LOCUS       NM_052875               3661 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens VPS26 retromer complex component B (VPS26B), mRNA.
ACCESSION   NM_052875
VERSION     NM_052875.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3661)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 3661)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 3661)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 3661)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   5  (bases 1 to 3661)
  AUTHORS   Bugarcic,A., Vetter,I., Chalmers,S., Kinna,G., Collins,B.M. and
            Teasdale,R.D.
  TITLE     Vps26B-retromer negatively regulates plasma membrane
            resensitization of PAR-2
  JOURNAL   Cell Biol Int 39 (11), 1299-1306 (2015)
   PUBMED   26113136
  REMARK    GeneRIF: Authors propose that PAR-2 plasma membrane repopulation is
            regulated by Vps26B-retromer, describing a potential novel role for
            this complex.
REFERENCE   6  (bases 1 to 3661)
  AUTHORS   Hein,M.Y., Hubner,N.C., Poser,I., Cox,J., Nagaraj,N., Toyoda,Y.,
            Gak,I.A., Weisswange,I., Mansfeld,J., Buchholz,F., Hyman,A.A. and
            Mann,M.
  TITLE     A human interactome in three quantitative dimensions organized by
            stoichiometries and abundances
  JOURNAL   Cell 163 (3), 712-723 (2015)
   PUBMED   26496610
REFERENCE   7  (bases 1 to 3661)
  AUTHORS   McGough,I.J., Steinberg,F., Jia,D., Barbuti,P.A., McMillan,K.J.,
            Heesom,K.J., Whone,A.L., Caldwell,M.A., Billadeau,D.D., Rosen,M.K.
            and Cullen,P.J.
  TITLE     Retromer binding to FAM21 and the WASH complex is perturbed by the
            Parkinson disease-linked VPS35(D620N) mutation
  JOURNAL   Curr Biol 24 (14), 1670-1676 (2014)
   PUBMED   24980502
  REMARK    Erratum:[Curr Biol. 2014 Jul 21;24(14):1678. doi:
            10.1016/j.cub.2014.07.004.. PMID: 28903028]
REFERENCE   8  (bases 1 to 3661)
  AUTHORS   Bugarcic,A., Zhe,Y., Kerr,M.C., Griffin,J., Collins,B.M. and
            Teasdale,R.D.
  TITLE     Vps26A and Vps26B subunits define distinct retromer complexes
  JOURNAL   Traffic 12 (12), 1759-1773 (2011)
   PUBMED   21920005
  REMARK    GeneRIF: Colocalization of Vps26 paralogues with different
            endosomally located Rab proteins shows prolonged association of
            Vps26B-retromer with maturing endosomes relative to
            Vps26A-retromer.
REFERENCE   9  (bases 1 to 3661)
  AUTHORS   Kerr,M.C., Bennetts,J.S., Simpson,F., Thomas,E.C., Flegg,C.,
            Gleeson,P.A., Wicking,C. and Teasdale,R.D.
  TITLE     A novel mammalian retromer component, Vps26B
  JOURNAL   Traffic 6 (11), 991-1001 (2005)
   PUBMED   16190980
REFERENCE   10 (bases 1 to 3661)
  AUTHORS   Haft,C.R., de la Luz Sierra,M., Bafford,R., Lesniak,M.A., Barr,V.A.
            and Taylor,S.I.
  TITLE     Human orthologs of yeast vacuolar protein sorting proteins Vps26,
            29, and 35: assembly into multimeric complexes
  JOURNAL   Mol Biol Cell 11 (12), 4105-4116 (2000)
   PUBMED   11102511
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC098386.1, BC014128.2, BC013255.1, BC007799.2, AP000859.4 and
            AV735504.1.
