaagaag ggcaagaggc agaaggagaa
      781 gcctgacatt cctcccgcag tccctgccaa agctccgata gcccccacgt tccataaacc
      841 gaagctgctg aaaccacaga gaaaagtcac gctgccaaag attgctgagg aaaacttaac
      901 ctatgccgaa ctggagctga tcaaacccca ccgggctgcc aaaggcgccc ccaccagcac
      961 tgtctacgcc cagatcctct tcgaggagaa caagctgtag tacagcgtcc acctccaagg
     1021 ttctatttaa tacctgccac ccagtgattt atgaagcctt ggagacaaag cccttatgtc
     1081 tgtattttca ctcatgcctt ctgagtggtg gggagcccct tttcagcagc attctgggtg
     1141 cctttgaaga ggtacaagcc tgctctcccc aaaagaatcg gggccacagc tcttgacaga
     1201 tctcccggga caagatgcgc ctgggtttga gccctgagcg taaggattct gatcctgaga
     1261 gcagccaagg agattttctg ctgagccaaa ccccttcaca tttttctcct ctttccccag
     1321 gttttcttta aaatcgtttt taaatcttaa ttttactctc tactcttcct gtatccacga
     1381 tacaagctca cagtatatag ctagaggaaa tgccattatg gacccaactg taagatggca
     1441 catatgttgg ttttccaagg atcagatggc attgccaggg ccacagccaa ctgctgattg
     1501 ccagcaccac ctgagatggc atctcttgtt ttaaatagat gcactaaccc tgaagattaa
     1561 ggccagaggg gcagactgac tagagaagta taaggtctgt ctctgaatgc catggtgccc
     1621 acctatgaga ccctgaggcc gcaggacaag aagaacacca ttctagaggg cttccagccc
     1681 tttcacaagg tggacctgta ctgatagaga aacacactct ctaagaagtg cttactcacc
     1741 cttttccaaa ggagcacagg tgttggccat cagaagacac actggagcgc atgggcctct
     1801 tcactgtgtg ccaagctcag tcacctctga ttcagcccct gaaggtgtct gctgccaggt
     1861 gccctcaggg taggagagtg ggaagtacac gccaagctgg aaagtgtgtt ctgaagaccc
     1921 tcctcttgcc aagtgccttg cccattgcaa ccttgtgtgt gaattctaat gggtttgaat
     1981 gggggtcagg gtgcatgggg aagttgctct gtggaccttt gggacacagg aatcttggac
     2041 ttactggcag gggatccatt ctgaaagcac catcctgtca actgtgttat tgaggacatt
     2101 tcttgatgtg agtatagtct gggtggctat ttactgccca ctatagaaat tgtttgacta
     2161 tgtagtggac catgtatata tgataaatta tctattttaa acacagctgg ggtatgagtt
     2221 gtgccctcta tatagctgtg tgaacttggc taaatttctt atcccctaat gacctcagac
     2281 tccatgtttg tgtaaagacg acttaacttc ccatagaatt cttgagggta aaatgggata
     2341 atgaatcttg ccagttctag aaactgtaaa ttgctacaca aatgctctgt gttgacattc
     2401 atgctaaagc cagtctgcat tttcaaaatg aaaatttctt cactatttaa ggctttcatt
     2461 gcaataactt taaaaaccaa atatttgtcc accaacttag ccctacagta atgttcccaa
     2521 agactcatga gagtttatgg tttattggaa agggtccaaa ttggaagcag atattgattt
     2581 tctgggagca aactggtctg cctttacaaa gtggaagttc accctctctg gataacacct
     2641 gtgtctcatt cctccctctc tgccagatct cgaaggcact gaataaacca tgcagctttt
     2701 gaggaagaaa gaaccatttg gaagaactca ctagaacttc tttgagcatc tctttgggag
     2761 gggaggatat atggttagca caccatttat ataataatta tcacagggat ttttaatttt
     2821 atcatggcag tgttctgaca gatgtatagt gttttgaggg cagaggatga tctcctaatt
     2881 tgcccaaaga gccttatggg tttgtggggc tctgggggtg ccaaatggga aggagagggg
     2941 gcacatgaaa aggaaatggc gggaagaggg caacaggcca gggggtaata tcttcccagg
     3001 ccccttaggc ctctacagaa cggaaatgaa cttcattcac ccccaaaccc acccacttaa
     3061 atccaaagag agcttagggt tattatgcat ggacaggaac acattctacc aagaacacat
     3121 gctcttaaga gctagtagct cccagttaga gtcaaaccag tcattgttat attatagatt
     3181 gaatccagcc tctttctccc aaactgtggt catcactgca tgaatccaca ctaaggtgtg
     3241 tgaatgggaa cctgcagatt atctcctcct actgaaaatg ctgcccaggg gaatcttgga
     3301 agctatggac agcatccagg cagagctggt cccactgtta tctccagaag caaatgccca
     3361 agctgtgctc agaactggaa gcaatggatg acttgtatca ggtgcttgtt tgagaggata
     3421 tattgacatt attgccatag taagcttaaa aaaatgtgcc cactcattca ttctttgtcc
     3481 atggaccact aatcatgcat tgtcatttcc aaagataagg ggaaacatat cacatatcat
     3541 tgaaatagaa attagggaaa gtttgtcaat ttgttttcac tataaggcat caatggcaga
