LOCUS       NM_013245               4106 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens vacuolar protein sorting 4 homolog A (VPS4A), mRNA.
ACCESSION   NM_013245
VERSION     NM_013245.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4106)
  AUTHORS   Dvilansky,I., Altaras,Y., Kamenetsky,N., Nachmias,D. and Elia,N.
  TITLE     The human AAA-ATPase VPS4A isoform and its co-factor VTA1 have a
            unique function in regulating mammalian cytokinesis abscission
  JOURNAL   PLoS Biol 22 (4), e3002327 (2024)
   PUBMED   38687820
  REMARK    GeneRIF: The human AAA-ATPase VPS4A isoform and its co-factor VTA1
            have a unique function in regulating mammalian cytokinesis
            abscission.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4106)
  AUTHORS   Yang,Y., Chen,H.L., Wu,S.F. and Bao,W.
  TITLE     CHMP4B and VSP4A reverse GSDMD-mediated pyroptosis by cell membrane
            remodeling in endometrial carcinoma
  JOURNAL   Biochim Biophys Acta Gen Subj 1868 (1), 130497 (2024)
   PUBMED   37931722
  REMARK    GeneRIF: CHMP4B and VSP4A reverse GSDMD-mediated pyroptosis by cell
            membrane remodeling in endometrial carcinoma.
REFERENCE   3  (bases 1 to 4106)
  AUTHORS   Harel,S., Altaras,Y., Nachmias,D., Rotem-Dai,N., Dvilansky,I.,
            Elia,N. and Rousso,I.
  TITLE     Analysis of individual HIV-1 budding event using fast AFM reveals a
            multiplexed role for VPS4
  JOURNAL   Biophys J 121 (21), 4229-4238 (2022)
   PUBMED   36042696
  REMARK    GeneRIF: Analysis of individual HIV-1 budding event using fast AFM
            reveals a multiplexed role for VPS4.
REFERENCE   4  (bases 1 to 4106)
  AUTHORS   Chevalier,B., Baatallah,N., Najm,M., Castanier,S., Jung,V.,
            Pranke,I., Golec,A., Stoven,V., Marullo,S., Antigny,F.,
            Guerrera,I.C., Sermet-Gaudelus,I., Edelman,A. and Hinzpeter,A.
  TITLE     Differential CFTR-Interactome Proximity Labeling Procedures
            Identify Enrichment in Multiple SLC Transporters
  JOURNAL   Int J Mol Sci 23 (16), 8937 (2022)
   PUBMED   36012204
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4106)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   6  (bases 1 to 4106)
  AUTHORS   Howard,T.L., Stauffer,D.R., Degnin,C.R. and Hollenberg,S.M.
  TITLE     CHMP1 functions as a member of a newly defined family of vesicle
            trafficking proteins
  JOURNAL   J Cell Sci 114 (Pt 13), 2395-2404 (2001)
   PUBMED   11559748
REFERENCE   7  (bases 1 to 4106)
  AUTHORS   Hu,R.M., Han,Z.G., Song,H.D., Peng,Y.D., Huang,Q.H., Ren,S.X.,
            Gu,Y.J., Huang,C.H., Li,Y.B., Jiang,C.L., Fu,G., Zhang,Q.H.,
            Gu,B.W., Dai,M., Mao,Y.F., Gao,G.F., Rong,R., Ye,M., Zhou,J.,
            Xu,S.H., Gu,J., Shi,J.X., Jin,W.R., Zhang,C.K., Wu,T.M.,
            Huang,G.Y., Chen,Z., Chen,M.D. and Chen,J.L.
  TITLE     Gene expression profiling in the human
            hypothalamus-pituitary-adrenal axis and full-length cDNA cloning
  JOURNAL   Proc Natl Acad Sci U S A 97 (17), 9543-9548 (2000)
   PUBMED   10931946
REFERENCE   8  (bases 1 to 4106)
  AUTHORS   Lippincott-Schwartz,J., Roberts,T.H. and Hirschberg,K.
