LOCUS       NM_020314               3606 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens VPS35 endosomal protein sorting factor like (VPS35L),
            transcript variant 1, mRNA.
ACCESSION   NM_020314
VERSION     NM_020314.7
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3606)
  AUTHORS   Healy,M.D., McNally,K.E., Butkovic,R., Chilton,M., Kato,K.,
            Sacharz,J., McConville,C., Moody,E.R.R., Shaw,S.,
            Planelles-Herrero,V.J., Yadav,S.K.N., Ross,J., Borucu,U.,
            Palmer,C.S., Chen,K.E., Croll,T.I., Hall,R.J., Caruana,N.J.,
            Ghai,R., Nguyen,T.H.D., Heesom,K.J., Saitoh,S., Berger,I.,
            Schaffitzel,C., Williams,T.A., Stroud,D.A., Derivery,E.,
            Collins,B.M. and Cullen,P.J.
  TITLE     Structure of the endosomal Commander complex linked to
            Ritscher-Schinzel syndrome
  JOURNAL   Cell 186 (10), 2219-2237 (2023)
   PUBMED   37172566
REFERENCE   2  (bases 1 to 3606)
  AUTHORS   Otsuji,S., Nishio,Y., Tsujita,M., Rio,M., Huber,C.,
            Anton-Plagaro,C., Mizuno,S., Kawano,Y., Miyatake,S., Simon,M., van
            Binsbergen,E., van Jaarsveld,R.H., Matsumoto,N., Cormier-Daire,V.,
            J Cullen,P., Saitoh,S. and Kato,K.
  TITLE     Clinical diversity and molecular mechanism of VPS35L-associated
            Ritscher-Schinzel syndrome
  JOURNAL   J Med Genet 60 (4), 359-367 (2023)
   PUBMED   36113987
  REMARK    GeneRIF: Clinical diversity and molecular mechanism of
            VPS35L-associated Ritscher-Schinzel syndrome.
REFERENCE   3  (bases 1 to 3606)
  AUTHORS   Viard,J., Loe-Mie,Y., Daudin,R., Khelfaoui,M., Plancon,C.,
            Boland,A., Tejedor,F., Huganir,R.L., Kim,E., Kinoshita,M., Liu,G.,
            Haucke,V., Moncion,T., Yu,E., Hindie,V., Blehaut,H., Mircher,C.,
            Herault,Y., Deleuze,J.F., Rain,J.C., Simonneau,M. and
            Lepagnol-Bestel,A.M.
  TITLE     Chr21 protein-protein interactions: enrichment in proteins involved
            in intellectual disability, autism, and late-onset Alzheimer's
            disease
  JOURNAL   Life Sci Alliance 5 (12), e202101205 (2022)
   PUBMED   35914814
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3606)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   5  (bases 1 to 3606)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 3606)
  AUTHORS   Phillips-Krawczak,C.A., Singla,A., Starokadomskyy,P., Deng,Z.,
            Osborne,D.G., Li,H., Dick,C.J., Gomez,T.S., Koenecke,M.,
            Zhang,J.S., Dai,H., Sifuentes-Dominguez,L.F., Geng,L.N.,
            Kaufmann,S.H., Hein,M.Y., Wallis,M., McGaughran,J., Gecz,J.,
            Sluis,Bv., Billadeau,D.D. and Burstein,E.
  TITLE     COMMD1 is linked to the WASH complex and regulates endosomal
            trafficking of the copper transporter ATP7A
  JOURNAL   Mol Biol Cell 26 (1), 91-103 (2015)
   PUBMED   25355947
REFERENCE   7  (bases 1 to 3606)
  AUTHORS   Bailey,S.D., Xie,C., Do,R., Montpetit,A., Diaz,R., Mohan,V.,
            Keavney,B., Yusuf,S., Gerstein,H.C., Engert,J.C. and Anand,S.
  CONSRTM   DREAM investigators
  TITLE     Variation at the NFATC2 locus increases the risk of
            thiazolidinedione-induced edema in the Diabetes REduction
            Assessment with ramipril and rosiglitazone Medication (DREAM) study
  JOURNAL   Diabetes Care 33 (10), 2250-2253 (2010)
   PUBMED   20628086
  REMARK    GeneRIF: Observational study of gene-disease association,
            gene-environment interaction, and pharmacogenomic / toxicogenomic.
