LOCUS       NP_057310                182 aa            linear   PRI 28-APR-2025
DEFINITION  vacuolar protein sorting-associated protein 29 isoform 1 [Homo
            sapiens].
ACCESSION   NP_057310
VERSION     NP_057310.1
DBSOURCE    REFSEQ: accession NM_016226.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 182)
  AUTHORS   Yao,Y.Q. and Lv,J.L.
  TITLE     Potential functions and causal associations of VPS29 in
            hepatocellular carcinoma: a bioinformatic and Mendelian
            randomization study
  JOURNAL   Eur Rev Med Pharmacol Sci 27 (20), 9586-9600 (2023)
   PUBMED   37916325
  REMARK    GeneRIF: Potential functions and causal associations of VPS29 in
            hepatocellular carcinoma: a bioinformatic and Mendelian
            randomization study.
REFERENCE   2  (residues 1 to 182)
  AUTHORS   Healy,M.D., McNally,K.E., Butkovic,R., Chilton,M., Kato,K.,
            Sacharz,J., McConville,C., Moody,E.R.R., Shaw,S.,
            Planelles-Herrero,V.J., Yadav,S.K.N., Ross,J., Borucu,U.,
            Palmer,C.S., Chen,K.E., Croll,T.I., Hall,R.J., Caruana,N.J.,
            Ghai,R., Nguyen,T.H.D., Heesom,K.J., Saitoh,S., Berger,I.,
            Schaffitzel,C., Williams,T.A., Stroud,D.A., Derivery,E.,
            Collins,B.M. and Cullen,P.J.
  TITLE     Structure of the endosomal Commander complex linked to
            Ritscher-Schinzel syndrome
  JOURNAL   Cell 186 (10), 2219-2237 (2023)
   PUBMED   37172566
REFERENCE   3  (residues 1 to 182)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   4  (residues 1 to 182)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (residues 1 to 182)
  AUTHORS   Crawley-Snowdon,H., Yang,J.C., Zaccai,N.R., Davis,L.J.,
            Wartosch,L., Herman,E.K., Bright,N.A., Swarbrick,J.S.,
            Collins,B.M., Jackson,L.P., Seaman,M.N.J., Luzio,J.P., Dacks,J.B.,
            Neuhaus,D. and Owen,D.J.
  TITLE     Mechanism and evolution of the Zn-fingernail required for
            interaction of VARP with VPS29
  JOURNAL   Nat Commun 11 (1), 5031 (2020)
   PUBMED   33024112
  REMARK    GeneRIF: Mechanism and evolution of the Zn-fingernail required for
            interaction of VARP with VPS29.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 182)
  AUTHORS   Verges,M., Luton,F., Gruber,C., Tiemann,F., Reinders,L.G.,
            Huang,L., Burlingame,A.L., Haft,C.R. and Mostov,K.E.
  TITLE     The mammalian retromer regulates transcytosis of the polymeric
            immunoglobulin receptor
  JOURNAL   Nat Cell Biol 6 (8), 763-769 (2004)
   PUBMED   15247922
REFERENCE   7  (residues 1 to 182)
  AUTHORS   Haft,C.R., de la Luz Sierra,M., Bafford,R., Lesniak,M.A., Barr,V.A.
            and Taylor,S.I.
  TITLE     Human orthologs of yeast vacuolar protein sorting proteins Vps26,
            29, and 35: assembly into multimeric complexes
  JOURNAL   Mol Biol Cell 11 (12), 4105-4116 (2000)
   PUBMED   11102511
REFERENCE   8  (residues 1 to 182)
  AUTHORS   Edgar,A.J. and Polak,J.M.
  TITLE     Human homologues of yeast vacuolar protein sorting 29 and 35
  JOURNAL   Biochem Biophys Res Commun 277 (3), 622-630 (2000)
   PUBMED   11062004
REFERENCE   9  (residues 1 to 182)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
REFERENCE   10 (residues 1 to 182)
  AUTHORS   Seaman,M.N., McCaffery,J.M. and Emr,S.D.
  TITLE     A membrane coat complex essential for endosome-to-Golgi retrograde
            transport in yeast
  JOURNAL   J Cell Biol 142 (3), 665-681 (1998)
   PUBMED   9700157
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC095446.1, AL832866.1 and
            AC002350.1.
            
            Summary: This gene belongs to a group of vacuolar protein sorting
            (VPS) genes that, when functionally impaired, disrupt the efficient
            delivery of vacuolar hydrolases. The protein encoded by this gene
            is a component of a large multimeric complex, termed the retromer
            complex, which is involved in retrograde transport of proteins from
            endosomes to the trans-Golgi network. This VPS protein may be
            involved in the formation of the inner shell of the retromer coat
            for retrograde vesicles leaving the prevacuolar compartment.
            Alternative splice variants encoding different isoforms and
            representing non-protein coding transcripts have been found for
            this gene. [provided by RefSeq, Aug 2013].
            
            Transcript Variant: This variant (1) lacks two alternate exons
            compared to variant 3. The resulting isoform (1) has a shorter and
            distinct N-terminus compared to isoform 3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.408424.1,
                                           SRR7410570.509334.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142680, SAMEA2162895
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000549578.6/ ENSP00000447058.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..182
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q24.11"
     Protein         1..182
                     /product="vacuolar protein sorting-associated protein 29
                     isoform 1"
                     /EC_number="3.1.3.3"
                     /note="vacuolar sorting protein VPS29/PEP11; retromer
                     protein; x 007 protein; vacuolar protein
                     sorting-associated protein 29; hVPS29; PEP11 homolog;
                     vesicle protein sorting 29; vacuolar protein sorting 29
                     homolog; epididymis secretory sperm binding protein"
                     /calculated_mol_wt=20375
     Region          2..179
                     /region_name="MPP_Vps29"
                     /note="Homo sapiens Vps29 and related proteins,
                     metallophosphatase domain; cd07394"
                     /db_xref="CDD:163637"
     Site            order(8,10,39,62,86,115,117)
                     /site_type="active"
                     /db_xref="CDD:163637"
     Site            order(8,10,39,62,86,115,117)
                     /site_type="metal-binding"
                     /note="metal binding site [ion binding]"
                     /db_xref="CDD:163637"
     Site            order(8,10,14,39,62..63,86,91,115)
                     /site_type="other"
                     /note="Vps29:Vps35 subcomplex [polypeptide binding]"
                     /db_xref="CDD:163637"
     Site            50
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0007744|PubMed:19608861; propagated from
                     UniProtKB/Swiss-Prot (Q9UBQ0.1)"
     CDS             1..182
                     /gene="VPS29"
                     /gene_synonym="DC15; DC7; PEP11"
                     /coded_by="NM_016226.5:61..609"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS41832.1"
                     /db_xref="GeneID:51699"
                     /db_xref="HGNC:HGNC:14340"
                     /db_xref="MIM:606932"
ORIGIN      
        1 mlvlvlgdlh iphrcnslpa kfkkllvpgk iqhilctgnl ctkesydylk tlagdvhivr
       61 gdfdenlnyp eqkvvtvgqf kiglihghqv ipwgdmasla llqrqfdvdi lisghthkfe
      121 afehenkfyi npgsatgayn aletniipsf vlmdiqastv vtyvyqligd dvkverieyk
      181 kp
//
