LOCUS       NM_182607               3033 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens V-set and immunoglobulin domain containing 1 (VSIG1),
            transcript variant 2, mRNA.
ACCESSION   NM_182607
VERSION     NM_182607.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3033)
  AUTHORS   Satala,C.B., Jung,I., Kovacs,Z., Stefan-Van Staden,R.I., Molnar,C.,
            Bara,T., Patrichi,A.I. and Gurzu,S.
  TITLE     V-set and immunoglobulin domain containing 1 (VSIG1) as an emerging
            target for epithelial-mesenchymal transition of gastric cancer
  JOURNAL   Sci Rep 12 (1), 16241 (2022)
   PUBMED   36171238
  REMARK    GeneRIF: V-set and immunoglobulin domain containing 1 (VSIG1) as an
            emerging target for epithelial-mesenchymal transition of gastric
            cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3033)
  AUTHORS   Gurzu,S., Sugimura,H., Szederjesi,J., Szodorai,R., Braicu,C.,
            Kobori,L., Fodor,D. and Jung,I.
  TITLE     Interaction between cadherins, vimentin, and V-set and
            immunoglobulin domain containing 1 in gastric-type hepatocellular
            carcinoma
  JOURNAL   Histochem Cell Biol 156 (4), 377-390 (2021)
   PUBMED   34170400
  REMARK    GeneRIF: Interaction between cadherins, vimentin, and V-set and
            immunoglobulin domain containing 1 in gastric-type hepatocellular
            carcinoma.
REFERENCE   3  (bases 1 to 3033)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 3033)
  AUTHORS   Inoue,Y., Matsuura,S., Yoshimura,K., Iwashita,Y., Kahyo,T.,
            Kawase,A., Tanahashi,M., Maeda,M., Ogawa,H., Inui,N., Funai,K.,
            Shinmura,K., Niwa,H., Suda,T. and Sugimura,H.
  TITLE     Characterization of V-set and immunoglobulin domain containing 1
            exerting a tumor suppressor function in gastric, lung, and
            esophageal cancer cells
  JOURNAL   Cancer Sci 108 (8), 1701-1714 (2017)
   PUBMED   28603843
  REMARK    GeneRIF: Study showed that VSIG1 is expressed tissue specifically
            in both non-cancerous and cancerous tissues, and that VSIG1 has
            suppressive functions in proliferation, migration, and invasion in
            cancer cells.
REFERENCE   5  (bases 1 to 3033)
  AUTHORS   Chen,Y., Pan,K., Li,S., Xia,J., Wang,W., Chen,J., Zhao,J., Lu,L.,
            Wang,D., Pan,Q., Wang,Q., Li,Y., He,J. and Li,Q.
  TITLE     Decreased expression of V-set and immunoglobulin domain containing
            1 (VSIG1) is associated with poor prognosis in primary gastric
            cancer
  JOURNAL   J Surg Oncol 106 (3), 286-293 (2012)
   PUBMED   22095633
  REMARK    GeneRIF: VSIG1 expression was significantly reduced at both the
            mRNA and protein levels in gastric cancer tissues. loss of VSIG1
            expression was significantly correlated with poor overall survival
            and disease-free survival in gastric cancer patients.
REFERENCE   6  (bases 1 to 3033)
  AUTHORS   Kim,E., Lee,Y., Kim,J.S., Song,B.S., Kim,S.U., Huh,J.W., Lee,S.R.,
            Kim,S.H., Hong,Y. and Chang,K.T.
  TITLE     Extracellular domain of V-set and immunoglobulin domain containing
            1 (VSIG1) interacts with sertoli cell membrane protein, while its
            PDZ-binding motif forms a complex with ZO-1
  JOURNAL   Mol Cells 30 (5), 443-448 (2010)
   PUBMED   20957455
REFERENCE   7  (bases 1 to 3033)
  AUTHORS   Scanlan,M.J., Ritter,G., Yin,B.W., Williams,C. Jr., Cohen,L.S.,
            Coplan,K.A., Fortunato,S.R., Frosina,D., Lee,S.Y., Murray,A.E.,
            Chua,R., Filonenko,V.V., Sato,E., Old,L.J. and Jungbluth,A.A.