            (HuGE Navigator)
REFERENCE   8  (bases 1 to 3606)
  AUTHORS   Naukkarinen,J., Surakka,I., Pietilainen,K.H., Rissanen,A.,
            Salomaa,V., Ripatti,S., Yki-Jarvinen,H., van Duijn,C.M.,
            Wichmann,H.E., Kaprio,J., Taskinen,M.R. and Peltonen,L.
  CONSRTM   ENGAGE Consortium
  TITLE     Use of genome-wide expression data to mine the 'Gray Zone' of GWA
            studies leads to novel candidate obesity genes
  JOURNAL   PLoS Genet 6 (6), e1000976 (2010)
   PUBMED   20532202
  REMARK    GeneRIF: Observational study and genome-wide association study of
            gene-disease association. (HuGE Navigator)
            Publication Status: Online-Only
REFERENCE   9  (bases 1 to 3606)
  AUTHORS   Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
            Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
            Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
            Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
            Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
            Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
            Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am J Hum Genet 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   10 (bases 1 to 3606)
  AUTHORS   Loftus,B.J., Kim,U.J., Sneddon,V.P., Kalush,F., Brandon,R.,
            Fuhrmann,J., Mason,T., Crosby,M.L., Barnstead,M., Cronin,L.,
            Deslattes Mays,A., Cao,Y., Xu,R.X., Kang,H.L., Mitchell,S.,
            Eichler,E.E., Harris,P.C., Venter,J.C. and Adams,M.D.
  TITLE     Genome duplications and other features in 12 Mb of DNA sequence
            from human chromosome 16p and 16q
  JOURNAL   Genomics 60 (3), 295-308 (1999)
   PUBMED   10493829
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BP219237.1, AK290286.1, AL136744.1, DA452318.1 and AC002550.1.
            
            On May 17, 2019 this sequence version replaced NM_020314.6.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.154761.1, BX537867.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000417362.7/ ENSP00000395973.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                BP219237.1         288-302
            16-3127             AK290286.1         1-3112
            3128-3565           AL136744.1         2029-2466
            3566-3567           DA452318.1         40-41               c
            3568-3606           AC002550.1         42969-43007         c
FEATURES             Location/Qualifiers
     source          1..3606
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p12.3"
     gene            1..3606
                     /gene="VPS35L"
                     /gene_synonym="C16orf62; EC97; RTSC3"
                     /note="VPS35 endosomal protein sorting factor like"
                     /db_xref="GeneID:57020"
                     /db_xref="HGNC:HGNC:24641"
                     /db_xref="MIM:618981"
     exon            1..44
                     /gene="VPS35L"
                     /gene_synonym="C16orf62; EC97; RTSC3"
                     /inference="alignment:Splign:2.1.0"
     CDS             28..2919
                     /gene="VPS35L"
                     /gene_synonym="C16orf62; EC97; RTSC3"
                     /note="isoform 1 is encoded by transcript variant 1;
                     esophageal cancer associated protein; UPF0505 protein
                     C16orf62"
                     /codon_start=1
                     /product="VPS35 endosomal protein-sorting factor-like
                     isoform 1"
                     /protein_id="NP_064710.5"
                     /db_xref="CCDS:CCDS32397.3"
                     /db_xref="GeneID:57020"
                     /db_xref="HGNC:HGNC:24641"
                     /db_xref="MIM:618981"
                     /translation="MAVFPWHSRNRNYKAEFASCRLEAVPLEFGDYHPLKPITVTESK
                     TKKVNRKGSTSSTSSSSSSSVVDPLSSVLDGTDPLSMFAATADPAALAAAMDSSRRKR