  TITLE     Secretory protein trafficking and organelle dynamics in living
            cells
  JOURNAL   Annu Rev Cell Dev Biol 16, 557-589 (2000)
   PUBMED   11031247
  REMARK    Review article
REFERENCE   9  (bases 1 to 4106)
  AUTHORS   Scheuring,S., Bodor,O., Rohricht,R.A., Muller,S., Beyer,A. and
            Kohrer,K.
  TITLE     Cloning, characterisation, and functional expression of the Mus
            musculus SKD1 gene in yeast demonstrates that the mouse SKD1 and
            the yeast VPS4 genes are orthologues and involved in intracellular
            protein trafficking
  JOURNAL   Gene 234 (1), 149-159 (1999)
   PUBMED   10393249
REFERENCE   10 (bases 1 to 4106)
  AUTHORS   Finken-Eigen,M., Rohricht,R.A. and Kohrer,K.
  TITLE     The VPS4 gene is involved in protein transport out of a yeast
            pre-vacuolar endosome-like compartment
  JOURNAL   Curr Genet 31 (6), 469-480 (1997)
   PUBMED   9211789
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC026464.7 and AF255952.1.
            
            On Nov 22, 2018 this sequence version replaced NM_013245.2.
            
            Summary: The protein encoded by this gene is a member of the AAA
            protein family (ATPases associated with diverse cellular
            activities), and is the homolog of the yeast Vps4 protein. In
            humans, two paralogs of the yeast protein have been identified. The
            former share a high degree of aa sequence similarity with each
            other, and also with yeast Vps4 and mouse Skd1 proteins. The mouse
            Skd1 (suppressor of K+ transport defect 1) has been shown to be
            really an yeast Vps4 ortholog. Functional studies indicate that
            both human paralogs associate with the endosomal compartments, and
            are involved in intracellular protein trafficking, similar to Vps4
            protein in yeast. The gene encoding this paralog has been mapped to
            chromosome 16; the gene for the other resides on chromosome 18.
            [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.66661.1,
                                           SRR1803617.226430.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000254950.13/ ENSP00000254950.11
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-34                AC026464.7         36470-36503
            35-2210             AF255952.1         1-2176
            2211-4106           AC026464.7         50164-52059
FEATURES             Location/Qualifiers
     source          1..4106
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q22.1"
     gene            1..4106
                     /gene="VPS4A"
                     /gene_synonym="CIMDAG; SKD1; SKD1A; SKD2; VPS4; VPS4-1"
                     /note="vacuolar protein sorting 4 homolog A"
                     /db_xref="GeneID:27183"
                     /db_xref="HGNC:HGNC:13488"
                     /db_xref="MIM:609982"
     exon            1..183
                     /gene="VPS4A"
                     /gene_synonym="CIMDAG; SKD1; SKD1A; SKD2; VPS4; VPS4-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             163..1476
                     /gene="VPS4A"
