LOCUS       NM_080607               1936 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens V-set and transmembrane domain containing 2 like
            (VSTM2L), mRNA.
ACCESSION   NM_080607
VERSION     NM_080607.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1936)
  AUTHORS   Li,Y., Zhang,J., Cai,Y., Liu,H., Yang,W., Xu,Y. and Huang,M.
  TITLE     VSTM2L contributes to anoikis resistance and acts as a novel
            biomarker for metastasis and clinical outcome in ovarian cancer
  JOURNAL   Biochem Biophys Res Commun 658, 107-115 (2023)
   PUBMED   37030064
  REMARK    GeneRIF: VSTM2L contributes to anoikis resistance and acts as a
            novel biomarker for metastasis and clinical outcome in ovarian
            cancer.
REFERENCE   2  (bases 1 to 1936)
  AUTHORS   Liu,H., Zhang,Z., Zhen,P. and Zhou,M.
  TITLE     High Expression of VSTM2L Induced Resistance to Chemoradiotherapy
            in Rectal Cancer through Downstream IL-4 Signaling
  JOURNAL   J Immunol Res 2021, 6657012 (2021)
   PUBMED   33506057
  REMARK    GeneRIF: High Expression of VSTM2L Induced Resistance to
            Chemoradiotherapy in Rectal Cancer through Downstream IL-4
            Signaling.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1936)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 1936)
  AUTHORS   Grossmann,A., Benlasfer,N., Birth,P., Hegele,A., Wachsmuth,F.,
            Apelt,L. and Stelzl,U.
  TITLE     Phospho-tyrosine dependent protein-protein interaction network
  JOURNAL   Mol Syst Biol 11 (3), 794 (2015)
   PUBMED   25814554
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1936)
  AUTHORS   Rossini,L., Hashimoto,Y., Suzuki,H., Kurita,M., Gianfriddo,M.,
            Scali,C., Roncarati,R., Franceschini,D., Pollio,G., Trabalzini,L.,
            Terstappen,G.C., Matsuoka,M. and Caricasole,A.
  TITLE     VSTM2L is a novel secreted antagonist of the neuroprotective
            peptide Humanin
  JOURNAL   FASEB J 25 (6), 1983-2000 (2011)
   PUBMED   21393573
  REMARK    GeneRIF: VSTM2L is the first example of a secreted antagonist of
            humanin (HN) and may play a role in the modulation of HN biological
            function.
REFERENCE   6  (bases 1 to 1936)
  AUTHORS   Lim,J., Hao,T., Shaw,C., Patel,A.J., Szabo,G., Rual,J.F.,
            Fisk,C.J., Li,N., Smolyar,A., Hill,D.E., Barabasi,A.L., Vidal,M.
            and Zoghbi,H.Y.
  TITLE     A protein-protein interaction network for human inherited ataxias
            and disorders of Purkinje cell degeneration
  JOURNAL   Cell 125 (4), 801-814 (2006)
   PUBMED   16713569
REFERENCE   7  (bases 1 to 1936)
  AUTHORS   Deloukas,P., Matthews,L.H., Ashurst,J., Burton,J., Gilbert,J.G.,
            Jones,M., Stavrides,G., Almeida,J.P., Babbage,A.K., Bagguley,C.L.,
            Bailey,J., Barlow,K.F., Bates,K.N., Beard,L.M., Beare,D.M.,
            Beasley,O.P., Bird,C.P., Blakey,S.E., Bridgeman,A.M., Brown,A.J.,
            Buck,D., Burrill,W., Butler,A.P., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M., Clark,G., Clark,L.N., Clark,S.Y.,
            Clee,C.M., Clegg,S., Cobley,V.E., Collier,R.E., Connor,R.,
            Corby,N.R., Coulson,A., Coville,G.J., Deadman,R., Dhami,P.,
            Dunn,M., Ellington,A.G., Frankland,J.A., Fraser,A., French,L.,
            Garner,P., Grafham,D.V., Griffiths,C., Griffiths,M.N., Gwilliam,R.,
