LOCUS       NM_001301009            2927 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens V-set and transmembrane domain containing 2A (VSTM2A),
            transcript variant 2, mRNA.
ACCESSION   NM_001301009 XM_006715664
VERSION     NM_001301009.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2927)
  AUTHORS   Wang,L., Yilmaz,O., Veeneman,B.A., Zhang,Y., Dhanasekaran,S.M. and
            Mehra,R.
  TITLE     Gene of the month: VSTM2A
  JOURNAL   J Clin Pathol 77 (2), 73-76 (2024)
   PUBMED   38124011
  REMARK    GeneRIF: Gene of the month: VSTM2A.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2927)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 2927)
  AUTHORS   Dong,Y., Zhang,Y., Kang,W., Wang,G., Chen,H., Higashimori,A.,
            Nakatsu,G., Go,M., Tong,J.H., Zheng,S., To,K.F., Sung,J.J.,
            Yang,X., Ng,S.S. and Yu,J.
  TITLE     VSTM2A suppresses colorectal cancer and antagonizes Wnt signaling
            receptor LRP6
  JOURNAL   Theranostics 9 (22), 6517-6531 (2019)
   PUBMED   31588233
  REMARK    GeneRIF: VSTM2A suppresses colorectal cancer and antagonizes Wnt
            signaling receptor LRP6.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2927)
  AUTHORS   Wang,L., Zhang,Y., Chen,Y.B., Skala,S.L., Al-Ahmadie,H.A., Wang,X.,
            Cao,X., Veeneman,B.A., Chen,J., Cieslik,M., Qiao,Y., Su,F.,
            Vats,P., Siddiqui,J., Xiao,H., Sadimin,E.T., Epstein,J.I., Zhou,M.,
            Sangoi,A.R., Trpkov,K., Osunkoya,A.O., Giannico,G.A.,
            McKenney,J.K., Argani,P., Tickoo,S.K., Reuter,V.E.,
            Chinnaiyan,A.M., Dhanasekaran,S.M. and Mehra,R.
  TITLE     VSTM2A Overexpression Is a Sensitive and Specific Biomarker for
            Mucinous Tubular and Spindle Cell Carcinoma (MTSCC) of the Kidney
  JOURNAL   Am J Surg Pathol 42 (12), 1571-1584 (2018)
   PUBMED   30285995
  REMARK    GeneRIF: VSTM2A overexpression to be a sensitive and specific
            marker for mucinous tubular and spindle cell carcinoma of the
            kidney.
REFERENCE   5  (bases 1 to 2927)
  AUTHORS   Secco,B., Camire,E., Briere,M.A., Caron,A., Billong,A., Gelinas,Y.,
            Lemay,A.M., Tharp,K.M., Lee,P.L., Gobeil,S., Guimond,J.V.,
            Patey,N., Guertin,D.A., Stahl,A., Haddad,E., Marsolais,D.,
            Bosse,Y., Birsoy,K. and Laplante,M.
  TITLE     Amplification of Adipogenic Commitment by VSTM2A
  JOURNAL   Cell Rep 18 (1), 93-106 (2017)
   PUBMED   28052263
  REMARK    GeneRIF: VSTM2A is produced to preserve and amplify the adipogenic
            capability of adipose precursors.
REFERENCE   6  (bases 1 to 2927)
  AUTHORS   Wistow,G., Bernstein,S.L., Wyatt,M.K., Ray,S., Behal,A.,
            Touchman,J.W., Bouffard,G., Smith,D. and Peterson,K.
  TITLE     Expressed sequence tag analysis of human retina for the NEIBank
            Project: retbindin, an abundant, novel retinal cDNA and alternative
            splicing of other retina-preferred gene transcripts
  JOURNAL   Mol Vis 8, 196-204 (2002)
   PUBMED   12107411
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DN991972.1, BI758069.1, BI752069.1, BQ639021.1, BI458531.1 and
            EY892386.1.
            
            On May 21, 2020 this sequence version replaced NM_001301009.1.
