LOCUS       NM_001013661            1818 bp    mRNA    linear   PRI 13-FEB-2025
DEFINITION  Homo sapiens V-set and immunoglobulin domain containing 8 (VSIG8),
            mRNA.
ACCESSION   NM_001013661 XM_372802
VERSION     NM_001013661.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1818)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 1818)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   3  (bases 1 to 1818)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL590560.9.
            
            On Mar 30, 2005 this sequence version replaced XM_372802.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC132895.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145893 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000368100.1/ ENSP00000357080.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-185               AL590560.9         87445-87629         c
            186-364             AL590560.9         83706-83884         c
            365-566             AL590560.9         83062-83263         c
            567-788             AL590560.9         82717-82938         c
            789-908             AL590560.9         81496-81615         c
            909-1107            AL590560.9         80855-81053         c
            1108-1818           AL590560.9         79288-79998         c
FEATURES             Location/Qualifiers
     source          1..1818
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q23.2"
     gene            1..1818
                     /gene="VSIG8"
                     /note="V-set and immunoglobulin domain containing 8"
                     /db_xref="GeneID:391123"
                     /db_xref="HGNC:HGNC:32063"
                     /db_xref="MIM:621098"
     exon            1..185
                     /gene="VSIG8"
                     /inference="alignment:Splign:2.1.0"
     CDS             137..1381
                     /gene="VSIG8"
                     /note="V-set and immunoglobulin domain-containing protein
                     8"
                     /codon_start=1
                     /product="V-set and immunoglobulin domain-containing
                     protein 8 precursor"
                     /protein_id="NP_001013683.1"
                     /db_xref="CCDS:CCDS30913.1"
                     /db_xref="GeneID:391123"
                     /db_xref="HGNC:HGNC:32063"
                     /db_xref="MIM:621098"
                     /translation="MRVGGAFHLLLVCLSPALLSAVRINGDGQEVLYLAEGDNVRLGC
                     PYVLDPEDYGPNGLDIEWMQVNSDPAHHRENVFLSYQDKRINHGSLPHLQQRVRFAAS
                     DPSQYDASINLMNLQVSDTATYECRVKKTTMATRKVIVTVQARPAVPMCWTEGHMTYG
                     NDVVLKCYASGGSQPLSYKWAKISGHHYPYRAGSYTSQHSYHSELSYQESFHSSINQG
                     LNNGDLVLKDISRADDGLYQCTVANNVGYSVCVVEVKVSDSRRIGVIIGIVLGSLLAL
                     GCLAVGIWGLVCCCCGGSGAGGARGAFGYGNGGGVGGGACGDLASEIREDAVAPGCKA
                     SGRGSRVTHLLGYPTQNVSRSLRRKYAPPPCGGPEDVALAPCTAAAACEAGPSPVYVK
                     VKSAEPADCAEGPVQCKNGLLV"
     exon            186..364
                     /gene="VSIG8"
                     /inference="alignment:Splign:2.1.0"
     exon            365..566
                     /gene="VSIG8"
                     /inference="alignment:Splign:2.1.0"
     exon            567..788
                     /gene="VSIG8"
                     /inference="alignment:Splign:2.1.0"
     exon            789..908
                     /gene="VSIG8"
                     /inference="alignment:Splign:2.1.0"
     exon            909..1107
                     /gene="VSIG8"
                     /inference="alignment:Splign:2.1.0"
     exon            1108..1818
                     /gene="VSIG8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1796..1801
                     /regulatory_class="polyA_signal_sequence"
                     /gene="VSIG8"
                     /note="hexamer: AATAAA"
     polyA_site      1797
                     /gene="VSIG8"
     polyA_site      1818
                     /gene="VSIG8"
                     /note="major polyA site"
ORIGIN      
        1 actcattgca ccttcctgcc accccaggca gtgtctgggc cctcagctcc ccctccctcc
       61 acctaccccc tcacacccac cactacgacc ccacgggata cccagcccag acggaggaaa
      121 caccgagcct agagacatga gagttggagg agcattccac cttctactcg tgtgcctgag
      181 cccagcactg ctgtctgctg tgcggatcaa cggggatgga caggaggtcc tgtacctggc
      241 agaaggtgat aatgtgaggc tgggctgccc ctacgtcctg gaccctgagg actatggtcc
      301 caatgggctg gacatcgagt ggatgcaggt caactcagac cccgcccacc accgagagaa
      361 cgtgttcctt agttaccagg acaagaggat caaccatggc agccttcccc atctgcagca
      421 gagggtccgc tttgcagcct cagacccaag ccagtacgat gcctccatca acctcatgaa
      481 cctgcaggta tctgatacag ccacttatga gtgccgggtg aagaagacca ccatggccac
      541 ccggaaggtc attgtcactg tccaagcacg acctgcagtg cccatgtgct ggacagaggg
      601 ccacatgaca tatggcaacg atgtggtgct gaagtgctat gccagtgggg gctcccagcc
      661 cctctcctac aagtgggcca agatcagtgg gcaccattac ccctatcgag ctgggtctta
      721 cacctcccag cacagctacc actcagagct gtcctaccag gagtccttcc acagctccat
      781 aaaccaaggc ctgaacaatg gggacctggt gttgaaggat atctccagag cagatgatgg
      841 gctgtatcag tgcacagtgg ccaacaacgt gggctacagt gtttgtgtgg tggaggtgaa
      901 ggtctcagac tcccggcgta taggcgtgat catcggcatc gtcctgggct ctctgctcgc
      961 gctgggctgc ctggccgtag gcatctgggg gctcgtctgc tgctgctgcg ggggctccgg
     1021 ggctggcggc gcccgcggtg ccttcggcta cggcaacggc ggcggggtcg gcggaggggc
     1081 ctgcggcgac ttggctagtg agatcagaga ggacgccgtg gcgcccgggt gcaaggccag
     1141 cgggcgcggc agccgcgtca cccacctcct ggggtacccg acgcagaacg tcagccgctc
     1201 cctgcgccgc aagtacgcgc ctcccccctg cggcggcccc gaggacgtgg ccctggcgcc
     1261 ctgcaccgcc gccgccgcct gcgaagcggg cccctccccg gtctacgtca aggtcaagag
     1321 cgcggagccg gctgactgcg ccgaggggcc ggtgcagtgc aagaacggcc tcttggtgtg
     1381 agcgcgcgcg ccgggccggg ctgcgcccca gccaggagga gggcgcgggg ctctctgtct
     1441 gcagctgggg acacgtcggg gctggggacg acctcgctcg ccccaggctg ccaggcggct
     1501 gggggtgaag gcatttccct aaggaaatgc gtagggaggc agagcctcct ccccaaaagt
     1561 gggaaggggc gggcgagggc ggaggaaggc gatcctgagc cttctccgca cccccgggac
     1621 cgaaggcttg ggggagaggg agggaggagg aggctgagtg tcctagagcg gctgaggccg
     1681 gaggcctggt gtccccagcc taagcagagg gccccggggg ccgggtgggt gggggtctgt
     1741 ctggacgaat tgttctgtgt gtgaggtctg agctctgagg cagcagtgtt agcacaataa
     1801 agaaacattg agacgtga
//
