LOCUS       NM_014312               1163 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens V-set and immunoglobulin domain containing 2 (VSIG2),
            transcript variant 1, mRNA.
ACCESSION   NM_014312
VERSION     NM_014312.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1163)
  AUTHORS   Xu,J., Quan,G., Huang,W. and Jiang,J.
  TITLE     VSIG2 promotes malignant progression of pancreatic ductal
            adenocarcinoma by enhancing LAMTOR2-mediated mTOR activation
  JOURNAL   Cell Commun Signal 21 (1), 223 (2023)
   PUBMED   37626304
  REMARK    GeneRIF: VSIG2 promotes malignant progression of pancreatic ductal
            adenocarcinoma by enhancing LAMTOR2-mediated mTOR activation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1163)
  AUTHORS   Kariuki,S.N., Franek,B.S., Kumar,A.A., Arrington,J.,
            Mikolaitis,R.A., Utset,T.O., Jolly,M., Crow,M.K., Skol,A.D. and
            Niewold,T.B.
  TITLE     Trait-stratified genome-wide association study identifies novel and
            diverse genetic associations with serologic and cytokine phenotypes
            in systemic lupus erythematosus
  JOURNAL   Arthritis Res Ther 12 (4), R151 (2010)
   PUBMED   20659327
  REMARK    GeneRIF: Observational study and genome-wide association study of
            gene-disease association. (HuGE Navigator)
REFERENCE   3  (bases 1 to 1163)
  AUTHORS   Chretien,I., Marcuz,A., Courtet,M., Katevuo,K., Vainio,O.,
            Heath,J.K., White,S.J. and Du Pasquier,L.
  TITLE     CTX, a Xenopus thymocyte receptor, defines a molecular family
            conserved throughout vertebrates
  JOURNAL   Eur J Immunol 28 (12), 4094-4104 (1998)
   PUBMED   9862345
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC012567.1 and BC007313.2.
            
            On Nov 22, 2018 this sequence version replaced NM_014312.4.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC007313.2, AY358897.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142586, SAMEA2154405
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000326621.10/ ENSP00000318684.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-42                BC012567.1         22-63
            43-1163             BC007313.2         1-1121
FEATURES             Location/Qualifiers
     source          1..1163
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q24.2"
     gene            1..1163
                     /gene="VSIG2"
                     /gene_synonym="2210413P10Rik; CTH; CTXL"
                     /note="V-set and immunoglobulin domain containing 2"
                     /db_xref="GeneID:23584"
                     /db_xref="HGNC:HGNC:17149"
                     /db_xref="MIM:606011"
     exon            1..179
                     /gene="VSIG2"
                     /gene_synonym="2210413P10Rik; CTH; CTXL"
                     /inference="alignment:Splign:2.1.0"
     CDS             119..1102
                     /gene="VSIG2"
                     /gene_synonym="2210413P10Rik; CTH; CTXL"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; cortical thymocyte receptor (X. laevis CTX)
                     like; V-set and immunoglobulin domain-containing protein
                     2; CT-like protein; cortical thymocyte-like protein"
                     /codon_start=1
                     /product="V-set and immunoglobulin domain-containing
                     protein 2 isoform 1 precursor"
                     /protein_id="NP_055127.2"
                     /db_xref="CCDS:CCDS8452.1"
                     /db_xref="GeneID:23584"