                     /gene_synonym="CIMDAG; SKD1; SKD1A; SKD2; VPS4; VPS4-1"
                     /EC_number="3.6.4.6"
                     /note="vacuolar protein sorting factor 4A; SKD1-homolog;
                     vacuolar sorting protein 4; hVPS4"
                     /codon_start=1
                     /product="vacuolar protein sorting-associated protein 4A"
                     /protein_id="NP_037377.1"
                     /db_xref="CCDS:CCDS45517.1"
                     /db_xref="GeneID:27183"
                     /db_xref="HGNC:HGNC:13488"
                     /db_xref="MIM:609982"
                     /translation="MTTSTLQKAIDLVTKATEEDKAKNYEEALRLYQHAVEYFLHAIK
                     YEAHSDKAKESIRAKCVQYLDRAEKLKDYLRSKEKHGKKPVKENQSEGKGSDSDSEGD
                     NPEKKKLQEQLMGAVVMEKPNIRWNDVAGLEGAKEALKEAVILPIKFPHLFTGKRTPW
                     RGILLFGPPGTGKSYLAKAVATEANNSTFFSVSSSDLMSKWLGESEKLVKNLFELARQ
                     HKPSIIFIDEVDSLCGSRNENESEAARRIKTEFLVQMQGVGNNNDGTLVLGATNIPWV
                     LDSAIRRRFEKRIYIPLPEEAARAQMFRLHLGSTPHNLTDANIHELARKTEGYSGADI
                     SIIVRDSLMQPVRKVQSATHFKKVCGPSRTNPSMMIDDLLTPCSPGDPGAMEMTWMDV
                     PGDKLLEPVVCMSDMLRSLATTRPTVNADDLLKVKKFSEDFGQES"
     exon            184..295
                     /gene="VPS4A"
                     /gene_synonym="CIMDAG; SKD1; SKD1A; SKD2; VPS4; VPS4-1"
                     /inference="alignment:Splign:2.1.0"
     exon            296..443
                     /gene="VPS4A"
                     /gene_synonym="CIMDAG; SKD1; SKD1A; SKD2; VPS4; VPS4-1"
                     /inference="alignment:Splign:2.1.0"
     exon            444..505
                     /gene="VPS4A"
                     /gene_synonym="CIMDAG; SKD1; SKD1A; SKD2; VPS4; VPS4-1"
                     /inference="alignment:Splign:2.1.0"
     exon            506..625
                     /gene="VPS4A"
                     /gene_synonym="CIMDAG; SKD1; SKD1A; SKD2; VPS4; VPS4-1"
                     /inference="alignment:Splign:2.1.0"
     exon            626..782
                     /gene="VPS4A"
                     /gene_synonym="CIMDAG; SKD1; SKD1A; SKD2; VPS4; VPS4-1"
                     /inference="alignment:Splign:2.1.0"
     exon            783..931
                     /gene="VPS4A"
                     /gene_synonym="CIMDAG; SKD1; SKD1A; SKD2; VPS4; VPS4-1"
                     /inference="alignment:Splign:2.1.0"
     exon            932..1013
                     /gene="VPS4A"
                     /gene_synonym="CIMDAG; SKD1; SKD1A; SKD2; VPS4; VPS4-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1014..1233
                     /gene="VPS4A"
                     /gene_synonym="CIMDAG; SKD1; SKD1A; SKD2; VPS4; VPS4-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1234..1374
                     /gene="VPS4A"
                     /gene_synonym="CIMDAG; SKD1; SKD1A; SKD2; VPS4; VPS4-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1375..4106
                     /gene="VPS4A"
                     /gene_synonym="CIMDAG; SKD1; SKD1A; SKD2; VPS4; VPS4-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2184..2189
                     /regulatory_class="polyA_signal_sequence"
                     /gene="VPS4A"
