LOCUS       NM_024667               2706 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens VPS37B subunit of ESCRT-I (VPS37B), mRNA.
ACCESSION   NM_024667
VERSION     NM_024667.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2706)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 2706)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 2706)
  AUTHORS   Flower,T.G., Takahashi,Y., Hudait,A., Rose,K., Tjahjono,N.,
            Pak,A.J., Yokom,A.L., Liang,X., Wang,H.G., Bouamr,F., Voth,G.A. and
            Hurley,J.H.
  TITLE     A helical assembly of human ESCRT-I scaffolds reverse-topology
            membrane scission
  JOURNAL   Nat Struct Mol Biol 27 (6), 570-580 (2020)
   PUBMED   32424346
REFERENCE   4  (bases 1 to 2706)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 2706)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2706)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   7  (bases 1 to 2706)
  AUTHORS   Silvestri,L.S., Ruthel,G., Kallstrom,G., Warfield,K.L.,
            Swenson,D.L., Nelle,T., Iversen,P.L., Bavari,S. and Aman,M.J.
  TITLE     Involvement of vacuolar protein sorting pathway in Ebola virus
            release independent of TSG101 interaction
  JOURNAL   J Infect Dis 196 Suppl 2, S264-S270 (2007)
   PUBMED   17940959
REFERENCE   8  (bases 1 to 2706)
  AUTHORS   Morita,E., Sandrin,V., Alam,S.L., Eckert,D.M., Gygi,S.P. and
            Sundquist,W.I.
  TITLE     Identification of human MVB12 proteins as ESCRT-I subunits that
            function in HIV budding
  JOURNAL   Cell Host Microbe 2 (1), 41-53 (2007)
   PUBMED   18005716
REFERENCE   9  (bases 1 to 2706)
  AUTHORS   Stuchell,M.D., Garrus,J.E., Muller,B., Stray,K.M., Ghaffarian,S.,
            McKinnon,R., Krausslich,H.G., Morham,S.G. and Sundquist,W.I.
  TITLE     The human endosomal sorting complex required for transport
            (ESCRT-I) and its role in HIV-1 budding
  JOURNAL   J Biol Chem 279 (34), 36059-36071 (2004)
   PUBMED   15218037
REFERENCE   10 (bases 1 to 2706)
  AUTHORS   Lippincott-Schwartz,J., Roberts,T.H. and Hirschberg,K.
  TITLE     Secretory protein trafficking and organelle dynamics in living
            cells
  JOURNAL   Annu Rev Cell Dev Biol 16, 557-589 (2000)
   PUBMED   11031247
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK022812.1 and BU629695.1.
            
            On Nov 23, 2018 this sequence version replaced NM_024667.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.905275.1, AK022812.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1966682,
                                           SAMEA2142348 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000267202.7/ ENSP00000267202.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2378              AK022812.1         42-2419
            2379-2706           BU629695.1         20-347              c
FEATURES             Location/Qualifiers
     source          1..2706
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q24.31"
     gene            1..2706
                     /gene="VPS37B"
                     /note="VPS37B subunit of ESCRT-I"
                     /db_xref="GeneID:79720"
                     /db_xref="HGNC:HGNC:25754"
                     /db_xref="MIM:610037"
     exon            1..173
                     /gene="VPS37B"
                     /inference="alignment:Splign:2.1.0"
     CDS             63..920
                     /gene="VPS37B"
                     /note="hVps37B; ESCRT-I complex subunit VPS37B; vacuolar
                     protein sorting 37B; vacuolar protein sorting 37 homolog
                     B; VPS37B, ESCRT-I subunit"
                     /codon_start=1
                     /product="vacuolar protein sorting-associated protein 37B"
                     /protein_id="NP_078943.1"
                     /db_xref="CCDS:CCDS9239.1"
                     /db_xref="GeneID:79720"
                     /db_xref="HGNC:HGNC:25754"
                     /db_xref="MIM:610037"
                     /translation="MAGAGSEARFAGLSLVQLNELLEDEGQLTEMVQKMEETQNVQLN
                     KEMTLASNRSLAEGNLLYQPQLDTLKARLTQKYQELQVLFEAYQIKKTKLDRQSSSAS
                     LETLLALLQAEGAKIEEDTENMAEKFLDGELPLDSFIDVYQSKRKLAHMRRVKIEKLQ