                     DRDDNSVVGSDFEPWTNKRGEILARYTTTEKLSINLFMGSEKGKAGTATLAMSEKVRT
                     RLEELDDFEEGSQKELLNLTQQDYVNRIEELNQSLKDAWASDQKVKALKIVIQCSKLL
                     SDTSVIQFYPSKFVLITDILDTFGKLVYERIFSMCVDSRSVLPDHFSPENANDTAKET
                     CLNWFFKIASIRELIPRFYVEASILKCNKFLSKTGISECLPRLTCMIRGIGDPLVSVY
                     ARAYLCRVGMEVAPHLKETLNKNFFDFLLTFKQIHGDTVQNQLVVQGVELPSYLPLYP
                     PAMDWIFQCISYHAPEALLTEMMERCKKLGNNALLLNSVMSAFRAEFIATRSMDFIGM
                     IKECDESGFPKHLLFRSLGLNLALADPPESDRLQILNEAWKVITKLKNPQDYINCAEV
                     WVEYTCKHFTKREVNTVLADVIKHMTPDRAFEDSYPQLQLIIKKVIAHFHDFSVLFSV
                     EKFLPFLDMFQKESVRVEVCKCIMDAFIKHQQEPTKDPVILNALLHVCKTMHDSVNAL
                     TLEDEKRMLSYLINGFIKMVSFGRDFEQQLSFYVESRSMFCNLEPVLVQLIHSVNRLA
                     METRKVMKGNHSRKTAAFVRACVAYCFITIPSLAGIFTRLNLYLHSGQVALANQCLSQ
                     ADAFFKAAISLVPEVPKMINIDGKMRPSESFLLEFLCNFFSTLLIVPDHPEHGVLFLV
                     RELLNVIQDYTWEDNSDEKIRIYTCVLHLLSAMSQETYLYHIDKVDSNDSLYGGDSKF
                     LAENNKLCETVMAQILEHLKTLAKDEALKRQSSLGLSFFNSILAHGDLRNNKLNQLSV
                     NLWHLAQRHGCADTRTMVKTLEYIKKQSKQPDMTHLTELALRLPLQTRT"
     exon            45..144
                     /gene="VPS35L"
                     /gene_synonym="C16orf62; EC97; RTSC3"
                     /inference="alignment:Splign:2.1.0"
     exon            145..312
                     /gene="VPS35L"
                     /gene_synonym="C16orf62; EC97; RTSC3"
                     /inference="alignment:Splign:2.1.0"
     exon            313..435
                     /gene="VPS35L"
                     /gene_synonym="C16orf62; EC97; RTSC3"
                     /inference="alignment:Splign:2.1.0"
     exon            436..460
                     /gene="VPS35L"
                     /gene_synonym="C16orf62; EC97; RTSC3"
                     /inference="alignment:Splign:2.1.0"
     exon            461..537
                     /gene="VPS35L"
                     /gene_synonym="C16orf62; EC97; RTSC3"
                     /inference="alignment:Splign:2.1.0"
     exon            538..666
                     /gene="VPS35L"
                     /gene_synonym="C16orf62; EC97; RTSC3"
                     /inference="alignment:Splign:2.1.0"
     exon            667..751
                     /gene="VPS35L"
                     /gene_synonym="C16orf62; EC97; RTSC3"
                     /inference="alignment:Splign:2.1.0"
     exon            752..811
                     /gene="VPS35L"
                     /gene_synonym="C16orf62; EC97; RTSC3"
                     /inference="alignment:Splign:2.1.0"
     exon            812..908
                     /gene="VPS35L"
                     /gene_synonym="C16orf62; EC97; RTSC3"
                     /inference="alignment:Splign:2.1.0"
     exon            909..956
                     /gene="VPS35L"
                     /gene_synonym="C16orf62; EC97; RTSC3"
                     /inference="alignment:Splign:2.1.0"
     exon            957..1050
                     /gene="VPS35L"
                     /gene_synonym="C16orf62; EC97; RTSC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1051..1128
                     /gene="VPS35L"
                     /gene_synonym="C16orf62; EC97; RTSC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1129..1251
                     /gene="VPS35L"
                     /gene_synonym="C16orf62; EC97; RTSC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1252..1298
                     /gene="VPS35L"
                     /gene_synonym="C16orf62; EC97; RTSC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1299..1410
                     /gene="VPS35L"
                     /gene_synonym="C16orf62; EC97; RTSC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1411..1527
                     /gene="VPS35L"
