LOCUS       NM_019086               5009 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens V-set and immunoglobulin domain containing 10
            (VSIG10), mRNA.
ACCESSION   NM_019086 XM_942676 XM_946216
VERSION     NM_019086.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5009)
  AUTHORS   Gautam,Y., Caldwell,J., Kottyan,L., Chehade,M., Dellon,E.S.,
            Rothenberg,M.E. and Mersha,T.B.
  CONSRTM   Consortium of Eosinophilic Gastrointestinal Disease Researchers
            (CEGIR) investigators
  TITLE     Genome-wide admixture and association analysis identifies African
            ancestry-specific risk loci of eosinophilic esophagitis in African
            Americans
  JOURNAL   J Allergy Clin Immunol 151 (5), 1337-1350 (2023)
   PUBMED   36400179
  REMARK    GeneRIF: Genome-wide admixture and association analysis identifies
            African ancestry-specific risk loci of eosinophilic esophagitis in
            African Americans.
REFERENCE   2  (bases 1 to 5009)
  AUTHORS   Kim,D.S., Choi,D. and Hahn,Y.
  TITLE     Loss of ancestral N-glycosylation sites in conserved proteins
            during human evolution
  JOURNAL   Int J Mol Med 36 (6), 1685-1692 (2015)
   PUBMED   26458842
REFERENCE   3  (bases 1 to 5009)
  AUTHORS   Cook-Sather,S.D., Li,J., Goebel,T.K., Sussman,E.M., Rehman,M.A. and
            Hakonarson,H.
  TITLE     TAOK3, a novel genome-wide association study locus associated with
            morphine requirement and postoperative pain in a retrospective
            pediatric day surgery population
  JOURNAL   Pain 155 (9), 1773-1783 (2014)
   PUBMED   24909733
REFERENCE   4  (bases 1 to 5009)
  AUTHORS   Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
            Gibbs,R.A. and Butte,N.F.
  TITLE     Novel genetic loci identified for the pathophysiology of childhood
            obesity in the Hispanic population
  JOURNAL   PLoS One 7 (12), e51954 (2012)
   PUBMED   23251661
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC026366.20, DA995625.1, BC034471.2 and AC131238.3.
            
            On Nov 23, 2018 this sequence version replaced NM_019086.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC028698.2, AK000681.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000359236.10/ ENSP00000352172.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6                 AC026366.20        3486-3491           c
            7-67                DA995625.1         2-62
            68-765              BC034471.2         1-698
            766-766             AC131238.3         40265-40265         c
            767-2356            BC034471.2         700-2289
            2357-5009           AC131238.3         21493-24145         c
FEATURES             Location/Qualifiers
     source          1..5009
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q24.23"
     gene            1..5009
                     /gene="VSIG10"
                     /note="V-set and immunoglobulin domain containing 10"
                     /db_xref="GeneID:54621"
                     /db_xref="HGNC:HGNC:26078"
     exon            1..419
                     /gene="VSIG10"
                     /inference="alignment:Splign:2.1.0"
     CDS             341..1963
                     /gene="VSIG10"
                     /note="V-set and immunoglobulin domain-containing protein
                     10"
                     /codon_start=1
                     /product="V-set and immunoglobulin domain-containing
                     protein 10 precursor"
                     /protein_id="NP_061959.2"
                     /db_xref="CCDS:CCDS44992.1"
                     /db_xref="GeneID:54621"
                     /db_xref="HGNC:HGNC:26078"
                     /translation="MAAGGSAPEPRVLVCLGALLAGWVAVGLEAVVIGEVHENVTLHC
                     GNISGLRGQVTWYRNNSEPVFLLSSNSSLRPAEPRFSLVDATSLHIESLSLGDEGIYT
                     CQEILNVTQWFQVWLQVASGPYQIEVHIVATGTLPNGTLYAARGSQVDFSCNSSSRPP
                     PVVEWWFQALNSSSESFGHNLTVNFFSLLLISPNLQGNYTCLALNQLSKRHRKVTTEL