  TITLE     Glycoprotein A34, a novel target for antibody-based cancer
            immunotherapy
  JOURNAL   Cancer Immun 6, 2 (2006)
   PUBMED   16405301
  REMARK    GeneRIF: expressed, both at the mRNA and protein level, in gastric,
            esophageal, and ovarian cancers, while expression in normal tissues
            was restricted to testis and stomach
            Publication Status: Online-Only
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BX648658.1 and AL031177.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_182607.4.
            
            Summary: This gene encodes a member of the junctional adhesion
            molecule (JAM) family. The encoded protein contains multiple
            glycosylation sites at the N-terminal region, and multiple
            phosphorylation sites and glutamic acid/proline (EP) repeats at the
            C-terminal region. The gene is expressed in normal stomach and
            testis, as well as in gastric, esophageal and ovarian cancers.
            Alternatively spliced transcript variants encoding different
            isoforms have been found for this gene. [provided by RefSeq, Dec
            2009].
            
            Transcript Variant: This variant (2) lacks an in-frame coding exon,
            as compared to variant 1. The resulting isoform (2) lacks an
            internal segment, as compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX648658.1, BX640913.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2142586
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000217957.10/ ENSP00000217957.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1391              BX648658.1         96-1486
            1392-2367           AL031177.1         30521-31496
            2368-3033           BX648658.1         2463-3128
FEATURES             Location/Qualifiers
     source          1..3033
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq22.3"
     gene            1..3033
                     /gene="VSIG1"
                     /gene_synonym="1700062D20Rik; dJ889N15.1; GPA34"
                     /note="V-set and immunoglobulin domain containing 1"
                     /db_xref="GeneID:340547"
                     /db_xref="HGNC:HGNC:28675"
                     /db_xref="MIM:300620"
     exon            1..115
                     /gene="VSIG1"
                     /gene_synonym="1700062D20Rik; dJ889N15.1; GPA34"
                     /inference="alignment:Splign:2.1.0"
     CDS             67..1230
                     /gene="VSIG1"
                     /gene_synonym="1700062D20Rik; dJ889N15.1; GPA34"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; V-set and immunoglobulin domain-containing
                     protein 1; glycoprotein A34; cell surface A33 antigen"
                     /codon_start=1
                     /product="V-set and immunoglobulin domain-containing
                     protein 1 isoform 2 precursor"
                     /protein_id="NP_872413.1"
                     /db_xref="CCDS:CCDS14535.1"
                     /db_xref="GeneID:340547"
                     /db_xref="HGNC:HGNC:28675"
                     /db_xref="MIM:300620"
                     /translation="MVFAFWKVFLILSCLAGQVSVVQVTIPDGFVNVTVGSNVTLICI
                     YTTTVASREQLSIQWSFFHKKEMEPISIYFSQGGQAVAIGQFKDRITGSNDPGNASIT
