LOCUS       NM_017966               2673 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens VPS37C subunit of ESCRT-I (VPS37C), mRNA.
ACCESSION   NM_017966 XM_373413
VERSION     NM_017966.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2673)
  AUTHORS   Lu,Y., Ma,W.B., Ren,G.M., Liu,X., Li,Y.T., Wang,T., Zhan,Y.Q.,
            Xiang,S.S., Yu,M., Li,C.Y., Yang,X.M. and Yin,R.H.
  TITLE     VPS37C facilitates erythroid differentiation by promoting EKLF
            stability
  JOURNAL   Biochem Biophys Res Commun 671, 229-235 (2023)
   PUBMED   37307706
  REMARK    GeneRIF: VPS37C facilitates erythroid differentiation by promoting
            EKLF stability.
REFERENCE   2  (bases 1 to 2673)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 2673)
  AUTHORS   Flower,T.G., Takahashi,Y., Hudait,A., Rose,K., Tjahjono,N.,
            Pak,A.J., Yokom,A.L., Liang,X., Wang,H.G., Bouamr,F., Voth,G.A. and
            Hurley,J.H.
  TITLE     A helical assembly of human ESCRT-I scaffolds reverse-topology
            membrane scission
  JOURNAL   Nat Struct Mol Biol 27 (6), 570-580 (2020)
   PUBMED   32424346
REFERENCE   4  (bases 1 to 2673)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 2673)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2673)
  AUTHORS   Morita,E., Sandrin,V., Chung,H.Y., Morham,S.G., Gygi,S.P.,
            Rodesch,C.K. and Sundquist,W.I.
  TITLE     Human ESCRT and ALIX proteins interact with proteins of the midbody
            and function in cytokinesis
  JOURNAL   EMBO J 26 (19), 4215-4227 (2007)
   PUBMED   17853893
  REMARK    Erratum:[EMBO J. 2012 Jul 18;31(14):3228]
REFERENCE   7  (bases 1 to 2673)
  AUTHORS   Morita,E., Sandrin,V., Alam,S.L., Eckert,D.M., Gygi,S.P. and
            Sundquist,W.I.
  TITLE     Identification of human MVB12 proteins as ESCRT-I subunits that
            function in HIV budding
  JOURNAL   Cell Host Microbe 2 (1), 41-53 (2007)
   PUBMED   18005716
REFERENCE   8  (bases 1 to 2673)
  AUTHORS   Eastman,S.W., Martin-Serrano,J., Chung,W., Zang,T. and
            Bieniasz,P.D.
  TITLE     Identification of human VPS37C, a component of endosomal sorting
            complex required for transport-I important for viral budding
  JOURNAL   J Biol Chem 280 (1), 628-636 (2005)
   PUBMED   15509564
  REMARK    GeneRIF: VPS37C as a functional component of mammalian endosomal
            sorting complex required for transport-I
REFERENCE   9  (bases 1 to 2673)
  AUTHORS   Stuchell,M.D., Garrus,J.E., Muller,B., Stray,K.M., Ghaffarian,S.,
            McKinnon,R., Krausslich,H.G., Morham,S.G. and Sundquist,W.I.
  TITLE     The human endosomal sorting complex required for transport
            (ESCRT-I) and its role in HIV-1 budding
  JOURNAL   J Biol Chem 279 (34), 36059-36071 (2004)
   PUBMED   15218037
REFERENCE   10 (bases 1 to 2673)
  AUTHORS   Lippincott-Schwartz,J., Roberts,T.H. and Hirschberg,K.
  TITLE     Secretory protein trafficking and organelle dynamics in living
            cells
  JOURNAL   Annu Rev Cell Dev Biol 16, 557-589 (2000)
   PUBMED   11031247
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL834261.1 and BM450171.1.
            
            On Nov 22, 2018 this sequence version replaced NM_017966.4.