                     LVYYPPPSAPQCWAQMASGSFMLQLTCRWDGGYPDPDFLWIEEPGGVIVGKSKLGVEM
                     LSESQLSDGKKFKCVTSHIVGPESGASCMVQIRGPSLLSEPMKTCFTGGNVTLTCQVS
                     GAYPPAKILWLRNLTQPEVIIQPSSRHLITQDGQNSTLTIHNCSQDLDEGYYICRADS
                     PVGVREMEIWLSVKEPLNIGGIVGTIVSLLLLGLAIISGLLLHYSPVFCWKVGNTSRG
                     QNMDDVMVLVDSEEEEEEEEEEEEDAAVGEQEGAREREELPKEIPKQDHIHRVTALVN
                     GNIEQMGNGFQDLQDDSSEEQSDIVQEEDRPV"
     exon            420..701
                     /gene="VSIG10"
                     /inference="alignment:Splign:2.1.0"
     exon            702..1004
                     /gene="VSIG10"
                     /inference="alignment:Splign:2.1.0"
     exon            1005..1265
                     /gene="VSIG10"
                     /inference="alignment:Splign:2.1.0"
     exon            1266..1559
                     /gene="VSIG10"
                     /inference="alignment:Splign:2.1.0"
     exon            1560..1670
                     /gene="VSIG10"
                     /inference="alignment:Splign:2.1.0"
     exon            1671..1686
                     /gene="VSIG10"
                     /inference="alignment:Splign:2.1.0"
     exon            1687..1907
                     /gene="VSIG10"
                     /inference="alignment:Splign:2.1.0"
     exon            1908..5009
                     /gene="VSIG10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4989..4994
                     /regulatory_class="polyA_signal_sequence"
                     /gene="VSIG10"
                     /note="hexamer: AATAAA"
     polyA_site      5009
                     /gene="VSIG10"
                     /note="major polyA site"
ORIGIN      
        1 agaggaagtt gggctcccgc ctggctggga ggcgggaggg atcccgctcc tgttgttttc
       61 cgccggcagg agtaggctgg cgggcgcagg gggcggggtg cgccctccct ccccggccag
      121 ggcgctcggg agcggggacc cgagcctgca gccgagctcc gctgccggcc ctggacactc
      181 ggctcagcca agcatccttc ctgggggccg aggaagtggg gccactctgc cgttccgagg
      241 acctgggagg agccctcggt accccgggcc ccggggccct ggggcacaca cgtccagccc
      301 agcccgagcc tgcgtttcct gagccgggat ctggggcgag atggccgcag gcggcagtgc
      361 gcccgagccc cgcgtcctcg tctgcctcgg ggcgctcctg gccggctggg tcgccgtagg
      421 attggaggct gttgtcattg gagaagttca tgagaatgtt actctgcact gtggcaacat
      481 ctcgggactg aggggccagg tgacctggta ccggaacaac tcggagcctg tcttccttct
      541 ctcgtccaac tctagcctcc ggccagctga gcctcgcttc tctctagtgg atgccacctc
      601 cctgcacatt gaatcgctga gcctgggaga tgagggaatc tacacctgcc aggagatcct
      661 gaatgtgact cagtggttcc aagtgtggct gcaggtggcc agcggcccct atcagattga
      721 ggtccacatc gtggccaccg gcacactccc caacggcacc ctctacgcag ccaggggctc
      781 ccaggtggac ttcagctgca acagcagctc caggccacca cccgtggttg aatggtggtt
      841 ccaggccctg aattccagca gcgagtcctt tggccacaac ctgacagtca actttttctc
      901 actgttactg atatcgccaa acctccaagg gaactacacc tgtttagcct tgaatcagct
      961 cagcaagaga catcgaaagg tgaccaccga gctcctggtc tactatcccc ctccatcagc
     1021 tccccagtgc tgggcacaga tggcatcagg atcgttcatg ttgcagctta cctgtcgctg
     1081 ggatggggga taccctgacc ctgacttcct gtggatagaa gagccaggag gtgtaatcgt
     1141 ggggaagtca aagctggggg tggaaatgct gagcgagtcc cagctgtcgg atggcaagaa
     1201 gttcaagtgt gttacaagcc acatagttgg gccagagtcg ggcgccagct gcatggtgca
     1261 gatcaggggt ccctcccttc tctctgagcc catgaagact tgcttcactg ggggcaatgt
     1321 gacgcttaca tgccaggtgt ctggggccta cccccctgcc aagatcctgt ggctgaggaa
     1381 ccttacccag cccgaggtga tcatccagcc tagcagccgc catctcatta cccaggatgg
     1441 ccagaactcc accctcacta tccacaactg ctcccaggac ctggatgagg gctactacat
     1501 ctgccgagct gacagccctg taggggtgag ggagatggaa atctggctga gtgtgaaaga
     1561 acctttaaat atcgggggga ttgtgggaac cattgtgagc ctccttctgc tgggactggc
     1621 cattatctca gggcttctgt tgcattatag ccctgtgttc tgctggaaag taggaaacac
     1681 ttccagggga caaaacatgg atgatgtcat ggttttggtg gattcagaag aggaagagga
     1741 ggaggaggag gaggaggagg aagatgctgc agtaggggaa caggagggag cacgtgagag
