LOCUS       NM_001163922            3689 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens V-set and immunoglobulin domain containing 10 like
            (VSIG10L), mRNA.
ACCESSION   NM_001163922 XM_001718903 XM_085831 XM_937000
VERSION     NM_001163922.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3689)
  AUTHORS   Fecteau,R.E., Kong,J., Kresak,A., Brock,W., Song,Y., Fujioka,H.,
            Elston,R., Willis,J.E., Lynch,J.P., Markowitz,S.D., Guda,K. and
            Chak,A.
  TITLE     Association Between Germline Mutation in VSIG10L and Familial
            Barrett Neoplasia
  JOURNAL   JAMA Oncol 2 (10), 1333-1339 (2016)
   PUBMED   27467440
  REMARK    GeneRIF: VSIG10L is a candidate familial Barrett esophagus
            susceptibility gene, with a putative role in maintaining normal
            esophageal homeostasis.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC008750.9 and AC063977.6.
            
            On Sep 30, 2020 this sequence version replaced NM_001163922.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074967.3905299.1,
                                           SRR14038194.3271346.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000335624.5/ ENSP00000335623.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-55                AC008750.9         15035-15089         c
            56-910              AC008750.9         14103-14957         c
            911-1204            AC008750.9         13383-13676         c
            1205-1489           AC008750.9         12965-13249         c
            1490-1744           AC008750.9         11838-12092         c
            1745-2023           AC008750.9         10880-11158         c
            2024-2320           AC008750.9         10188-10484         c
            2321-2434           AC008750.9         7141-7254           c
            2435-2589           AC008750.9         6741-6895           c
            2590-3689           AC063977.6         210702-211801       c
FEATURES             Location/Qualifiers
     source          1..3689
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.41"
     gene            1..3689
                     /gene="VSIG10L"
                     /note="V-set and immunoglobulin domain containing 10 like"
                     /db_xref="GeneID:147645"
                     /db_xref="HGNC:HGNC:27111"
                     /db_xref="MIM:617740"
     exon            1..55
                     /gene="VSIG10L"
                     /inference="alignment:Splign:2.1.0"
     CDS             16..2619
                     /gene="VSIG10L"
                     /note="V-set and immunoglobulin domain-containing protein
                     10-like; VSIG10-like protein"
                     /codon_start=1
                     /product="V-set and immunoglobulin domain-containing
                     protein 10-like precursor"
                     /protein_id="NP_001157394.1"
                     /db_xref="CCDS:CCDS54300.1"
                     /db_xref="GeneID:147645"
                     /db_xref="HGNC:HGNC:27111"
                     /db_xref="MIM:617740"
                     /translation="MDNPQALPLFLLLASLVGILTLRASSGLQQTNFSSAFSSDSKSS
                     SQGLGVEVPSIKPPSWKVPDQFLDSKASAGISDSSWFPEALSSNMSGSFWSNVSAEGQ
                     DLSPVSPFSETPGSEVFPDISDPQVPAKDPKPSFTVKTPASNISTQVSHTKLSVEAPD
                     SKFSPDDMDLKLSAQSPESKFSAETHSAASFPQQVGGPLAVLVGTTIRLPLVPIPNPG
                     PPTSLVVWRRGSKVLAAGGLGPGAPLISLDPAHRDHLRFDQARGVLELASAQLDDAGV
                     YTAEVIRAGVSQQTHEFTVGVYEPLPQLSVQPKAPETEEGAAELRLRCLGWGPGRGEL
