LOCUS       NM_022153               4714 bp    mRNA    linear   PRI 03-SEP-2024
DEFINITION  Homo sapiens V-set immunoregulatory receptor (VSIR), mRNA.
ACCESSION   NM_022153
VERSION     NM_022153.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4714)
  AUTHORS   Chen,H., Molberg,K., Carrick,K., Niu,S., Rivera Colon,G., Gwin,K.,
            Lewis,C., Lea,J., Panwar,V., Zheng,W., Castrillon,D.H. and Lucas,E.
  TITLE     Expression and Prognostic Significance of LAG-3, TIGIT, VISTA, and
            IDO1 in Endometrial Serous Carcinoma
  JOURNAL   Mod Pathol 37 (8), 100532 (2024)
   PUBMED   38848896
  REMARK    GeneRIF: Expression and Prognostic Significance of LAG-3, TIGIT,
            VISTA, and IDO1 in Endometrial Serous Carcinoma.
REFERENCE   2  (bases 1 to 4714)
  AUTHORS   Chen,L., Zhou,B., Tang,M., Yao,Y., Zhao,Y., Hu,Y., Lin,Y., Ji,J.
            and Jiao,Q.
  TITLE     Aberrant expression of B7-H4 and B7-H5 contributes to the
            development of cutaneous squamous cell carcinoma
  JOURNAL   Arch Dermatol Res 316 (7), 382 (2024)
   PUBMED   38850312
  REMARK    GeneRIF: Aberrant expression of B7-H4 and B7-H5 contributes to the
            development of cutaneous squamous cell carcinoma.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4714)
  AUTHORS   Ta,H.M., Roy,D., Zhang,K., Alban,T., Juric,I., Dong,J.,
            Parthasarathy,P.B., Patnaik,S., Delaney,E., Gilmour,C., Zakeri,A.,
            Shukla,N., Rupani,A., Phoon,Y.P., Liu,C., Avril,S., Gastman,B.,
            Chan,T. and Wang,L.L.
  TITLE     LRIG1 engages ligand VISTA and impairs tumor-specific CD8+ T cell
            responses
  JOURNAL   Sci Immunol 9 (95), eadi7418 (2024)
   PUBMED   38758807
  REMARK    GeneRIF: LRIG1 engages ligand VISTA and impairs tumor-specific
            CD8[+] T cell responses.
REFERENCE   4  (bases 1 to 4714)
  AUTHORS   Rezagholizadeh,F., Tajik,F., Talebi,M., Taha,S.R., Shariat
            Zadeh,M., Farhangnia,P., Hosseini,H.S., Nazari,A., Mollazadeh
            Ghomi,S., Kamrani Mousavi,S.M., Haeri Moghaddam,N.,
            Khorramdelazad,H., Joghataei,M.T. and Safari,E.
  TITLE     Unraveling the potential of CD8, CD68, and VISTA as diagnostic and
            prognostic markers in patients with pancreatic ductal
            adenocarcinoma
  JOURNAL   Front Immunol 15, 1283364 (2024)
   PUBMED   38357542
  REMARK    GeneRIF: Unraveling the potential of CD8, CD68, and VISTA as
            diagnostic and prognostic markers in patients with pancreatic
            ductal adenocarcinoma.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4714)
  AUTHORS   Zhang,K., Zakeri,A., Alban,T., Dong,J., Ta,H.M., Zalavadia,A.H.,
            Branicky,A., Zhao,H., Juric,I., Husich,H., Parthasarathy,P.B.,
            Rupani,A., Drazba,J.A., Chakraborty,A.A., Ching-Cheng Huang,S.,
            Chan,T., Avril,S. and Wang,L.L.
  TITLE     VISTA promotes the metabolism and differentiation of
            myeloid-derived suppressor cells by STAT3 and polyamine-dependent
            mechanisms
  JOURNAL   Cell Rep 43 (1), 113661 (2024)
   PUBMED   38175754
  REMARK    GeneRIF: VISTA promotes the metabolism and differentiation of
            myeloid-derived suppressor cells by STAT3 and polyamine-dependent
            mechanisms.
REFERENCE   6  (bases 1 to 4714)
  AUTHORS   Wan,D., Gong,Y., Qin,W., Zhang,P., Li,J., Wei,L., Zhou,X., Li,H.,
            Qiu,X., Zhong,F., He,L., Yu,J., Yao,G., Jiang,H., Qian,L., Yu,Y.,
            Shu,H., Chen,X., Xu,H., Guo,M., Pan,Z., Chen,Y., Ge,C., Yang,S. and
            Gu,J.
