LOCUS       NM_005997               1511 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens vacuolar protein sorting 72 homolog (VPS72),
            transcript variant 2, mRNA.
ACCESSION   NM_005997
VERSION     NM_005997.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1511)
  AUTHORS   Xu,X., Wang,W., He,Y., Yao,Y. and Yang,B.
  TITLE     Prognostic marker VPS72 could promote the malignant progression of
            prostate cancer
  JOURNAL   BMC Cancer 24 (1), 713 (2024)
   PUBMED   38858662
  REMARK    GeneRIF: Prognostic marker VPS72 could promote the malignant
            progression of prostate cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1511)
  AUTHORS   Liu,F., Liao,Z., Qin,L., Zhang,Z., Zhang,Q., Han,S., Zeng,W.,
            Zhang,H., Liu,Y., Song,J., Chen,W., Zhu,H., Liang,H., Chen,X.,
            Zhang,B. and Zhang,Z.
  TITLE     Targeting VPS72 inhibits ACTL6A/MYC axis activity in HCC
            progression
  JOURNAL   Hepatology 78 (5), 1384-1401 (2023)
   PUBMED   36631007
  REMARK    GeneRIF: Targeting VPS72 inhibits ACTL6A/MYC axis activity in HCC
            progression.
REFERENCE   3  (bases 1 to 1511)
  AUTHORS   Chen,T., Tu,Y., Lv,D., Lin,K., Tang,H. and Huang,W.
  TITLE     Vacuolar protein sorting-associated protein 72 homolog (VPS72)
            binding to lysine acetyltransferase 5 (KAT5) promotes the
            proliferation, invasion and migration of hepatocellular carcinoma
            through regulating phosphatidylinositol 3-kinase (PI3K)/protein
            kinase B (AKT) signaling pathway
  JOURNAL   Bioengineered 13 (4), 9197-9210 (2022)
   PUBMED   35383533
  REMARK    GeneRIF: Vacuolar protein sorting-associated protein 72 homolog
            (VPS72) binding to lysine acetyltransferase 5 (KAT5) promotes the
            proliferation, invasion and migration of hepatocellular carcinoma
            through regulating phosphatidylinositol 3-kinase (PI3K)/protein
            kinase B (AKT) signaling pathway.
REFERENCE   4  (bases 1 to 1511)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   5  (bases 1 to 1511)
  AUTHORS   Umemoto,T., Yamato,M., Ishihara,J., Shiratsuchi,Y., Utsumi,M.,
            Morita,Y., Tsukui,H., Terasawa,M., Shibata,T., Nishida,K.,
            Kobayashi,Y., Petrich,B.G., Nakauchi,H., Eto,K. and Okano,T.
  TITLE     Integrin-alphavbeta3 regulates thrombopoietin-mediated maintenance
            of hematopoietic stem cells
  JOURNAL   Blood 119 (1), 83-94 (2012)
   PUBMED   22096247
REFERENCE   6  (bases 1 to 1511)
  AUTHORS   Jin,J., Cai,Y., Yao,T., Gottschalk,A.J., Florens,L., Swanson,S.K.,
            Gutierrez,J.L., Coleman,M.K., Workman,J.L., Mushegian,A.,
            Washburn,M.P., Conaway,R.C. and Conaway,J.W.
  TITLE     A mammalian chromatin remodeling complex with similarities to the
            yeast INO80 complex
  JOURNAL   J Biol Chem 280 (50), 41207-41212 (2005)
   PUBMED   16230350
REFERENCE   7  (bases 1 to 1511)
  AUTHORS   Cai,Y., Jin,J., Florens,L., Swanson,S.K., Kusch,T., Li,B.,
            Workman,J.L., Washburn,M.P., Conaway,R.C. and Conaway,J.W.
  TITLE     The mammalian YL1 protein is a shared subunit of the TRRAP/TIP60
            histone acetyltransferase and SRCAP complexes
  JOURNAL   J Biol Chem 280 (14), 13665-13670 (2005)
   PUBMED   15647280
  REMARK    GeneRIF: Results identify YL1 as a subunit of the TRRAP/TIP60 HAT
            complex, and also as a component of a novel mammalian multiprotein
            complex that includes the SNF2-related helicase SRCAP.
REFERENCE   8  (bases 1 to 1511)
  AUTHORS   Doyon,Y., Selleck,W., Lane,W.S., Tan,S. and Cote,J.