            
            On Nov 22, 2018 this sequence version replaced NM_052875.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC098386.1, SRR1803615.50846.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000281187.10/ ENSP00000281187.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 BC098386.1         68-76
            10-1605             BC014128.2         1-1596
            1606-2008           BC013255.1         873-1275
            2009-2993           BC007799.2         1-985
            2994-2994           AP000859.4         22477-22477
            2995-3654           BC007799.2         987-1646
            3655-3661           AV735504.1         249-255
FEATURES             Location/Qualifiers
     source          1..3661
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q25"
     gene            1..3661
                     /gene="VPS26B"
                     /gene_synonym="Pep8b"
                     /note="VPS26 retromer complex component B"
                     /db_xref="GeneID:112936"
                     /db_xref="HGNC:HGNC:28119"
                     /db_xref="MIM:610027"
     exon            1..675
                     /gene="VPS26B"
                     /gene_synonym="Pep8b"
                     /inference="alignment:Splign:2.1.0"
     CDS             453..1463
                     /gene="VPS26B"
                     /gene_synonym="Pep8b"
                     /note="vesicle protein sorting 26B"
                     /codon_start=1
                     /product="vacuolar protein sorting-associated protein 26B"
                     /protein_id="NP_443107.1"
                     /db_xref="CCDS:CCDS8495.1"
                     /db_xref="GeneID:112936"
                     /db_xref="HGNC:HGNC:28119"
                     /db_xref="MIM:610027"
                     /translation="MSFFGFGQSVEVEILLNDAESRKRAEHKTEDGKKEKYFLFYDGE
                     TVSGKVSLALKNPNKRLEHQGIKIEFIGQIELYYDRGNHHEFVSLVKDLARPGEITQS
                     QAFDFEFTHVEKPYESYTGQNVKLRYFLRATISRRLNDVVKEMDIVVHTLSTYPELNS
                     SIKMEVGIEDCLHIEFEYNKSKYHLKDVIVGKIYFLLVRIKIKHMEIDIIKRETTGTG
                     PNVYHENDTIAKYEIMDGAPVRGESIPIRLFLAGYELTPTMRDINKKFSVRYYLNLVL
                     IDEEERRYFKQQEVVLWRKGDIVRKSMSHQAAIASQRFEGTTSLGEVRTPSQLSDNNC
                     RQ"
     exon            676..832
                     /gene="VPS26B"
                     /gene_synonym="Pep8b"
                     /inference="alignment:Splign:2.1.0"
     exon            833..997
                     /gene="VPS26B"
                     /gene_synonym="Pep8b"
                     /inference="alignment:Splign:2.1.0"
     exon            998..1173
                     /gene="VPS26B"
                     /gene_synonym="Pep8b"
                     /inference="alignment:Splign:2.1.0"
     exon            1174..1316
                     /gene="VPS26B"
                     /gene_synonym="Pep8b"
                     /inference="alignment:Splign:2.1.0"
     exon            1317..3661
                     /gene="VPS26B"
                     /gene_synonym="Pep8b"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3619..3624
                     /regulatory_class="polyA_signal_sequence"
                     /gene="VPS26B"
                     /gene_synonym="Pep8b"
                     /note="hexamer: AAGAAA"
     polyA_site      3661
                     /gene="VPS26B"
                     /gene_synonym="Pep8b"
                     /note="major polyA site"
ORIGIN      
        1 ggagccgccg aagcgcctcg gtgcgttgca ccgccggagg ctgggcagct cgcagcgctg
       61 ctcggcgctg gaccccaccc ggcaggcgca ggccacccac acccggctct gtgcggctgc
      121 cccccgcagc attgcacggc cgaccctcgc ccgcccactg ccaccggccg cgggactggc
      181 tgggactggc tcggccgagg gcactgctcc tcggtgcatt gctgctcggg cgccgcagcc
      241 cgcagccgcc agcctccccc ggccgtgccc ctcccccgtg gagccggctg tccgtcggcg
      301 cccactgccc ggcggcagcg gcggagccag gcagccccgc ggcggccgag cgcgctcgcg
      361 catcgggccc tctggccttc tttacctagg gcagcccgcg ccccggtgcg agggagcggt
      421 ccttaccgag acccgcccgg cccggcggtg cgatgagctt cttcggcttc gggcagagcg
