LOCUS       NM_007268               1807 bp    mRNA    linear   PRI 11-SEP-2024
DEFINITION  Homo sapiens V-set and immunoglobulin domain containing 4 (VSIG4),
            transcript variant 1, mRNA.
ACCESSION   NM_007268
VERSION     NM_007268.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1807)
  AUTHORS   Chong,Y.Y., Thiagarajan,S., Tan,Q.X., Lim,H.J., Tan,J.W.,
            Hendrikson,J., Ng,G., Liu,Y., Chong,C.Y.L., Guo,W., Ngo,N.T.,
            Leow,W.Q., Loh,T., Sam,X.X., Lim,T.K.H., Cai,M., Seo,C.J.,
            Wong,J.S.M., Soo,K.C., Chia,C.S., Shannon,N.B. and Ong,C.J.
  TITLE     The immunomodulatory role of paracrine signalling factor VSIG4 in
            peritoneal metastases
  JOURNAL   Sci Rep 14 (1), 17522 (2024)
   PUBMED   39080370
  REMARK    GeneRIF: The immunomodulatory role of paracrine signalling factor
            VSIG4 in peritoneal metastases.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1807)
  AUTHORS   Liao,Y., Deng,C. and Wang,X.
  TITLE     VSIG4 ameliorates intestinal inflammation through inhibiting
            macrophages NLRP3 inflammasome and pyroptosis
  JOURNAL   Tissue Cell 86, 102285 (2024)
   PUBMED   38113649
  REMARK    GeneRIF: VSIG4 ameliorates intestinal inflammation through
            inhibiting macrophages NLRP3 inflammasome and pyroptosis.
REFERENCE   3  (bases 1 to 1807)
  AUTHORS   Tang,C., Zhang,S., Teymur,A., Yang,B., Nazir,F., Cai,Q., Saxena,R.,
            Olsen,N.J., Mohan,C. and Wu,T.
  TITLE     V-Set Immunoglobulin Domain-Containing Protein 4 as a Novel Serum
            Biomarker of Lupus Nephritis and Renal Pathology Activity
  JOURNAL   Arthritis Rheumatol 75 (9), 1573-1585 (2023)
   PUBMED   37163449
  REMARK    GeneRIF: V-Set Immunoglobulin Domain-Containing Protein 4 as a
            Novel Serum Biomarker of Lupus Nephritis and Renal Pathology
            Activity.
REFERENCE   4  (bases 1 to 1807)
  AUTHORS   Duan,Y., Chu,H., Brandl,K., Jiang,L., Zeng,S., Meshgin,N.,
            Papachristoforou,E., Argemi,J., Mendes,B.G., Wang,Y., Su,H.,
            Sun,W., Llorente,C., Hendrikx,T., Liu,X., Hosseini,M.,
            Kisseleva,T., Brenner,D.A., Bataller,R., Ramachandran,P., Karin,M.,
            Fu,W. and Schnabl,B.
  TITLE     CRIg on liver macrophages clears pathobionts and protects against
            alcoholic liver disease
  JOURNAL   Nat Commun 12 (1), 7172 (2021)
   PUBMED   34887405
  REMARK    GeneRIF: CRIg on liver macrophages clears pathobionts and protects
            against alcoholic liver disease.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1807)
  AUTHORS   Vogt,L., Schmitz,N., Kurrer,M.O., Bauer,M., Hinton,H.I., Behnke,S.,
            Gatto,D., Sebbel,P., Beerli,R.R., Sonderegger,I., Kopf,M.,
            Saudan,P. and Bachmann,M.F.
  TITLE     VSIG4, a B7 family-related protein, is a negative regulator of T
            cell activation
  JOURNAL   J Clin Invest 116 (10), 2817-2826 (2006)
   PUBMED   17016562
  REMARK    GeneRIF: The specific expression of VSIG4 on resting macrophages
            suggests that VSIG4 may be important for the maintenance of T cell
            unresponsiveness in healthy tissues.
REFERENCE   6  (bases 1 to 1807)
  AUTHORS   Lee,M.Y., Kim,W.J., Kang,Y.J., Jung,Y.M., Kang,Y.M., Suk,K.,
            Park,J.E., Choi,E.M., Choi,B.K., Kwon,B.S. and Lee,W.H.
  TITLE     Z39Ig is expressed on macrophages and may mediate inflammatory
            reactions in arthritis and atherosclerosis
  JOURNAL   J Leukoc Biol 80 (4), 922-928 (2006)
   PUBMED   16882875
  REMARK    GeneRIF: These data indicate that the macrophage Z39Ig is involved
            in the pathogenesis of inflammatory diseases through chemokine
            induction, which will promote the migration of inflammatory cells
            into the lesion area, and MMP-9 induction.
