LOCUS       NM_003385               2428 bp    mRNA    linear   PRI 03-AUG-2024
DEFINITION  Homo sapiens visinin like 1 (VSNL1), transcript variant 1, mRNA.
ACCESSION   NM_003385
VERSION     NM_003385.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2428)
  AUTHORS   Tage,H., Yamaguchi,K., Nakagawa,S., Kasuga,S., Takane,K.,
            Furukawa,Y. and Ikenoue,T.
  TITLE     Visinin-like 1, a novel target gene of the Wnt/beta-catenin
            signaling pathway, is involved in apoptosis resistance in
            colorectal cancer
  JOURNAL   Cancer Med 12 (12), 13426-13437 (2023)
   PUBMED   37096864
  REMARK    GeneRIF: Visinin-like 1, a novel target gene of the
            Wnt/beta-catenin signaling pathway, is involved in apoptosis
            resistance in colorectal cancer.
REFERENCE   2  (bases 1 to 2428)
  AUTHORS   Halbgebauer,S., Steinacker,P., Riedel,D., Oeckl,P.,
            Anderl-Straub,S., Lombardi,J., von Arnim,C.A.F., Nagl,M., Giese,A.,
            Ludolph,A.C. and Otto,M.
  TITLE     Visinin-like protein 1 levels in blood and CSF as emerging markers
            for Alzheimer's and other neurodegenerative diseases
  JOURNAL   Alzheimers Res Ther 14 (1), 175 (2022)
   PUBMED   36419075
  REMARK    GeneRIF: Visinin-like protein 1 levels in blood and CSF as emerging
            markers for Alzheimer's and other neurodegenerative diseases.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2428)
  AUTHORS   Yan,X.J., Li,Y.B., Liu,W., Dai,W.M. and Wang,C.L.
  TITLE     Predictive value of serum visinin-like protein-1 for early
            neurologic deterioration and three-month clinical outcome in acute
            primary basal ganglia hemorrhage: A prospective and observational
            study
  JOURNAL   Clin Chim Acta 531, 62-67 (2022)
   PUBMED   35292254
  REMARK    GeneRIF: Predictive value of serum visinin-like protein-1 for early
            neurologic deterioration and three-month clinical outcome in acute
            primary basal ganglia hemorrhage: A prospective and observational
            study.
REFERENCE   4  (bases 1 to 2428)
  AUTHORS   He,C., Liu,W., Xiong,Y., Wang,Y., Pan,L., Luo,L., Tu,Y., Song,R.
            and Chen,W.
  TITLE     VSNL1 Promotes Cell Proliferation, Migration, and Invasion in
            Colorectal Cancer by Binding with COL10A1
  JOURNAL   Ann Clin Lab Sci 52 (1), 60-72 (2022)
   PUBMED   35181619
  REMARK    GeneRIF: VSNL1 Promotes Cell Proliferation, Migration, and Invasion
            in Colorectal Cancer by Binding with COL10A1.
            Erratum:[Ann Clin Lab Sci. 2022 May;52(3):510.. PMID: 35777801]
REFERENCE   5  (bases 1 to 2428)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   6  (bases 1 to 2428)
  AUTHORS   Braunewell,K.H., Spilker,C., Behnisch,T. and Gundelfinger,E.D.
  TITLE     The neuronal calcium-sensor protein VILIP modulates cyclic AMP
            accumulation in stably transfected C6 glioma cells: amino-terminal
            myristoylation determines functional activity
  JOURNAL   J Neurochem 68 (5), 2129-2139 (1997)
   PUBMED   9109541
  REMARK    GeneRIF: VILIP-1 modulates cAMP-accumulation in C6 glioma cells
REFERENCE   7  (bases 1 to 2428)
  AUTHORS   Lenz,S.E., Braunewell,K.H., Weise,C., Nedlina-Chittka,A. and
            Gundelfinger,E.D.
  TITLE     The neuronal EF-hand Ca(2+)-binding protein VILIP: interaction with
            cell membrane and actin-based cytoskeleton
  JOURNAL   Biochem Biophys Res Commun 225 (3), 1078-1083 (1996)
   PUBMED   8780737
  REMARK    GeneRIF: VILIP-1 interacts with cell membrane and actin-based
            cytoskeleton
REFERENCE   8  (bases 1 to 2428)
  AUTHORS   Polymeropoulos,M.H., Ide,S., Soares,M.B. and Lennon,G.G.
