LOCUS       NM_015289               4832 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens VPS39 subunit of HOPS complex (VPS39), transcript
            variant 2, mRNA.
ACCESSION   NM_015289 XM_031720
VERSION     NM_015289.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4832)
  AUTHORS   Zhou,Y., Liu,Y., Gupta,S., Paramo,M.I., Hou,Y., Mao,C., Luo,Y.,
            Judd,J., Wierbowski,S., Bertolotti,M., Nerkar,M., Jehi,L.,
            Drayman,N., Nicolaescu,V., Gula,H., Tay,S., Randall,G., Wang,P.,
            Lis,J.T., Feschotte,C., Erzurum,S.C., Cheng,F. and Yu,H.
  TITLE     A comprehensive SARS-CoV-2-human protein-protein interactome
            reveals COVID-19 pathobiology and potential host therapeutic
            targets
  JOURNAL   Nat Biotechnol 41 (1), 128-139 (2023)
   PUBMED   36217030
REFERENCE   2  (bases 1 to 4832)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 4832)
  AUTHORS   Chen,D., Zheng,Q., Sun,L., Ji,M., Li,Y., Deng,H. and Zhang,H.
  TITLE     ORF3a of SARS-CoV-2 promotes lysosomal exocytosis-mediated viral
            egress
  JOURNAL   Dev Cell 56 (23), 3250-3263 (2021)
   PUBMED   34706264
REFERENCE   4  (bases 1 to 4832)
  AUTHORS   Chen,Z., Wang,C., Feng,X., Nie,L., Tang,M., Zhang,H., Xiong,Y.,
            Swisher,S.K., Srivastava,M. and Chen,J.
  TITLE     Interactomes of SARS-CoV-2 and human coronaviruses reveal host
            factors potentially affecting pathogenesis
  JOURNAL   EMBO J 40 (17), e107776 (2021)
   PUBMED   34232536
REFERENCE   5  (bases 1 to 4832)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 4832)
  AUTHORS   Peralta,E.R., Martin,B.C. and Edinger,A.L.
  TITLE     Differential effects of TBC1D15 and mammalian Vps39 on Rab7
            activation state, lysosomal morphology, and growth factor
            dependence
  JOURNAL   J Biol Chem 285 (22), 16814-16821 (2010)
   PUBMED   20363736
  REMARK    GeneRIF: although only TBC1D15/Rab7-GAP altered Rab7-GTP levels,
            both Rab7-GAP and mVps39 regulate lysosomal morphology and play a
            role in maintaining growth factor dependence
REFERENCE   7  (bases 1 to 4832)
  AUTHORS   Zhu,G.D., Salazar,G., Zlatic,S.A., Fiza,B., Doucette,M.M.,
            Heilman,C.J., Levey,A.I., Faundez,V. and L'hernault,S.W.
  TITLE     SPE-39 family proteins interact with the HOPS complex and function
            in lysosomal delivery
  JOURNAL   Mol Biol Cell 20 (4), 1223-1240 (2009)
   PUBMED   19109425
REFERENCE   8  (bases 1 to 4832)
  AUTHORS   Schroder,B., Wrocklage,C., Pan,C., Jager,R., Kosters,B.,
            Schafer,H., Elsasser,H.P., Mann,M. and Hasilik,A.
  TITLE     Integral and associated lysosomal membrane proteins
  JOURNAL   Traffic 8 (12), 1676-1686 (2007)
   PUBMED   17897319
REFERENCE   9  (bases 1 to 4832)
  AUTHORS   Felici,A., Wurthner,J.U., Parks,W.T., Giam,L.R., Reiss,M.,
            Karpova,T.S., McNally,J.G. and Roberts,A.B.
  TITLE     TLP, a novel modulator of TGF-beta signaling, has opposite effects
            on Smad2- and Smad3-dependent signaling
  JOURNAL   EMBO J 22 (17), 4465-4477 (2003)
   PUBMED   12941698
  REMARK    GeneRIF: propose that TLP might regulate the balance of Smad2 and
            Smad3 signaling by localizing Smad4 intracellularly, thus
            contributing to cellular specificity of TGF-beta transcriptional
            responses in both normal and pathophysiology
REFERENCE   10 (bases 1 to 4832)
  AUTHORS   Caplan,S., Hartnell,L.M., Aguilar,R.C., Naslavsky,N. and
            Bonifacino,J.S.
  TITLE     Human Vam6p promotes lysosome clustering and fusion in vivo
  JOURNAL   J Cell Biol 154 (1), 109-122 (2001)
   PUBMED   11448994
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB461120.1, AF281052.1,
            AK074193.1 and AC036103.8.
