LOCUS       NM_001146339            2065 bp    mRNA    linear   PRI 04-AUG-2024
DEFINITION  Homo sapiens V-set and transmembrane domain containing 2B (VSTM2B),
            transcript variant 1, mRNA.
ACCESSION   NM_001146339 XM_001715383 XM_002343644 XM_292785 XM_939057
VERSION     NM_001146339.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2065)
  AUTHORS   Wade,T.D., Gordon,S., Medland,S., Bulik,C.M., Heath,A.C.,
            Montgomery,G.W. and Martin,N.G.
  TITLE     Genetic variants associated with disordered eating
  JOURNAL   Int J Eat Disord 46 (6), 594-608 (2013)
   PUBMED   23568457
REFERENCE   2  (bases 1 to 2065)
  AUTHORS   Grassi,M.A., Tikhomirov,A., Ramalingam,S., Below,J.E., Cox,N.J. and
            Nicolae,D.L.
  TITLE     Genome-wide meta-analysis for severe diabetic retinopathy
  JOURNAL   Hum Mol Genet 20 (12), 2472-2481 (2011)
   PUBMED   21441570
REFERENCE   3  (bases 1 to 2065)
  AUTHORS   Trynka,G., Zhernakova,A., Romanos,J., Franke,L., Hunt,K.A.,
            Turner,G., Bruinenberg,M., Heap,G.A., Platteel,M., Ryan,A.W., de
            Kovel,C., Holmes,G.K., Howdle,P.D., Walters,J.R., Sanders,D.S.,
            Mulder,C.J., Mearin,M.L., Verbeek,W.H., Trimble,V., Stevens,F.M.,
            Kelleher,D., Barisani,D., Bardella,M.T., McManus,R., van Heel,D.A.
            and Wijmenga,C.
  TITLE     Coeliac disease-associated risk variants in TNFAIP3 and REL
            implicate altered NF-kappaB signalling
  JOURNAL   Gut 58 (8), 1078-1083 (2009)
   PUBMED   19240061
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   4  (bases 1 to 2065)
  AUTHORS   Grimwood,J., Gordon,L.A., Olsen,A., Terry,A., Schmutz,J.,
            Lamerdin,J., Hellsten,U., Goodstein,D., Couronne,O.,
            Tran-Gyamfi,M., Aerts,A., Altherr,M., Ashworth,L., Bajorek,E.,
            Black,S., Branscomb,E., Caenepeel,S., Carrano,A., Caoile,C.,
            Chan,Y.M., Christensen,M., Cleland,C.A., Copeland,A., Dalin,E.,
            Dehal,P., Denys,M., Detter,J.C., Escobar,J., Flowers,D.,
            Fotopulos,D., Garcia,C., Georgescu,A.M., Glavina,T., Gomez,M.,
            Gonzales,E., Groza,M., Hammon,N., Hawkins,T., Haydu,L., Ho,I.,
            Huang,W., Israni,S., Jett,J., Kadner,K., Kimball,H., Kobayashi,A.,
            Larionov,V., Leem,S.H., Lopez,F., Lou,Y., Lowry,S., Malfatti,S.,
            Martinez,D., McCready,P., Medina,C., Morgan,J., Nelson,K.,
            Nolan,M., Ovcharenko,I., Pitluck,S., Pollard,M., Popkie,A.P.,
            Predki,P., Quan,G., Ramirez,L., Rash,S., Retterer,J., Rodriguez,A.,
            Rogers,S., Salamov,A., Salazar,A., She,X., Smith,D., Slezak,T.,
            Solovyev,V., Thayer,N., Tice,H., Tsai,M., Ustaszewska,A., Vo,N.,
            Wagner,M., Wheeler,J., Wu,K., Xie,G., Yang,J., Dubchak,I.,
            Furey,T.S., DeJong,P., Dickson,M., Gordon,D., Eichler,E.E.,
            Pennacchio,L.A., Richardson,P., Stubbs,L., Rokhsar,D.S.,
            Myers,R.M., Rubin,E.M. and Lucas,S.M.
  TITLE     The DNA sequence and biology of human chromosome 19
  JOURNAL   Nature 428 (6982), 529-535 (2004)
   PUBMED   15057824
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC011474.6.
