LOCUS       NM_004869               3337 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens vacuolar protein sorting 4 homolog B (VPS4B), mRNA.
ACCESSION   NM_004869
VERSION     NM_004869.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3337)
  AUTHORS   Lai,W.Q., Xia,H.F., Chen,G.H., Wang,X.L., Yang,J.G., Wu,L.Z.,
            Zhao,Y.F., Jia,Y.L. and Chen,G.
  TITLE     p-AKT/VPS4B regulates the small extracellular vesicle size in
            venous malformation endothelial cells
  JOURNAL   Oral Dis 30 (3), 1273-1285 (2024)
   PUBMED   37154262
  REMARK    GeneRIF: p-AKT/VPS4B regulates the small extracellular vesicle size
            in venous malformation endothelial cells.
REFERENCE   2  (bases 1 to 3337)
  AUTHORS   Harel,S., Altaras,Y., Nachmias,D., Rotem-Dai,N., Dvilansky,I.,
            Elia,N. and Rousso,I.
  TITLE     Analysis of individual HIV-1 budding event using fast AFM reveals a
            multiplexed role for VPS4
  JOURNAL   Biophys J 121 (21), 4229-4238 (2022)
   PUBMED   36042696
  REMARK    GeneRIF: Analysis of individual HIV-1 budding event using fast AFM
            reveals a multiplexed role for VPS4.
REFERENCE   3  (bases 1 to 3337)
  AUTHORS   Neggers,J.E., Paolella,B.R., Asfaw,A., Rothberg,M.V., Skipper,T.A.,
            Yang,A., Kalekar,R.L., Krill-Burger,J.M., Dharia,N.V., Kugener,G.,
            Kalfon,J., Yuan,C., Dumont,N., Gonzalez,A., Abdusamad,M., Li,Y.Y.,
            Spurr,L.F., Wu,W.W., Durbin,A.D., Wolpin,B.M., Piccioni,F.,
            Root,D.E., Boehm,J.S., Cherniack,A.D., Tsherniak,A., Hong,A.L.,
            Hahn,W.C., Stegmaier,K., Golub,T.R., Vazquez,F. and Aguirre,A.J.
  TITLE     Synthetic Lethal Interaction between the ESCRT Paralog Enzymes
            VPS4A and VPS4B in Cancers Harboring Loss of Chromosome 18q or 16q
  JOURNAL   Cell Rep 33 (11), 108493 (2020)
   PUBMED   33326793
  REMARK    GeneRIF: Synthetic Lethal Interaction between the ESCRT Paralog
            Enzymes VPS4A and VPS4B in Cancers Harboring Loss of Chromosome 18q
            or 16q.
            Erratum:[Cell Rep. 2021 Jul 13;36(2):109367. doi:
            10.1016/j.celrep.2021.109367.. PMID: 34260938]
REFERENCE   4  (bases 1 to 3337)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 3337)
  AUTHORS   Li,Q., Lu,F., Chen,T., Zhang,K., Lu,Y., Li,X., Wang,Y., Liu,L.,
            Tian,Q., Xiong,F. and Chen,D.
  TITLE     VPS4B mutation impairs the osteogenic differentiation of dental
            follicle cells derived from a patient with dentin dysplasia type I
  JOURNAL   Int J Oral Sci 12 (1), 22 (2020)
   PUBMED   32737282
  REMARK    GeneRIF: VPS4B mutation impairs the osteogenic differentiation of
            dental follicle cells derived from a patient with dentin dysplasia
            type I.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3337)
  AUTHORS   Bishop,N. and Woodman,P.
  TITLE     ATPase-defective mammalian VPS4 localizes to aberrant endosomes and
            impairs cholesterol trafficking
  JOURNAL   Mol Biol Cell 11 (1), 227-239 (2000)
   PUBMED   10637304
REFERENCE   7  (bases 1 to 3337)
  AUTHORS   Lippincott-Schwartz,J., Roberts,T.H. and Hirschberg,K.
  TITLE     Secretory protein trafficking and organelle dynamics in living
            cells
  JOURNAL   Annu Rev Cell Dev Biol 16, 557-589 (2000)
   PUBMED   11031247
  REMARK    Review article
REFERENCE   8  (bases 1 to 3337)
  AUTHORS   Scheuring,S., Bodor,O., Rohricht,R.A., Muller,S., Beyer,A. and
            Kohrer,K.
