LOCUS       NM_001077621            1618 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens VPS37D subunit of ESCRT-I (VPS37D), mRNA.
ACCESSION   NM_001077621 XM_376631 XM_379866 XM_939403
VERSION     NM_001077621.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1618)
  AUTHORS   Flower,T.G., Takahashi,Y., Hudait,A., Rose,K., Tjahjono,N.,
            Pak,A.J., Yokom,A.L., Liang,X., Wang,H.G., Bouamr,F., Voth,G.A. and
            Hurley,J.H.
  TITLE     A helical assembly of human ESCRT-I scaffolds reverse-topology
            membrane scission
  JOURNAL   Nat Struct Mol Biol 27 (6), 570-580 (2020)
   PUBMED   32424346
REFERENCE   2  (bases 1 to 1618)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1618)
  AUTHORS   Cornelis,M.C., Byrne,E.M., Esko,T., Nalls,M.A., Ganna,A.,
            Paynter,N., Monda,K.L., Amin,N., Fischer,K., Renstrom,F.,
            Ngwa,J.S., Huikari,V., Cavadino,A., Nolte,I.M., Teumer,A., Yu,K.,
            Marques-Vidal,P., Rawal,R., Manichaikul,A., Wojczynski,M.K.,
            Vink,J.M., Zhao,J.H., Burlutsky,G., Lahti,J., Mikkila,V.,
            Lemaitre,R.N., Eriksson,J., Musani,S.K., Tanaka,T., Geller,F.,
            Luan,J., Hui,J., Magi,R., Dimitriou,M., Garcia,M.E., Ho,W.K.,
            Wright,M.J., Rose,L.M., Magnusson,P.K., Pedersen,N.L., Couper,D.,
            Oostra,B.A., Hofman,A., Ikram,M.A., Tiemeier,H.W.,
            Uitterlinden,A.G., van Rooij,F.J., Barroso,I., Johansson,I.,
            Xue,L., Kaakinen,M., Milani,L., Power,C., Snieder,H., Stolk,R.P.,
            Baumeister,S.E., Biffar,R., Gu,F., Bastardot,F., Kutalik,Z.,
            Jacobs,D.R. Jr., Forouhi,N.G., Mihailov,E., Lind,L., Lindgren,C.,
            Michaelsson,K., Morris,A., Jensen,M., Khaw,K.T., Luben,R.N.,
            Wang,J.J., Mannisto,S., Perala,M.M., Kahonen,M., Lehtimaki,T.,
            Viikari,J., Mozaffarian,D., Mukamal,K., Psaty,B.M., Doring,A.,
            Heath,A.C., Montgomery,G.W., Dahmen,N., Carithers,T., Tucker,K.L.,
            Ferrucci,L., Boyd,H.A., Melbye,M., Treur,J.L., Mellstrom,D.,
            Hottenga,J.J., Prokopenko,I., Tonjes,A., Deloukas,P., Kanoni,S.,
            Lorentzon,M., Houston,D.K., Liu,Y., Danesh,J., Rasheed,A.,
            Mason,M.A., Zonderman,A.B., Franke,L., Kristal,B.S.,
            Karjalainen,J., Reed,D.R., Westra,H.J., Evans,M.K., Saleheen,D.,
            Harris,T.B., Dedoussis,G., Curhan,G., Stumvoll,M., Beilby,J.,
            Pasquale,L.R., Feenstra,B., Bandinelli,S., Ordovas,J.M., Chan,A.T.,
            Peters,U., Ohlsson,C., Gieger,C., Martin,N.G., Waldenberger,M.,
            Siscovick,D.S., Raitakari,O., Eriksson,J.G., Mitchell,P.,
            Hunter,D.J., Kraft,P., Rimm,E.B., Boomsma,D.I., Borecki,I.B.,
            Loos,R.J., Wareham,N.J., Vollenweider,P., Caporaso,N., Grabe,H.J.,
            Neuhouser,M.L., Wolffenbuttel,B.H., Hu,F.B., Hypponen,E.,
            Jarvelin,M.R., Cupples,L.A., Franks,P.W., Ridker,P.M., van
            Duijn,C.M., Heiss,G., Metspalu,A., North,K.E., Ingelsson,E.,
            Nettleton,J.A., van Dam,R.M. and Chasman,D.I.