  TITLE     Large-scale cDNA transfection screening for genes related to cancer
            development and progression
  JOURNAL   Proc Natl Acad Sci U S A 101 (44), 15724-15729 (2004)
   PUBMED   15498874
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2004 Dec 14:101(50):17565]
REFERENCE   7  (bases 1 to 4714)
  AUTHORS   Zhang,Z. and Henzel,W.J.
  TITLE     Signal peptide prediction based on analysis of experimentally
            verified cleavage sites
  JOURNAL   Protein Sci 13 (10), 2819-2824 (2004)
   PUBMED   15340161
REFERENCE   8  (bases 1 to 4714)
  AUTHORS   Colland,F., Jacq,X., Trouplin,V., Mougin,C., Groizeleau,C.,
            Hamburger,A., Meil,A., Wojcik,J., Legrain,P. and Gauthier,J.M.
  TITLE     Functional proteomics mapping of a human signaling pathway
  JOURNAL   Genome Res 14 (7), 1324-1332 (2004)
   PUBMED   15231748
REFERENCE   9  (bases 1 to 4714)
  AUTHORS   Deloukas,P., Earthrowl,M.E., Grafham,D.V., Rubenfield,M.,
            French,L., Steward,C.A., Sims,S.K., Jones,M.C., Searle,S.,
            Scott,C., Howe,K., Hunt,S.E., Andrews,T.D., Gilbert,J.G.,
            Swarbreck,D., Ashurst,J.L., Taylor,A., Battles,J., Bird,C.P.,
            Ainscough,R., Almeida,J.P., Ashwell,R.I., Ambrose,K.D.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Bates,K.,
            Beasley,H., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.C.,
            Burrill,W., Burton,J., Cahill,P., Camire,D., Carter,N.P.,
            Chapman,J.C., Clark,S.Y., Clarke,G., Clee,C.M., Clegg,S., Corby,N.,
            Coulson,A., Dhami,P., Dutta,I., Dunn,M., Faulkner,L., Frankish,A.,
            Frankland,J.A., Garner,P., Garnett,J., Gribble,S., Griffiths,C.,
            Grocock,R., Gustafson,E., Hammond,S., Harley,J.L., Hart,E.,
            Heath,P.D., Ho,T.P., Hopkins,B., Horne,J., Howden,P.J., Huckle,E.,
            Hynds,C., Johnson,C., Johnson,D., Kana,A., Kay,M., Kimberley,A.M.,
            Kershaw,J.K., Kokkinaki,M., Laird,G.K., Lawlor,S., Lee,H.M.,
            Leongamornlert,D.A., Laird,G., Lloyd,C., Lloyd,D.M., Loveland,J.,
            Lovell,J., McLaren,S., McLay,K.E., McMurray,A.,
            Mashreghi-Mohammadi,M., Matthews,L., Milne,S., Nickerson,T.,
            Nguyen,M., Overton-Larty,E., Palmer,S.A., Pearce,A.V., Peck,A.I.,
            Pelan,S., Phillimore,B., Porter,K., Rice,C.M., Rogosin,A.,
            Ross,M.T., Sarafidou,T., Sehra,H.K., Shownkeen,R., Skuce,C.D.,
            Smith,M., Standring,L., Sycamore,N., Tester,J., Thorpe,A.,
            Torcasso,W., Tracey,A., Tromans,A., Tsolas,J., Wall,M., Walsh,J.,
            Wang,H., Weinstock,K., West,A.P., Willey,D.L., Whitehead,S.L.,
            Wilming,L., Wray,P.W., Young,L., Chen,Y., Lovering,R.C.,
            Moschonas,N.K., Siebert,R., Fechtel,K., Bentley,D., Durbin,R.,
            Hubbard,T., Doucette-Stamm,L., Beck,S., Smith,D.R. and Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 10
  JOURNAL   Nature 429 (6990), 375-381 (2004)
   PUBMED   15164054
REFERENCE   10 (bases 1 to 4714)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AY358379.1 and AL731541.6.