     3601 aactacatat gagtaatttt caaaatagac cattgcttaa atgtttaaat gaagctaaaa
     3661 gaagtatgaa cccattggtt agagtgcagt ggcttctttc aggcagacag cagatgctct
     3721 cagatttggt ggtgagtttt ggccttggca tggttggcat ggagtcagca caggaagccg
     3781 ggaggtatga aggggcatcc acctgggtga aactgtcttg ccaagccaaa gccccgaggc
     3841 ctgccctgaa gcagctgtag tggaggagag gcctgggatt ccttagagtc acctttttac
     3901 gaatgtaccg ccactctgtt agctcacagg gaaaataagg aaaagccagg cctcccacct
     3961 cttgactctt gtgagagtga agacaacatg gggcatttag aaaatatatt tttagtgtat
     4021 gataatgtgg gctggcccac acagcaatga gcccaaagac cccctcgctt tgggaattat
     4081 tcatggccct gctcatcaca gcctctgata tgcatgactg taacctaggc tgagccaaga
     4141 atggagctca tgccagaaat ggtcctaagc atgcacatgg ccccctggaa tatcaaaatc
     4201 ctggggagaa agaaatcatc tttgccttgg gcagtgaagc tggaatggca catatctatc
     4261 tgttgccaca tctcctgcct agtggagaag ccttggaagg caacagacac tgagcaagca
     4321 gcagggagga gaatgtcctg gaagggcagg actctaccca agtccctaac atccccagac
     4381 tcttctcttc cataaactct ctaattactc tgctgtttaa atcctggttt tggtcaagcc
     4441 agtcaggttg cataaagaat atgaatacag tatgcatcaa agttgcttcc cagaacagga
     4501 agcaaaacaa acaaacaaac aaacaaacaa aatactgata tcagtaccca gggtgcccaa
     4561 ttaggtcaca cccagtggct gcattgcagc ccctgagctc ctgctgcacc gtgtgtcctg
     4621 ctgcccgagt gggccccacc ctgggttctg aagatgccct tcttaatgga gagctcccga
     4681 tggagggctc caggactgat gctctcccta aggaagggag gcctcagatt tggagaggga
     4741 caccaacagg accagaggag gactgagggg cactggcacc aataagtgga agggaacagc
     4801 gtggtaacaa aaaagagcca tgccacttgc atgctggagg gagtcttttt gtgtcagcct
     4861 aaagcttagg ctggtgtcca tgtggaacat gacatctttc cagtatccct gatccaggaa
     4921 actgcagtga gacccaggtg acccagctct gtgtcatttg gagcccatta aaaagtgagg
     4981 cagccacatg gcggggacat tgaccccact ccagaccaca ctcccatctc catacatagg
     5041 atagaaactg ttcatcagga aggaaaacca aacagaaatt cgtggtctag gggaggggtc
     5101 tgcattcagc atggccatgc tgggctggag tggctgtggg gtgtccagat agatgggcat
     5161 gtagactagt gctttctcaa cctttaatgc atgcacaaat catcgagatc ttgttaaaat
     5221 gtagatcctg ggtgggcacg gtggctcacg cctgtaatcc cagcactttg ggaggctgag
     5281 gcgggcggat catgaggtca ggagatcgag accatcctgg ctaacacggt gaaaccctgt
     5341 ctctactaaa aatacaaaaa attagccagg catggtggtg ggtgcctgta gtcccagcta
     5401 ctcgggaggc tgaggcagga gaatggcatg aacccgggag gcggagcttg cagtgagccg
     5461 agatcgtgct gctgcactcc agcctgggca atagagtgag attccgtctc aaaaaaaaaa
     5521 aaaaaaaaaa tgtagatcct ggctcaggag gtctgggata ggacctggga ttctgagttt
     5581 ctaacaagct cccagggatg tccatgcttc tggtccctga accacacttt gagtgacaag
     5641 gatgtaaact gttggaaaca tggatctggt gctcattgcg ggaaaggggg tgtcctcagg
     5701 gcataggtca cagccaaagc cctgacagcg ggcaagagtc ccagggagag gctgcctgca
     5761 cattgaggag gggaagggct gggcctgagc agtggggagc atccatgctg gcaggtatgc
     5821 agcaggcaag gagatccagg tggagatcag aggacagtga cagtcacagc agcaggggag
     5881 agccaggaga aagctgctcc taggggtgtc tcaaaggaag aagggatctg cagtgtgaac
     5941 tctgcagagg gcagggagaa tagaggttaa gcctttgctc attctgaatt aattgattac
     6001 tgctttttaa aagtgctttc tttctctggg aaaaaaaaaa cattccccag tgcctaaggc
     6061 taacagacgt gggcgctgag ctgtgtctgg tctgctgagt gtattttccc cagagcaatc
     6121 ctcatcttct cagggggtgg ggatttggac aagactcttc ctgaacacgc agcgtggtgg
     6181 ggaagggtgg ccatggaggt tttctgttcc ttctgttgtc actggtgaaa gacgacttgg
     6241 tgcccaattt ctaataaaca caatgctatt agcgtcactc caatttagtg tctgattgtt
     6301 aaatgttaat gtactgcact ctacagtttt aaatataatt agagatgttt acagctttgg
     6361 ttaaatgcac cttgttcttc cacattaaac tttattacaa gcgtcctcca tcaa
//