  CONSRTM   Coffee and Caffeine Genetics Consortium; International Parkinson's
            Disease Genomics Consortium (IPDGC); North American Brain
            Expression Consortium (NABEC); UK Brain Expression Consortium
            (UKBEC)
  TITLE     Genome-wide meta-analysis identifies six novel loci associated with
            habitual coffee consumption
  JOURNAL   Mol Psychiatry 20 (5), 647-656 (2015)
   PUBMED   25288136
  REMARK    Review article
REFERENCE   4  (bases 1 to 1618)
  AUTHORS   Weissglas-Volkov,D., Aguilar-Salinas,C.A., Nikkola,E., Deere,K.A.,
            Cruz-Bautista,I., Arellano-Campos,O., Munoz-Hernandez,L.L.,
            Gomez-Munguia,L., Ordonez-Sanchez,M.L., Reddy,P.M., Lusis,A.J.,
            Matikainen,N., Taskinen,M.R., Riba,L., Cantor,R.M.,
            Sinsheimer,J.S., Tusie-Luna,T. and Pajukanta,P.
  TITLE     Genomic study in Mexicans identifies a new locus for triglycerides
            and refines European lipid loci
  JOURNAL   J Med Genet 50 (5), 298-308 (2013)
   PUBMED   23505323
REFERENCE   5  (bases 1 to 1618)
  AUTHORS   Agromayor,M., Soler,N., Caballe,A., Kueck,T., Freund,S.M.,
            Allen,M.D., Bycroft,M., Perisic,O., Ye,Y., McDonald,B., Scheel,H.,
            Hofmann,K., Neil,S.J., Martin-Serrano,J. and Williams,R.L.
  TITLE     The UBAP1 subunit of ESCRT-I interacts with ubiquitin via a SOUBA
            domain
  JOURNAL   Structure 20 (3), 414-428 (2012)
   PUBMED   22405001
REFERENCE   6  (bases 1 to 1618)
  AUTHORS   Hurley,J.H. and Hanson,P.I.
  TITLE     Membrane budding and scission by the ESCRT machinery: it's all in
            the neck
  JOURNAL   Nat Rev Mol Cell Biol 11 (8), 556-566 (2010)
   PUBMED   20588296
  REMARK    Review article
REFERENCE   7  (bases 1 to 1618)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   8  (bases 1 to 1618)
  AUTHORS   Morita,E., Sandrin,V., Alam,S.L., Eckert,D.M., Gygi,S.P. and
            Sundquist,W.I.
  TITLE     Identification of human MVB12 proteins as ESCRT-I subunits that
            function in HIV budding
  JOURNAL   Cell Host Microbe 2 (1), 41-53 (2007)
   PUBMED   18005716
REFERENCE   9  (bases 1 to 1618)
  AUTHORS   Stuchell,M.D., Garrus,J.E., Muller,B., Stray,K.M., Ghaffarian,S.,
            McKinnon,R., Krausslich,H.G., Morham,S.G. and Sundquist,W.I.
  TITLE     The human endosomal sorting complex required for transport
            (ESCRT-I) and its role in HIV-1 budding
  JOURNAL   J Biol Chem 279 (34), 36059-36071 (2004)
   PUBMED   15218037
REFERENCE   10 (bases 1 to 1618)
  AUTHORS   Lippincott-Schwartz,J., Roberts,T.H. and Hirschberg,K.
  TITLE     Secretory protein trafficking and organelle dynamics in living
            cells
  JOURNAL   Annu Rev Cell Dev Biol 16, 557-589 (2000)
   PUBMED   11031247
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC073846.6 and AY081952.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001077621.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC029730.1, SRR3476690.88291.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000324941.5/ ENSP00000320416.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                AC073846.6         99101-99113         c
            14-1618             AY081952.1         1-1605
FEATURES             Location/Qualifiers
     source          1..1618
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q11.23"
     gene            1..1618
                     /gene="VPS37D"
                     /gene_synonym="WBSCR24"
                     /note="VPS37D subunit of ESCRT-I"
                     /db_xref="GeneID:155382"
                     /db_xref="HGNC:HGNC:18287"
                     /db_xref="MIM:610039"
     exon            1..266
                     /gene="VPS37D"
                     /gene_synonym="WBSCR24"
                     /inference="alignment:Splign:2.1.0"
     CDS             129..884
                     /gene="VPS37D"
                     /gene_synonym="WBSCR24"
                     /note="Williams-Beuren syndrome critical region protein