  TITLE     Structural and functional conservation of the NuA4 histone
            acetyltransferase complex from yeast to humans
  JOURNAL   Mol Cell Biol 24 (5), 1884-1896 (2004)
   PUBMED   14966270
REFERENCE   9  (bases 1 to 1511)
  AUTHORS   Horikawa,I., Tanaka,H., Yuasa,Y., Suzuki,M., Shimizu,M. and
            Oshimura,M.
  TITLE     Forced expression of YL-1 protein suppresses the
            anchorage-independent growth of Kirsten sarcoma virus-transformed
            NIH3T3 cells
  JOURNAL   Exp Cell Res 220 (1), 11-17 (1995)
   PUBMED   7664828
REFERENCE   10 (bases 1 to 1511)
  AUTHORS   Horikawa,I., Tanaka,H., Yuasa,Y., Suzuki,M. and Oshimura,M.
  TITLE     Molecular cloning of a novel human cDNA on chromosome 1q21 and its
            mouse homolog encoding a nuclear protein with DNA-binding ability
  JOURNAL   Biochem Biophys Res Commun 208 (3), 999-1007 (1995)
   PUBMED   7702631
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DQ655941.2, D43642.1,
            AA128103.1 and AW194498.1.
            
            On Jun 2, 2019 this sequence version replaced NM_005997.2.
            
            Summary: The protein encoded by this gene is a shared subunit of
            two multi-component complexes, the histone acetyltransferase
            complex TRRAP/TIP60 as well as the chromatin remodeling
            SRCAP-containing complex. The TRRAP/TIP60 complex acetylates
            nucleosomal histones important for transcriptional regulation,
            double strand DNA break repair and apoptosis. The SRCAP-containing
            complex catalyzes the exchange of histone H2A with the histone
            variant Htz1 (H2AFZ) into nucleosomes. This protein may be
            responsible for binding H2AFZ, which has a role in chromosome
            segregation. This protein may also have a role in regulating
            long-term hematopoietic stem cell activity. Alternative splicing
            results in multiple transcript variants that encode different
            protein isoforms. [provided by RefSeq, Aug 2012].
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site in the 3' coding region, compared to variant 1. This
            results in a shorter protein (isoform 2), compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D43642.1, BC003151.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000368892.9/ ENSP00000357887.5
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-33                DQ655941.2         18-50
            34-1357             D43642.1           1-1324
            1358-1507           AA128103.1         1-150               c
            1508-1511           AW194498.1         20-23               c
FEATURES             Location/Qualifiers
     source          1..1511
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.3"
     gene            1..1511
                     /gene="VPS72"
                     /gene_synonym="CFL1; Swc2; TCFL1; YL-1; YL1"
                     /note="vacuolar protein sorting 72 homolog"
                     /db_xref="GeneID:6944"
                     /db_xref="HGNC:HGNC:11644"
                     /db_xref="MIM:600607"
     exon            1..193
                     /gene="VPS72"
                     /gene_synonym="CFL1; Swc2; TCFL1; YL-1; YL1"
                     /inference="alignment:Splign:2.1.0"
     CDS             77..1171
                     /gene="VPS72"
                     /gene_synonym="CFL1; Swc2; TCFL1; YL-1; YL1"
                     /note="isoform 2 is encoded by transcript variant 2;
                     vacuolar protein sorting-associated protein 72 homolog;
                     transformation suppressor gene YL-1; transcription
                     factor-like 1"
                     /codon_start=1
                     /product="vacuolar protein sorting-associated protein 72
                     homolog isoform 2"
                     /protein_id="NP_005988.1"
                     /db_xref="CCDS:CCDS989.1"
                     /db_xref="GeneID:6944"
                     /db_xref="HGNC:HGNC:11644"
                     /db_xref="MIM:600607"