  TITLE     Sequence characterization and genetic mapping of the human VSNL1
            gene, a homologue of the rat visinin-like peptide RNVP1
  JOURNAL   Genomics 29 (1), 273-275 (1995)
   PUBMED   8530085
REFERENCE   9  (bases 1 to 2428)
  AUTHORS   Kuno,T., Kajimoto,Y., Hashimoto,T., Mukai,H., Shirai,Y., Saheki,S.
            and Tanaka,C.
  TITLE     cDNA cloning of a neural visinin-like Ca(2+)-binding protein
  JOURNAL   Biochem Biophys Res Commun 184 (3), 1219-1225 (1992)
   PUBMED   1375457
REFERENCE   10 (bases 1 to 2428)
  AUTHORS   Kose,A., Ito,A., Saito,N. and Tanaka,C.
  TITLE     Electron microscopic localization of gamma- and beta II-subspecies
            of protein kinase C in rat hippocampus
  JOURNAL   Brain Res 518 (1-2), 209-217 (1990)
   PUBMED   2202488
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BI544338.1, BC022012.2,
            BF055598.1 and AC097377.3.
            
            On May 17, 2019 this sequence version replaced NM_003385.4.
            
            Summary: This gene is a member of the visinin/recoverin subfamily
            of neuronal calcium sensor proteins. The encoded protein is
            strongly expressed in granule cells of the cerebellum where it
            associates with membranes in a calcium-dependent manner and
            modulates intracellular signaling pathways of the central nervous
            system by directly or indirectly regulating the activity of
            adenylyl cyclase. Alternatively spliced transcript variants have
            been observed, but their full-length nature has not been
            determined. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.102015.1,
                                           SRR1660807.147814.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000295156.9/ ENSP00000295156.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                BI544338.1         158-168
            12-911              BC022012.2         5-904
            912-1846            BC022012.2         909-1843
            1847-1849           BF055598.1         182-184
            1850-2428           AC097377.3         58293-58871
FEATURES             Location/Qualifiers
     source          1..2428
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p24.2"
     gene            1..2428
                     /gene="VSNL1"
                     /gene_synonym="HLP3; HPCAL3; HUVISL1; VILIP; VILIP-1"
                     /note="visinin like 1"
                     /db_xref="GeneID:7447"
                     /db_xref="HGNC:HGNC:12722"
                     /db_xref="MIM:600817"
     exon            1..223
                     /gene="VSNL1"
                     /gene_synonym="HLP3; HPCAL3; HUVISL1; VILIP; VILIP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            224..390
                     /gene="VSNL1"
                     /gene_synonym="HLP3; HPCAL3; HUVISL1; VILIP; VILIP-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             229..804
                     /gene="VSNL1"
                     /gene_synonym="HLP3; HPCAL3; HUVISL1; VILIP; VILIP-1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     hippocalcin-like protein 3; visinin-like protein 1; VLP-1"
                     /codon_start=1
                     /product="visinin-like protein 1 isoform 1"
                     /protein_id="NP_003376.2"
                     /db_xref="CCDS:CCDS1689.1"
                     /db_xref="GeneID:7447"
                     /db_xref="HGNC:HGNC:12722"
                     /db_xref="MIM:600817"
                     /translation="MGKQNSKLAPEVMEDLVKSTEFNEHELKQWYKGFLKDCPSGRLN
                     LEEFQQLYVKFFPYGDASKFAQHAFRTFDKNGDGTIDFREFICALSITSRGSFEQKLN
                     WAFNMYDLDGDGKITRVEMLEIIEAIYKMVGTVIMMKMNEDGLTPEQRVDKIFSKMDK
                     NKDDQITLDEFKEAAKSDPSIVLLLQCDIQK"
     exon            391..606
                     /gene="VSNL1"
                     /gene_synonym="HLP3; HPCAL3; HUVISL1; VILIP; VILIP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            607..2428