            Hall,R.E., Hammond,S., Harley,J.L., Heath,P.D., Ho,S., Holden,J.L.,
            Howden,P.J., Huckle,E., Hunt,A.R., Hunt,S.E., Jekosch,K.,
            Johnson,C.M., Johnson,D., Kay,M.P., Kimberley,A.M., King,A.,
            Knights,A., Laird,G.K., Lawlor,S., Lehvaslaiho,M.H., Leversha,M.,
            Lloyd,C., Lloyd,D.M., Lovell,J.D., Marsh,V.L., Martin,S.L.,
            McConnachie,L.J., McLay,K., McMurray,A.A., Milne,S., Mistry,D.,
            Moore,M.J., Mullikin,J.C., Nickerson,T., Oliver,K., Parker,A.,
            Patel,R., Pearce,T.A., Peck,A.I., Phillimore,B.J.,
            Prathalingam,S.R., Plumb,R.W., Ramsay,H., Rice,C.M., Ross,M.T.,
            Scott,C.E., Sehra,H.K., Shownkeen,R., Sims,S., Skuce,C.D.,
            Smith,M.L., Soderlund,C., Steward,C.A., Sulston,J.E., Swann,M.,
            Sycamore,N., Taylor,R., Tee,L., Thomas,D.W., Thorpe,A., Tracey,A.,
            Tromans,A.C., Vaudin,M., Wall,M., Wallis,J.M., Whitehead,S.L.,
            Whittaker,P., Willey,D.L., Williams,L., Williams,S.A., Wilming,L.,
            Wray,P.W., Hubbard,T., Durbin,R.M., Bentley,D.R., Beck,S. and
            Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 20
  JOURNAL   Nature 414 (6866), 865-871 (2001)
   PUBMED   11780052
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK056177.1 and BC033818.1.
            
            On Nov 23, 2018 this sequence version replaced NM_080607.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.741605.1, AL834410.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000373461.9/ ENSP00000362560.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1807              AK056177.1         24-1830
            1808-1936           BC033818.1         1770-1898
FEATURES             Location/Qualifiers
     source          1..1936
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q11.23"
     gene            1..1936
                     /gene="VSTM2L"
                     /gene_synonym="C20orf102; dJ1118M15.2"
                     /note="V-set and transmembrane domain containing 2 like"
                     /db_xref="GeneID:128434"
                     /db_xref="HGNC:HGNC:16096"
                     /db_xref="MIM:616537"
     exon            1..345
                     /gene="VSTM2L"
                     /gene_synonym="C20orf102; dJ1118M15.2"
                     /inference="alignment:Splign:2.1.0"
     CDS             225..839
                     /gene="VSTM2L"
                     /gene_synonym="C20orf102; dJ1118M15.2"
                     /note="V-set and transmembrane domain-containing protein
                     2-like protein"
                     /codon_start=1
                     /product="V-set and transmembrane domain-containing
                     protein 2-like protein precursor"
                     /protein_id="NP_542174.1"
                     /db_xref="CCDS:CCDS13299.1"
                     /db_xref="GeneID:128434"
                     /db_xref="HGNC:HGNC:16096"
                     /db_xref="MIM:616537"
                     /translation="MGAPLAVALGALHYLALFLQLGGATRPAGHAPWDNHVSGHALFT
                     ETPHDMTARTGEDVEMACSFRGSGSPSYSLEIQWWYVRSHRDWTDKQAWASNQLKASQ
                     QEDAGKEATKISVVKVVGSNISHKLRLSRVKPTDEGTYECRVIDFSDGKARHHKVKAY
                     LRVQPGENSVLHLPEAPPAAPAPPPPKPGKELRKRSVDQEACSL"
     exon            346..515