            
            On Feb 27, 2020 this sequence version replaced NM_015289.4.
            
            Summary: This gene encodes a protein that may promote clustering
            and fusion of late endosomes and lysosomes. The protein may also
            act as an adaptor protein that modulates the transforming growth
            factor-beta response by coupling the transforming growth
            factor-beta receptor complex to the Smad pathway. Alternative
            splicing results in multiple transcript variants. [provided by
            RefSeq, Jul 2014].
            
            Transcript Variant: This variant (2) lacks an alternate in-frame
            exon in the 5' coding region, compared to variant 1, resulting in
            an isoform (b) that is shorter than isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX537404.1, AF281052.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000318006.10/ ENSP00000326534.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-8                 DB461120.1         24-31
            9-4820              AF281052.1         1-4812
            4821-4823           AK074193.1         1335-1337
            4824-4832           AC036103.8         82198-82206         c
FEATURES             Location/Qualifiers
     source          1..4832
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q15.1"
     gene            1..4832
                     /gene="VPS39"
                     /gene_synonym="hVam6p; TLP; VAM6"
                     /note="VPS39 subunit of HOPS complex"
                     /db_xref="GeneID:23339"
                     /db_xref="HGNC:HGNC:20593"
                     /db_xref="MIM:612188"
     exon            1..224
                     /gene="VPS39"
                     /gene_synonym="hVam6p; TLP; VAM6"
                     /inference="alignment:Splign:2.1.0"
     CDS             152..2779
                     /gene="VPS39"
                     /gene_synonym="hVam6p; TLP; VAM6"
                     /note="isoform b is encoded by transcript variant 2;
                     TRAP1-like protein; vam6/Vps39-like protein; VPS39, HOPS
                     complex subunit; vacuolar protein sorting 39 homolog"
                     /codon_start=1
                     /product="vam6/Vps39-like protein isoform b"
                     /protein_id="NP_056104.2"
                     /db_xref="CCDS:CCDS10083.1"
                     /db_xref="GeneID:23339"
                     /db_xref="HGNC:HGNC:20593"
                     /db_xref="MIM:612188"
                     /translation="MHDAFEPVPILEKLPLQIDCLAAWEEWLLVGTKQGHLLLYRIRK
                     DVGCNRFEVTLEKSNKNFSKKIQQIHVVSQFKILVSLLENNIYVHDLLTFQQITTVSK
                     AKGASLFTCDLQHTETGEEVLRMCVAVKKKLQLYFWKDREFHELQGDFSVPDVPKSMA
                     WCENSICVGFKRDYYLIRVDGKGSIKELFPTGKQLEPLVAPLADGKVAVGQDDLTVVL
                     NEEGICTQKCALNWTDIPVAMEHQPPYIIAVLPRYVEIRTFEPRLLVQSIELQRPRFI
                     TSGGSNIIYVASNHFVWRLIPVPMATQIQQLLQDKQFELALQLAEMKDDSDSEKQQQI
                     HHIKNLYAFNLFCQKRFDESMQVFAKLGTDPTHVMGLYPDLLPTDYRKQLQYPNPLPV
                     LSGAELEKAHLALIDYLTQKRSQLVKKLNDSDHQSSTSPLMEGTPTIKSKKKLLQIID
                     TTLLKCYLHTNVALVAPLLRLENNHCHIEESEHVLKKAHKYSELIILYEKKGLHEKAL
                     QVLVDQSKKANSPLKGHERTVQYLQHLGTENLHLIFSYSVWVLRDFPEDGLKIFTEDL
                     PEVESLPRDRVLGFLIENFKGLAIPYLEHIIHVWEETGSRFHNCLIQLYCEKVQGLMK
                     EYLLSFPAGKTPVPAGEEEGELGEYRQKLLMFLEISSYYDPGRLICDFPFDGLLEERA
                     LLLGRMGKHEQALFIYVHILKDTRMAEEYCHKHYDRNKDGNKDVYLSLLRMYLSPPSI
                     HCLGPIKLELLEPKANLQAALQVLELHHSKLDTTKALNLLPANTQINDIRIFLEKVLE
                     ENAQKKRFNQVLKNLLHAEFLRVQEERILHQQVKCIITEEKVCMVCKKKIGNSAFARY
