LOCUS       NM_004896               4227 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens VPS26 retromer complex component A (VPS26A),
            transcript variant 1, mRNA.
ACCESSION   NM_004896
VERSION     NM_004896.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4227)
  AUTHORS   Healy,M.D., McNally,K.E., Butkovic,R., Chilton,M., Kato,K.,
            Sacharz,J., McConville,C., Moody,E.R.R., Shaw,S.,
            Planelles-Herrero,V.J., Yadav,S.K.N., Ross,J., Borucu,U.,
            Palmer,C.S., Chen,K.E., Croll,T.I., Hall,R.J., Caruana,N.J.,
            Ghai,R., Nguyen,T.H.D., Heesom,K.J., Saitoh,S., Berger,I.,
            Schaffitzel,C., Williams,T.A., Stroud,D.A., Derivery,E.,
            Collins,B.M. and Cullen,P.J.
  TITLE     Structure of the endosomal Commander complex linked to
            Ritscher-Schinzel syndrome
  JOURNAL   Cell 186 (10), 2219-2237 (2023)
   PUBMED   37172566
REFERENCE   2  (bases 1 to 4227)
  AUTHORS   Hou,J., Wu,H., Xu,B., Shang,J., Xu,X., Li,G., Zhang,H., Zhang,W.,
            Deng,Y., Hong,X., Hu,T., Zhang,M. and Zhan,Y.
  TITLE     The Prognostic Value and the Oncogenic and Immunological Roles of
            Vacuolar Protein Sorting Associated Protein 26 A in Pancreatic
            Adenocarcinoma
  JOURNAL   Int J Mol Sci 24 (4), 3486 (2023)
   PUBMED   36834898
  REMARK    GeneRIF: The Prognostic Value and the Oncogenic and Immunological
            Roles of Vacuolar Protein Sorting Associated Protein 26 A in
            Pancreatic Adenocarcinoma.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4227)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   4  (bases 1 to 4227)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 4227)
  AUTHORS   Seaman,M.N., Harbour,M.E., Tattersall,D., Read,E. and Bright,N.
  TITLE     Membrane recruitment of the cargo-selective retromer subcomplex is
            catalysed by the small GTPase Rab7 and inhibited by the Rab-GAP
            TBC1D5
  JOURNAL   J Cell Sci 122 (Pt 14), 2371-2382 (2009)
   PUBMED   19531583
  REMARK    GeneRIF: Membrane recruitment of the cargo-selective retromer
            subcomplex VPS35/29/26 is catalysed by the small GTPase Rab7 and
            inhibited by the Rab-GAP TBC1D5.
REFERENCE   6  (bases 1 to 4227)
  AUTHORS   Arighi,C.N., Hartnell,L.M., Aguilar,R.C., Haft,C.R. and
            Bonifacino,J.S.
  TITLE     Role of the mammalian retromer in sorting of the cation-independent
            mannose 6-phosphate receptor
  JOURNAL   J Cell Biol 165 (1), 123-133 (2004)
   PUBMED   15078903
REFERENCE   7  (bases 1 to 4227)
  AUTHORS   Seaman,M.N.
  TITLE     Cargo-selective endosomal sorting for retrieval to the Golgi
            requires retromer
  JOURNAL   J Cell Biol 165 (1), 111-122 (2004)
   PUBMED   15078902
REFERENCE   8  (bases 1 to 4227)
  AUTHORS   Reddy,J.V. and Seaman,M.N.
  TITLE     Vps26p, a component of retromer, directs the interactions of Vps35p
            in endosome-to-Golgi retrieval
  JOURNAL   Mol Biol Cell 12 (10), 3242-3256 (2001)
   PUBMED   11598206
REFERENCE   9  (bases 1 to 4227)
  AUTHORS   Haft,C.R., de la Luz Sierra,M., Bafford,R., Lesniak,M.A., Barr,V.A.
            and Taylor,S.I.
  TITLE     Human orthologs of yeast vacuolar protein sorting proteins Vps26,
            29, and 35: assembly into multimeric complexes
  JOURNAL   Mol Biol Cell 11 (12), 4105-4116 (2000)
   PUBMED   11102511
REFERENCE   10 (bases 1 to 4227)
  AUTHORS   Mao,M., Fu,G., Wu,J.S., Zhang,Q.H., Zhou,J., Kan,L.X., Huang,Q.H.,
            He,K.L., Gu,B.W., Han,Z.G., Shen,Y., Gu,J., Yu,Y.P., Xu,S.H.,
            Wang,Y.X., Chen,S.J. and Chen,Z.