                     /gene="VSNL1"
                     /gene_synonym="HLP3; HPCAL3; HUVISL1; VILIP; VILIP-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1574..1579
                     /regulatory_class="polyA_signal_sequence"
                     /gene="VSNL1"
                     /gene_synonym="HLP3; HPCAL3; HUVISL1; VILIP; VILIP-1"
                     /note="hexamer: AATAAA"
     polyA_site      1593
                     /gene="VSNL1"
                     /gene_synonym="HLP3; HPCAL3; HUVISL1; VILIP; VILIP-1"
     regulatory      1828..1833
                     /regulatory_class="polyA_signal_sequence"
                     /gene="VSNL1"
                     /gene_synonym="HLP3; HPCAL3; HUVISL1; VILIP; VILIP-1"
                     /note="hexamer: AATAAA"
     polyA_site      1849
                     /gene="VSNL1"
                     /gene_synonym="HLP3; HPCAL3; HUVISL1; VILIP; VILIP-1"
                     /note="major polyA site"
ORIGIN      
        1 aatctgcagc agagatttac ccgagcgtgt tgcggcagcg gctgggcttg caaggcgcga
       61 tccaagaggg atttaagcag cccagagctc cagagaaaaa gagagcgaga gagaaccaca
      121 cacagagacg gcttaagcgt ttacccgaat taaatatata tttttaaaaa gaactgttga
      181 gttttatcat tttcgttaag tgaccgtgcg cagcgctgta actgcaggat ggggaagcag
      241 aatagcaaac tggcccctga agtgatggag gacctggtga agagcacaga gtttaatgag
      301 catgaactca agcagtggta caaaggattt ctcaaggact gtccaagtgg gaggctaaat
      361 ctcgaggaat ttcagcagct ctatgtgaag ttctttcctt atggagacgc ctccaagttt
      421 gcccagcatg ccttccgaac cttcgacaag aatggggacg gcaccattga cttccgagag
      481 ttcatctgcg ctctgtccat cacctccagg ggcagctttg agcagaagct gaactgggcc
      541 ttcaatatgt atgacctgga tggtgatggc aagatcaccc gagtggagat gctggagatc
      601 atcgaggcta tctacaaaat ggtaggcact gtgatcatga tgaaaatgaa tgaggatggc
      661 ctgacgcctg agcagcgagt agacaagatt ttcagcaaga tggataagaa caaagatgac
      721 cagattacac tggatgaatt caaagaagct gcaaagagcg acccttccat tgtattactt
      781 ctgcagtgcg acatccagaa atgagctgat gtcaatgcta tggactgcac aaaagtctca
      841 atgttccatt cagtctgcag ctattcacac acacacacac acacacacac acacacacac
      901 acacacacac aaatattgct tggactacct ataaatggac ttgcttcttg tgtttgaaac
      961 actcgtgtgc atgagaatgt catttgctaa tgaattttaa aagcatatat aaaacaaaac
     1021 aaacaacctg ccacaatgtg atatgtgtaa tatcatttca taaaaatccc tcttcctcca
     1081 aagcctgggc agaaatgtgc tgcaaagagt tatatgactt cttgttcatg ttttgctaat
     1141 gctcgtatct ccttgattac ataatgttag tagcactgag acccccatgg taatgtaact
     1201 taattataag ctatgtcact accctcctgt aaaatactat tggacagaca cagagggacc
     1261 cttggctcct gtgtctggtc cacacaccac agaagcttgt attatcagtg aatataaatg
     1321 tactacattt gcatgccttt tgggtttgcc ttaattctta cctcatttgc atcctatcga
     1381 tctggaaaga gctgttttgg atgaatgcag tataaaatgt aaaaaccctg ctaaatgact
     1441 tattgattaa gtatatctat ctatatatac atatacacaa agatattatt tatcgaaagt
     1501 aaaaaagatg gaagtgtatt ggtttctgtt tgaattttca aaggcttcca atgtggtggc
     1561 aataaatgtc ccaaataaat ttataacaat tgattttccc cctaattctt attttataat
     1621 tttaaaattg cagcagttgc tagcaacaac ttactaaatc tactcttaaa tatacaactt
     1681 tggaatttga agaattaatg acaacaaaag ggaaaaaagc aactttccaa cttttcatcc
     1741 aggctcccaa aagagggaca acgaacatgg catgtgaaaa gtaaaacaga tttgttcatt
     1801 ccgaaaaaaa aatgttcatt ctatgacaat aaattttatc tcagtgtgac tttggtgcta
     1861 acaacgtatg ttcagtgcaa ctacgtggag ctgtgcacac acagcaggta ggctgcaggt
     1921 gtcccccaac ataagtcagt aggaaagaag acatctgtct tcccaaatct aaagtaggca
     1981 aaaaataaca gaagtagcta tttttaataa cagaacagaa ctctgactct tttgatcttg
     2041 aaggaggcag aagagattcc atcaaaacct ctaaaagcag gtttgcattt tcagaacatg
     2101 cccccctaga gagttgagtt ttttacacag cactacccgg tagtactttc tctgatgatg
     2161 ggaaggtcta catctgcaca gcacgctagc tataactgca catatggcta ctgagcactt
     2221 caagtatggc tagcgtgact aaggaactga attttatact gtaattaagt gtaatttgcc
     2281 acatatagct agtggcttta gtaacagaca gtttagtgct atattattta ttcaagtact
     2341 ttttatcaaa ttcgtttttt accgaattcg ttttttacca ttctttattt gtcttaggat
     2401 cattacataa cactaaacta gggtctaa
//