                     /gene_synonym="CIMDAG; SKD1; SKD1A; SKD2; VPS4; VPS4-1"
                     /note="hexamer: AATAAA"
     polyA_site      2215
                     /gene="VPS4A"
                     /gene_synonym="CIMDAG; SKD1; SKD1A; SKD2; VPS4; VPS4-1"
                     /note="major polyA site"
     regulatory      2274..2279
                     /regulatory_class="polyA_signal_sequence"
                     /gene="VPS4A"
                     /gene_synonym="CIMDAG; SKD1; SKD1A; SKD2; VPS4; VPS4-1"
                     /note="hexamer: ATTAAA"
     polyA_site      2295
                     /gene="VPS4A"
                     /gene_synonym="CIMDAG; SKD1; SKD1A; SKD2; VPS4; VPS4-1"
     polyA_site      4013
                     /gene="VPS4A"
                     /gene_synonym="CIMDAG; SKD1; SKD1A; SKD2; VPS4; VPS4-1"
     regulatory      4083..4088
                     /regulatory_class="polyA_signal_sequence"
                     /gene="VPS4A"
                     /gene_synonym="CIMDAG; SKD1; SKD1A; SKD2; VPS4; VPS4-1"
                     /note="hexamer: AATAAA"
     polyA_site      4106
                     /gene="VPS4A"
                     /gene_synonym="CIMDAG; SKD1; SKD1A; SKD2; VPS4; VPS4-1"
ORIGIN      
        1 gccctcggac tcggctcccg ctgcgagcgg ccgccctgcc cgcgcaccgc gctcagcgcc
       61 caccgccggg cttcccgcgc cggacccagt acctcggctc cccggggccg gaccgaggcc
      121 gcaagcagcg ccgcggggtg tggggcggac ccaggagatg aaatgacaac gtcaaccctc
      181 cagaaagcca ttgatctggt gacgaaagcc acagaggagg acaaagccaa gaactacgag
      241 gaggcgctgc ggctgtacca gcatgcggtg gagtacttcc tccacgctat caagtatgag
      301 gcccacagcg acaaggccaa ggagagcatt cgagccaagt gcgtgcagta cctagaccgg
      361 gccgagaagc tgaaggatta tttacgaagc aaagagaaac acggcaagaa gccagtcaaa
      421 gagaaccaga gtgagggcaa gggcagtgac agtgacagtg aaggggataa tccggagaaa
      481 aagaaactgc aagaacagct gatgggtgcc gtcgtgatgg agaagcccaa catacggtgg
      541 aacgacgtgg ccgggctgga gggggccaag gaggccctca aagaagctgt cattttgcca
      601 atcaaattcc cacacttgtt cacaggcaag cgcaccccct ggcgggggat tctgctgttc
      661 ggaccccctg gcacagggaa atcctacctg gccaaagccg tggcaacaga ggccaacaac
      721 tccaccttct tctctgtgtc ctcctcagat ctgatgtcca agtggctggg ggagagtgaa
      781 aagctggtca agaacctgtt tgagctggcc aggcagcaca agccctccat catcttcatc
      841 gatgaggtgg attccctctg cgggtcccga aatgaaaatg agagtgaggc cgcccggagg
      901 atcaaaacgg agttcttggt ccagatgcag ggggtgggga ataacaatga tgggactctg
      961 gttcttggag ccacaaacat cccatgggtg ttggattcgg ccatcaggag gaggtttgaa
     1021 aaacgaattt atatcccctt gccggaggaa gctgcccgcg cccagatgtt ccggttgcat
     1081 ctcgggagca ctccccacaa cctcacggat gcaaacatcc acgagctggc ccggaagacg
     1141 gaaggctact cgggcgcgga catcagcatc atcgtgcggg actctctcat gcagcccgtg
     1201 aggaaggtgc agtcggccac acacttcaaa aaggtctgtg gcccctctcg caccaacccc
     1261 agcatgatga ttgatgacct cctgactcca tgctcaccag gggacccagg agccatggag
     1321 atgacttgga tggatgtccc tggggacaaa ctcttagagc ctgtggtttg catgtcggac
     1381 atgctgcggt ctctggccac cacccggccc acggtgaatg cagacgacct cctgaaagtg
     1441 aagaaattct cagaggactt tgggcaagag agttaaaagc tgcttcactt gggcaatggt
     1501 gaaggtggga ggttgattgg ggcaaatcca ggcactcccc atgtcaacag ccagacaggg