                     24; vacuolar protein sorting 37 homolog D; Williams Beuren
                     syndrome chromosome region 24; ESCRT-I complex subunit
                     VPS37D; williams-Beuren syndrome region protein 24;
                     VPS37D, ESCRT-I subunit; williams-Beuren syndrome
                     chromosomal region 24 protein; vacuolar protein sorting
                     37D"
                     /codon_start=1
                     /product="vacuolar protein sorting-associated protein 37D"
                     /protein_id="NP_001071089.1"
                     /db_xref="CCDS:CCDS43596.1"
                     /db_xref="GeneID:155382"
                     /db_xref="HGNC:HGNC:18287"
                     /db_xref="MIM:610039"
                     /translation="MYRARAARAGPEPGSPGRFGILSTGQLRDLLQDEPKLDRIVRLS
                     RKFQGLQLEREACLASNYALAKENLALRPRLEMGRAALAIKYQELREVAENCADKLQR
                     LEESMHRWSPHCALGWLQAELEEAEQEAEEQMEQLLLGEQSLEAFLPAFQRGRALAHL
                     RRTQAEKLQELLRRRERSAQPAPTSAADPPKSFPAAAVLPTGAARGPPAVPRSLPPLD
                     SRPVPPLKGSPGCPLGPAPLLSPRPSQPEPPHR"
     exon            267..438
                     /gene="VPS37D"
                     /gene_synonym="WBSCR24"
                     /inference="alignment:Splign:2.1.0"
     exon            439..521
                     /gene="VPS37D"
                     /gene_synonym="WBSCR24"
                     /inference="alignment:Splign:2.1.0"
     exon            522..1618
                     /gene="VPS37D"
                     /gene_synonym="WBSCR24"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1596..1601
                     /regulatory_class="polyA_signal_sequence"
                     /gene="VPS37D"
                     /gene_synonym="WBSCR24"
                     /note="hexamer: AATAAA"
     polyA_site      1618
                     /gene="VPS37D"
                     /gene_synonym="WBSCR24"
                     /note="major polyA site"
ORIGIN      
        1 ggagcggtgc gtgcggccgg agccggagcg gatcctggag ccggagcgga gcggagcgga
       61 gcggagccgg ggcggagcgg gccgagcggg ccgagccagc agccgagctg ggggcgcggg
      121 cgggcggcat gtaccgggcc cgggcggcgc gggcggggcc ggagcccggc agcccggggc
      181 gctttgggat cctcagcacc gggcagctcc gggacctgct tcaggatgag cccaagctgg
      241 accggatcgt gcggctcagc aggaagttcc agggcctgca gctggagcgt gaggcctgcc
      301 tggcctccaa ctacgcgctg gccaaggaga acctggccct gcggccccgc ctggagatgg
      361 gccgggctgc cctggccatc aaataccagg agcttcgtga ggtggccgag aactgcgcgg
      421 acaagctgca gcgactggag gaaagcatgc atcgctggag tccccactgc gcgctgggct
      481 ggctgcaggc tgagctagaa gaggcggagc aggaggcaga ggagcagatg gagcagctgc
      541 tgctcgggga gcaaagcctg gaggccttcc tgcctgcctt ccagcgtggc cgcgccctgg
      601 cccacctgag gcggacgcag gcagagaagc tgcaggagct gctgcggcgt cgggagcgtt
      661 ctgcccagcc ggcccccacc tcggctgctg atccccccaa atccttcccg gctgcagctg
      721 tcctgcccac tggggccgcc cgggggccac cagcagtgcc ccggagcctg ccccccttgg
      781 actcccgccc agtgccccca ctgaagggct cccccgggtg ccccctcggc ccggcccccc
      841 tgctgagccc tcggccctcg cagccagagc ccccccaccg gtaggatcca cggtgcggcc
      901 ccccagttgg ggggcctaga caaacttgat gcgtggctcc tcctcctccc ccactgcctg
      961 ggtgggggga ggggcaggcc cctccccctg gcctcaggca ggccctggcc ctggaggctg
     1021 agctggggag gagggtcccc tggaagaggc ccgagagggg gctgggggtg ggtgggcagg
     1081 gctttatgcc tctggcgctg aagacaccct gccttttttg tttccgtgcc ccggggcctc
     1141 tagggtgatg gaccagcccc gttaaagaac ttgactcaac tacaggggcc tgggaagatg
     1201 cctgggtccc ctaggggcct tgccaagggg acctgtcgca ccccaccact ccactgggct
     1261 cgcacaacgc caaggccgcc aggagtgttt tacatcatgt cctgagccta cctttccccc
     1321 aaattctggg gcccacagcc taggagccag gtgatcaggc ctcggctgtg gggccaggga
     1381 caccatggcc ctggggctac tacgtgtcca cacatgctcc agaccctggg gcaaggtagg
     1441 ccaggggctt ctgacctgtg caggtgagag tgggccatac ccaggaaaga ccattctgta
     1501 tttttctgtc cctgtctcct tagaatggaa gctttttgag ggcaggtcct tgtctttgta
     1561 cgttctgtcc ccagccccgc ctcttagggg ccgtcaataa atgtgatgat gaggatga
//