                     SWSRDGRALEAAESEGAETPRMRSEGDQLLIVRPVRSDHARYTCRVRSPFGHREAAAD
                     VSVFYGPDPPTITVSSDRDAAPARFVTAGSNVTLRCAAASRPPADITWSLADPAEAAV
                     PAGSRLLLPAVGPGHAGTYACLAANPRTGRRRRSLLNLTVADLPPGAPQCSVEGGPGD
                     RSLRFRCSWPGGAPAASLQFQGLPEGIRAGPVSSVLLAAVPAHPRLSGVPITCLARHL
                     VATRTCTVTPEAPREVLLHPLVAETRLGEAEVALEASGCPPPSRASWAREGRPLAPGG
                     GSRLRLSQDGRKLHIGNFSLDWDLGNYSVLCSGALGAGGDQITLIGPSISSWRLQRAR
                     DAAVLTWDVERGALISSFEIQAWPDGPALGRTSTYRDWVSLLILGPQERSAVVPLPPR
                     NPGTWTFRILPILGGQPGTPSQSRVYRAGPTLSHGAIAGIVLGSLLGLALLAVLLLLC
                     ICCLCRFRGKTPEKKKHPSTLVPVVTPSEKKMHSVTPVEISWPLDLKVPLEDHSSTRA
                     YQAQTPVQLSL"
     exon            56..910
                     /gene="VSIG10L"
                     /inference="alignment:Splign:2.1.0"
     exon            911..1204
                     /gene="VSIG10L"
                     /inference="alignment:Splign:2.1.0"
     exon            1205..1489
                     /gene="VSIG10L"
                     /inference="alignment:Splign:2.1.0"
     exon            1490..1744
                     /gene="VSIG10L"
                     /inference="alignment:Splign:2.1.0"
     exon            1745..2023
                     /gene="VSIG10L"
                     /inference="alignment:Splign:2.1.0"
     exon            2024..2320
                     /gene="VSIG10L"
                     /inference="alignment:Splign:2.1.0"
     exon            2321..2434
                     /gene="VSIG10L"
                     /inference="alignment:Splign:2.1.0"
     exon            2435..2589
                     /gene="VSIG10L"
                     /inference="alignment:Splign:2.1.0"
     exon            2590..3689
                     /gene="VSIG10L"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3395..3400
                     /regulatory_class="polyA_signal_sequence"
                     /gene="VSIG10L"
                     /note="hexamer: CATAAA"
     polyA_site      3418
                     /gene="VSIG10L"
                     /note="major polyA site"
     regulatory      3516..3521
                     /regulatory_class="polyA_signal_sequence"
                     /gene="VSIG10L"
                     /note="hexamer: AATAAA"
     polyA_site      3540
                     /gene="VSIG10L"
     regulatory      3671..3676
                     /regulatory_class="polyA_signal_sequence"
                     /gene="VSIG10L"
                     /note="hexamer: AATAAA"
     polyA_site      3689
                     /gene="VSIG10L"
ORIGIN      
        1 agtgaggcca gcaccatgga caacccacag gctctgccac tcttcctact cctggcctcc
       61 ttggtaggga tcctcaccct cagagcctct tctggacttc agcaaaccaa cttctcctct
      121 gccttctctt cagactcaaa gagctcttcc caggggctgg gtgtggaagt tccctccatc
      181 aaacctccca gctggaaagt tccagatcag ttcctggatt caaaagcctc tgctggaatc
      241 tctgattcca gctggtttcc tgaggccctg agttccaaca tgtctgggtc cttctggtca
      301 aatgtttctg ctgagggcca agatttgagc ccggtttccc ccttctctga aacccctggt
      361 tctgaagtat ttcctgatat ttcggatcct caagttcctg ccaaagaccc caagccttcc
      421 ttcactgtta agaccccagc ttcaaacatt tctactcaag tctcccatac caaactgtct
      481 gttgaggccc cagattcaaa attctccccg gatgatatgg atcttaaact ctctgcccag
      541 agccctgaat ccaaattttc tgcagagacc cactcagctg caagctttcc ccagcaggtg
      601 gggggcccac tcgctgtgct ggtggggacc accatccggc tccccctagt cccaatcccc
      661 aaccctgggc cccccacctc tctggtggtc tggcgccggg gctcaaaggt gctggcagct
      721 gggggcctgg ggccaggggc acctctgatc agcctggacc ctgctcaccg agaccacctg
      781 cgatttgacc aggcccgggg ggttctggag ctcgcctctg cccagctgga cgatgcaggg
