LOCUS       NM_018228               3408 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens vertebrae development associated (VRTN), mRNA.
ACCESSION   NM_018228
VERSION     NM_018228.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3408)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 3408)
  AUTHORS   Mikawa,S., Sato,S., Nii,M., Morozumi,T., Yoshioka,G., Imaeda,N.,
            Yamaguchi,T., Hayashi,T. and Awata,T.
  TITLE     Identification of a second gene associated with variation in
            vertebral number in domestic pigs
  JOURNAL   BMC Genet 12, 5 (2011)
   PUBMED   21232157
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CX165172.1 and BC053325.1.
            
            On Nov 22, 2018 this sequence version replaced NM_018228.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC053325.1, AK001673.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA2146236
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000256362.5/ ENSP00000256362.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-21                CX165172.1         9-29
            22-3408             BC053325.1         13-3399
FEATURES             Location/Qualifiers
     source          1..3408
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q24.3"
     gene            1..3408
                     /gene="VRTN"
                     /gene_synonym="C14orf115; vertnin"
                     /note="vertebrae development associated"
                     /db_xref="GeneID:55237"
                     /db_xref="HGNC:HGNC:20223"
                     /db_xref="MIM:620468"
     exon            1..182
                     /gene="VRTN"
                     /gene_synonym="C14orf115; vertnin"
                     /inference="alignment:Splign:2.1.0"
     exon            183..3408
                     /gene="VRTN"
                     /gene_synonym="C14orf115; vertnin"
                     /inference="alignment:Splign:2.1.0"
     CDS             184..2292
                     /gene="VRTN"
                     /gene_synonym="C14orf115; vertnin"
                     /note="vertebrae development homolog (pig)"
                     /codon_start=1
                     /product="vertnin"
                     /protein_id="NP_060698.2"
                     /db_xref="CCDS:CCDS9830.1"
                     /db_xref="GeneID:55237"
                     /db_xref="HGNC:HGNC:20223"
                     /db_xref="MIM:620468"
                     /translation="MTSRNQLVQKVLQELQEAVECEGLEGLIGASLEAKQVLSSFTLP
                     TCREGGPGLQVLEVDSVALSLYPEDAPRNMLPLVCKGEGSLLFEAASMLLWGDAGLSL
                     ELRARTVVEMLLHRHYYLQGMIDSKVMLQAVRYSLCSEESPEMTSLPPATLEAIFDAD
                     VKASCFPSSFSNVWHLYALASVLQRNIYSIYPMRNLKIRPYFNRVIRPRRCDHVPSTL
                     HIMWAGQPLTSHFFRHQYFAPVVGLEEVEAEGAPGVAPALPALAPLSSPAKTLELLNR
                     EPGLSYSHLCERYSVTKSTFYRWRRQSQEHRQKVAARFSAKHFLQDSFHRGGVVPLQQ
                     FLQRFPEISRSTYYAWKHELLGSGTCPALPPREVLGMEELEKLPEEQVAEEELECSAL
                     AVSSPGMVLMQRAKLYLEHCISLNTLVPYRCFKRRFPGISRSTYYNWRRKALRRNPSF
                     KPAPALSAAGTPQLASVGEGAVIPWKSEAEEGAGNATGEDPPAPGELLPLRMPLSRWQ
                     RRLRRAARRQVLSGHLPFCRFRLRYPSLSPSAFWVWKSLARGWPRGLSKLQVPVPTLG
                     KGGQEAEEKQEKEAGRDVTAVMAPPVGASSEDVEGGPSREGALQEGATAQGQPHSGPL
                     LSQPVVAAAGGRDGRMLVMDMIATTKFKAQAKLFLQKRFQSKSFPSYKEFSALFPLTA
                     RSTYYMWKRALYDGLTLVDG"
     regulatory      3386..3391
                     /regulatory_class="polyA_signal_sequence"
                     /gene="VRTN"
                     /gene_synonym="C14orf115; vertnin"
                     /note="hexamer: AATAAA"
     polyA_site      3408
                     /gene="VRTN"
                     /gene_synonym="C14orf115; vertnin"
                     /note="major polyA site"
ORIGIN      
        1 agttggctgt agacggtcca tgctcaatgg tcctctacag atatgaaact ggttctggag
       61 tgagacgagc tcggctgggg acgctacttg agaaggcctt tccccacagg gtgacttaaa
      121 tgtcccaggc tggaaggtgg agcgagaagt ggatgccccc agggctctgg gtcacactcc