     1561 ctccagggct tgtcccagtc aatacagagt tccctctgct gtctggccgt ctgccaggga
     1621 gccagaagga agggccttgc agccacagag acactccact gccctggggc acacagtgga
     1681 cactgctctt cctacttcct cctctcctgg atgctcatca gctccttctg cctccccccc
     1741 ttttttttcc atcttttgtt cccctaaatt aatgctgctt ggattttcat cttatttata
     1801 aagataaaat cacctggaag tgtcaaggag tggggcgggg tggcggggga gaagcagccg
     1861 tgctgccagg tcacccagac ctccagacag ccggctagcc ccactgcccg ttccttttac
     1921 gcccaagttt tgctccttga gagcagattg gctgatgccc ctgcaacccc agcccaagct
     1981 ctgcctcaaa gaccgagtga cataagccat tcccaccctc ctaggttcac atccagggct
     2041 gtgtcttcct tgggggagga gatggtgtcg tttagatcag ggtaaggcag tcaggcgggt
     2101 gttcaccact gccttttctt cctctgagcg tgagaacact gaacccagcc actgcccctg
     2161 ggtccctgtc ctggaaatgg tctaataaat ccttttccct tcttgagcta cccaagtgat
     2221 ctcatctttc cttgactctt aactgagact ctgaagggcc acccttgctt ccaattaaaa
     2281 gaccctctgg ttttctgtct cctctctttt ctaaagcaga gcaggaaaca gaacactgca
     2341 gttcttaggc ctgttctcca gtcaggtgtg caaggcctcc tccccttaag gcctcagaag
     2401 tttggctggg gatgtttgtg ggatccagac agttcttgcc gttgttcggc ctacagatca
     2461 gagactgcaa agtgggagcc ctgcgtacca gacccgtcct gcagctgtgt ttgtttggtt
     2521 tggtctgccg ctaacattta aaagtcgaga gttgctgggc gcggtggctc acgcctgtaa
     2581 tcccagcact ttgggccgct aacatttaaa agtcgagagt tgctgggcgc ggtggctcac
     2641 gcctgtaatc ccagcacttt gggaggccga cgcgggcgga tcacaaggtc aggaaatcga
     2701 gaacatcctg gctaacacag tgaaaccccg tctcactaaa aataaaaaaa ttagccgggc
     2761 gtggtggtgg gcgcctgcag tcccagctac ttgggaggct gaggcaggag aatggcgtga
     2821 acccggggga cggagcttgc agtgagccga gatcgcgcca ctgcactcca gcctgggcga
     2881 cagagcaaga ctctgtctca aaaaaaaaaa aaaagtcgag agttgacata aaaattcaga
     2941 attctgactt ctagaagatt aaattaggta atgttgggcc tgcgtcctca tggggcagcc
     3001 tgtcagcggc cactaagtag aggctgctct gtacagaagg ggtcccccat ccccactcat
     3061 ctgtgttgcc tgcccagata gccccatggc catttcagtt tgcgaccccc aacagaccaa
     3121 ggacccagag ctggcagccc tggacccacg tccggcaggc agtgaagctg cagaggctgt
     3181 cccacgttta ccccatgcat ataaacagac caaagtcaaa gcacattcac acagaaagac
     3241 ctggcctagt aaatgaagct tatagcctgc aaagggcttt gttccaacct tccctctcca
     3301 aaacccagta ctgctcctct acctttcaaa cctggttggg ccagaactga ttacatggcc
     3361 aactcttggc tcacactggg cttgcactgg gccatttctt tgctctggtt cagagcctct
     3421 gcagaagtga gctaactttg gatcagtagc tccaacactt ggctccagtg ctggcaggtt
     3481 acccctcaac catagcagct gggatctttg tggcttgggg gtgcttgtgt aagttcttgg
     3541 ttatgtgccc tcagccacca ggatatgaac cgtgtctgca gagcttcact ttagtgagct
     3601 tacaagtttt taaattttta cttctagtta catttacttg aatcagaacg ttgtttcctc
     3661 attcctactg cttaaacacc ttgacaagtc ctaggggtta acaaaggtta gcatggctat
     3721 ggtccatccc tgtgctctag ttagagcgtg aagacacctg actttccagt tgtctctctc
     3781 catgaccagc aacaggaacc actgacgctg aactttggac agtggcctca gactctggct
     3841 gccagcacac aacctgccat catcgatgtt aaacatgctg acatgtgcag aggagtttcc
     3901 tccctgaaat gctctgaaat tcacttctct gcctggggat tctgttataa accttctgcc
     3961 tacattggct ttcactgtgg aagttgattt ctaaaactct gatgagctca caacgttgac
     4021 atgtatatgc gttttttgtg agtgcttcct gctcaaagtg ggagagattt tactggaaat
     4081 gcaataaagt ttgcatttta ttgcta
//