            
            Summary: VPS37C is a subunit of ESCRT-I (endosomal sorting complex
            required for transport I), a complex in the class E vacuolar
            protein sorting (VPS) pathway required for sorting ubiquitinated
            transmembrane proteins into internal vesicles of multivesicular
            bodies (Eastman et al., 2005 [PubMed 15509564]).[supplied by OMIM,
            Mar 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.1109350.1, AL834261.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2147596 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000301765.10/ ENSP00000301765.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-586               AL834261.1         27-612
            587-634             BM450171.1         575-622
            635-2673            AL834261.1         661-2699
FEATURES             Location/Qualifiers
     source          1..2673
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q12.2"
     gene            1..2673
                     /gene="VPS37C"
                     /note="VPS37C subunit of ESCRT-I"
                     /db_xref="GeneID:55048"
                     /db_xref="HGNC:HGNC:26097"
                     /db_xref="MIM:610038"
     exon            1..36
                     /gene="VPS37C"
                     /inference="alignment:Splign:2.1.0"
     exon            37..135
                     /gene="VPS37C"
                     /inference="alignment:Splign:2.1.0"
     CDS             43..1110
                     /gene="VPS37C"
                     /note="hVps37C; ESCRT-I complex subunit VPS37C; vacuolar
                     protein sorting 37C; vacuolar protein sorting 37 homolog
                     C; VPS37C, ESCRT-I subunit"
                     /codon_start=1
                     /product="vacuolar protein sorting-associated protein 37C"
                     /protein_id="NP_060436.4"
                     /db_xref="CCDS:CCDS31573.1"
                     /db_xref="GeneID:55048"
                     /db_xref="HGNC:HGNC:26097"
                     /db_xref="MIM:610038"
                     /translation="METLKDKTLQELEELQNDSEAIDQLALESPEVQDLQLEREMALA
                     TNRSLAERNLEFQGPLEISRSNLSDRYQELRKLVERCQEQKAKLEKFSSALQPGTLLD
                     LLQVEGMKIEEESEAMAEKFLEGEVPLETFLENFSSMRMLSHLRRVRVEKLQEVVRKP
                     RASQELAGDAPPPRPPPPVRPVPQGTPPVVEEQPQPPLAMPPYPLPYSPSPSLPVGPT
                     AHGALPPAPFPVVSQPSFYSGPLGPTYPAAQLGPRGAAGYSWSPQRSMPPRPGYPGTP
                     MGASGPGYPLRGGRAPSPGYPQQSPYPATGGKPPYPIQPQLPSFPGQPQPSVPLQPPY
                     PPGPAPPYGFPPPPGPAWPGY"
     exon            136..307
                     /gene="VPS37C"
                     /inference="alignment:Splign:2.1.0"
     exon            308..390
                     /gene="VPS37C"
                     /inference="alignment:Splign:2.1.0"
     exon            391..2673
                     /gene="VPS37C"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2653..2658
                     /regulatory_class="polyA_signal_sequence"
                     /gene="VPS37C"
                     /note="hexamer: AATAAA"
     polyA_site      2673
                     /gene="VPS37C"
                     /note="major polyA site"
ORIGIN      
        1 aacccgcggt ggcggcggcg acggcggccc tggcagggaa ggatggagac gctgaaggat