      841 gtctacacgg ctgaggtcat ccgggcaggg gtctcccagc agactcacga gttcacggtg
      901 ggtgtgtatg agcccctacc ccagctgtcg gttcagccca aggctccaga gacagaggag
      961 ggggcggccg agctccggct gcgctgcctg gggtgggggc caggtcgcgg ggagctgagc
     1021 tggagccggg acggacgcgc cctggaggcg gcggaatcgg agggagccga gacgccccgg
     1081 atgcgctcag agggcgacca gctgctcatc gtgcgccctg tgcgcagcga ccacgcccgg
     1141 tacacttgcc gcgtccgcag ccccttcggc cacagggagg ctgccgccga cgtcagcgtc
     1201 ttctacggcc cggacccgcc gaccatcacg gtctcctcgg accgcgacgc cgcgcctgcc
     1261 cgctttgtca ccgcgggcag taacgtgacc ttgcgctgcg ccgccgcctc gcggccgccc
     1321 gccgacatca cgtggagcct ggcggacccg gccgaggccg cggtgcccgc ggggtcgcgc
     1381 ctcctgctgc ccgcggtcgg accgggccac gcaggcacct acgcctgcct ggcggcgaac
     1441 ccgcgtaccg gccgccgccg ccgctcgctg ctcaacctta cagtggcgga cctgcccccc
     1501 ggggccccac agtgctcagt tgaagggggt cccggggacc gcagcctccg cttccgctgc
     1561 tcgtggcccg gcggggcccc tgctgcctcc ctgcagttcc agggtctccc cgaaggcatc
     1621 cgcgccgggc cagtgtcctc tgtgctgctg gcggccgtcc ccgcccaccc ccggctcagc
     1681 ggcgtcccca tcacctgcct tgctcgccac ctggtggcca cgcgtacctg cacagtcacg
     1741 ccggaggccc cccgagaggt gctgctgcat ccgctggtgg cagagacacg gttgggggag
     1801 gcagaggtgg cactggaggc ctctggttgt cccccaccct cacgggcatc ctgggcccgg
     1861 gaagggaggc ccctggctcc aggaggcggg agtcgcctgc ggctcagtca agatgggcgg
     1921 aaactccaca tcggcaactt cagcctggat tgggacctgg gaaattactc cgtgctgtgc
     1981 agtggggcgc tgggtgctgg cggtgaccag atcaccctca ttggaccctc catatcctcg
     2041 tggaggcttc agagagccag agatgcagcc gtgctgactt gggatgtgga gcgcggggcc
     2101 ctgatcagca gttttgagat ccaggcatgg ccagatgggc ctgctctggg caggacttcc
     2161 acctacaggg actgggtctc cctgctcatc ctggggcctc aggagcggtc agccgtggtg
     2221 ccccttccac ctcggaaccc agggacctgg acctttcgga tcctgcccat cctggggggc
     2281 cagccaggga ctccatcaca aagccgggtc taccgggccg gccccacgtt gagccatggg
     2341 gccatcgctg gcatcgtcct gggctccctg ctgggcctgg cgctgctagc cgtacttctc
     2401 ctcctttgca tctgctgcct gtgccgcttt cgtggaaaga ctcctgagaa aaagaagcat
     2461 ccttctacct tggtccccgt ggtcaccccc tcagaaaaga agatgcatag tgtgacccca
     2521 gtggagattt catggcctct ggacctcaaa gtccctctgg aggaccacag ctcaactagg
     2581 gcctaccaag cacagacccc agttcagttg tctctgtagg cggaggctca aagactgttc
     2641 gcgcagccac acaggtgtga tcagagccag tggtctgccc tgcacagggc gttttgggcc
     2701 agaacttcct atttcactcc agcagcagcc agggcctgct atgactgagg gttggaccct
     2761 gaaagtggga ctttctgtct ccctctcttg ctgcagaaga agagtcttcc tgtatttgtg
     2821 caagtaagga gatgtgactt cttggctggg aaactcttgc tgatctaact gtgtggtttg
     2881 cacaacctcc aagcctctgc agcagacagg cagggcttgc tgtgttgctc tgagctagag
     2941 agggagcttg gccatgttct ctgaaaaggt ccccttacat tcactttgcc acctgtaggc
     3001 cacaccccat ccagctccca gcatcttcat cttaaaacag atcagatcat gtcactcttc
     3061 tctttaaacg cttctacggc ctgtgcattt cccttcagat attatccaaa ctcatcgtcg
     3121 tgaccttcaa aaccttgtgg tctggcctct gttggcctcc ctgacctccc ctcccaattc
     3181 tttctctgcc cccggactcc agtatcacag tctgtctctc agccacaatt tattttgccc
     3241 ctagagtttg ctgtgcttat aacacttctt tttcccatat gtcattcatt tctcaagtct
     3301 aagagtagca gttaccatct tagacgaccg ttcccttacc cctcccttag tcttgggtta
     3361 agtcccagaa tccttgaatt tgccgttcct gatacataaa tatgtaattt cttgtgtggc
     3421 ctgagactct ctctctaaac taagggcttt acaaaagcag agaccacatc attaactcag
     3481 cacttaaccc agagcctcac acacagcagg caatcaataa atatttgttg actgatcaaa
     3541 tgttttggtg ccagtgaaga gttgggcttg ctgctgctgt cttcagcgta agtcttgctt
     3601 tttcagctgg gtttctaatt gagaatttag agagtgcatt ggtgaggatt cttttgactg
     3661 caagtaacaa aataaaatgg tggcaagaa
//