                     PNGVVVHYFCSKEVNPADT"
     exon            225..290
                     /gene="VPS39"
                     /gene_synonym="hVam6p; TLP; VAM6"
                     /inference="alignment:Splign:2.1.0"
     exon            291..355
                     /gene="VPS39"
                     /gene_synonym="hVam6p; TLP; VAM6"
                     /inference="alignment:Splign:2.1.0"
     exon            356..398
                     /gene="VPS39"
                     /gene_synonym="hVam6p; TLP; VAM6"
                     /inference="alignment:Splign:2.1.0"
     exon            399..493
                     /gene="VPS39"
                     /gene_synonym="hVam6p; TLP; VAM6"
                     /inference="alignment:Splign:2.1.0"
     exon            494..592
                     /gene="VPS39"
                     /gene_synonym="hVam6p; TLP; VAM6"
                     /inference="alignment:Splign:2.1.0"
     exon            593..685
                     /gene="VPS39"
                     /gene_synonym="hVam6p; TLP; VAM6"
                     /inference="alignment:Splign:2.1.0"
     exon            686..869
                     /gene="VPS39"
                     /gene_synonym="hVam6p; TLP; VAM6"
                     /inference="alignment:Splign:2.1.0"
     exon            870..990
                     /gene="VPS39"
                     /gene_synonym="hVam6p; TLP; VAM6"
                     /inference="alignment:Splign:2.1.0"
     exon            991..1111
                     /gene="VPS39"
                     /gene_synonym="hVam6p; TLP; VAM6"
                     /inference="alignment:Splign:2.1.0"
     exon            1112..1241
                     /gene="VPS39"
                     /gene_synonym="hVam6p; TLP; VAM6"
                     /inference="alignment:Splign:2.1.0"
     exon            1242..1384
                     /gene="VPS39"
                     /gene_synonym="hVam6p; TLP; VAM6"
                     /inference="alignment:Splign:2.1.0"
     exon            1385..1528
                     /gene="VPS39"
                     /gene_synonym="hVam6p; TLP; VAM6"
                     /inference="alignment:Splign:2.1.0"
     exon            1529..1670
                     /gene="VPS39"
                     /gene_synonym="hVam6p; TLP; VAM6"
                     /inference="alignment:Splign:2.1.0"
     exon            1671..1757
                     /gene="VPS39"
                     /gene_synonym="hVam6p; TLP; VAM6"
                     /inference="alignment:Splign:2.1.0"
     exon            1758..1831
                     /gene="VPS39"
                     /gene_synonym="hVam6p; TLP; VAM6"
                     /inference="alignment:Splign:2.1.0"
     exon            1832..1930
                     /gene="VPS39"
                     /gene_synonym="hVam6p; TLP; VAM6"
                     /inference="alignment:Splign:2.1.0"
     exon            1931..2048
                     /gene="VPS39"
                     /gene_synonym="hVam6p; TLP; VAM6"
                     /inference="alignment:Splign:2.1.0"
     exon            2049..2177
                     /gene="VPS39"
                     /gene_synonym="hVam6p; TLP; VAM6"
                     /inference="alignment:Splign:2.1.0"
     exon            2178..2280
                     /gene="VPS39"
                     /gene_synonym="hVam6p; TLP; VAM6"
                     /inference="alignment:Splign:2.1.0"
     exon            2281..2326
                     /gene="VPS39"
                     /gene_synonym="hVam6p; TLP; VAM6"
                     /inference="alignment:Splign:2.1.0"
     exon            2327..2476
                     /gene="VPS39"
                     /gene_synonym="hVam6p; TLP; VAM6"