                     ISHMQPADSGIYICDVNNPPDFLGQNQGILNVSVLVKPSKPLCSVQGRPETGHTISLS
                     CLSALGTPSPVYYWHKLEGRDIVPVKENFNPTTGILVIGNLTNFEQGYYQCTAINRLG
                     NSSCEIDLTSSHPEVGIIVGALIGSLVGAAIIISVVCFARNKAKAKAKERNSKTIAEL
                     EPMTKINPRGESEAMPREDATQLEVTLPSSIHETGPDTIQEPDYEPKPTQEPAPEPAP
                     GSEPMAVPDLDIELELEPETQSELEPEPEPEPESEPGVVVEPLSEDEKGVVKA"
     exon            116..279
                     /gene="VSIG1"
                     /gene_synonym="1700062D20Rik; dJ889N15.1; GPA34"
                     /inference="alignment:Splign:2.1.0"
     exon            280..478
                     /gene="VSIG1"
                     /gene_synonym="1700062D20Rik; dJ889N15.1; GPA34"
                     /inference="alignment:Splign:2.1.0"
     exon            479..634
                     /gene="VSIG1"
                     /gene_synonym="1700062D20Rik; dJ889N15.1; GPA34"
                     /inference="alignment:Splign:2.1.0"
     exon            635..754
                     /gene="VSIG1"
                     /gene_synonym="1700062D20Rik; dJ889N15.1; GPA34"
                     /inference="alignment:Splign:2.1.0"
     exon            755..896
                     /gene="VSIG1"
                     /gene_synonym="1700062D20Rik; dJ889N15.1; GPA34"
                     /inference="alignment:Splign:2.1.0"
     exon            897..3033
                     /gene="VSIG1"
                     /gene_synonym="1700062D20Rik; dJ889N15.1; GPA34"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1374..1379
                     /regulatory_class="polyA_signal_sequence"
                     /gene="VSIG1"
                     /gene_synonym="1700062D20Rik; dJ889N15.1; GPA34"
                     /note="hexamer: AATAAA"
     polyA_site      1400
                     /gene="VSIG1"
                     /gene_synonym="1700062D20Rik; dJ889N15.1; GPA34"
                     /note="major polyA site"
     regulatory      2922..2927
                     /regulatory_class="polyA_signal_sequence"
                     /gene="VSIG1"
                     /gene_synonym="1700062D20Rik; dJ889N15.1; GPA34"
                     /note="hexamer: AATAAA"
     polyA_site      2946
                     /gene="VSIG1"
                     /gene_synonym="1700062D20Rik; dJ889N15.1; GPA34"
                     /note="major polyA site"
     regulatory      3010..3015
                     /regulatory_class="polyA_signal_sequence"
                     /gene="VSIG1"
                     /gene_synonym="1700062D20Rik; dJ889N15.1; GPA34"
                     /note="hexamer: AATAAA"
     polyA_site      3033
                     /gene="VSIG1"
                     /gene_synonym="1700062D20Rik; dJ889N15.1; GPA34"
ORIGIN      
        1 aatttgagac tcagcctagt ccaggcaagc tactggcacc tgctgctctc aactaacctc
       61 cacacaatgg tgttcgcatt ttggaaggtc tttctgatcc taagctgcct tgcaggtcag
      121 gttagtgtgg tgcaagtgac catcccagac ggtttcgtga acgtgactgt tggatctaat
      181 gtcactctca tctgcatcta caccaccact gtggcctccc gagaacagct ttccatccag
      241 tggtctttct tccataagaa ggagatggag ccaatttcta tttacttttc tcaaggtgga
      301 caagctgtag ccatcgggca atttaaagat cgaattacag ggtccaacga tccaggtaat
      361 gcatctatca ctatctcgca tatgcagcca gcagacagtg gaatttacat ctgcgatgtt