                     /gene_synonym="C16orf62; EC97; RTSC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1528..1581
                     /gene="VPS35L"
                     /gene_synonym="C16orf62; EC97; RTSC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1582..1662
                     /gene="VPS35L"
                     /gene_synonym="C16orf62; EC97; RTSC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1663..1725
                     /gene="VPS35L"
                     /gene_synonym="C16orf62; EC97; RTSC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1726..1811
                     /gene="VPS35L"
                     /gene_synonym="C16orf62; EC97; RTSC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1812..1892
                     /gene="VPS35L"
                     /gene_synonym="C16orf62; EC97; RTSC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1893..1956
                     /gene="VPS35L"
                     /gene_synonym="C16orf62; EC97; RTSC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1957..2055
                     /gene="VPS35L"
                     /gene_synonym="C16orf62; EC97; RTSC3"
                     /inference="alignment:Splign:2.1.0"
     exon            2056..2133
                     /gene="VPS35L"
                     /gene_synonym="C16orf62; EC97; RTSC3"
                     /inference="alignment:Splign:2.1.0"
     exon            2134..2248
                     /gene="VPS35L"
                     /gene_synonym="C16orf62; EC97; RTSC3"
                     /inference="alignment:Splign:2.1.0"
     exon            2249..2388
                     /gene="VPS35L"
                     /gene_synonym="C16orf62; EC97; RTSC3"
                     /inference="alignment:Splign:2.1.0"
     exon            2389..2554
                     /gene="VPS35L"
                     /gene_synonym="C16orf62; EC97; RTSC3"
                     /inference="alignment:Splign:2.1.0"
     exon            2555..2673
                     /gene="VPS35L"
                     /gene_synonym="C16orf62; EC97; RTSC3"
                     /inference="alignment:Splign:2.1.0"
     exon            2674..2820
                     /gene="VPS35L"
                     /gene_synonym="C16orf62; EC97; RTSC3"
                     /inference="alignment:Splign:2.1.0"
     exon            2821..3606
                     /gene="VPS35L"
                     /gene_synonym="C16orf62; EC97; RTSC3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3108..3113
                     /regulatory_class="polyA_signal_sequence"
                     /gene="VPS35L"
                     /gene_synonym="C16orf62; EC97; RTSC3"
                     /note="hexamer: ATTAAA"
     polyA_site      3132
                     /gene="VPS35L"
                     /gene_synonym="C16orf62; EC97; RTSC3"
                     /note="major polyA site"
     regulatory      3547..3552
                     /regulatory_class="polyA_signal_sequence"
                     /gene="VPS35L"
                     /gene_synonym="C16orf62; EC97; RTSC3"
                     /note="hexamer: AATAAA"
     polyA_site      3567
                     /gene="VPS35L"
                     /gene_synonym="C16orf62; EC97; RTSC3"
                     /note="major polyA site"
ORIGIN      
        1 agaacaagcg gtcatgtgac tgggaagatg gccgtctttc cttggcactc caggaatagg
       61 aactacaaag ctgaatttgc atcatgccga ctggaggctg taccattgga gtttggggac
      121 tatcaccctc tgaaacccat aactgtcaca gagtcaaaga caaagaaagt gaaccggaaa
      181 ggaagcactt cttccacgtc ctcctcctcc tccagctccg tggtggaccc gctgagcagc
      241 gtcctcgatg ggactgaccc cctctccatg tttgcagcca ctgctgaccc cgcagccttg
      301 gcagctgcca tggacagctc cagaaggaaa cgtgatagag atgataactc cgttgtagga
      361 tcggattttg agccttggac caacaaacgg ggagaaatcc ttgcccggta caccactacc
      421 gaaaagctgt ctattaatct gtttatggga tctgaaaaag gcaaagctgg gactgccaca
      481 ttggcaatgt cagagaaggt gcggacccgg ctggaggagc tggatgactt tgaggagggt