  TITLE     Cloning, characterisation, and functional expression of the Mus
            musculus SKD1 gene in yeast demonstrates that the mouse SKD1 and
            the yeast VPS4 genes are orthologues and involved in intracellular
            protein trafficking
  JOURNAL   Gene 234 (1), 149-159 (1999)
   PUBMED   10393249
REFERENCE   9  (bases 1 to 3337)
  AUTHORS   Mao,M., Fu,G., Wu,J.S., Zhang,Q.H., Zhou,J., Kan,L.X., Huang,Q.H.,
            He,K.L., Gu,B.W., Han,Z.G., Shen,Y., Gu,J., Yu,Y.P., Xu,S.H.,
            Wang,Y.X., Chen,S.J. and Chen,Z.
  TITLE     Identification of genes expressed in human CD34(+) hematopoietic
            stem/progenitor cells by expressed sequence tags and efficient
            full-length cDNA cloning
  JOURNAL   Proc Natl Acad Sci U S A 95 (14), 8175-8180 (1998)
   PUBMED   9653160
REFERENCE   10 (bases 1 to 3337)
  AUTHORS   Finken-Eigen,M., Rohricht,R.A. and Kohrer,K.
  TITLE     The VPS4 gene is involved in protein transport out of a yeast
            pre-vacuolar endosome-like compartment
  JOURNAL   Curr Genet 31 (6), 469-480 (1997)
   PUBMED   9211789
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA306069.1 and AF195514.1.
            
            On Nov 23, 2018 this sequence version replaced NM_004869.3.
            
            Summary: The protein encoded by this gene is a member of the AAA
            protein family (ATPases associated with diverse cellular
            activities), and is the homolog of the yeast Vps4 protein. In
            humans, two paralogs of the yeast protein have been identified. The
            former share a high degree of aa sequence similarity with each
            other, and also with yeast Vps4 and mouse Skd1 proteins. Mouse Skd1
            (suppressor of K+ transport defect 1) has been shown to be a yeast
            Vps4 ortholog. Functional studies indicate that both human paralogs
            associate with the endosomal compartments, and are involved in
            intracellular protein trafficking, similar to Vps4 protein in
            yeast. The gene encoding this paralog has been mapped to chromosome
            18; the gene for the other resides on chromosome 16. [provided by
            RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF195514.1, ERR4643909.5451.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000238497.10/ ENSP00000238497.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                DA306069.1         45-60
            17-3337             AF195514.1         1-3321
FEATURES             Location/Qualifiers
     source          1..3337
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18q21.33"
     gene            1..3337
                     /gene="VPS4B"
                     /gene_synonym="MIG1; SKD1; SKD1B; VPS4-2"
                     /note="vacuolar protein sorting 4 homolog B"
                     /db_xref="GeneID:9525"
                     /db_xref="HGNC:HGNC:10895"
                     /db_xref="MIM:609983"
     exon            1..244
                     /gene="VPS4B"
                     /gene_synonym="MIG1; SKD1; SKD1B; VPS4-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             218..1552
                     /gene="VPS4B"
                     /gene_synonym="MIG1; SKD1; SKD1B; VPS4-2"
                     /EC_number="3.6.4.6"
                     /note="suppressor of K+ transport defect 1; cell
                     migration-inducing 1; cell migration-inducing gene 1
                     protein; suppressor of K(+) transport growth defect 1;
                     vacuolar protein sorting 4B"
                     /codon_start=1
                     /product="vacuolar protein sorting-associated protein 4B"
                     /protein_id="NP_004860.2"