            
            On Nov 22, 2018 this sequence version replaced NM_022153.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.102915.1,
                                           SRR1803613.107577.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000394957.8/ ENSP00000378409.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1948              AY358379.1         61-2008
            1949-4714           AL731541.6         92327-95092         c
FEATURES             Location/Qualifiers
     source          1..4714
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q22.1"
     gene            1..4714
                     /gene="VSIR"
                     /gene_synonym="B7-H5; B7H5; C10orf54; DD1alpha; Dies1;
                     GI24; PD-1H; PP2135; SISP1; VISTA"
                     /note="V-set immunoregulatory receptor"
                     /db_xref="GeneID:64115"
                     /db_xref="HGNC:HGNC:30085"
                     /db_xref="MIM:615608"
     exon            1..163
                     /gene="VSIR"
                     /gene_synonym="B7-H5; B7H5; C10orf54; DD1alpha; Dies1;
                     GI24; PD-1H; PP2135; SISP1; VISTA"
                     /inference="alignment:Splign:2.1.0"
     CDS             82..1017
                     /gene="VSIR"
                     /gene_synonym="B7-H5; B7H5; C10orf54; DD1alpha; Dies1;
                     GI24; PD-1H; PP2135; SISP1; VISTA"
                     /note="platelet receptor GI24; sisp-1; stress-induced
                     secreted protein-1; Death Domain1alpha; V-domain Ig
                     suppressor of T cell activation; V-set domain-containing
                     immunoregulatory receptor; V-type immunoglobulin
                     domain-containing suppressor of T-cell activation; PDCD1
                     homolog"
                     /codon_start=1
                     /product="V-type immunoglobulin domain-containing
                     suppressor of T-cell activation precursor"
                     /protein_id="NP_071436.1"
                     /db_xref="CCDS:CCDS31218.1"
                     /db_xref="GeneID:64115"
                     /db_xref="HGNC:HGNC:30085"
                     /db_xref="MIM:615608"
                     /translation="MGVPTALEAGSWRWGSLLFALFLAASLGPVAAFKVATPYSLYVC
                     PEGQNVTLTCRLLGPVDKGHDVTFYKTWYRSSRGEVQTCSERRPIRNLTFQDLHLHHG
                     GHQAANTSHDLAQRHGLESASDHHGNFSITMRNLTLLDSGLYCCLVVEIRHHHSEHRV
                     HGAMELQVQTGKDAPSNCVVYPSSSQDSENITAAALATGACIVGILCLPLILLLVYKQ
                     RQAASNRRAQELVRMDSNIQGIENPGFEASPPAQGIPEAKVRHPLSYVAQRQPSESGR
                     HLLSEPSTPLSPPGPGDVFFPSLDPVPDSPNFEVI"
     exon            164..592
                     /gene="VSIR"
                     /gene_synonym="B7-H5; B7H5; C10orf54; DD1alpha; Dies1;
                     GI24; PD-1H; PP2135; SISP1; VISTA"
                     /inference="alignment:Splign:2.1.0"
     exon            593..649
                     /gene="VSIR"
                     /gene_synonym="B7-H5; B7H5; C10orf54; DD1alpha; Dies1;
                     GI24; PD-1H; PP2135; SISP1; VISTA"
                     /inference="alignment:Splign:2.1.0"
     exon            650..757
                     /gene="VSIR"
                     /gene_synonym="B7-H5; B7H5; C10orf54; DD1alpha; Dies1;
                     GI24; PD-1H; PP2135; SISP1; VISTA"
                     /inference="alignment:Splign:2.1.0"
     exon            758..785
                     /gene="VSIR"
                     /gene_synonym="B7-H5; B7H5; C10orf54; DD1alpha; Dies1;
                     GI24; PD-1H; PP2135; SISP1; VISTA"
                     /inference="alignment:Splign:2.1.0"
     exon            786..979
                     /gene="VSIR"