                     /gene="VSTM2L"
                     /gene_synonym="C20orf102; dJ1118M15.2"
                     /inference="alignment:Splign:2.1.0"
     exon            516..566
                     /gene="VSTM2L"
                     /gene_synonym="C20orf102; dJ1118M15.2"
                     /inference="alignment:Splign:2.1.0"
     exon            567..1936
                     /gene="VSTM2L"
                     /gene_synonym="C20orf102; dJ1118M15.2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1916..1921
                     /regulatory_class="polyA_signal_sequence"
                     /gene="VSTM2L"
                     /gene_synonym="C20orf102; dJ1118M15.2"
                     /note="hexamer: AATAAA"
     polyA_site      1936
                     /gene="VSTM2L"
                     /gene_synonym="C20orf102; dJ1118M15.2"
                     /note="major polyA site"
ORIGIN      
        1 gcagtcggag gcggccggct gggcgtgcgc tcgctccccg aagccggggc tgggccggag
       61 ccgggcgagg gctgggagct gggccgggtc cggggacagc gggcgagggg cagctgccgg
      121 agccgggcag ccaggccgct cagggcaggg gacagctggc gccggttctg cggtctccgg
      181 ggcccagatg tgaggcggcg gcgcccccgg cccgagagcg cacgatgggg gccccgctcg
      241 ccgtagcgct gggcgccctc cactacctgg cacttttcct gcaactcggc ggcgccacgc
      301 ggcccgccgg ccacgcgccc tgggacaacc acgtctccgg ccacgccctg ttcacagaga
      361 caccccatga catgacagca cggacgggcg aggacgtgga gatggcctgc tccttccgcg
      421 gcagcggctc cccctcctac tcgctggaga tccagtggtg gtatgtacgg agccaccggg
      481 actggaccga caagcaggcg tgggcctcga accagctaaa agcatctcag caggaagacg
      541 cagggaagga ggcaaccaaa ataagtgtgg tcaaggtggt gggcagcaac atctcccaca
      601 agctgcgcct gtcccgggtg aagcccacgg acgaaggcac ctacgagtgc cgcgtcatcg
      661 acttcagcga cggcaaggcc cggcaccaca aggtcaaggc ctacctgcgg gtgcagccag
      721 gggagaactc cgtcctgcat ctgcccgaag cccctcccgc cgcgcccgcc ccgccgcccc
      781 ccaagccagg caaggagctg aggaagcgct cggtggacca ggaggcctgc agcctctaga
      841 ctgatgcccc tgcccccgcc catccgcccc cacgctgtac agagtgcatg aggagccgcc
      901 ggaccaccgg ggaccgactg cctgcgtcca gccgcgcccc atccccgagg ccgcctgtgg
      961 ccaccatgtc ggccctcttt ccaccacccc ttgctcagca tgtaagcccc acccacccct
     1021 gccctttcag acccctgcgg tgacctggct cggagaaggt ggccctgggc accaaggggc
     1081 caaccgccct gaacactggg gcagggacca tgctggggcc cggggccacc cccttcctgt
     1141 caccagcttc tgtggagtcc agtgttttgc tttgcttgct tgtcccccat cctgtcctga
     1201 gccggggccc cccagcctcg cctccctcct cctaccatcc ctcacttgga cctgggggtg
     1261 tggacagtga cccctccctg aatatggact tgaatcttct gagcagaact agggcctctc
     1321 ccctggtgaa gacccaggga acccaggagg gcccttctgg ggcagtggct ctgcagggtc
     1381 actcatggag gcctagggga acagcgagat gccccaccac ctcctggcga gtccttcctg
     1441 ttcagctccc tgtgcgaccc tccagggatg caggggatcc aggattctct gccctgtcac
     1501 acggcgagtc agaagggagg ggcctttccc tcggacccat ggccccaggc agagttttgc
     1561 accagcagga cccctttgag ggccttcaag gctctcccag gagtccccct ctgccggccc
     1621 cccaatgccc cagctccctc ttgggtcctg tgccaagtcc gccccagggc ctggggctgt
     1681 tgggagccaa gggccccctg gtactcagtt ccctcacgat tcccgatcac gggcacacct
     1741 gccccctggt tatttgtaaa tatttctatt ggacccaatt ctcctcggaa ttggctggca
     1801 cctctggctg ccgcagctca gtgatgacgt gggggaggtg ggagaggccg agggctttgc
     1861 ctaggggtgg gttgccctgt atacatgatc cagtctgtga ctaccagcca acctgaataa
     1921 agcggtttta aaaaaa
//