REFERENCE   7  (bases 1 to 1807)
  AUTHORS   Helmy,K.Y., Katschke,K.J. Jr., Gorgani,N.N., Kljavin,N.M.,
            Elliott,J.M., Diehl,L., Scales,S.J., Ghilardi,N. and van Lookeren
            Campagne,M.
  TITLE     CRIg: a macrophage complement receptor required for phagocytosis of
            circulating pathogens
  JOURNAL   Cell 124 (5), 915-927 (2006)
   PUBMED   16530040
  REMARK    GeneRIF: Results report the identification and characterization of
            a Complement Receptor of the Immunoglobulin superfamily, CRIg, that
            binds complement fragments C3b and iC3b.
REFERENCE   8  (bases 1 to 1807)
  AUTHORS   Kim,J.K., Choi,E.M., Shin,H.I., Kim,C.H., Hwang,S.H., Kim,S.M. and
            Kwon,B.S.
  TITLE     Characterization of monoclonal antibody specific to the Z39Ig
            protein, a member of immunoglobulin superfamily
  JOURNAL   Immunol Lett 99 (2), 153-161 (2005)
   PUBMED   16009265
REFERENCE   9  (bases 1 to 1807)
  AUTHORS   Walker,M.G.
  TITLE     Z39Ig is co-expressed with activated macrophage genes
  JOURNAL   Biochim Biophys Acta 1574 (3), 387-390 (2002)
   PUBMED   11997108
REFERENCE   10 (bases 1 to 1807)
  AUTHORS   Langnaese,K., Colleaux,L., Kloos,D.U., Fontes,M. and Wieacker,P.
  TITLE     Cloning of Z39Ig, a novel gene with immunoglobulin-like domains
            located on human chromosome X
  JOURNAL   Biochim Biophys Acta 1492 (2-3), 522-525 (2000)
   PUBMED   11004523
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BX482258.1, BP292528.1 and
            AJ132502.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_007268.2.
            
            Summary: This gene encodes a v-set and immunoglobulin-domain
            containing protein that is structurally related to the B7 family of
            immune regulatory proteins. The encoded protein may be a negative
            regulator of T-cell responses. This protein is also a receptor for
            the complement component 3 fragments C3b and iC3b. Alternate
            splicing results in multiple transcript variants. [provided by
            RefSeq, May 2010].
            
            Transcript Variant: This variant (1) is also called CRIg(L). It
            encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ132502.1, AK075153.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142670, SAMEA2142853
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000374737.9/ ENSP00000363869.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                BX482258.1         47-57
            12-37               BP292528.1         54-79
            38-1807             AJ132502.1         1-1770
FEATURES             Location/Qualifiers
     source          1..1807
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq12"
     gene            1..1807
                     /gene="VSIG4"
                     /gene_synonym="CRIg; Z39IG"
                     /note="V-set and immunoglobulin domain containing 4"
                     /db_xref="GeneID:11326"
                     /db_xref="HGNC:HGNC:17032"
                     /db_xref="MIM:300353"
     exon            1..137
                     /gene="VSIG4"
                     /gene_synonym="CRIg; Z39IG"
                     /inference="alignment:Splign:2.1.0"
     CDS             83..1282
                     /gene="VSIG4"
                     /gene_synonym="CRIg; Z39IG"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; Ig superfamily protein; complement receptor of
                     the immunoglobulin superfamily; V-set and immunoglobulin
                     domain-containing protein 4; protein Z39Ig"
                     /codon_start=1
                     /product="V-set and immunoglobulin domain-containing
                     protein 4 isoform 1 precursor"
                     /protein_id="NP_009199.1"
                     /db_xref="CCDS:CCDS14383.1"
                     /db_xref="GeneID:11326"
                     /db_xref="HGNC:HGNC:17032"
                     /db_xref="MIM:300353"
                     /translation="MGILLGLLLLGHLTVDTYGRPILEVPESVTGPWKGDVNLPCTYD
                     PLQGYTQVLVKWLVQRGSDPVTIFLRDSSGDHIQQAKYQGRLHVSHKVPGDVSLQLST
                     LEMDDRSHYTCEVTWQTPDGNQVVRDKITELRVQKLSVSKPTVTTGSGYGFTVPQGMR