            
            Transcript Variant: This variant (2) differs in the 3' coding
            region due to the use of an alternate splice site in the
            3'-terminal exon, compared to variant 1. The encoded isoform (2)
            has a longer and distinct C-terminus, compared to isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.245423.1,
                                           SRR1803611.7125.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2142348
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000402613.4/ ENSP00000384103.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-389               DN991972.1         51-439
            390-1000            BI758069.1         102-712
            1001-1115           BI752069.1         589-703
            1116-1711           BQ639021.1         25-620
            1712-2278           BI458531.1         76-642
            2279-2927           EY892386.1         417-1065
FEATURES             Location/Qualifiers
     source          1..2927
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p11.2"
     gene            1..2927
                     /gene="VSTM2A"
                     /gene_synonym="VSTM2"
                     /note="V-set and transmembrane domain containing 2A"
                     /db_xref="GeneID:222008"
                     /db_xref="HGNC:HGNC:28499"
     exon            1..435
                     /gene="VSTM2A"
                     /gene_synonym="VSTM2"
                     /inference="alignment:Splign:2.1.0"
     CDS             357..1079
                     /gene="VSTM2A"
                     /gene_synonym="VSTM2"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; V-set and transmembrane domain containing 2;
                     V-set and transmembrane domain-containing protein 2A;
                     hypothetical protein MGC33530"
                     /codon_start=1
                     /product="V-set and transmembrane domain-containing
                     protein 2A isoform 2 precursor"
                     /protein_id="NP_001287938.1"
                     /db_xref="CCDS:CCDS75604.1"
                     /db_xref="GeneID:222008"
                     /db_xref="HGNC:HGNC:28499"
                     /translation="MMGIFLVYVGFVFFSVLYVQQGLSSQAKFTEFPRNVTATEGQNV
                     EMSCAFQSGSASVYLEIQWWFLRGPEDLDPGAEGAGAQVELLPDRDPDSDGTKISTVK
                     VQGNDISHKLQISKVRKKDEGLYECRVTDANYGELQEHKAQAYLKVNANSHARRMQAF
                     EASPMWLQDMKPRKNVSAAIPSSIHGSANQRTHSTSSPQVVAKIPKQSPQSAKSKSPV
                     KSTERTAKLTLNSKHHPAPTVL"
     exon            436..602
                     /gene="VSTM2A"
                     /gene_synonym="VSTM2"
                     /inference="alignment:Splign:2.1.0"
     exon            603..653
                     /gene="VSTM2A"
                     /gene_synonym="VSTM2"
                     /inference="alignment:Splign:2.1.0"
     exon            654..990
                     /gene="VSTM2A"
                     /gene_synonym="VSTM2"
                     /inference="alignment:Splign:2.1.0"
     exon            991..2927
                     /gene="VSTM2A"
                     /gene_synonym="VSTM2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2352..2357
                     /regulatory_class="polyA_signal_sequence"
                     /gene="VSTM2A"
                     /gene_synonym="VSTM2"
                     /note="hexamer: ATTAAA"
     regulatory      2359..2364
                     /regulatory_class="polyA_signal_sequence"
                     /gene="VSTM2A"
                     /gene_synonym="VSTM2"
                     /note="hexamer: ATTAAA"
     polyA_site      2369
                     /gene="VSTM2A"
                     /gene_synonym="VSTM2"
                     /note="major polyA site"
     polyA_site      2382
                     /gene="VSTM2A"
                     /gene_synonym="VSTM2"
     regulatory      2906..2911
                     /regulatory_class="polyA_signal_sequence"