      181 aggatgactt ctcggaacca gctggtgcag aaggtgctgc aggagctgca ggaagcagtg
      241 gagtgcgaag gcctggaggg tctcataggt gcttccttgg aggccaagca ggtcctgtct
      301 tccttcactc tccccacctg ccgggaggga ggccctggcc tccaggtgct ggaagtggac
      361 tcggtggccc tgagcctgta tccagaagat gctccacgga acatgctgcc gctggtgtgc
      421 aagggggagg gcagcctgct gttcgaggcg gccagcatgc tgctgtgggg tgacgcaggc
      481 ctcagcctgg agctgcgggc ccgcaccgtg gtagagatgc tgctgcacag acactactac
      541 ctccagggca tgatcgactc caaagtgatg ctgcaggccg tgcgctactc cctatgctct
      601 gaggagtccc ctgagatgac cagcttgccc cccgccacgc tggaggccat cttcgatgcc
      661 gacgtcaagg cctcctgttt ccccagcagc ttctccaacg tgtggcactt gtatgctctc
      721 gcctctgtcc tccagcggaa catctactcc atctacccca tgcgcaacct caagatccgg
      781 ccctacttca accgtgtcat ccggccccgc cgctgcgacc acgtgccctc cacgctgcac
      841 atcatgtggg ctggccagcc cctcaccagc cacttcttcc gccaccagta ctttgcccct
      901 gtggtggggc tggaagaggt ggaggctgaa ggtgcccctg gcgtggcccc agctcttcca
      961 gccctggccc cactctcatc gccggccaag accctggagc tgctcaaccg tgaacctggc
     1021 ctcagctact ctcacctctg tgagcgctac agcgtcacca aaagcacctt ctaccgctgg
     1081 cggcggcagt cccaggagca ccggcagaag gttgctgccc gcttctccgc caagcacttc
     1141 ctgcaggaca gcttccaccg ggggggcgtc gtgccacttc agcagttcct ccagcggttc
     1201 ccggagatct cccgctcaac ctactatgcc tggaagcatg agctgctggg ctctggcacc
     1261 tgcccggcct tgccccccag ggaggtgctg ggcatggagg agctagagaa gctgccggag
     1321 gagcaggtgg ctgaggagga gctggagtgc tccgcactgg cggtgtcaag ccctggaatg
     1381 gtcttaatgc agcgggccaa gttgtacctg gagcattgca tctccctgaa cacactggta
     1441 ccctatcgct gcttcaaacg caggttccct ggcatctcac ggtccactta ttataattgg
     1501 cggcgaaagg ccctccggag gaaccccagc ttcaagccgg caccagccct ctctgctgct
     1561 gggactcccc agctagcatc tgttggggaa ggggctgtaa ttccttggaa gagtgaggcg
     1621 gaagaggggg cagggaatgc cacaggtgag gaccctcccg cccccgggga gctcctgcca
     1681 ctaaggatgc ccctgtcccg ttggcagagg cgtctgcgca gggctgcccg caggcaggtg
     1741 ctgagtgggc atctcccttt ctgccgcttc cgcctccgct accccagcct gtcaccttct
     1801 gccttttggg tctggaagag tcttgctcgg ggttggccca gaggcctgtc caaacttcag
     1861 gtgccggtcc ccaccttggg caaagggggg caggaggctg aggagaagca ggagaaggag
     1921 gctggcaggg atgtgacagc tgtgatggcc ccacctgtgg gggcttcttc agaagatgta
     1981 gagggagggc cttccagaga gggggccctg caggaggggg ccacagccca gggccagccc
     2041 cacagtgggc ccttgctgag ccaacctgtg gtggcagcag cgggtggcag ggatggccgg
     2101 atgctggtga tggacatgat cgctaccacg aagttcaagg cccaggccaa gctgttcttg
     2161 cagaagcgct tccagtccaa gagctttccc tcctacaagg agttcagtgc cctctttccc
     2221 ctcactgccc gctccacata ctacatgtgg aagcgagccc tctatgacgg cctgaccctg
     2281 gtagatggct gacagggagg tacaaaaggg gctgggaaga agggggacca gtttggagag
     2341 ggtcagggac ctgagctgac cccaggcttg gccaggatgt cctttgctct gggtcccaca
     2401 gtgtctaccc taagtccaag ggtatatttg tgttattttc tggctccagg acagagaatg
     2461 ccagaaatca gccatctggt ctcccgtagg aaactgtggg accagagata tcctctttcg
     2521 ttgtttgctg gtcatatttt tactgttatg atttagtttt tggttttgat ttgagtgggt
     2581 tggttggccc ccttgctgga gttggaagcc gtatgtatgt cagggggttt agaggggggt
     2641 tggttagcta gagctgcttt cagcttttcc tggagacaaa aggagtgtta tagcatgatc
     2701 atcggtccca ctgggcagaa cgttatcttc agtttctttt gggggttggc atcctcttta
     2761 ctcagttgtt tcccaaagga acattaggct cgaatatggg ggccaggtgt ggtggcttat
     2821 gcctgtaatc ctagcgcttt gggaggccaa ggcaggagga tcacttgagg ctaggagtta
     2881 gagaccaccc tgggcaatgt agtgagacct catctcttag aaaaaaaaaa agaaagaaaa
     2941 tcaaatgtag agctgatcag cagcttgtgc ctggcatccc caagggagaa ggtgccaggt
     3001 cagcaggagc agcagcaggg atgtatagaa agaaccacag ctggcctcta aaggatggca
     3061 ctgaggcacc ggagatcttg aggcactgga gatcactgag gggctggcct gtcccctgca
     3121 aggagtgtgg gaccaggtgg ggcaaggctg ggagatgcag gctctgtttg cagattatgg
     3181 cccagagtct ctgcttgtgg gtgcttgatc cacctgctgg gaccctgcag tcctcggcca
     3241 gcctggctgt cagttgggga ttccaccttt ctgctgagcg tcttctcgga gctggaggcc
     3301 catcttcagt gagagatcac aaagcggcca ggcaggtggg agactgaatt tgccttgttc
     3361 gagagtaacg tttgaaaacc aaagaaataa agtgatgcag tgcccaca
//
