LOCUS       NM_001317843            3355 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens V-set and transmembrane domain containing 2A (VSTM2A),
            transcript variant 3, mRNA.
ACCESSION   NM_001317843 XM_011515196
VERSION     NM_001317843.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3355)
  AUTHORS   Wang,L., Yilmaz,O., Veeneman,B.A., Zhang,Y., Dhanasekaran,S.M. and
            Mehra,R.
  TITLE     Gene of the month: VSTM2A
  JOURNAL   J Clin Pathol 77 (2), 73-76 (2024)
   PUBMED   38124011
  REMARK    GeneRIF: Gene of the month: VSTM2A.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3355)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 3355)
  AUTHORS   Dong,Y., Zhang,Y., Kang,W., Wang,G., Chen,H., Higashimori,A.,
            Nakatsu,G., Go,M., Tong,J.H., Zheng,S., To,K.F., Sung,J.J.,
            Yang,X., Ng,S.S. and Yu,J.
  TITLE     VSTM2A suppresses colorectal cancer and antagonizes Wnt signaling
            receptor LRP6
  JOURNAL   Theranostics 9 (22), 6517-6531 (2019)
   PUBMED   31588233
  REMARK    GeneRIF: VSTM2A suppresses colorectal cancer and antagonizes Wnt
            signaling receptor LRP6.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3355)
  AUTHORS   Wang,L., Zhang,Y., Chen,Y.B., Skala,S.L., Al-Ahmadie,H.A., Wang,X.,
            Cao,X., Veeneman,B.A., Chen,J., Cieslik,M., Qiao,Y., Su,F.,
            Vats,P., Siddiqui,J., Xiao,H., Sadimin,E.T., Epstein,J.I., Zhou,M.,
            Sangoi,A.R., Trpkov,K., Osunkoya,A.O., Giannico,G.A.,
            McKenney,J.K., Argani,P., Tickoo,S.K., Reuter,V.E.,
            Chinnaiyan,A.M., Dhanasekaran,S.M. and Mehra,R.
  TITLE     VSTM2A Overexpression Is a Sensitive and Specific Biomarker for
            Mucinous Tubular and Spindle Cell Carcinoma (MTSCC) of the Kidney
  JOURNAL   Am J Surg Pathol 42 (12), 1571-1584 (2018)
   PUBMED   30285995
  REMARK    GeneRIF: VSTM2A overexpression to be a sensitive and specific
            marker for mucinous tubular and spindle cell carcinoma of the
            kidney.
REFERENCE   5  (bases 1 to 3355)
  AUTHORS   Secco,B., Camire,E., Briere,M.A., Caron,A., Billong,A., Gelinas,Y.,
            Lemay,A.M., Tharp,K.M., Lee,P.L., Gobeil,S., Guimond,J.V.,
            Patey,N., Guertin,D.A., Stahl,A., Haddad,E., Marsolais,D.,
            Bosse,Y., Birsoy,K. and Laplante,M.
  TITLE     Amplification of Adipogenic Commitment by VSTM2A
  JOURNAL   Cell Rep 18 (1), 93-106 (2017)
   PUBMED   28052263
  REMARK    GeneRIF: VSTM2A is produced to preserve and amplify the adipogenic
            capability of adipose precursors.
REFERENCE   6  (bases 1 to 3355)
  AUTHORS   Wistow,G., Bernstein,S.L., Wyatt,M.K., Ray,S., Behal,A.,
            Touchman,J.W., Bouffard,G., Smith,D. and Peterson,K.
  TITLE     Expressed sequence tag analysis of human retina for the NEIBank
            Project: retbindin, an abundant, novel retinal cDNA and alternative
            splicing of other retina-preferred gene transcripts
  JOURNAL   Mol Vis 8, 196-204 (2002)
   PUBMED   12107411
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BI755592.1, BC028404.1, BI553644.1 and AC069313.5.
            
            On Jun 2, 2019 this sequence version replaced NM_001317843.1.
            
            Transcript Variant: This variant (3) lacks one exon, and its 3'
            terminal exon extends past a splice site that is used in variant 1.