                     /gene="VSTM2A"
                     /gene_synonym="VSTM2"
                     /note="hexamer: AATAAA"
     polyA_site      2927
                     /gene="VSTM2A"
                     /gene_synonym="VSTM2"
                     /note="major polyA site"
ORIGIN      
        1 acttcccgag ccggctccgt gtttagggag ggcagtgatc acgcaagccg gagcggcggg
       61 ctgacgttgg acgagctgcc aggtagctga aagcaggcag ccaggcagcc gagacacttc
      121 ccagcgattc cagcctgggc tccgcaggaa gcctcgctga atcccagcca gctggttcta
      181 accttccaga atcgcaatcc cttctcccca cagccagccc tcgccaagca agcagcagga
      241 tgtttgcagt gtcgcgccca gggctctgag actgagcctg ccatccactc gcacgccttt
      301 ctttcagggc ttttcggctg ttggctacac tgatgtgacc cccctccctt tttggaatga
      361 tggggatctt tttggtgtat gttggatttg ttttcttttc cgttttatat gtacaacaag
      421 ggctttcttc tcaagcaaaa tttaccgagt ttccgcggaa cgtgacggcg accgaggggc
      481 agaatgtgga gatgtcctgc gccttccaga gcggctccgc ctcggtgtat ctggagatcc
      541 aatggtggtt cctgcggggg ccggaggacc tggatcccgg ggccgagggg gccggcgcgc
      601 aggtggagct cttgcccgac agagacccgg acagcgacgg gaccaagatc agcacagtga
      661 aagtccaagg caatgacatc tcccacaagc ttcagatttc caaagtgagg aaaaaggatg
      721 aaggcttata tgagtgcagg gtgactgatg ccaactacgg ggagcttcag gaacacaagg
      781 cccaggccta tctgaaagtc aatgccaaca gccatgcccg cagaatgcag gccttcgaag
      841 cctcgcccat gtggctgcag gatatgaagc cccgcaagaa cgtctccgca gccatcccca
      901 gcagcatcca tggctctgcc aaccaacgaa cgcactccac ctccagccct caagtggtag
      961 ccaaaatccc caaacaaagt ccacaatcag caaagagcaa atcgcctgta aaatctacgg
     1021 agcggacagc aaagttgacc ctaaactcca agcaccaccc tgcacccact gtactctaat
     1081 tcactacaca aggagcgcct gcttccggaa gcataaatga agaggctatc acatgctttg
     1141 ttgatcatat tttctttggc aaaacactga tcttttattt taagagaatt aacgtgaagt
     1201 gatagaacgt tttctaatag caagatctat tttttccctt ttctttcggc gactaaaatc
     1261 atctcactga ctgctcaagg gttggcctga atgtcatcag gatagggaat atttactatg
     1321 gataccacta atttcctact aaaggaccca gcatcttcag gaagcaaaca gagatcaaaa
     1381 ggctacagaa cagaagctat catcagacaa aacccccttt ttaggggaag aacaaaacta
     1441 tcaacactgc aagtcaacaa ggaggacatt actttaagga ataacatgag aaagaaattt
     1501 ttttattttc cccttttttt cttggatttt tcttcttttt cttgattaca gttcttgttc
     1561 aatggtggca agtgctggtt atggccaatc tccgtcaatc ctaggaggtt tatagaacta
     1621 cattttgagt gttctatatt tcagtgtatt ttaattcatt ttgcaattcc tgtgtatgca
     1681 aacctgataa attctgtaaa ttgcttatag tatgtgtgct ataacttcaa agtagatgta
     1741 ctgcgaccct catgcaagct gatttttatc attatatata taaatatata cttaagaata
     1801 tctgtgtgtt gggccaatga ccaacttttt ttgacgaagc atttgttttt cgttgataat
     1861 tcatacactg cgtgaatttt gtaattcatt gtttcacttc cacaggtttg acagctgcag
     1921 atggtctcta ttgtcctctg cttcattctg gaaagtgcat attcaaaatt gtatcagtct
     1981 ctgatcgatg aattaatttt gttatgtctg tgctaagttg gaatttacta tgttccttta
     2041 tacatggtgt ttattgaggt ttgagagtct cttgactgtg aagaatgtac actgtctggt
     2101 tttgacagct atttctgtat tattatcatt ataatcttgt caaatagaaa tgttgcttct
     2161 agaaaatttg cctaggaggc gaatgtgggg aaggtgaagc actcaccata attccctaaa
     2221 ttcatgttag aacatttctt gctatggtta aaaatgctgc ttcctttgac ctttatgaat
     2281 ttctgtacct ttgtcattct gttacctttg tcattctgtt atttgcgcta attatatttt
     2341 aatgtctcct aattaaaaat taaaatttgg ttgttggcta aatacaatat gcaaaagatg
     2401 atggcaggtc cccgactaaa gaagattaat gtgttcagtt ttcactggtt aagtgaatta
     2461 taattttaaa tattccattc ttatttatgt ctttatgata attcagacta ttttattttg
     2521 aacctgtttt ctactctggc aaagaaagat aggcagaact attagtgttc catatacatt
     2581 atggaataga taaagcttga gagataaatg acctaagttt tccttccaga gagactcttc
     2641 cattttctct cattacaaaa ccagaagatc agctatgtgg ggccatcagc tcccagccta
     2701 aggtcctata acccgaagct tgaaggcaat cagtacctct gcttttcaaa ggtaaatgca
     2761 ttcattttct ttgattcagt tataagcaag tatatatttt cataatattc ttgacattac
     2821 ctgagaaata atacttcatg ctaaatcttt tactgccact tttctcattc atttggttta
     2881 tcatttcagt ttaatgagaa aaattaataa aggttttgat tgcacta
//