                     /db_xref="CCDS:CCDS11983.1"
                     /db_xref="GeneID:9525"
                     /db_xref="HGNC:HGNC:10895"
                     /db_xref="MIM:609983"
                     /translation="MSSTSPNLQKAIDLASKAAQEDKAGNYEEALQLYQHAVQYFLHV
                     VKYEAQGDKAKQSIRAKCTEYLDRAEKLKEYLKNKEKKAQKPVKEGQPSPADEKGNDS
                     DGEGESDDPEKKKLQNQLQGAIVIERPNVKWSDVAGLEGAKEALKEAVILPIKFPHLF
                     TGKRTPWRGILLFGPPGTGKSYLAKAVATEANNSTFFSISSSDLVSKWLGESEKLVKN
                     LFQLARENKPSIIFIDEIDSLCGSRSENESEAARRIKTEFLVQMQGVGVDNDGILVLG
                     ATNIPWVLDSAIRRRFEKRIYIPLPEPHARAAMFKLHLGTTQNSLTEADFRELGRKTD
                     GYSGADISIIVRDALMQPVRKVQSATHFKKVRGPSRADPNHLVDDLLTPCSPGDPGAI
                     EMTWMDVPGDKLLEPVVSMSDMLRSLSNTKPTVNEHDLLKLKKFTEDFGQEG"
     exon            245..356
                     /gene="VPS4B"
                     /gene_synonym="MIG1; SKD1; SKD1B; VPS4-2"
                     /inference="alignment:Splign:2.1.0"
     exon            357..513
                     /gene="VPS4B"
                     /gene_synonym="MIG1; SKD1; SKD1B; VPS4-2"
                     /inference="alignment:Splign:2.1.0"
     exon            514..581
                     /gene="VPS4B"
                     /gene_synonym="MIG1; SKD1; SKD1B; VPS4-2"
                     /inference="alignment:Splign:2.1.0"
     exon            582..701
                     /gene="VPS4B"
                     /gene_synonym="MIG1; SKD1; SKD1B; VPS4-2"
                     /inference="alignment:Splign:2.1.0"
     exon            702..858
                     /gene="VPS4B"
                     /gene_synonym="MIG1; SKD1; SKD1B; VPS4-2"
                     /inference="alignment:Splign:2.1.0"
     exon            859..1007
                     /gene="VPS4B"
                     /gene_synonym="MIG1; SKD1; SKD1B; VPS4-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1008..1089
                     /gene="VPS4B"
                     /gene_synonym="MIG1; SKD1; SKD1B; VPS4-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1090..1309
                     /gene="VPS4B"
                     /gene_synonym="MIG1; SKD1; SKD1B; VPS4-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1310..1450
                     /gene="VPS4B"
                     /gene_synonym="MIG1; SKD1; SKD1B; VPS4-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1451..3337
                     /gene="VPS4B"
                     /gene_synonym="MIG1; SKD1; SKD1B; VPS4-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3204..3209
                     /regulatory_class="polyA_signal_sequence"
                     /gene="VPS4B"
                     /gene_synonym="MIG1; SKD1; SKD1B; VPS4-2"
                     /note="hexamer: AGTAAA"
     polyA_site      3222
                     /gene="VPS4B"
                     /gene_synonym="MIG1; SKD1; SKD1B; VPS4-2"
                     /note="major polyA site"
     regulatory      3310..3315
                     /regulatory_class="polyA_signal_sequence"
                     /gene="VPS4B"
                     /gene_synonym="MIG1; SKD1; SKD1B; VPS4-2"
                     /note="hexamer: ATTAAA"
     polyA_site      3337
                     /gene="VPS4B"
                     /gene_synonym="MIG1; SKD1; SKD1B; VPS4-2"
ORIGIN      
        1 agagggcctc gggattgcgg aagtttggtg gggagggtcg gagctctggt ggagagagtg
       61 ttgtctaaaa caagttccgg aagggaggct gcccttcgcg gtccgagaac caccggcctc
      121 cccagtttga gggctgttac cccgtgcgcg cttcgacgtt gctgctgttg gctctcctcg
      181 cccctcgttc ccttgggaac cgcctgggaa ctccgccatg tcatccactt cgcccaacct
      241 ccagaaagcg atagatctgg ctagcaaagc agcgcaagaa gacaaggctg ggaactacga
      301 agaagccctt cagctctatc agcatgctgt gcagtatttt cttcatgtcg ttaaatatga