                     /gene_synonym="B7-H5; B7H5; C10orf54; DD1alpha; Dies1;
                     GI24; PD-1H; PP2135; SISP1; VISTA"
                     /inference="alignment:Splign:2.1.0"
     exon            980..4714
                     /gene="VSIR"
                     /gene_synonym="B7-H5; B7H5; C10orf54; DD1alpha; Dies1;
                     GI24; PD-1H; PP2135; SISP1; VISTA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1928..1933
                     /regulatory_class="polyA_signal_sequence"
                     /gene="VSIR"
                     /gene_synonym="B7-H5; B7H5; C10orf54; DD1alpha; Dies1;
                     GI24; PD-1H; PP2135; SISP1; VISTA"
                     /note="hexamer: ATTAAA"
     polyA_site      1965
                     /gene="VSIR"
                     /gene_synonym="B7-H5; B7H5; C10orf54; DD1alpha; Dies1;
                     GI24; PD-1H; PP2135; SISP1; VISTA"
                     /note="major polyA site"
     regulatory      4690..4695
                     /regulatory_class="polyA_signal_sequence"
                     /gene="VSIR"
                     /gene_synonym="B7-H5; B7H5; C10orf54; DD1alpha; Dies1;
                     GI24; PD-1H; PP2135; SISP1; VISTA"
                     /note="hexamer: AGTAAA"
     polyA_site      4714
                     /gene="VSIR"
                     /gene_synonym="B7-H5; B7H5; C10orf54; DD1alpha; Dies1;
                     GI24; PD-1H; PP2135; SISP1; VISTA"
                     /note="major polyA site"
ORIGIN      
        1 agtcgcggga ggcttccccg cgccggccgc gtcccgcccg ctccccggca ccagaagttc
       61 ctctgcgcgt ccgacggcga catgggcgtc cccacggccc tggaggccgg cagctggcgc
      121 tggggatccc tgctcttcgc tctcttcctg gctgcgtccc taggtccggt ggcagccttc
      181 aaggtcgcca cgccgtattc cctgtatgtc tgtcccgagg ggcagaacgt caccctcacc
      241 tgcaggctct tgggccctgt ggacaaaggg cacgatgtga ccttctacaa gacgtggtac
      301 cgcagctcga ggggcgaggt gcagacctgc tcagagcgcc ggcccatccg caacctcacg
      361 ttccaggacc ttcacctgca ccatggaggc caccaggctg ccaacaccag ccacgacctg
      421 gctcagcgcc acgggctgga gtcggcctcc gaccaccatg gcaacttctc catcaccatg
      481 cgcaacctga ccctgctgga tagcggcctc tactgctgcc tggtggtgga gatcaggcac
      541 caccactcgg agcacagggt ccatggtgcc atggagctgc aggtgcagac aggcaaagat
      601 gcaccatcca actgtgtggt gtacccatcc tcctcccagg atagtgaaaa catcacggct
      661 gcagccctgg ctacgggtgc ctgcatcgta ggaatcctct gcctccccct catcctgctc
      721 ctggtctaca agcaaaggca ggcagcctcc aaccgccgtg cccaggagct ggtgcggatg
      781 gacagcaaca ttcaagggat tgaaaacccc ggctttgaag cctcaccacc tgcccagggg
      841 atacccgagg ccaaagtcag gcaccccctg tcctatgtgg cccagcggca gccttctgag
      901 tctgggcggc atctgctttc ggagcccagc acccccctgt ctcctccagg ccccggagac
      961 gtcttcttcc catccctgga ccctgtccct gactctccaa actttgaggt catctagccc
     1021 agctggggga cagtgggctg ttgtggctgg gtctggggca ggtgcatttg agccagggct
     1081 ggctctgtga gtggcctcct tggcctcggc cctggttccc tccctcctgc tctgggctca
     1141 gatactgtga catcccagaa gcccagcccc tcaacccctc tggatgctac atggggatgc
     1201 tggacggctc agcccctgtt ccaaggattt tggggtgctg agattctccc ctagagacct
     1261 gaaattcacc agctacagat gccaaatgac ttacatctta agaagtctca gaacgtccag
     1321 cccttcagca gctctcgttc tgagacatga gccttgggat gtggcagcat cagtgggaca
     1381 agatggacac tgggccaccc tcccaggcac cagacacagg gcacggtgga gagacttctc
     1441 ccccgtggcc gccttggctc ccccgttttg cccgaggctg ctcttctgtc agacttcctc
     1501 tttgtaccac agtggctctg gggccaggcc tgcctgccca ctggccatcg ccaccttccc
     1561 cagctgcctc ctaccagcag tttctctgaa gatctgtcaa caggttaagt caatctgggg
     1621 cttccactgc ctgcattcca gtccccagag cttggtggtc ccgaaacggg aagtacatat
     1681 tggggcatgg tggcctccgt gagcaaatgg tgtcttgggc aatctgaggc caggacagat