  TITLE     Identification of genes expressed in human CD34(+) hematopoietic
            stem/progenitor cells by expressed sequence tags and efficient
            full-length cDNA cloning
  JOURNAL   Proc Natl Acad Sci U S A 95 (14), 8175-8180 (1998)
   PUBMED   9653160
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA498726.1, AF054179.1,
            BX647725.1 and AL596223.3.
            
            On Nov 22, 2018 this sequence version replaced NM_004896.4.
            
            Summary: This gene belongs to a group of vacuolar protein sorting
            (VPS) genes. The encoded protein is a component of a large
            multimeric complex, termed the retromer complex, involved in
            retrograde transport of proteins from endosomes to the trans-Golgi
            network. The close structural similarity between the yeast and
            human proteins that make up this complex suggests a similarity in
            function. Expression studies in yeast and mammalian cells indicate
            that this protein interacts directly with VPS35, which serves as
            the core of the retromer complex. Alternative splicing results in
            multiple transcript variants encoding different isoforms. [provided
            by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.223537.1,
                                           SRR1803612.31994.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000263559.11/ ENSP00000263559.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-22                DA498726.1         26-47
            23-954              AF054179.1         2-933
            955-1859            BX647725.1         825-1729
            1860-4034           AL596223.3         3146-5320
            4035-4227           BX647725.1         3910-4102
FEATURES             Location/Qualifiers
     source          1..4227
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q22.1"
     gene            1..4227
                     /gene="VPS26A"
                     /gene_synonym="HB58; Hbeta58; PEP8A; VPS26"
                     /note="VPS26 retromer complex component A"
                     /db_xref="GeneID:9559"
                     /db_xref="HGNC:HGNC:12711"
                     /db_xref="MIM:605506"
     exon            1..103
                     /gene="VPS26A"
                     /gene_synonym="HB58; Hbeta58; PEP8A; VPS26"
                     /inference="alignment:Splign:2.1.0"
     CDS             101..1084
                     /gene="VPS26A"
                     /gene_synonym="HB58; Hbeta58; PEP8A; VPS26"
                     /note="isoform 1 is encoded by transcript variant 1;
                     vacuolar protein sorting-associated protein 26A; vesicle
                     protein sorting 26A; vacuolar protein sorting 26 homolog
                     A; VPS26 retromer complex comonent A"
                     /codon_start=1
                     /product="vacuolar protein sorting-associated protein 26A
                     isoform 1"
                     /protein_id="NP_004887.2"
                     /db_xref="CCDS:CCDS7286.1"
                     /db_xref="GeneID:9559"
                     /db_xref="HGNC:HGNC:12711"
                     /db_xref="MIM:605506"
                     /translation="MSFLGGFFGPICEIDIVLNDGETRKMAEMKTEDGKVEKHYLFYD
                     GESVSGKVNLAFKQPGKRLEHQGIRIEFVGQIELFNDKSNTHEFVNLVKELALPGELT
                     QSRSYDFEFMQVEKPYESYIGANVRLRYFLKVTIVRRLTDLVKEYDLIVHQLATYPDV
                     NNSIKMEVGIEDCLHIEFEYNKSKYHLKDVIVGKIYFLLVRIKIQHMELQLIKKEITG
                     IGPSTTTETETIAKYEIMDGAPVKGESIPIRLFLAGYDPTPTMRDVNKKFSVRYFLNL
                     VLVDEEDRRYFKQQEIILWRKAPEKLRKQRTNFHQRFESPESQASAEQPEM"
     exon            104..253
                     /gene="VPS26A"
                     /gene_synonym="HB58; Hbeta58; PEP8A; VPS26"
                     /inference="alignment:Splign:2.1.0"