      421 aacaaccccc cagactttct cggccaaaac caaggcatcc tcaacgtcag tgtgttagtg
      481 aaaccttcta agcccctttg tagcgttcaa ggaagaccag aaactggcca cactatttcc
      541 ctttcctgtc tctctgcgct tggaacacct tcccctgtgt actactggca taaacttgag
      601 ggaagagaca tcgtgccagt gaaagaaaac ttcaacccaa ccaccgggat tttggtcatt
      661 ggaaatctga caaattttga acaaggttat taccagtgta ctgccatcaa cagacttggc
      721 aatagttcct gcgaaatcga tctcacttct tcacatccag aagttggaat cattgttggg
      781 gccttgattg gtagcctggt aggtgccgcc atcatcatct ctgttgtgtg cttcgcaagg
      841 aataaggcaa aagcaaaggc aaaagaaaga aattctaaga ccatcgcgga acttgagcca
      901 atgacaaaga taaacccaag gggagaaagc gaagcaatgc caagagaaga cgctacccaa
      961 ctagaagtaa ctctaccatc ttccattcat gagactggcc ctgataccat ccaagaacca
     1021 gactatgagc caaagcctac tcaggagcct gccccagagc ctgccccagg atcagagcct
     1081 atggcagtgc ctgaccttga catcgagctg gagctggagc cagaaacgca gtcggaattg
     1141 gagccagagc cagagccaga gccagagtca gagcctgggg ttgtagttga gcccttaagt
     1201 gaagatgaaa agggagtggt taaggcatag gctggtggcc taagtacagc attaatcatt
     1261 aaggaaccca ttactgccat ttggaattca aataacctaa ccaacctcca cctcctcctt
     1321 ccattttgac caaccttctt ctaacaaggt gctcattcct actatgaatc cagaataaac
     1381 acgccaagat aacagctaaa tcagcaaggg ttcctgtatt accaatatag aatactaaca
     1441 attttactaa cacgtaagca taacaaatga cagggcaagt gatttctaac ttagttgagt
     1501 tttgcaacag tacctgtgtt gttatttcag aaaatattat ttctctcttt ttaactactc
     1561 ttttttttta ttttagacag agtcttgctc cgtcgcgcag gctgtgatcg tagtggtgcg
     1621 atctcggctc actgcaacct ccgctccctg ggttcaagcg attctcctgc ctgagcctcc
     1681 tgagtagctg ggactacagg cacgtgccac cacgcccggc taattttttg tatttttagt
     1741 agagatgggg tttcacgttg ttagccagga tggtctccat ctcctgacct catgatccgc
     1801 ccaccttggc ctcccaaaat gctgggatta caggcatgag ccactgcgcc cggcctcttt
     1861 ttagctactc ttatgttcca catgcacata tgacaaggtg gcattaatta gattcaatat
     1921 tatttctagg aatagttcct cattcatttt tatattgacc actaagaaaa taattcatca
     1981 gcattatctc atagattgga aaattttctc caaatacaat agaggagaat atgtaaaggg
     2041 tatacattaa ttggtacgta gcatttaaaa tcaggtctta taattaatgc ttcattcctc
     2101 atattagatt tcccaagaaa tcaccctggt atccaatatc tgagcatggc aaatttaaaa
     2161 aataacacaa tttcttgcct gtaaccctag cactttggga ggccgaggca ggtggatcac
     2221 ctgaggtcag gagttcgaga ccagcctggc caacatggcg aaaccccttc tctactaaaa
     2281 atacaaaaat tagctgggcg tggtagtgca tgcctgtaat cccagctact tgggaggctg
     2341 aggcaggaga atcgcttgaa cccaggaggt ggaggttgca gtgagccgag attgtgccac
     2401 tgcactccaa cctgggtgac agagtgagat tccatctgaa aaacaaaaac aaaaacagaa
     2461 aacaaacaaa caaaaaacaa aaaatcccca caactttgtc aaataatgta caggcaaaca
     2521 ctttcaaata taatttcctt cagtgaatac aaaatgttga tatcataggt gatgtacaat
     2581 ttagttttga atgagttatt atgttatcac tgtgtctgat gttatctact ttgaaaggca
     2641 gtccagaaaa gtgttctaag tgaactctta agatctattt tagataattt caactaatta
     2701 aataacctgt tttactgcct gtacattcca cattaataaa gcgataccaa tcttatatga
     2761 atgctaatat tactaaaatg cactgatatc acttcttctt cccctgttga aaagctttct
     2821 catgatcata tttcacccac atctcacctt gaagaaactt acaggtagac ttaccttttc
     2881 acttgtggaa ttaatcatat ttaaatctta ctttaaggct caataaataa tactcataat
     2941 gtctcatttt agtgactcct aaggctagtc cttttataaa caactttttc tgacatagca
     3001 tttatgtata ataaaccaga catttaaagt gta
//