            This results in a novel 3' coding region and 3' UTR, compared to
            variant 1. The encoded isoform (3) has a shorter and distinct
            C-terminus, compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.39282.1, BC028404.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2142348
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-80                BI755592.1         50-129
            81-605              BC028404.1         6-530
            606-606             BI553644.1         463-463
            607-784             BC028404.1         532-709
            785-2726            AC069313.5         79783-81724
            2727-3351           BC028404.1         2650-3274
            3352-3355           AC069313.5         82350-82353
FEATURES             Location/Qualifiers
     source          1..3355
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p11.2"
     gene            1..3355
                     /gene="VSTM2A"
                     /gene_synonym="VSTM2"
                     /note="V-set and transmembrane domain containing 2A"
                     /db_xref="GeneID:222008"
                     /db_xref="HGNC:HGNC:28499"
     exon            1..435
                     /gene="VSTM2A"
                     /gene_synonym="VSTM2"
                     /inference="alignment:Splign:2.1.0"
     CDS             357..1091
                     /gene="VSTM2A"
                     /gene_synonym="VSTM2"
                     /note="isoform 3 precursor is encoded by transcript
                     variant 3; V-set and transmembrane domain containing 2;
                     V-set and transmembrane domain-containing protein 2A;
                     hypothetical protein MGC33530"
                     /codon_start=1
                     /product="V-set and transmembrane domain-containing
                     protein 2A isoform 3 precursor"
                     /protein_id="NP_001304772.1"
                     /db_xref="CCDS:CCDS83185.1"
                     /db_xref="GeneID:222008"
                     /db_xref="HGNC:HGNC:28499"
                     /translation="MMGIFLVYVGFVFFSVLYVQQGLSSQAKFTEFPRNVTATEGQNV
                     EMSCAFQSGSASVYLEIQWWFLRGPEDLDPGAEGAGAQVELLPDRDPDSDGTKISTVK
                     VQGNDISHKLQISKVRKKDEGLYECRVTDANYGELQEHKAQAYLKVNANSHARRMQAF
                     EASPMWLQDMKPRKNVSAAIPSSIHGSANQRTHSTSSPQVVAKIPKQSPQSGMETHFE
                     PFILPLTNAPQKGQSYRVDRFMNGDF"
     exon            436..602
                     /gene="VSTM2A"
                     /gene_synonym="VSTM2"
                     /inference="alignment:Splign:2.1.0"
     exon            603..653
                     /gene="VSTM2A"
                     /gene_synonym="VSTM2"
                     /inference="alignment:Splign:2.1.0"
     exon            654..3355
                     /gene="VSTM2A"
                     /gene_synonym="VSTM2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1273..1278
                     /regulatory_class="polyA_signal_sequence"
                     /gene="VSTM2A"
                     /gene_synonym="VSTM2"
                     /note="hexamer: AATAAA"
     polyA_site      1300
                     /gene="VSTM2A"
                     /gene_synonym="VSTM2"
                     /note="major polyA site"
     regulatory      3333..3338
                     /regulatory_class="polyA_signal_sequence"
                     /gene="VSTM2A"
                     /gene_synonym="VSTM2"
                     /note="hexamer: AATAAA"
     polyA_site      3355
                     /gene="VSTM2A"
                     /gene_synonym="VSTM2"
                     /note="major polyA site"
ORIGIN      
        1 acttcccgag ccggctccgt gtttagggag ggcagtgatc acgcaagccg gagcggcggg
       61 ctgacgttgg acgagctgcc aggtagctga aagcaggcag ccaggcagcc gagacacttc
      121 ccagcgattc cagcctgggc tccgcaggaa gcctcgctga atcccagcca gctggttcta
      181 accttccaga atcgcaatcc cttctcccca cagccagccc tcgccaagca agcagcagga