     exon            254..329
                     /gene="VPS26A"
                     /gene_synonym="HB58; Hbeta58; PEP8A; VPS26"
                     /inference="alignment:Splign:2.1.0"
     exon            330..486
                     /gene="VPS26A"
                     /gene_synonym="HB58; Hbeta58; PEP8A; VPS26"
                     /inference="alignment:Splign:2.1.0"
     exon            487..651
                     /gene="VPS26A"
                     /gene_synonym="HB58; Hbeta58; PEP8A; VPS26"
                     /inference="alignment:Splign:2.1.0"
     exon            652..758
                     /gene="VPS26A"
                     /gene_synonym="HB58; Hbeta58; PEP8A; VPS26"
                     /inference="alignment:Splign:2.1.0"
     exon            759..827
                     /gene="VPS26A"
                     /gene_synonym="HB58; Hbeta58; PEP8A; VPS26"
                     /inference="alignment:Splign:2.1.0"
     exon            828..970
                     /gene="VPS26A"
                     /gene_synonym="HB58; Hbeta58; PEP8A; VPS26"
                     /inference="alignment:Splign:2.1.0"
     exon            971..4227
                     /gene="VPS26A"
                     /gene_synonym="HB58; Hbeta58; PEP8A; VPS26"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2655..2660
                     /regulatory_class="polyA_signal_sequence"
                     /gene="VPS26A"
                     /gene_synonym="HB58; Hbeta58; PEP8A; VPS26"
                     /note="hexamer: AATAAA"
     polyA_site      2676
                     /gene="VPS26A"
                     /gene_synonym="HB58; Hbeta58; PEP8A; VPS26"
                     /note="major polyA site"
     regulatory      2697..2702
                     /regulatory_class="polyA_signal_sequence"
                     /gene="VPS26A"
                     /gene_synonym="HB58; Hbeta58; PEP8A; VPS26"
                     /note="hexamer: ATTAAA"
     polyA_site      2719
                     /gene="VPS26A"
                     /gene_synonym="HB58; Hbeta58; PEP8A; VPS26"
     regulatory      4202..4207
                     /regulatory_class="polyA_signal_sequence"
                     /gene="VPS26A"
                     /gene_synonym="HB58; Hbeta58; PEP8A; VPS26"
                     /note="hexamer: ATTAAA"
     polyA_site      4227
                     /gene="VPS26A"
                     /gene_synonym="HB58; Hbeta58; PEP8A; VPS26"
ORIGIN      
        1 gaggtcacgt gacggagcgc cggagcggag ggagccgggg ctgggagttc tcctgaggga
       61 agaggagtgg agtagggggg acgcggcggc ggcgttgaca atgagttttc ttggaggctt
      121 ttttggtcca atttgtgaga tcgatattgt tcttaatgat ggggaaacca ggaaaatggc
      181 agaaatgaaa actgaagatg gcaaagtaga aaaacactat ctcttctatg acggagaatc
      241 cgtttcagga aaggtaaacc tagcctttaa gcaacctgga aagaggctag aacaccaagg
      301 aattagaatt gaatttgtag gtcaaattga acttttcaat gacaagagta atactcatga
      361 atttgtaaac ctagtgaaag aactagcctt acctggagaa ctgactcaga gcagaagtta
      421 tgattttgaa tttatgcaag ttgaaaagcc atatgaatct tacatcggtg ccaatgtccg
      481 cttgaggtat tttcttaaag tgacaatagt gagaagactg acagatttgg taaaagagta
      541 tgatcttatt gttcaccagc ttgccaccta tcctgatgtt aacaactcta ttaagatgga
      601 agtgggcatt gaagattgtc tacatataga atttgaatat aataaatcaa agtatcattt
      661 aaaggatgtg attgttggaa aaatttactt cttattagta agaataaaaa tacaacatat
      721 ggagttacag ctgatcaaaa aagagatcac aggaattgga cccagtacca caacagaaac
      781 agaaacaatc gccaaatatg aaataatgga tggtgcacca gtaaaaggtg aatcaattcc
      841 aataaggcta tttttagcag gatatgaccc aactccaaca atgagagatg tgaacaaaaa
      901 attttcagta aggtactttt tgaatttagt gcttgttgat gaggaagacc ggaggtactt
      961 caaacagcag gagataattt tatggagaaa agctcctgaa aaactgagga aacagagaac
     1021 aaactttcac cagcgatttg aatctccaga atcacaggca tctgccgaac agcctgaaat
     1081 gtgaactgaa caggagaaaa aaagaaaagc aaaaaactcc tgtaaccctt gagattaagt