      541 tcccaaaagg agctgttgaa cttgactcag caggattacg tgaaccgcat agaggagctc
      601 aaccaatcgc tgaaggatgc ctgggcctca gaccagaaag tgaaggctct aaaaatagtc
      661 atccagtgtt caaagcttct ttcagacacc agtgttattc agttctaccc aagcaaattt
      721 gtccttatca ccgacatact tgatacattt ggaaagctcg tgtacgagcg catcttttcc
      781 atgtgtgtgg atagccgcag cgtcttacca gatcactttt ctccagagaa tgcaaatgac
      841 acggccaagg aaacatgcct aaattggttt ttcaagattg cctccatcag ggaactcatt
      901 ccaagatttt acgtggaggc atccatcctg aaatgtaaca aattcctctc caaaacggga
      961 atttcagagt gcctgccccg gttgacatgc atgatcagag ggatcggaga cccactagtg
     1021 tcggtgtatg cccgtgccta cctgtgccgg gtgggaatgg aagtggcccc acatctcaaa
     1081 gaaaccctaa ataagaactt ttttgacttc ctccttacgt tcaaacagat tcatggggat
     1141 acggtccaga accagctggt ggtccaagga gtggagctcc catcttacct ccccttgtac
     1201 ccgcctgcca tggactggat cttccagtgc atctcctacc atgcccccga ggctctgctg
     1261 accgagatga tggaaaggtg taagaaacta ggaaacaatg ccttgctgtt gaattctgtg
     1321 atgtctgcct tccgggctga gttcatcgcc acaaggtcta tggatttcat tggcatgatt
     1381 aaagagtgtg atgaatctgg tttccccaag catcttcttt ttcgatcact gggattaaac
     1441 ttggccttgg ctgatcctcc tgagagtgac cgacttcaga ttctcaacga agcttggaaa
     1501 gtcatcacta agctgaagaa cccacaggac tacattaatt gtgccgaagt gtgggtggaa
     1561 tacacctgca agcatttcac gaaacgagag gtgaataccg ttttggcaga tgtcatcaag
     1621 cacatgactc cagatcgtgc atttgaagat tcctaccccc agcttcagtt aataattaag
     1681 aaagttattg cccacttcca tgacttctca gttcttttct cagtggaaaa atttctgccg
     1741 tttctggaca tgttccaaaa agagagtgtg cgggtggagg tttgcaaatg catcatggac
     1801 gcctttatca agcatcaaca agagcccacc aaggacccgg tcatcttgaa tgcccttttg
     1861 catgtttgca agaccatgca tgactctgtg aatgcactca ctcttgagga tgagaaaaga
     1921 atgctgtcat atttgattaa tggatttata aaaatggttt cctttggccg tgattttgaa
     1981 caacagctga gtttttatgt tgagtccagg tcgatgtttt gcaatctgga gcctgttctt
     2041 gtgcagttga ttcatagtgt gaaccggttg gcaatggaga caagaaaagt aatgaaagga
     2101 aatcattcca gaaagacagc tgcatttgtc cgggcctgtg ttgcctactg cttcatcacc
     2161 atcccctccc tggcgggcat cttcacacgt ctcaatctct acctgcattc tggtcaggtg
     2221 gccttggcca accagtgcct ctcccaagct gatgcttttt tcaaagccgc tataagcctt
     2281 gttccggaag ttccaaagat gattaatatt gatgggaaga tgcggccatc ggaatcgttc
     2341 cttctggaat tcctctgcaa tttcttttct actttattaa tagttccgga tcatcctgaa
     2401 catggggtcc tgtttcttgt tcgagagctt ctcaacgtga tccaggacta cacctgggag
     2461 gacaacagcg atgagaaaat ccgcatctac acctgcgtcc tgcatctcct ctccgccatg
     2521 agccaggaga cgtaccttta ccacatagac aaagtggact ccaacgacag cctctacggg
     2581 ggagactcca agttcctggc agaaaacaac aagctgtgtg agacggtgat ggctcagatc
     2641 ctagagcatc tgaaaaccct ggccaaggac gaggccctga agcgccagag ctcgttgggc
     2701 ctttccttct ttaacagcat cttggcccat ggggacctac gcaacaacaa gctcaaccag
     2761 ctctccgtca acctgtggca cctggcacag aggcacggct gtgcagacac caggaccatg
     2821 gtgaaaacgc tagaatacat caagaagcaa agcaaacaac cagacatgac tcatctgacg
     2881 gagctggccc tcagactccc tctgcaaaca aggacctgac ccccgggccc atccccaggc
     2941 tcagggactc tggtgccaaa tccagaaaga tctgctctgc tgccctgaac tcttacggca
     3001 atttaggttt ctcatttttc ttttcttttt acatatgtac aaattgtttt aagctttggc
     3061 ctctatccag gttattctga caatgaagaa atgggagttg tcagagcatt aaaatgcaat
     3121 cttcactaag aagcagtctc tgtgttgtct ttgcacaagt ggccttcggt ctactcagcc
     3181 cgatctgatg ggccttttta gcaagagaga aacaagaatg caagtaacat ctttcttctc
     3241 tggaaggtgt ttgttttttc atagtttaga aataaggact ttaaaagtgg actgcttttc
     3301 aaagtgccac tgttccagac ccattccatt ccagactttg taccttaaag ttagagcaca
     3361 cccaaagtct ggaactgtgt tacctgaacc cctatggagg atttataaaa ggcagaaata
     3421 gcactccatt aactcttttt cctatcaaaa gcagctcttg attggactta gaatctgtgt
     3481 tggtggatca aaggagaaag cgaggtcaaa tttgagattc tctgtggctt cagtatacag
     3541 taactgaata aatgtcctga aggagcattt atgttcatga ctgttcattt aattacttct
     3601 gactgt
//