                     /inference="alignment:Splign:2.1.0"
     exon            2477..2611
                     /gene="VPS39"
                     /gene_synonym="hVam6p; TLP; VAM6"
                     /inference="alignment:Splign:2.1.0"
     exon            2612..2703
                     /gene="VPS39"
                     /gene_synonym="hVam6p; TLP; VAM6"
                     /inference="alignment:Splign:2.1.0"
     exon            2704..4832
                     /gene="VPS39"
                     /gene_synonym="hVam6p; TLP; VAM6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4801..4806
                     /regulatory_class="polyA_signal_sequence"
                     /gene="VPS39"
                     /gene_synonym="hVam6p; TLP; VAM6"
                     /note="hexamer: AATAAA"
     regulatory      4810..4815
                     /regulatory_class="polyA_signal_sequence"
                     /gene="VPS39"
                     /gene_synonym="hVam6p; TLP; VAM6"
                     /note="hexamer: AATAAA"
     polyA_site      4823
                     /gene="VPS39"
                     /gene_synonym="hVam6p; TLP; VAM6"
                     /note="major polyA site"
     polyA_site      4832
                     /gene="VPS39"
                     /gene_synonym="hVam6p; TLP; VAM6"
                     /note="major polyA site"
ORIGIN      
        1 ggggttgacg atggctgtgt tgttgaaggg cctgtagccg gggggttcct ggccggatcc
       61 cggtctaccc ttagcccaga ctcgttccgg accccagccc ggcccggaac actctgggcg
      121 agacggcggt ggcaactctc cccttgccgc catgcacgac gctttcgagc cagtgccgat
      181 cctagaaaag ctgcctctgc aaatcgactg tctggctgcc tgggaggaat ggcttcttgt
      241 gggaaccaaa caaggacatc ttcttctcta taggattcgg aaggacgttg gttgcaacag
      301 atttgaagtg acactagaga aatccaataa gaacttctcc aaaaagattc agcagatcca
      361 tgtggtttcc cagtttaaga ttctggtcag cttgttagaa aataacattt atgtccatga
      421 cctattgaca tttcaacaaa tcactacggt ttcaaaggca aagggagcat cactgtttac
      481 ttgtgacctc cagcacacag agaccggtga ggaggtgtta cggatgtgtg tggcagtaaa
      541 aaagaagctg cagctctatt tctggaagga cagggaattt catgaattgc agggggactt
      601 tagtgtgcca gatgtgccca agtccatggc gtggtgtgaa aattctatct gtgtgggttt
      661 caagagagac tactacctaa taagggtgga tggaaagggg tccatcaaag agctctttcc
      721 aacaggaaaa cagctggagc ccttagttgc acctctggca gatggaaaag tggctgtggg
      781 ccaggatgat ctcaccgtgg tactcaatga ggaagggatc tgcacacaga aatgtgccct
      841 gaactggacg gacataccag tggccatgga gcaccagcct ccctacatca ttgcagtgtt
      901 gcctcgatat gttgagatcc gaacatttga accgaggctt ctggtccaaa gcattgaatt
      961 gcaaaggccc cgtttcatta cctcaggagg atcaaacatt atctatgtgg ccagcaatca
     1021 ttttgtttgg agactcatcc ctgtccccat ggcaacccaa atccaacaac ttctccagga
     1081 caagcagttt gaattggctc tgcagctcgc agaaatgaaa gatgattctg acagtgaaaa
     1141 gcagcaacaa attcatcaca tcaagaactt gtatgccttc aacctcttct gccagaagcg
     1201 ttttgatgag tccatgcagg tctttgctaa acttggcaca gatcccaccc atgtgatggg
     1261 cctgtaccct gacctgctgc ccacagacta cagaaagcag ttgcagtatc ccaacccatt
     1321 gcctgtgctc tccggggctg aattggagaa ggctcactta gctctgattg actacctgac
     1381 acagaaacga agtcaattgg taaagaagct gaatgactct gatcaccagt caagcacctc
     1441 accgctcatg gaaggcactc ccaccatcaa atccaagaag aagctgctac aaatcatcga
     1501 caccaccctg ctcaagtgct atctccatac aaatgtggcc ctggtggccc ccttgctacg
     1561 cctggagaac aatcactgcc acatcgagga gagcgagcac gtgctaaaga aggctcacaa
     1621 gtacagtgag cttatcatcc tgtatgagaa gaaggggctc cacgagaaag ctctgcaggt
     1681 gctcgtggac cagtccaaga aagccaactc ccctctgaaa ggccacgaga ggacagtgca
     1741 gtatctgcag catctgggca cagaaaacct gcatttgatt ttctcctact cagtgtgggt
     1801 gctgagagac ttcccagaag atggcctgaa gatatttact gaagatctcc cggaagtgga