     1801 agaggagttg ccaaaagaaa tacctaagca ggaccacatt cacagagtga ccgccttggt
     1861 gaatgggaac atagaacaga tgggaaatgg attccaggat cttcaagatg acagcagtga
     1921 ggagcaaagt gacattgttc aagaagaaga caggccagtc tgaagaagag gatggtccat
     1981 ggttgtcttg ctctgaaagc ttggagagct acattgaaga cgagctcttc attcagcttt
     2041 gactccacct gcacccctgg cgggggcttg cactaacaat gtttgggtct cagcaaaaaa
     2101 caaaaccaag cacacacatc tttccttcca tgtattgaaa aacattggtt tgatttgctc
     2161 taagttttcc caatgatgtt taaaagcttt gagaaggaaa gctgctttgg tgtctgaggt
     2221 gccacttctg ctgtgaatcc tggctttatc caggttgatc tactgtgata gatgctgatt
     2281 tagagggaac agaggtcagg gaagcactgg gtcttggtgc cttttgccgc tttttttttt
     2341 tttttttttt ttttttgaga cggagtctcc ctctattgcc caggctggag tgcaatggca
     2401 cgatcttggc tcaccacaac ttctgcctcc caggttcaag cgattctcct gcctcagcca
     2461 cggcaccttg caaatatcag ctccttggaa caggtgaagt tccaggtacc aatgccaatc
     2521 agaggaaggc agtttggttc aggctttgga gttagaaaca cctgaagttg aatctgggct
     2581 ctgttgcttc cttctttcat gggctagagc acgactcttt acctctctct tggcctcaat
     2641 ttcctcacct gtaaaataga tgaggaagct gctcacttat tattgtctcg ttctgaaagc
     2701 ttggaaagct acatcgaaga tgagctcttc attcagcttt gatttgacct gtacccctgg
     2761 tgggggattg cactggcaac atttgggtct cagcaaaaaa accaagcaca cacatctttc
     2821 cttccattta ttgaaaaaca tctttgtaag atccattcat tgaaaaacat aatccattta
     2881 ttgaaaaata tctttgtaag atcacctgct aaatatgaaa atctgacttg aatttgtact
     2941 ctttaaagtt gcgtatctgc tctagtgggc aggacctagg gcttaaaggg gaacttcctt
     3001 tctccatttc taagaactgg gactctaaaa tgagaagctg gttgtctgaa gtaaccctgc
     3061 aggtgtggtt ggggaaggtc tgttttcttg gatgaaggaa ctaaactaag catatcagag
     3121 cactgtctta accagtttta tttccctgga gatagaattc ttttaaaaag agttagggag
     3181 ctggtaatag gaagtgcctt tcattataac tacattttgc agagcttcat atttatatac
     3241 aagcctccta ggtgatacac tgttagcttg cagactttcc tatgcttcat ttctcctgtt
     3301 gctttcaaag aaggcaggag acacgtttaa taacggagta tctggtgata agaattgctt
     3361 gggcaaacca gctcatctgg actctttctc agtcttggaa gtgggaagag gaaaacttgt
     3421 ttccttcctg cttcttaagg atattctgag ggtacactga tcaataacac taaatttgga
     3481 atgaaaatac catgtgatga gtttagcctg ctgatgcttc cagtagatcc ttgtatagtt
     3541 tcaagattta agttttccga tttcatataa atttcttaaa gtcgaggacc ttataagggt
     3601 gcaatggatg tttgctaaat atgaaaaact gacttgaatt tgcactcttt aatgttgcgt
     3661 atctgctcta gtgggcagga cctagggctt aaaggggaac ttcctttctc caattctagg
     3721 aactgggact ctaaaatgag aagctggttg tctgaagtaa ccctgcaggt gtggttgggg
     3781 aaggtctgtt ttcttggatg aagggattaa actgagcaaa tcactagaag tatgccctgt
     3841 cccctgctca gaacactggg gagctcaaga gtgggctgca atgtgcaccc ctcaggaata
     3901 gctgtgaatt gcaggtctac tggctttttg ctttttgtct tttgctgcaa ggtaccccac
     3961 gtacttaacc attctcaaca gtgtaaatca gtgtcatttt agaatgagat actcagcttg
     4021 cttctaaagt cactgaatta ctgagtgagt ctctccttta gagtcttcgg caaccaaatt
     4081 ccagaattga agagtctact actcagaggc aacaagatta aaaaaagaaa acacaaaaac
     4141 tgttgaggtg aaaaaaaaaa aaaaccctag ctaggaacac agagaatgtt ttgtaggatc
     4201 actgggatat tttccacaac ttcctcttct ctagcacaca catctgttga taggaaatat
     4261 ttgagggttt ttccactacc aaatgggagc ttcatggtcc tggtgtcaaa cactataaac
     4321 ctttgaccag ctgagctgtg actgctgtca catatctgag tcctgtgtgc acagtaatat
     4381 cctgggtcag gtaaaatcca ggtcttcaag ttttaaggat tttttgaaga attcgggctt
     4441 ctttaagacg atccatgccc aaatccacaa gcttgttgac agtggattac agtttgtgtg
     4501 gcaaagtcca agttgttaca ctgtgcttta aaaaaaatct tatctgcatg tattgttaac
     4561 ttagagacca tgagatctat ttatcaggac caggaagata cacacttcag gtccattgca
     4621 actgactttt ttcttgtttt tctcaaaccc tggtggagcc tgggaagggg gcctccacaa
     4681 ttctgtggct ttgatattag ccccaattct cacaagcaca tacaagcccc ataattgccg
     4741 caggaaaaca caagatggaa aattgcaata acccatgcac tgagacttag aaaatcatcc
     4801 ttactaggca aaatgtatta tgatgcaata agtgccaact gatatttctc acgttgggac
     4861 tggccaggaa ctgctgcaaa gaaaaataag cagctccttc tccattattt acattttaag
     4921 atgtggtggg gggaggttgg gagaaattag ttctgaggtt atcatatgcc ttttttaaaa
     4981 gataatggaa taaagctatt tttaagtaa
//