      241 tgtttgcagt gtcgcgccca gggctctgag actgagcctg ccatccactc gcacgccttt
      301 ctttcagggc ttttcggctg ttggctacac tgatgtgacc cccctccctt tttggaatga
      361 tggggatctt tttggtgtat gttggatttg ttttcttttc cgttttatat gtacaacaag
      421 ggctttcttc tcaagcaaaa tttaccgagt ttccgcggaa cgtgacggcg accgaggggc
      481 agaatgtgga gatgtcctgc gccttccaga gcggctccgc ctcggtgtat ctggagatcc
      541 aatggtggtt cctgcggggg ccggaggacc tggatcccgg ggccgagggg gccggcgcgc
      601 aggtggagct cttgcccgac agagacccgg acagcgacgg gaccaagatc agcacagtga
      661 aagtccaagg caatgacatc tcccacaagc ttcagatttc caaagtgagg aaaaaggatg
      721 aaggcttata tgagtgcagg gtgactgatg ccaactacgg ggagcttcag gaacacaagg
      781 cccaggccta tctgaaagtc aatgccaaca gccatgcccg cagaatgcag gccttcgaag
      841 cctcgcccat gtggctgcag gatatgaagc cccgcaagaa cgtctccgca gccatcccca
      901 gcagcatcca tggctctgcc aaccaacgaa cgcactccac ctccagccct caagtggtag
      961 ccaaaatccc caaacaaagt ccacaatcag gtatggaaac ccatttcgag ccttttattt
     1021 taccactcac aaacgctcca cagaaaggtc agtcgtatag agtagacaga tttatgaatg
     1081 gtgattttta aaatcggaga cctagttcag tgcaagtgat tatgagaggt gagcaccgag
     1141 cctgcaccaa ttcactcaga gctcaaagca tgtgggtgca ccccgtcagt cccctagtgg
     1201 tgcttcattt ccagggcatc tgagagctgg actctggttt ttatcctttc tgtatttaca
     1261 cattataaga acaataaatc atgtaatgtt ggttacatta caaatgcatg ttcattttct
     1321 ctacagattt atgtatcgat aatgacccaa attaagaggc tttcacttaa tcaaaatgta
     1381 aatgagagag acatgccata tcatgcattt tcagcgaccc atagctctaa gcaggactat
     1441 tctccaaggg cttttgattt tgaaggagaa acctcagctg cctgtgatga tgataatgga
     1501 aggatggagg ggggattgaa gactgtaagt ggtgcagaga taaggcaact cctctgtgaa
     1561 tttgccttcc aggccaattt agaagcttag tcacaggatt ctgaaggcag ctgtgcaagt
     1621 taaagctgtt ctgaatggca ttaatgtatg cagtcattca gccaatggaa atgcgtggaa
     1681 gttttaacct tgatgtggga taaaggcttc gtggaatgag cagtaccctg cacaaccccg
     1741 cggccgtccc gatttcctca aacacgtgac atgggatgaa gggagcacaa acatactgac
     1801 tttatccttc tttaggtttt tccctaaaga agtattgatg ctaccatcag taatggaaaa
     1861 ttacattgct aatatttaag gtctcttcag ccattaaatt aaaaagtctg attacttcac
     1921 caggatgatt tctgagatct catctcatat cgtcctgaat acacacacac acacacacac
     1981 acgcacacac acacacatct cagaaatcat cctaatcaaa tatagacttt atatatatca
     2041 aatatatata tacatgtaga aatacatata ggtatgtatc tttaagtcct tgcttgtgaa
     2101 caatgctttt aaatgttttt aaaatactgt atgccaaaat aggttttctc ttaatgcttt
     2161 acttcctaat ggatgtgatt tgcagatttg tagggcactt ggattagggt tctctgagtt
     2221 tgccctgcct tataatgtag atgagcaact ctcctggcat gccttggtca ttgcaattta
     2281 tgtcagtctg atgaacagat ggcttagcct ctctgaagcc caatgtgtgt ggatttgtct
     2341 aatttttttc tttataatct tttctgctta ccaaattaaa ggacaaacta gtatagctgg
     2401 aacatatatg tgtgtatcca tacacactaa acacacaggt atatgctaaa ttgtaatggt
     2461 aaccaaatga tggttacaac tttgtgacta ttatttgagg aagatttaat gtctttggag
     2521 tgattttccc ctctttcttc acattatcat aaaagaagtt agacactaca ggcaagatta
     2581 cagagtagcc taagcagaca atttacaacc taattagcaa gaactccaaa tcatggaagt
     2641 gaaattatta ttatcctaca tagactgttc caagttagat gtcatcaatc tgttcggcag
     2701 aataaaatca aacagattac ctattccaag tgaagaattc caagggtaga atgaaatgct
     2761 ttatctattt ctagaatgtt ttcttagctt ttggggttta ataatgcaat ctcaaaatat
     2821 ctatttattt tattttaata tctcttagcg ctgtgattag tgctaaatga taaactctag
     2881 atctcttcta acaattatca aataaaaatt actgctcttt ttgcatccca ttgccagcct
     2941 tgctgtcaga ttcaaaattg ctttttctag agttaaaggt agaaggagag aaaaaagtga
     3001 ctcatgaagt ctatattcat taaaagtcct gttcactaaa catatctgct tatatcaaag
     3061 agtaacttga aatatctgaa aatatttaat ttcaatattt ccaaccagtg aatactggat
     3121 aatattttta tatacttcta tcaacatttt ctaatttcga tttcagaagc tggggcagtc
     3181 cagtcactca ctttacttat gtgtaagttc ctatacttgc acaattatta tatatgattc
     3241 agtatctggg gtggatattt atatattata ttcactgtaa tacccacatc ctgatttatg
     3301 atttttgcct cacgattttc agattatatt caaataaagc ttatttcaat accca
//