                     /db_xref="HGNC:HGNC:17149"
                     /db_xref="MIM:606011"
                     /translation="MAELPGPFLCGALLGFLCLSGLAVEVKVPTEPLSTPLGKTAELT
                     CTYSTSVGDSFALEWSFVQPGKPISESHPILYFTNGHLYPTGSKSKRVSLLQNPPTVG
                     VATLKLTDVHPSDTGTYLCQVNNPPDFYTNGLGLINLTVLVPPSNPLCSQSGQTSVGG
                     STALRCSSSEGAPKPVYNWVRLGTFPTPSPGSMVQDEVSGQLILTNLSLTSSGTYRCV
                     ATNQMGSASCELTLSVTEPSQGRVAGALIGVLLGVLLLSVAAFCLVRFQKERGKKPKE
                     TYGGSDLREDAIAPGISEHTCMRADSSKGFLERPSSASTVTTTKSKLPMVV"
     exon            180..337
                     /gene="VSIG2"
                     /gene_synonym="2210413P10Rik; CTH; CTXL"
                     /inference="alignment:Splign:2.1.0"
     exon            338..545
                     /gene="VSIG2"
                     /gene_synonym="2210413P10Rik; CTH; CTXL"
                     /inference="alignment:Splign:2.1.0"
     exon            546..704
                     /gene="VSIG2"
                     /gene_synonym="2210413P10Rik; CTH; CTXL"
                     /inference="alignment:Splign:2.1.0"
     exon            705..824
                     /gene="VSIG2"
                     /gene_synonym="2210413P10Rik; CTH; CTXL"
                     /inference="alignment:Splign:2.1.0"
     exon            825..969
                     /gene="VSIG2"
                     /gene_synonym="2210413P10Rik; CTH; CTXL"
                     /inference="alignment:Splign:2.1.0"
     exon            970..1163
                     /gene="VSIG2"
                     /gene_synonym="2210413P10Rik; CTH; CTXL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1144..1149
                     /regulatory_class="polyA_signal_sequence"
                     /gene="VSIG2"
                     /gene_synonym="2210413P10Rik; CTH; CTXL"
                     /note="hexamer: ATTAAA"
     polyA_site      1163
                     /gene="VSIG2"
                     /gene_synonym="2210413P10Rik; CTH; CTXL"
                     /note="major polyA site"
ORIGIN      
        1 agtctcgctc ctgcccagcc cgggcggctg cccttgggtg ctcccttccc tgcccgacac
       61 ccagaccgac cttgaccgcc cacctggcag gagcaggaca ggacggccgg acgcggccat
      121 ggccgagctc ccggggccct ttctctgcgg ggccctgcta ggcttcctgt gcctgagtgg
      181 gctggccgtg gaggtgaagg tacccacaga gccgctgagc acgcccctgg ggaagacagc
      241 cgagctgacc tgcacctaca gcacgtcggt gggagacagc ttcgccctgg agtggagctt
      301 tgtgcagcct gggaaaccca tctctgagtc ccatccaatc ctgtacttca ccaatggcca
      361 tctgtatcca actggttcta agtcaaagcg ggtcagcctg cttcagaacc cccccacagt
      421 gggggtggcc acactgaaac tgactgacgt ccacccctca gatactggaa cctacctctg
      481 ccaagtcaac aacccaccag atttctacac caatgggttg gggctaatca accttactgt
      541 gctggttccc cccagtaatc ccttatgcag tcagagtgga caaacctctg tgggaggctc
      601 tactgcactg agatgcagct cttccgaggg ggctcctaag ccagtgtaca actgggtgcg
      661 tcttggaact tttcctacac cttctcctgg cagcatggtt caagatgagg tgtctggcca
      721 gctcattctc accaacctct ccctgacctc ctcgggcacc taccgctgtg tggccaccaa
      781 ccagatgggc agtgcatcct gtgagctgac cctctctgtg accgaaccct cccaaggccg
      841 agtggccgga gctctgattg gggtgctcct gggcgtgctg ttgctgtcag ttgctgcgtt
      901 ctgcctggtc aggttccaga aagagagggg gaagaagccc aaggagacat atgggggtag
      961 tgaccttcgg gaggatgcca tcgctcctgg gatctctgag cacacttgta tgagggctga
     1021 ttctagcaag gggttcctgg aaagaccctc gtctgccagc accgtgacga ccaccaagtc
     1081 caagctccct atggtcgtgt gacttctccc gatccctgag ggcggtgagg gggaatatca
     1141 ataattaaag tctgtgggta cca
//