            
            On Jun 23, 2020 this sequence version replaced NM_001146339.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038195.1817218.1,
                                           SRR18074969.3395027.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743, SAMEA2154665
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000335523.8/ ENSP00000335038.6
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-672               AC011474.6         133370-134041
            673-857             AC011474.6         134587-134771
            858-887             AC011474.6         135809-135838
            888-1359            AC011474.6         137195-137666
            1360-2065           AC011474.6         171222-171927
FEATURES             Location/Qualifiers
     source          1..2065
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q12"
     gene            1..2065
                     /gene="VSTM2B"
                     /note="V-set and transmembrane domain containing 2B"
                     /db_xref="GeneID:342865"
                     /db_xref="HGNC:HGNC:33595"
     exon            1..672
                     /gene="VSTM2B"
                     /inference="alignment:Splign:2.1.0"
     CDS             591..1448
                     /gene="VSTM2B"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; V-set and transmembrane domain-containing
                     protein 2B"
                     /codon_start=1
                     /product="V-set and transmembrane domain-containing
                     protein 2B isoform 1 precursor"
                     /protein_id="NP_001139811.1"
                     /db_xref="CCDS:CCDS46034.1"
                     /db_xref="GeneID:342865"
                     /db_xref="HGNC:HGNC:33595"
                     /translation="MEQRNRLGALGYLPPLLLHALLLFVADAAFTEVPKDVTVREGDD
                     IEMPCAFRASGATSYSLEIQWWYLKEPPRELLHELALSVPGARSKVTNKDATKISTVR
                     VQGNDISHRLRLSAVRLQDEGVYECRVSDYSDDDTQEHKAQAMLRVLSRFAPPNMQAA
                     EAVSHIQSSGPRRHGPASAANANNAGAASRTTSEPGRGDKSPPPGSPPAAIDPAVPEA
                     AAASAAHTPTTTVAAAAAASSASPPSGQAVLLRQRHGSGTGRSYTTDPLLSLLLLALH
                     KFLRLLLGH"
     exon            673..857
                     /gene="VSTM2B"
                     /inference="alignment:Splign:2.1.0"
     exon            858..887
                     /gene="VSTM2B"
                     /inference="alignment:Splign:2.1.0"
     exon            888..1359
                     /gene="VSTM2B"
                     /inference="alignment:Splign:2.1.0"
     exon            1360..2065
                     /gene="VSTM2B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1975..1980
                     /regulatory_class="polyA_signal_sequence"
                     /gene="VSTM2B"
                     /note="hexamer: AATAAA"
     polyA_site      1997
                     /gene="VSTM2B"
     regulatory      2043..2048
                     /regulatory_class="polyA_signal_sequence"
                     /gene="VSTM2B"
                     /note="hexamer: AATAAA"
     polyA_site      2065
                     /gene="VSTM2B"
                     /note="major polyA site"
ORIGIN      
        1 gcctctctcc ggctccgggt ccgccacgcc ggacccgctc tccccgcgct gcgctgggtc
       61 ggacgccagg tctgcgcgcc gcggctgagc gcccactcgc cctgcggaaa gagccgcgga
      121 ggaaccggcg ggggcggctg cgggagccga aggaggtggc aatcgggagc agaaccagaa
      181 ggagacaggg aggcagaagc tcgcggctcc gtggcacgca ctccctcggc cagggatggg
      241 tcccggcgcg gcccagcccc tgcccggccc gccgggcaga gactgaaccg cggatcccca
      301 ccgtcctgtg gacgaccgga cagagagagg cactgaccga tcgccagcag cctcccggtg
      361 ggaccgcgtc tcctgcacac cccgcgcagc gccccccgcc ggagccgcac cgggcaagcc
      421 ggcgagggag cggggctgat tggcggccgc cggcggccag gggagggggc gccgcgcggg
      481 gccatggcag gctcggaggc gtcctagccc gagccggagc cgatccgagc ccacgcggcc
      541 gccgcctctc cgctcccggg cccccgccgc caccgcgccc cccgcgggag atggaacagc
      601 ggaaccggct cggtgccctc ggatacctgc cgcctctgct gctgcatgcc ctgctgctct
      661 tcgtggccga cgctgcattc acagaagtcc ccaaagatgt gacagtacgg gagggagacg
      721 acatcgaaat gccctgcgcg ttccgggcca gcggagccac ctcgtattcg ctggagattc
      781 agtggtggta cctcaaggag ccaccccggg agctgctgca cgagctggcg ctcagcgtgc
      841 cgggcgcccg gagcaaggta acaaataagg atgcaactaa aatcagcacc gtacgcgtcc
      901 agggcaatga catctcacac cggcttcggc tgtctgccgt gcggctgcag gacgagggcg
      961 tgtacgagtg ccgcgtgtcg gactacagcg acgacgacac gcaggagcac aaggcccagg
     1021 cgatgctgcg cgtgctctcg cgcttcgcgc cgcccaacat gcaggccgcc gaggccgtgt
     1081 cccacatcca gagcagcggc ccgcgtcgcc acggcccagc cagcgccgcc aacgccaaca
     1141 acgcgggcgc cgcgagccgt accacctccg agcccggccg cggcgacaag agcccgccgc
     1201 ccgggagccc tcccgccgcc atcgatcccg cagtccccga ggccgcggca gcctcggcgg
     1261 cccacacgcc caccaccaca gtcgcggcag ctgctgctgc ctcgtcagcg tcgccgccat
     1321 cgggacaggc ggtcctgctg cgccagaggc acggctcggg caccggccgt agctacacca
     1381 cagacccact cttgtccctg ctcctgttag ctctgcataa gttcctgcgc ctgctcttgg
     1441 gacattgaca gacaagacca acccgagcat ctcagaggcc gcacatgacc tgcccggggc
     1501 cctcggtgag gaccatgtcg ctggatggac acagagagac tgagagacgc atgaaaaagt
     1561 ccacatggaa aataaataaa tcatattttt gggaaagtta cacaaatgta gaacacctaa
     1621 aataatgcat ctagtttcca aataatttgg agtttggccc atgcagtctg catgggaatc
     1681 aatgatttct ctacttcaat gtagttttct tttctacact ttccctccaa gtcttcattt
     1741 tgcacgaact gttgagcagt tatctttagg ataatatgta caaatgttgg ggtcaaagcc
     1801 ttttgacaaa gcaaaatatt tttagtagat tattgtgttt aggatttttt tttaatttac
     1861 tttttttctt tgggggcttt tcttttttat taaattattt cttttgaggc attttgatta
     1921 aaaaagacac atcttatcat aattaaaatt cactgtcaat aatatttatt tttaaataaa
     1981 gattggaaac aaggtcagac acttgtttat aaactgtatt gtatattgct gaagaacagt
     2041 tgaataaaaa acaactttga aataa
//