     1861 gtctctgcca cgtgatcgag tcctcggctt cttaatagag aattttaagg gtctggctat
     1921 tccttatctg gaacacatca tccatgtttg ggaggagaca ggctctcggt tccacaactg
     1981 cctgatccag ctatactgtg agaaggtgca aggtctgatg aaggagtatc tcctgtcctt
     2041 ccctgcaggc aaaaccccag tcccagctgg agaggaagag ggtgagctgg gagaataccg
     2101 gcaaaagctc ctcatgttct tggagatttc cagctactat gatccaggcc ggctcatctg
     2161 tgattttccc tttgatggcc tcttagaaga acgagctctc ctgttggggc gcatggggaa
     2221 acatgaacaa gctcttttca tttatgtcca catcttgaag gatacaagga tggctgagga
     2281 gtactgccac aaacactatg accgaaacaa agatggcaac aaagatgtgt atctgtccct
     2341 gcttcggatg tacctgtcgc cccccagcat tcactgcctg gggccaatca agctggaact
     2401 actggagcca aaagccaacc tccaggccgc tctgcaggtc ctcgagctac accacagcaa
     2461 actggacacc accaaggccc tcaaccttct gccagcaaac actcagatca atgacatacg
     2521 catcttcctg gaaaaggtct tggaagaaaa tgcacaaaag aaacggttca atcaagtgct
     2581 caagaacctt ctccatgcag aattcctgag ggtccaggaa gagcggattt tacaccagca
     2641 ggtgaagtgc atcatcacag aggagaaggt gtgcatggtg tgtaagaaga agattgggaa
     2701 cagtgcattt gcaagatacc ccaatggagt ggtcgtccat tacttctgtt ccaaagaggt
     2761 aaacccagct gacacttgag cccagcatcc tggggatcca gcggatggac agcttggctc
     2821 tcccagagag gtgaaggagc acctggcctt aggaatcctg gctgccacca ccacaaggct
     2881 ccccatttgg acattactgg ctatcttgtg ccctggaaca actctgaatt aattagactc
     2941 atggtctggc attgccagct ttttaatggg aaaagagatt agttatacct tataccatta
     3001 tgttgtgggc aattccagag aattcagtac ctgcttggtc aggaggatgt gcaccatctt
     3061 gcctttgcac accagtcacc tgaacaagga aacttgtcac aagtgtttgt aaccatgggg
     3121 ttgttcatca agggcttttc tattaagtac atgacttcac aaggaccgct cagcatggct
     3181 cactggagag ttccatgaga gaacagcact caagcttctg gccgcatgga cccgatggct
     3241 cgcattctgt gtagtgtttt acgtctccat ggtaactgtg ccctgcaccc ctcggtagcc
     3301 gccctgttag ttttcagtct ccttttcttt ctcaccattt atcacttccc tcactgccct
     3361 acccaggctt tctctcccac ttccctgact ctgggaataa ctaatattta agcaaggtaa
     3421 gatgagaagc aaggggtctc agttctagga atacagtgct agttgattgt caggtatgtt
     3481 gtaaatagac cctctttggc catacactcc atgcctagat gcctcggaga gcatcattct
     3541 ctgcctaggc aaggccctgc atcccttgcc tcaggccggg ctgagtgtga ctgcagctcc
     3601 tgaggatggg cctgccctgt ctggggtatg cgtgatccct agatacatgt tcccacagag
     3661 gtgcctgctc cgtcttcgct caccagacac tcaggcaggc tggcttagtc tttgtgcgtg
     3721 gcgattttgt gctctgggcc ctttctcttt ttccagccag tttccattca cttgccttac
     3781 agcctgccct ggccgtcact ccccagcttt gttcagcaat ggtgtggttg gagagttgtg
     3841 ctgggatagc gcaggaaggt gggtcccggc aacacgcagg ggatgagtgg acctggaact
     3901 gacaatggcg tgctgccaag tgttcctgag aggtgtttag gcacagcaga ggggacgcgg
     3961 ggggcaagaa cagcaggacg ctggtttaaa aataactcac cgccaaacct gtggagcagt
     4021 gtggggcatc ctgccagagg tgcacaggct ggagtttcag gcactgcagg ctgatgacac
     4081 acagggagag tggccctgcc tcctgtcctc cccggggttt ttgcagactc gaagtctcac
     4141 tgcaccagtg tctttgatgg tggtgagggt gggtgatggt gcccagcacc aacagtttta
     4201 gtggcctgtc cttgacctgc cgtggtcctt tgtaaactat ggctccatgc tgtgtgacag
     4261 atcaacgtgc tgatggtaag tagactaggc ttccccaggc atgccgtccg tgggggcctg
     4321 aagagacagt gagtgccatt ggccccattc gcagatgtgg gagactctgc tcaggcctgt
     4381 gaggctgggc agcccttcac cagagttcgg aggagcagtg tgtggcgcca cgtcccgact
     4441 ggccataccc acacagaagc agtgctgccc ggggcctcat ctgggccagc ttggactctg
     4501 cttcctccag gagcagcagg gaagctctgg gccacctccc tggatagcag gaacttgacc
     4561 tgccatgtgt gccctgcctt cctggccagc tgtgcttgtt atcttccatt ctcacaaact
     4621 gtctttgaag caatagaata aagaatgtgt gttttctttc ctggtataca tacatgatcc
     4681 catgctccca agctccattc ttccttccct caactctctg ccctccacag agctatggag
     4741 aaggctggag atgaaagctt tgtagtgagg actgataaag atctcatcac tgctccttat
     4801 aataaaccta ataaagcaag aaaccaagcc ta
//