     1741 gttgccccac ccactggaga tggtgctgag ggaggtgggt ggggccttct gggaaggtga
     1801 gtggagaggg gcacctgccc cccgccctcc ccatccccta ctcccactgc tcagcgcggg
     1861 ccattgcaag ggtgccacac aatgtcttgt ccaccctggg acacttctga gtatgaagcg
     1921 ggatgctatt aaaaactaca tggggaaaca ggtgcaaacc ctggagatgg attgtaagag
     1981 ccagtttaaa tctgcactct gctgctcctc ccccaccccc accttccact ccatacaatc
     2041 tgggcctggt ggagtcttcg cttcagagcc attcggccag gtgcgggtga tgttcccatc
     2101 tcctgcttgt gggcatgccc tggctttgtt tttatacaca taggcaaggt gagtcctctg
     2161 tggaattgtg attgaaggat tttaaagcag gggaggagag tagggggcat ctctgtacac
     2221 tctgggggta aaacagggaa ggcagtgcct gagcatgggg acaggtgagg tggggctggg
     2281 cagaccccct gtagcgttta gcaggatggg ggccccaggt actgtggaga gcatagtcca
     2341 gcctgggcat ttgtctccta gcagcctaca ctggctctgc tgagctgggc ctgggtgctg
     2401 aaagccagga tttggggcta ggcgggaaga tgttcgccca attgcttggg gggttggggg
     2461 gatggaaaag gggagcacct ctaggctgcc tggcagcagt gagccctggg cctgtggcta
     2521 cagccaggga accccacctg gacacatggc cctgcttcta agccccccag ttaggcccaa
     2581 aggaatggtc cactgagggc ctcctgctct gcctgggctg ggccaggggc tttgaggaga
     2641 gggtaaacat aggcccggag atggggctga cacctcgagt ggccagaata tgcccaaacc
     2701 ccggcttctc ccttgtccct aggcagaggg gggtcccttc ttttgttccc tctggtcacc
     2761 acaatgcttg atgccagctg ccataggaag agggtgctgg ctggccatgg tggcacacac
     2821 ctgtcctccc agcactttgc agggctgagg tggaaggacc gcttaagccc aggtgttcaa
     2881 ggctgctgtg agctgtgttc gagccactac actccagcct ggggacggag caaaactttg
     2941 cctcaaaaca aattttaaaa agaaagaaag aaggaaagag ggtatgtttt tcacaattca
     3001 tgggggcctg catggcagga gtggggacag gacacctgct gttcctggag tcgaaggaca
     3061 agcccacagc ccagattccg gttctcccaa ctcaggaaga gcatgccctg ccctctgggg
     3121 aggctggcct ggccccagcc ctcagctgct gaccttgagg cagagacaac ttctaagaat
     3181 ttggctgcca gaccccaggc ctggctgctg ctgtgtggag agggaggcgg cccgcagcag
     3241 aacagccacc gcacttcctc ctcagcttcc tctggtgcgg ccctgccctc tcttctctgg
     3301 acccttttac aactgaacgc atctgggctt cgtggtttcc tgttttcagc gaaatttact
     3361 ctgagctccc agttccatct tcatccatgg ccacaggccc tgcctacaac gcactaggga
     3421 cgtccctccc tgctgctgct ggggaggggc aggctgctgg agccgccctc tgagttgccc
     3481 gggatggtag tgcctctgat gccagccctg gtggctgtgg gctggggtgc atgggagagc
     3541 tgggtgcgag aacatggcgc ctccaggggg cgggaggagc actaggggct ggggcaggag
     3601 gctcctggag cgctggattc gtggcacagt ctgaggccct gagagggaaa tccatgcttt
     3661 taagaactaa ttcattgtta ggagatcaat caggaattag gggccatctt acctatctcc
     3721 tgacattcac agtttaatag agacttcctg cctttattcc ctcccaggga gaggctgaag
     3781 gaatggaatt gaaagcacca tttggagggt tttgctgaca cagcggggac tgctcagcac
     3841 tccctaaaaa cacaccatgg aggccactgg tgactgctgg tgggcaggct ggccctgcct
     3901 gggggagtcc gtggcgatgg gcgctggggt ggaggtgcag gagccccagg acctgctttt
     3961 caaaagactt ctgcctgacc agagctccca ctacatgcag tggcccaggg cagaggggct
     4021 gatacatggc ctttttcagg gggtgctcct cgcggggtgg acttgggagt gtgcagtggg
     4081 acagggggct gcaggggtcc tgccaccacc gagcaccaac ttggcccctg gggtcctgcc
     4141 tcatgaatga ggccttcccc agggctggcc tgactgtgct gggggctggg ttaacgtttt
     4201 ctcagggaac cacaatgcac gaaagaggaa ctggggttgc taaccaggat gctgggaaca
     4261 aaggcctctt gaagcccagc cacagcccag ctgagcatga ggcccagccc atagacggca
     4321 caggccacct ggcccattcc ctgggcattc cctgctttgc attgctgctt ctcttcaccc
     4381 catggaggct atgtcaccct aactatcctg gaatgtgttg agagggattc tgaatgatca
     4441 atatagcttg gtgagacagt gccgagatag atagccatgt ctgccttggg cacgggagag
     4501 ggaagtggca gcatgcatgc tgtttcttgg ccttttctgt tagaatactt ggtgctttcc
     4561 aacacacttt cacatgtgtt gtaacttgtt tgatccaccc ccttccctga aaatcctggg
     4621 aggttttatt gctgccattt aacacagagg gcaatagagg ttctgaaagg tctgtgtctt
     4681 gtcaaaacaa gtaaacggtg gaactacgac taaa
//