                     /translation="MSLAGGRAPRKTAGNRLSGLLEAEEEDEFYQTTYGGFTEESGDD
                     EYQGDQSDTEDEVDSDFDIDEGDEPSSDGEAEEPRRKRRVVTKAYKEPLKSLRPRKVN
                     TPAGSSQKAREEKALLPLELQDDGSDSRKSMRQSTAEHTRQTFLRVQERQGQSRRRKG
                     PHCERPLTQEELLREAKITEELNLRSLETYERLEADKKKQVHKKRKCPGPIITYHSVT
                     VPLVGEPGPKEENVDIEGLDPAPSVSALTPHAGTGPVNPPARCSRTFITFSDDATFEE
                     WFPQGRPPKVPVREVCPVTHRPALYRDPVTDIPYATARAFKIIREAYKKYITAHGLPP
                     TASALGPGPPPPEPLPGSGPRALRQKIVIK"
     exon            194..346
                     /gene="VPS72"
                     /gene_synonym="CFL1; Swc2; TCFL1; YL-1; YL1"
                     /inference="alignment:Splign:2.1.0"
     exon            347..461
                     /gene="VPS72"
                     /gene_synonym="CFL1; Swc2; TCFL1; YL-1; YL1"
                     /inference="alignment:Splign:2.1.0"
     exon            462..638
                     /gene="VPS72"
                     /gene_synonym="CFL1; Swc2; TCFL1; YL-1; YL1"
                     /inference="alignment:Splign:2.1.0"
     exon            639..783
                     /gene="VPS72"
                     /gene_synonym="CFL1; Swc2; TCFL1; YL-1; YL1"
                     /inference="alignment:Splign:2.1.0"
     exon            784..1511
                     /gene="VPS72"
                     /gene_synonym="CFL1; Swc2; TCFL1; YL-1; YL1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1335..1340
                     /regulatory_class="polyA_signal_sequence"
                     /gene="VPS72"
                     /gene_synonym="CFL1; Swc2; TCFL1; YL-1; YL1"
                     /note="hexamer: AATAAA"
     polyA_site      1352
                     /gene="VPS72"
                     /gene_synonym="CFL1; Swc2; TCFL1; YL-1; YL1"
                     /note="major polyA site"
     regulatory      1483..1488
                     /regulatory_class="polyA_signal_sequence"
                     /gene="VPS72"
                     /gene_synonym="CFL1; Swc2; TCFL1; YL-1; YL1"
                     /note="hexamer: TATAAA"
     polyA_site      1511
                     /gene="VPS72"
                     /gene_synonym="CFL1; Swc2; TCFL1; YL-1; YL1"
ORIGIN      
        1 agtgatgtcg agcgtcgagc tcccaaaacc gagctggtga ggggctgcag gtggcggcgc
       61 agtctcggta ggcggtatga gtttggctgg gggccgggca ccccggaaga ccgctgggaa
      121 ccggctttct gggcttttgg aggcagagga ggaagatgag ttctaccaga cgacttatgg
      181 gggtttcaca gaggaatccg gagatgatga gtatcaaggg gaccagtcag acacagagga
      241 cgaagtggac tctgactttg acattgatga aggggatgaa ccatccagtg atggagaagc
      301 agaagagcca agaaggaagc gccgagtagt caccaaggcc tataaggaac ctctcaagag
      361 cttaaggcct cgaaaggtca acaccccggc tggtagctct cagaaggcgc gagaagagaa
      421 ggcactactg ccattagaac tacaagatga cggctctgac agtcggaagt ctatgcgtca
      481 gtctacagct gagcatacac gacaaacgtt ccttcgggta caggagaggc agggccagtc
      541 aagacggcga aaggggcccc actgtgagcg gccactaacc caggaggaac tgctccggga
      601 ggccaagatc acagaagagc ttaatttacg gtcactggag acatatgagc ggctcgaggc
      661 tgataaaaag aagcaggttc ataagaagcg gaagtgcccc gggcccataa tcacctatca
      721 ttcagtgaca gtgccacttg ttggggagcc aggccccaag gaagagaacg ttgacataga
      781 aggacttgat cctgctccct cggtgtctgc attgactcct catgctggga ctggacccgt
      841 caacccccct gctcgctgct cacgtacctt catcactttt agtgatgatg caactttcga
      901 ggaatggttc ccccaagggc ggcccccaaa agtccctgtt cgtgaggtct gtccagtgac
      961 ccatcgtcca gccctatacc gggaccctgt tacagacata ccctatgcca ctgctcgagc
     1021 cttcaagatc attcgtgagg cttacaagaa gtacattact gcccatggac tgccgcccac
     1081 tgcctcagcc ctgggccccg gcccgccacc tcctgagccc ctccctggct ctgggccccg
     1141 agccttgcgc cagaaaattg tcattaaatg aagagatgtc tagtcctcag aaacttcttt
     1201 cctgccctga ttggggctct tgctgttccg tttcttctcc ctgcttctcc cctttgtcat
     1261 ctctgatctt tgcctaatct gtttcttttt ccttttcccc tagttcttac aggtttcgtt
     1321 gtgtttttta atctaataaa atagaaagat cccttttgtc tggtgtccag tctagggttg
     1381 ggagcaagaa gtatttgaat acctgcatat atttgggtct ttattcgata gcatttatta
     1441 tgagctgtcc tttctaaatt gtattcattc ctccaactaa attataaaca tctgaaaatt
     1501 gcacaccaaa a
//