      481 tggaggtgga aatccttctg aacgatgcag agagtaggaa gcgggccgag cacaagacgg
      541 aggacgggaa gaaggagaaa tatttcctct tctacgacgg ggagacggtc tccgggaagg
      601 tgagccttgc cctcaagaac cccaacaagc ggctggagca ccagggcatc aagatcgagt
      661 tcatcgggca gatcgaactc tactacgatc gcgggaacca ccatgagttt gtgtccctgg
      721 tgaaggacct ggcccggcct ggagagatca cccagtcgca ggccttcgac tttgagttta
      781 cccacgtgga gaagccgtat gagtcctaca cagggcagaa tgtgaagcta cgctatttcc
      841 ttcgtgctac catcagccgc cgcctcaatg atgttgtcaa agagatggac attgtagttc
      901 acacactcag cacataccca gagctgaact cttccatcaa gatggaggtt gggattgagg
      961 actgtctgca cattgaattt gagtacaata aatccaaata ccacttgaaa gatgtcattg
     1021 tagggaagat atacttcctg ctggtgagaa tcaaaatcaa gcacatggag atagacatca
     1081 tcaagcgaga aacgacgggt acaggcccca acgtgtacca tgagaatgac acgatagcca
     1141 agtacgagat catggacggg gcaccagtgc gaggagagtc catcccgatc cggctcttcc
     1201 tggccgggta tgagctcacg cccaccatgc gggacatcaa caagaagttc tctgtgcgct
     1261 attacctcaa cctggtgctg atagacgagg aggagcggcg ctacttcaag cagcaggaag
     1321 tggtgttgtg gcggaagggt gacatcgtac ggaagagcat gtcccaccag gcggccatcg
     1381 cctcacagcg ctttgagggc accacctccc tgggtgaggt gcggaccccc agccagctgt
     1441 ctgacaacaa ctgcaggcag taggccccca gggccgagaa gatgctgggc acccacccag
     1501 cacccccatc taccaacacc agcggctggg ggcgggggcg gaccttgtga ggctcagttg
     1561 acccgttact tgcaacctga aaacaaatca tgtttttgac ttaaattctt ttctctggag
     1621 aacccaaggg gcttggggtg ggaagcagtc tctccttggg attctgcggc cgatgtggga
     1681 tagaagaggt agcatcctgg aagccagcct ctctggggaa catgagcccc cttcctcggg
     1741 gggctgcctt gcgtcttaga ggagggagag cagagagcac gcatccttgg ctcctggctc
     1801 tctgagcttc ctgatacagg atctgagcat gtccctggga ttctgagctg ccaacagggc
     1861 cctgggtagt cacatcttgt actccccttt gctgtcccgg aggtagtggc aggagttggg
     1921 ccagccccca ctaagtggca ggggaagact cacgattggg aagctacctc tttgggaatc
     1981 ttggatgtgg tgatctcaag ttcccacagg ccacctcctt ctggccactc actgctggga
     2041 cccaggcacc tcccttctcc atcctctctg gattgtcagt aatgtcctgg aacagaagcc
     2101 tgtgggatgg ccttgggcac ggagaagccc tggggtcagt gtcgtgcacg gatggcggca
     2161 gtgttgaacc caggaggctg aacccggccc accacggaag atgagtgcat ggcaaccgcc
     2221 tgccttcacg tcgctccact tggtaacccc aaggtctggg ctgttctagg tattgcttca
     2281 cgtgccccag caagccctta acaagagggc ctggttccct gaagaaccaa tcccaggaag
     2341 gggccttgat ccctccgcct tgctgagagt gaaccctcgt ctctcctcac cctccatttc
     2401 atttctggga attggggctt agtttcgaac ctttggcaag gctgttctta ctaatgccca
     2461 agccccttta cccctctccc tataggttac acaggggaga ccagggcctc ggcagaagac
     2521 tgctgccaca cttccgaatc attctgcttg ccaaataggt catcttcacc agttgactga
     2581 cccaagttta ggaccattgg tatcgtgtgt ttaaaaaaca catataaaaa aactcttgtg
     2641 aatattcttg ttatgctaga gaggaaggta cttctccctc tacggctctg cgctggggcc
     2701 tatggtagta aagttgttta ctgtcctttt tctgcttccc ctggaaatga caggcattac
     2761 tctcccattg gcctcccttc cctttataga aagaccaagc aggccccact ggccaagagg
     2821 tacggtattt ggcagtctga gttctcagta atttggaaag ttaaggagtt ggttcctgtg
     2881 tcacctttca gttagtgtgg gaaaggaaga cttctgtttt cctgagatca gtgcagtctc
     2941 aggcctttgg cagggctcat ggatcagagc tgagactgga gggagaggca ttttgggtag
     3001 cctaggaggg cgactggcgg cagcagaacc gaggaaggca aggttgtttc ccccacgctg
     3061 tgtcctgtgt tcaggtgcga cacacaatcc tcatgggaac aggatcaccc atgcgctgcc
     3121 cttgatgatc aaggttgggg cttaagtgga taagggaggc aagttctggg ttccttgcct
     3181 tttcagagca tgaggtcagg ctctgtatcc ctccttttcc tagctgatat tctaactaga
     3241 agcatttgtc aattcctttg cctcccaact gacaacacac gttcattttc caaccttcct
     3301 aacatcttaa acctttcttc tgggagaact agaagacaga atttgctttg attctctcag
     3361 gcgctgtgca caagccaggt cttctgtttt ctctttctta ctctacccac attcttgcct
     3421 tctctatcca actgtgaaag tgaggggagg ctcctgtccc cctctcttaa ggtccccaaa
     3481 cctgggagtg cataggtact aaatcaagca gtgcaacttg taattaagca gctgcagtgt
     3541 ttacatgttt cttaatgtgt catcttttca atggctgtat taaaagaaga acgtttgttt
     3601 taatggtctt tctgattaaa gaaagcccct gtggctttgg aggcattgtg cccacggtcc
     3661 a
//