      361 agcacagggt gataaagcca agcaaagtat cagggcaaag tgtacagaat atcttgatag
      421 agcagaaaaa ctaaaggagt acctgaaaaa taaagagaaa aaagcacaga agccagtgaa
      481 agaaggacag ccgagtccag cagatgagaa ggggaatgac agtgatgggg aaggagaatc
      541 tgatgatcct gaaaaaaaga aactacagaa tcaacttcaa ggtgccattg ttatagaacg
      601 accaaatgtg aaatggagtg acgttgctgg acttgaagga gccaaagaag cactgaaaga
      661 ggctgtgata ctgcctatta aatttcctca tctttttaca ggcaagagaa caccttggag
      721 gggaatccta ttatttgggc cgcctggaac aggaaagtcc tacttagcca aagctgtagc
      781 aacagaagcc aacaactcaa catttttttc aatatcttcc tctgatcttg tttctaagtg
      841 gctaggtgaa agtgaaaaac tggttaagaa tttattccaa cttgccagag agaacaagcc
      901 ctccattatc ttcattgatg aaattgattc tctctgtggt tcaagaagtg aaaatgaaag
      961 tgaagccgca cgtagaatta agacggagtt cctagtgcaa atgcaagggg ttggtgtaga
     1021 caatgatgga attttggttc tgggagctac aaatataccc tgggttctgg attctgccat
     1081 taggcgaaga tttgagaaac gaatttatat tcccttgccg gaaccccatg cccgagcagc
     1141 aatgtttaaa ctgcacctag ggaccactca gaacagtctc acggaagcag actttcggga
     1201 acttgggagg aaaacagatg gttattcagg ggcagatata agtatcattg tacgtgatgc
     1261 ccttatgcag cctgttagga aagtacagtc agctactcat tttaaaaagg ttcgcggacc
     1321 ttcccgagct gatcctaacc atcttgtaga tgatctgcta acaccttgct ctccaggtga
     1381 ccctggtgcc attgaaatga catggatgga tgtccctgga gataaacttt tggagccagt
     1441 tgtttccatg tcggatatgt tgcggtcact atctaacaca aaacctacag tcaatgaaca
     1501 tgacttgttg aaattaaaga agtttacaga agattttggt caagaaggct aagccaaaga
     1561 caaggaagat gcttaccata tgtattcttt ctttcataga tatttttgtc tatttggatc
     1621 gcattaattg tttccagtaa aactctttta ccacagggaa atacacatct cacttcagag
     1681 ttccattagg ttttatattg tacttttcct ccattactta ttaaatactc ctattaacaa
     1741 aaggtacaaa ataacaggtt atgaggaaat gagcgatata tgaacggcat aaaaacagaa
     1801 attacccagt aaaaaggatg tcagaaattg acatacaaat atttacaatt tttatgaatg
     1861 gtggtctttg caaagagcat ttatattttc tttttttttt actaaaatga tatagggttt
     1921 attttatatt ttcaaaaaaa ttgttaaaca tcattcttat caatgtaaaa tttacgttat
     1981 taaaaaatta caaatgatag aatctttact cagggatggg caataaaaca gcaaagagct
     2041 ttgtgattgg gtttgaaaga ttttgaatta tagacagtgc tcttaatagt ttttaataag
     2101 ttgatatttt tttctgtgta gatttaaata atttctttaa aagcgtaagc tttggctggg
     2161 catggtggct tatgcctgta atcccagcac tttgggaggc tacgatgggt ggatcacctg
     2221 aggtcaggag ttcaagacca gtctggccaa catggtgaaa tgccgtctct actaaaaata
     2281 caaaaattag ctgggcatga tggcgagtgt ctgtaatccc agctactcag gaggctgagg
     2341 cgggagaatc acttgaacct gggaggcaga ggttgcagtg agctgagatc gcgctactgc
     2401 attccagcct gggcgccgag atagcgccat tgcactccag cctgggcgac tgaataaaac
     2461 tctgtctcaa aaaaaaacaa aaacggtaag cttttatatt taattaactg atacctttca
     2521 ctgtgcaatc tcaagaggaa gattttctaa attagacatt gtctttacct taaagaagaa
     2581 aattgtctat ttcagtgtct tttttagcaa gattgaccaa aacaggtggt aggtgtgtaa
     2641 tttttaactg tcatgaaata ctgtaatgcg cacctttgct aataaggaaa tggtctccct
     2701 ttgaattatg ggaagtttct tgtctgtgat atggggtgtc tgtgtacata tatgtatatt
     2761 tcctttttta atacaggata ataatatggg gtcttgtcct tcacctttta agttcaggga
     2821 acagtttgtc ctgaccacac atatgttatc agtgtaatgc tttatgaagc tttagaaatg
     2881 agctcatgac tcattaaaaa ataataaacg atgctatttt aatattttca aataaataat
     2941 ctgaggatgt gtttcatact ttagcatcaa cgctgagttg tgccttgtag aattgcattg
     3001 tctatacatg caaaagacta ttaagttagg atgaactaga ttccctaatt acagtgaaat
     3061 tctatcttgc aaatgctata gaataacttg cattttaaag tgtatttgca cattttacat
     3121 atgctatgtg gttgcctttg ggttttctgt acagattgtt tttgttatta aatggaaaag
     3181 gcctgaatta tgctcttatg tgaagtaaat tgatataacc tattgactgt attctgtgta
     3241 ttattcttta ttttgggacc ttctgtgtaa aagaaaatat tacctaaatt ggttagatac
     3301 aaagaaatca ttaaaattat taatgtatat atgaaaa
//