       61 aagaccctgc aggagctgga ggagttgcag aatgactcgg aggcgattga ccagctggcc
      121 ctggagtccc ctgaggtcca ggacctacag ctggaacggg agatggcact ggccaccaac
      181 cggagcctgg cagagcggaa cttggagttc cagggtcccc tggagatcag ccgctcaaac
      241 ctctcggata gataccagga gctccggaag ctcgtggagc ggtgccagga gcagaaggca
      301 aagctggaga aattttcttc agcactgcag ccagggacct tgttagacct tctgcaggtg
      361 gaaggcatga agatcgaaga agagtccgag gccatggctg agaagttcct ggagggcgag
      421 gtgcccctgg aaacgttcct ggagaatttt tcctccatga ggatgctgtc ccacctgcgc
      481 cgggttcgcg tggaaaagct ccaggaagtg gtgaggaagc ccagggcttc ccaggagctg
      541 gccggcgatg cccctccacc ccgtccacca cccccggtgc gcccagtccc ccagggaaca
      601 ccccctgtgg ttgaagagca gccgcagcca ccattagcca tgcctcccta ccctttgccc
      661 tacagcccat cccccagcct gcctgtgggc cccactgccc atggagccct gccaccggcc
      721 cctttcccag tagtgtccca gccctccttc tacagcgggc ctctgggccc cacttacccg
      781 gcagcccagc ttggacccag gggtgctgcg ggttactcct ggtccccaca gaggagcatg
      841 ccaccccggc cgggctatcc tgggacccca atgggtgcct ctgggcctgg gtaccccttg
      901 cggggaggca gggcccccag tcctggttat cctcaacagt ccccataccc cgcaacagga
      961 ggaaaacctc cctacccaat acagcctcag ctccccagct ttccaggcca gccccagccc
     1021 tcagtgcccc tgcagccccc ttatcccccc gggcccgccc ctccctatgg gttcccacca
     1081 ccgccggggc ctgcctggcc tgggtattag acacactcct ggccctcggc ccctccctag
     1141 tcccacccac gctcaacctt tggcccagcc atcgccgaga ttcgagggtc aactggaagt
     1201 ggcgttggtg ctccctgtgg acttgcgtcg gcacccagag gccttggagg gacaaggcac
     1261 tgggcggtgt gactggtcat ggcacttgct ggccttctgg ccagaggtcc tcctggaagc
     1321 ccctcctttc agtgcctggc tgcagcggtg ctagccaggc tggagtccag cacctctcgc
     1381 cggtgtctgt gtgagtgagc gcatgtgcgc atttatgagc atctacttgc ggctgcactc
     1441 agggccattt gaacccagtg cagagttatc tctatgagga ggccccgggt ctccagcccc
     1501 ctccatctcc cctggggttt ggcatatttg acatggagcc ccatgccaag ggatgcagct
     1561 gttggtgtct gtccagtcca ttcaaggcta gcctgcccat gcactgtggc aggggttgga
     1621 ttggagggag agaacagagt tgggaaaaac aacaggtttg agtcctataa agccataatt
     1681 taactccagt agctgatgtc agacaagctt gtcctatgtc ctatttgagt ggcagcagcg
     1741 ccagcccagc aagaaggctg ggggttgtca aggttgtccc cagaccttgc ttgcagtggt
     1801 tggagaaccc agggggctgc cttgggccct ctggccagag ggaagcgggc agctctagcc
     1861 ctggagattg tggtcacatt ggggcttgtt taggattgga gggccaggtc acctccccag
     1921 ccaccctccc ttctctcctc tggggtcccc actttagggc gactttgccc gaggcccacg
     1981 catccatcca ctcctttagt gccttgaatc tcattcacaa gcagccccct cccttcccct
     2041 ccccttctca ctctgttgat gtaatcctcc cacccccagt gtccatccta agacaggcat
     2101 caaaagaggc cctaacttta cttcccaaat ggtgcttttt aaaaaacacc atcactacat
     2161 taggggcaat tttttcacac ctccctgtct tcagaatgta aagggtgggg attatgtctc
     2221 tgtttaatat gcagccccct gcactgtggg gtttggggca tgttcagtaa taagaatgaa
     2281 tacaatagac aaagggggtg tgatgagtgt taacttggtt gttccagagg taaaccaggt
     2341 ctcagggaag agcctggagc tgctattgct taggaagttg tacgtgcctt gaaatgtcca
     2401 ctacctgagg acgcagcatc tggtgggccc ggggctgctg gggccaagga gggaccttga
     2461 ccttctggtg cctgcccctc cccggcctat gtgccatccg cgtgacgcta ggtcagcgct
     2521 gccggttctt taccaaatgt gcttgcttct cctaagttat ttataaagag aaatcactaa
     2581 tggactctac tggtttgagt gcttctgagc tggatgaccg accgcctgta tgtttgtgta
     2641 attaattgcc ataataaact ttgatgagtc aca
//