                     EMVLKGQRLPQALAPLPPRLPELAPTAPLPYPAPEASGPPAVAPRRIPPPPPPVPAGR
                     LATPFTAAMSSGQAVPYPGLQCPPLPPRVGLPTQQGFSSQFVSPYPPPLPQRPPPRLP
                     PHQPGFILQ"
     exon            174..345
                     /gene="VPS37B"
                     /inference="alignment:Splign:2.1.0"
     exon            346..428
                     /gene="VPS37B"
                     /inference="alignment:Splign:2.1.0"
     exon            429..2706
                     /gene="VPS37B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2688..2693
                     /regulatory_class="polyA_signal_sequence"
                     /gene="VPS37B"
                     /note="hexamer: AATAGA"
     polyA_site      2706
                     /gene="VPS37B"
                     /note="major polyA site"
ORIGIN      
        1 gcttccggtc ggcggagcct ggtggccgca gcggcggtgg cgacgacggc cgagacgtgg
       61 ggatggcggg cgccgggagc gaagcccggt tcgccgggct gtcgctggtg cagctcaacg
      121 agctgctgga ggacgagggc cagctgacgg agatggtgca gaagatggag gagacacaga
      181 atgttcagct taacaaagaa atgacacttg ccagcaaccg gagcctggca gaaggaaacc
      241 ttttgtacca gccccagctg gacacgttga aagcacgctt gacccagaaa taccaggaac
      301 tccaggttct ctttgaagcc tatcagataa agaagaccaa attagacaga cagtctagca
      361 gtgcttcctt ggagaccctg ttagcacttc ttcaggcaga aggggccaag attgaggaag
      421 acactgagaa catggcagag aagtttctgg atggagaact tcctctggat tccttcattg
      481 atgtctatca gagcaaacgg aaactggccc acatgcgacg ggtgaaaatc gagaagctcc
      541 aggagatggt cctaaagggg cagagactcc cacaggccct ggccccgctg ccccccaggc
      601 tgcccgaact ggcacctacc gccccccttc cctaccctgc cccagaggcc agtgggcctc
      661 ctgccgttgc acctcggcgc atcccccccc caccaccccc ggtgcctgcg ggacgcttag
      721 ccaccccgtt tactgcggcc atgagttcgg gacaggccgt gccgtaccca ggattacagt
      781 gcccgcccct gcccccccgc gtgggcctcc ccactcagca aggattctct tcgcagttcg
      841 tgtccccata tccgccacct ctccctcaga gacccccgcc ccggctccct ccacaccagc
      901 cgggtttcat cctccagtga gcgccggcgc ggtccttccc gggagacttc ttccacctgg
      961 cgtgttgtgc tctgctcacg ggaaggaggc tggaggtccg ctctgtgcca agggctctgg
     1021 ggccctgggc cagcgtgtct gtctgatttt agaactgtag gtcagtggtg agtagtagga
     1081 gcccaggctt tgggcatcaa ggcagttgtg tgtgccgggt tacagcctga cacctgtgcg
     1141 ttgcatcggt ttgcattatc cgtgtgattt ctaagtatct tagcgttgat gaactcatgt
     1201 ttgggaagaa ataggcctct cccccagtcc catttagaat cgtggtcctt ctgttgcagc
     1261 tttatttaat gagcatggtt catgatactt attttatttt cgaaagacag tcctatgtgt
     1321 ctcacccacc ggccactgca gccctggtga gggcgggtgg gcgccggccg gcctggaaga
     1381 gcgccgtggc tgggccacca cctgtggctg cgttgttgct cactgaatct gttggggaga
     1441 ggtcaccata gtcaccgcct gacctggctg ctgctcttgc ttcagagcca caagcaaagt
     1501 ttgcactggg cccactgccg agtccagagg ccggagaacg gccactggtg tgggagggga
     1561 gcgcacgagt gggactttgc acagcaaatt gtgtccccag ctcctcctct cccgcctgcc
     1621 tggagccggc cctgaaggtt tctatgaaga aataatcccc caatattttt actacgtgtg
     1681 tgattttcct gttttatatt gaaaaaactt ttttgacact cccaagacca ttcagggaaa
     1741 ttttataaaa aatgcagata ctgtcttgag cagatcgaaa tgccgatgaa gtggatgcaa
     1801 tttccttttg tgcaagcagt gcacggtgcc cccccctcgg gtgtccgtgc tgtgccttag
     1861 cttccccagg tgccgggact cacacctgct aggggctggg caaggccccg gctctgcttt
     1921 ctctgaaggg cttgtccaag ttcattgccc tgttacaggt ggtcaagacg tccggccgcc
     1981 ttgacccagg ctacccttag ccaatatcct ctgcccctgg gtggctggtg gctgggcctc
     2041 agggtgggca acgttagggg tttggcgaaa gcccgcccca tgggattgag ggacggggct
     2101 gcactccaac cgtctgcacc tgctcttccc ccacccctgt gggacctcat cttcacgtgc
     2161 catgtgtgct gaaggcccag ggcccagcag ggggcagtgg cacctgttga cggaaaaggc
     2221 cgaggtgctt accagtggac cttctggccc gcccctcccc tgtcacttgt cgggcatcca
     2281 gggccccgac ctgtgcctag ccgccagggt gacagaaggc agaactgaag cggggtctgg
     2341 gccacgggcc aggccactgc cttttgtcct cagtgaccgt acattcctgc tctcggactt
     2401 gaactctact gtaactgttt tcttaaagga aatgaagctg tacaggacga ttcactgcca
     2461 tgccagtcag gcgggcttgc catgttctgt gaatctcgag tgagcggtgc cacccgcccc
     2521 catacctccg ccaccggccg ctgtcgggga tgccacagcc tgccacggtc gcagccagac
     2581 gtgagcttgg cattgaagtt gcaaagcggc ccctggccgg gctcgccgtc gctgtccagg
     2641 gccgtgtccg gtgctgtggc tgtaaagctg taggaccctt tttaataaat agagaattat
     2701 taataa
//
