LOCUS       NM_001288793             607 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens V-set and transmembrane domain containing 1 (VSTM1),
            transcript variant 4, mRNA.
ACCESSION   NM_001288793
VERSION     NM_001288793.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 607)
  AUTHORS   Miao,N. and Wang,J.
  TITLE     New insights into the role of the immune inhibitory receptor VSTM1
            in autoimmune disease
  JOURNAL   Cell Mol Immunol 21 (1), 95-96 (2024)
   PUBMED   37935837
  REMARK    GeneRIF: New insights into the role of the immune inhibitory
            receptor VSTM1 in autoimmune disease.
REFERENCE   2  (bases 1 to 607)
  AUTHORS   Jiang,X., Xiao,X., Li,H., Gong,Y., Wang,M., Yang,H., Zhao,L.,
            Jiang,Y., Wei,Y., Zhao,C., Li,J., Chen,Y., Feng,S., Deng,H., Ma,S.,
            Xu,Y., Liu,Y., Tsokos,G.C., Jiang,M. and Zhang,X.
  TITLE     Oxidized galectin-1 in SLE fails to bind the inhibitory receptor
            VSTM1 and increases reactive oxygen species levels in neutrophils
  JOURNAL   Cell Mol Immunol 20 (11), 1339-1351 (2023)
   PUBMED   37737309
  REMARK    GeneRIF: Oxidized galectin-1 in SLE fails to bind the inhibitory
            receptor VSTM1 and increases reactive oxygen species levels in
            neutrophils.
REFERENCE   3  (bases 1 to 607)
  AUTHORS   von Richthofen,H.J., Hafkamp,F.M.J., van Haperen,A., de Jong,E.C.
            and Meyaard,L.
  TITLE     VSTM1-v2 does not drive human Th17 cell differentiation: A
            replication study
  JOURNAL   PLoS One 18 (4), e0284404 (2023)
   PUBMED   37053248
  REMARK    GeneRIF: VSTM1-v2 does not drive human Th17 cell differentiation: A
            replication study.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 607)
  AUTHORS   Rumpret,M., von Richthofen,H.J., van der Linden,M.,
            Westerlaken,G.H.A., Talavera Ormeno,C., Low,T.Y., Ovaa,H. and
            Meyaard,L.
  TITLE     Recognition of S100 proteins by Signal Inhibitory Receptor on
            Leukocytes-1 negatively regulates human neutrophils
  JOURNAL   Eur J Immunol 51 (9), 2210-2217 (2021)
   PUBMED   34145909
  REMARK    GeneRIF: Recognition of S100 proteins by Signal Inhibitory Receptor
            on Leukocytes-1 negatively regulates human neutrophils.
REFERENCE   5  (bases 1 to 607)
  AUTHORS   von Richthofen,H.J., Gollnast,D., van Capel,T.M.M., Giovannone,B.,
            Westerlaken,G.H.A., Lutter,L., Oldenburg,B., Hijnen,D., van der
            Vlist,M., de Jong,E.C. and Meyaard,L.
  TITLE     Signal Inhibitory Receptor on Leukocytes-1 is highly expressed on
            lung monocytes, but absent on mononuclear phagocytes in skin and
            colon
  JOURNAL   Cell Immunol 357, 104199 (2020)
   PUBMED   32942189
  REMARK    GeneRIF: Signal Inhibitory Receptor on Leukocytes-1 is highly
            expressed on lung monocytes, but absent on mononuclear phagocytes
            in skin and colon.
REFERENCE   6  (bases 1 to 607)
  AUTHORS   Van Avondt,K., Fritsch-Stork,R., Derksen,R.H. and Meyaard,L.
  TITLE     Ligation of signal inhibitory receptor on leukocytes-1 suppresses
            the release of neutrophil extracellular traps in systemic lupus
            erythematosus
  JOURNAL   PLoS One 8 (10), e78459 (2013)
   PUBMED   24205237
  REMARK    GeneRIF: Signaling via the inhibitory receptor SIRL-1 was induced
            by ligation with anti-SIRL-1 specific antibodies.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 607)
  AUTHORS   Steevels,T.A., van Avondt,K., Westerlaken,G.H., Stalpers,F.,
            Walk,J., Bont,L., Coffer,P.J. and Meyaard,L.
  TITLE     Signal inhibitory receptor on leukocytes-1 (SIRL-1) negatively
            regulates the oxidative burst in human phagocytes
  JOURNAL   Eur J Immunol 43 (5), 1297-1308 (2013)
   PUBMED   23436183
  REMARK    GeneRIF: SIRL-1 negatively regulates the oxidative burst in human
            phagocytes.
REFERENCE   8  (bases 1 to 607)
  AUTHORS   Steevels,T.A., Lebbink,R.J., Westerlaken,G.H., Coffer,P.J. and
            Meyaard,L.
  TITLE     Signal inhibitory receptor on leukocytes-1 is a novel functional
            inhibitory immune receptor expressed on human phagocytes
  JOURNAL   J Immunol 184 (9), 4741-4748 (2010)
   PUBMED   20375307
  REMARK    GeneRIF: Signal inhibitory receptor on leukocytes-1 is a member of
            immunoglobulin superfamily ITIM; expressed by myeloid but not
            lymphoid cells; requires both of its ITIMs for full inhibition of
            Fc epsilon receptor type I-mediated mast cell degranulation.
REFERENCE   9  (bases 1 to 607)
  AUTHORS   Zhang,Z. and Henzel,W.J.