     1141 tcagcaggtt aaagatggtt gcagctggag ggggcggaaa aaggccaaaa ctccatatat
     1201 gttagtcttc ctttatctta cagcgcagca tttattttat gatataatga aatgttcgtt
     1261 catgtatata catttttaaa agtgctttct ttgaaacact ggaactttgt taagctgcct
     1321 tttttttttt aacttcctac tttgatgata agcactcaga tatatatcag cgtaaacatg
     1381 aaaaattttc atgtgagtag gctggtattt gtaattttgc tttctttctg cataatgttg
     1441 attataaatc ctctcttttc aggctaatga ttacctctta ttctctacat gcaaaaaatt
     1501 aaatattttg tgttcaaata aaattagaaa acctgagtgg cctcttgtgt cctgcagaga
     1561 tttaaaacat ggcatctcaa tatttttgag aactacattt gtttttaaca tatgtgtttg
     1621 agaaaagcat atggagtgtt tcaccgcagg cacttctgag taccattcca tggcttccag
     1681 aattttatcc tctttgaggt cttctgtgct atgaatatta gatttctttc cccaagggat
     1741 tatgtggcag gtcattatgg ccttcttttt tttggccata ttaagtaaca gttttgctat
     1801 attccagtag taccgttgtg tgttttctgc aatgtggagt tgacttagct tggcatttta
     1861 gatttgttaa aactattttt tccataaata ctttgaaaca tatttatata tttcaattta
     1921 aggaatcttt ttgccatgtg tatgcaaata ttattttctt catacattca ttttcttttc
     1981 aggggaaaat tttgggatgg gggactcagg aggacctgtg aagcatgtag ttatctagat
     2041 ctgggtaatt tcatgtttat taaactcgaa ctttggctag ttaaactcat attgaaactt
     2101 catctagtct cttaattttt taacactaaa ttcaagtcat ttgttttaag tctctaaaaa
     2161 agaagattgc agtcatccat tcatatgcat ggggtctgat cgcaaataca ctaaatgtgg
     2221 agtgtaggaa ccaaaatgaa acctgctgta tggaaactac tttcacttat ggttcattgg
     2281 tttttgtacc aatatttttt atgcacttca gtgcaagtct tgtcagttaa ccttacttta
     2341 tgagtaagct aaataaccca aattacattt ctttaaacct gttttactac tatggcactt
     2401 tgataaaatg gtcaggaacc aactttactg gcaaaagggt ccatgtacca ccatgtgctg
     2461 gagcatctgt tctacatgtg gatatctatg aatggtaatg ttttccttca tgtaagtgcc
     2521 tattcagagt ttcagaattt taaaatgcca aatattttca tggtcatttg catgtagtaa
     2581 gccagaaaat attcaaagag attttgaaaa ccaattgtat ttaaccagcc tcaaattgtg
     2641 caaccatgat gtataataaa gaatttgaaa cagaaactga gcttgctgtt tgcatgatta
     2701 aaatagctct gttctcaaat ctcttctcat tgttagattt attgtcgagg ataggattgt
     2761 tcaatagttt aggaagctgt aactgtgata atgaattttt ataaatatta ctggtttcaa
     2821 ttttaaatag atatataatg cttttaatag gctggcttaa aactgtcata tacaggatgc
     2881 ctatccgttt tgctcaagac tttttgtagc ataaccaatt tgaaaaaaat tcaaatttaa
     2941 tatttggtga tttcagtcaa aagtcagcca gctaattaga agtcataaac tgaaaaagaa
     3001 atttgtgtct ttaatgaaga gttacaatgt ctaatccatt ggttctcaac cctggctgca
     3061 tatcagaatc accttagaag cttttaaaat aaccaggccc gggtcctact ctgaccaata
     3121 aaataagaat ctcagagact gggccataag cattaaaaac aaaacaacct caaaaaaata
     3181 cctgtcatct cagccacttc aggagtctga ggcggaagga tcacctggaa ttcgagacca
     3241 gcctggccaa caaaaatgag accctatctc tacaaaaaaa ttaacaatga gctgggcatg
     3301 gtggcatgca cctgtatttc cagctattta ggaagctgag acaggaagat ccctttgaga
     3361 ggtgaagcca gctggacttc tgagttgcgt ggggacttgg agaacttttc tgtcttacaa
     3421 ggggattgta gaatgcacca atcaacactc tagctaggat tgtaaaacgc actctggcta
     3481 gctggaggtt tgtaaaatgt accaatcagt gcttgtgaaa acgcaccaat caggctgggc
     3541 acagtggctc acgcctgtaa tcccagcact ttgggaggct gaggcgggca gatcacctga
     3601 gttccaggag ttcgagacca gcctgaccaa cgtggagaaa ctccatctct accaaaaatg
     3661 cattagtcgg gcgtggtggc acatgcctgt aatcccagct actagggagg ctgaggcaga
     3721 attgcttgaa cccgggaggc agaggttgca gtgagccgag atcacaccaa tgcactccag
     3781 cctggctaga agtttgtaaa atggaccaac cagtgttctg tagaatggac caatcagcag
     3841 gacgtgggcg gggacaaata agagaataaa agctggccac cccccagcca gcagcggcaa
     3901 ccggctcggg tccccctcca tactgtggaa gctctgttct ttcactcttc acgatacatc
     3961 ttgctgctgc tcactctggg cctgtgccac atttaagagc tgtaacactc aaggcgaagg
     4021 tccacggctc cgttaagtca gcgagaccgc aaacccactg gaaggaacca actctggaca
     4081 caccttgagt acacgaattt gaaattacac tgaggtgatc atgccactgc actgtagctt
     4141 gggtgacaga gacaccatgt ctcaaaaatc tacccagagt tgggaaccac tgatctaaac
     4201 cattaaaatt tttatttctg tcactaa
//