                     ISLQCQARGSPPISYIWYKQQTNNQEPIKVATLSTLLFKPAVIADSGSYFCTAKGQVG
                     SEQHSDIVKFVVKDSSKLLKTKTEAPTTMTYPLKATSTVKQSWDWTTDMDGYLGETSA
                     GPGKSLPVFAIILIISLCCMVVFTMAYIMLCRKTSQQEHVYEAARAHAREANDSGETM
                     RVAIFASGCSSDEPTSQNLGNNYSDEPCIGQEYQIIAQINGNYARLLDTVPLDYEFLA
                     TEGKSVC"
     exon            138..494
                     /gene="VSIG4"
                     /gene_synonym="CRIg; Z39IG"
                     /inference="alignment:Splign:2.1.0"
     exon            495..776
                     /gene="VSIG4"
                     /gene_synonym="CRIg; Z39IG"
                     /inference="alignment:Splign:2.1.0"
     exon            777..839
                     /gene="VSIG4"
                     /gene_synonym="CRIg; Z39IG"
                     /inference="alignment:Splign:2.1.0"
     exon            840..917
                     /gene="VSIG4"
                     /gene_synonym="CRIg; Z39IG"
                     /inference="alignment:Splign:2.1.0"
     exon            918..1022
                     /gene="VSIG4"
                     /gene_synonym="CRIg; Z39IG"
                     /inference="alignment:Splign:2.1.0"
     exon            1023..1044
                     /gene="VSIG4"
                     /gene_synonym="CRIg; Z39IG"
                     /inference="alignment:Splign:2.1.0"
     exon            1045..1807
                     /gene="VSIG4"
                     /gene_synonym="CRIg; Z39IG"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1783..1788
                     /regulatory_class="polyA_signal_sequence"
                     /gene="VSIG4"
                     /gene_synonym="CRIg; Z39IG"
                     /note="hexamer: AATAAA"
     polyA_site      1807
                     /gene="VSIG4"
                     /gene_synonym="CRIg; Z39IG"
                     /note="major polyA site"
ORIGIN      
        1 acagacgctg gcggccacca gaagtttgag cctctttggt agcaggaggc tggaagaaag
       61 gacagaagta gctctggctg tgatggggat cttactgggc ctgctactcc tggggcacct
      121 aacagtggac acttatggcc gtcccatcct ggaagtgcca gagagtgtaa caggaccttg
      181 gaaaggggat gtgaatcttc cctgcaccta tgaccccctg caaggctaca cccaagtctt
      241 ggtgaagtgg ctggtacaac gtggctcaga ccctgtcacc atctttctac gtgactcttc
      301 tggagaccat atccagcagg caaagtacca gggccgcctg catgtgagcc acaaggttcc
      361 aggagatgta tccctccaat tgagcaccct ggagatggat gaccggagcc actacacgtg
      421 tgaagtcacc tggcagactc ctgatggcaa ccaagtcgtg agagataaga ttactgagct
      481 ccgtgtccag aaactctctg tctccaagcc cacagtgaca actggcagcg gttatggctt
      541 cacggtgccc cagggaatga ggattagcct tcaatgccag gctcggggtt ctcctcccat
      601 cagttatatt tggtataagc aacagactaa taaccaggaa cccatcaaag tagcaaccct
      661 aagtacctta ctcttcaagc ctgcggtgat agccgactca ggctcctatt tctgcactgc
      721 caagggccag gttggctctg agcagcacag cgacattgtg aagtttgtgg tcaaagactc
      781 ctcaaagcta ctcaagacca agactgaggc acctacaacc atgacatacc ccttgaaagc
      841 aacatctaca gtgaagcagt cctgggactg gaccactgac atggatggct accttggaga
      901 gaccagtgct gggccaggaa agagcctgcc tgtctttgcc atcatcctca tcatctcctt
      961 gtgctgtatg gtggttttta ccatggccta tatcatgctc tgtcggaaga catcccaaca
     1021 agagcatgtc tacgaagcag ccagggcaca tgccagagag gccaacgact ctggagaaac
     1081 catgagggtg gccatcttcg caagtggctg ctccagtgat gagccaactt cccagaatct
     1141 gggcaacaac tactctgatg agccctgcat aggacaggag taccagatca tcgcccagat
     1201 caatggcaac tacgcccgcc tgctggacac agttcctctg gattatgagt ttctggccac
     1261 tgagggcaaa agtgtctgtt aaaaatgccc cattaggcca ggatctgctg acataattgc
     1321 ctagtcagtc cttgccttct gcatggcctt cttccctgct acctctcttc ctggatagcc
     1381 caaagtgtcc gcctaccaac actggagccg ctgggagtca ctggctttgc cctggaattt
     1441 gccagatgca tctcaagtaa gccagctgct ggatttggct ctgggccctt ctagtatctc
     1501 tgccgggggc ttctggtact cctctctaaa taccagaggg aagatgccca tagcactagg
     1561 acttggtcat catgcctaca gacactattc aactttggca tcttgccacc agaagacccg
     1621 agggaggctc agctctgcca gctcagagga ccagctatat ccaggatcat ttctctttct
     1681 tcagggccag acagctttta attgaaattg ttatttcaca ggccagggtt cagttctgct
     1741 cctccactat aagtctaatg ttctgactct ctcctggtgc tcaataaata tctaatcata
     1801 acagcaa
//