  TITLE     Signal peptide prediction based on analysis of experimentally
            verified cleavage sites
  JOURNAL   Protein Sci 13 (10), 2819-2824 (2004)
   PUBMED   15340161
REFERENCE   10 (bases 1 to 607)
  AUTHORS   Harrington,J.J., Sherf,B., Rundlett,S., Jackson,P.D., Perry,R.,
            Cain,S., Leventhal,C., Thornton,M., Ramachandran,R.,
            Whittington,J., Lerner,L., Costanzo,D., McElligott,K., Boozer,S.,
            Mays,R., Smith,E., Veloso,N., Klika,A., Hess,J., Cothren,K., Lo,K.,
            Offenbacher,J., Danzig,J. and Ducar,M.
  TITLE     Creation of genome-wide protein expression libraries using random
            activation of gene expression
  JOURNAL   Nat Biotechnol 19 (5), 440-445 (2001)
   PUBMED   11329013
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AY358542.1, FJ584319.1 and AI457604.1.
            
            On Aug 14, 2020 this sequence version replaced NM_001288793.1.
            
            Transcript Variant: This variant (4) lacks three consecutive exons
            in the central coding region, but maintains the reading frame,
            compared to variant 1. The encoded isoform (4) is shorter, compared
            to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FJ584319.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2163105 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-109               AY358542.1         66-174
            110-482             FJ584319.1         1-373
            483-599             AY358542.1         908-1024
            600-607             AI457604.1         12-19               c
FEATURES             Location/Qualifiers
     source          1..607
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.42"
     gene            1..607
                     /gene="VSTM1"
                     /gene_synonym="SIRL-1; SIRL1; UNQ3033"
                     /note="V-set and transmembrane domain containing 1"
                     /db_xref="GeneID:284415"
                     /db_xref="HGNC:HGNC:29455"
                     /db_xref="MIM:616804"
     exon            1..154
                     /gene="VSTM1"
                     /gene_synonym="SIRL-1; SIRL1; UNQ3033"
                     /inference="alignment:Splign:2.1.0"
     CDS             121..471
                     /gene="VSTM1"
                     /gene_synonym="SIRL-1; SIRL1; UNQ3033"
                     /note="isoform 4 is encoded by transcript variant 4;
                     signal inhibitory receptor on leukocytes-1; V-set and
                     transmembrane domain-containing protein 1; LAIR homolog;
                     OSCAR-like transcript-1"
                     /codon_start=1
                     /product="V-set and transmembrane domain-containing
                     protein 1 isoform 4"
                     /protein_id="NP_001275722.1"
                     /db_xref="CCDS:CCDS74441.1"
                     /db_xref="GeneID:284415"
                     /db_xref="HGNC:HGNC:29455"
                     /db_xref="MIM:616804"
                     /translation="MTAEFLSLLCLDTRTIFVAIFSCISILLLFLSVFIIYRCSQHSS
                     SSEESTKRTSHSKLPEQEAAEADLSNMERVSLSTADPQGVTYAELSTSALSEAASDTT
                     QEPPGSHEYAALKV"
     exon            155..247
                     /gene="VSTM1"
                     /gene_synonym="SIRL-1; SIRL1; UNQ3033"
                     /inference="alignment:Splign:2.1.0"
     exon            248..275
                     /gene="VSTM1"
                     /gene_synonym="SIRL-1; SIRL1; UNQ3033"
                     /inference="alignment:Splign:2.1.0"
     exon            276..313
                     /gene="VSTM1"
                     /gene_synonym="SIRL-1; SIRL1; UNQ3033"
                     /inference="alignment:Splign:2.1.0"
     exon            314..351
                     /gene="VSTM1"
                     /gene_synonym="SIRL-1; SIRL1; UNQ3033"
                     /inference="alignment:Splign:2.1.0"
     exon            352..607
                     /gene="VSTM1"
                     /gene_synonym="SIRL-1; SIRL1; UNQ3033"
                     /inference="alignment:Splign:2.1.0"
     regulatory      576..581
                     /regulatory_class="polyA_signal_sequence"
                     /gene="VSTM1"
                     /gene_synonym="SIRL-1; SIRL1; UNQ3033"
                     /note="hexamer: AATAAA"
     polyA_site      607
                     /gene="VSTM1"
                     /gene_synonym="SIRL-1; SIRL1; UNQ3033"
                     /note="major polyA site"
ORIGIN      
        1 ctctatctgc acatcctggg gacgaaccgg gcagccggag agctgcggcc ggcccagtcc
       61 cgctccgcct ttgaagggta aaacccaagg cggggccttg gttctggcag aagggacgct
      121 atgaccgcag aattcctctc cctgctttgc ctcgacacca gaaccatctt tgtcgccatc
      181 ttcagctgca tctccatcct tctcctcttc ctctcagtct tcatcatcta cagatgcagc
      241 cagcacagtt catcatctga ggaatccacc aagagaacca gccattccaa acttccggag
      301 caggaggctg ccgaggcaga tttatccaat atggaaaggg tatctctctc gacggcagac
      361 ccccaaggag tgacctatgc tgagctaagc accagcgccc tgtctgaggc agcttcagac
      421 accacccagg agcccccagg atctcatgaa tatgcggcac tgaaagtgta gcaagaagac
      481 agccctggcc actaaaggag gggggatcgt gctggccaag gttatcggaa atctggagat
      541 gcagatactg tgtttccttg ctcttcgtcc atatcaataa aattaagttt ctcgtcttaa
      601 aaagaaa
//
