LOCUS       XM_047427256            2520 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens VPS11 core subunit of CORVET and HOPS
            complexes (VPS11), transcript variant X2, mRNA.
ACCESSION   XM_047427256
VERSION     XM_047427256.1
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000011.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2520
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
     gene            1..2520
                     /gene="VPS11"
                     /gene_synonym="DYT32; END1; HLD12; hVPS11; PEP5; RNF108"
                     /note="VPS11 core subunit of CORVET and HOPS complexes;
                     Derived by automated computational analysis using gene
                     prediction method: Gnomon. Supporting evidence includes
                     similarity to: 136 ESTs, 196 long SRA reads, 2 Proteins,
                     and 100% coverage of the annotated genomic feature by
                     RNAseq alignments, including 25 samples with support for
                     all annotated introns"
                     /db_xref="GeneID:55823"
                     /db_xref="HGNC:HGNC:14583"
                     /db_xref="MIM:608549"
     CDS             432..2171
                     /gene="VPS11"
                     /gene_synonym="DYT32; END1; HLD12; hVPS11; PEP5; RNF108"
                     /codon_start=1
                     /product="vacuolar protein sorting-associated protein 11
                     homolog isoform X1"
                     /protein_id="XP_047283212.1"
                     /db_xref="GeneID:55823"
                     /db_xref="HGNC:HGNC:14583"
                     /db_xref="MIM:608549"
                     /translation="MLFKKNLFEMAINLAKSQHLDSDGLAQIFMQYGDHLYSKGNHDG
                     AVQQYIRTIGKLEPSYVIRKFLDAQRIHNLTAYLQTLHRQSLANADHTTLLLNCYTKL
                     KDSSKLEEFIKKKSESEVHFDVETAIKVLRQAGYYSHALYLAENHAHHEWYLKIQLED
                     IKNYQEALRYIGKLPFEQAESNMKRYGKILMHHIPEQTTQLLKGLCTDYRPSLEGRSD
                     REAPGCRANSEEFIPIFANNPRELKAFLEHMSEVQPDSPQGIYDTLLELRLQNWAHEK
                     DPQVKEKLHAEAISLLKSGRFCDVFDKALVLCQMHDFQDGVLYLYEQGKLFQQIMHYH
                     MQHEQYRQVISVCERHGEQDPSLWEQALSYFARKEEDCKEYVAAVLKHIENKNLMPPL
                     LVVQTLAHNSTATLSVIRDYLVQKLQKQSQQIAQDELRVRRYREETTRIRQEIQELKA
                     SPKIFQKTKCSICNSALELPSVHFLCGHSFHQHCFESYSESDADCPTCLPENRKVMDM
                     IRAQEQKRDLHDQFQHQLKCSNDSFSVIADYFGRGVFNKLTLLTDPPTARLTSSLEAG
                     LQRDLLMHSRRGT"
ORIGIN      
        1 caagggcaac tatcctgtaa ctggattggc ctttcgccaa gcaggaaaga ccactcactt
       61 gtttgttgtg acaacagaga acgtccaggt cagagtttac cagcagggat tcacagagct
      121 ccgacaagca gattctaaac atctatgacc tgtgcaacaa gttcatagcc tatagcaccg
      181 tctttgagga tgtagtggat gtgcttgctg agtggggctc cctgtacgtg ctgacgcggg
      241 atgggcgggt ccacgcactg caggagaagg acacacagac caaactggag gcaaggccac
      301 caggctcgca gagctggcca caggcaccta gaagcagctg caggagcagg ttccccaagt
      361 catattggcc agggtgtttc cctccttgtg ggtcacagcc ttactcagct tccttagggt
      421 aggattataa gatgctgttt aagaagaacc tatttgagat ggcgattaac cttgccaaga
      481 gccagcatct ggacagtgat gggctggccc agattttcat gcagtatgga gaccatctct
      541 acagcaaggg caaccacgat ggggctgtcc agcaatatat ccgaaccatt ggaaagttgg
      601 agccatccta cgtgatccgc aagtttctgg atgcccagcg cattcacaac ctgactgcct
      661 acctgcagac cctgcaccga caatccctgg ccaatgccga ccataccacc ctgctcctca
      721 actgctatac caagctcaag gacagctcga agctggagga gttcatcaag aaaaagagtg
      781 agagtgaagt ccactttgat gtggagacag ccatcaaggt cctccggcag gctggctact
      841 actcccatgc cctgtatctg gcggagaacc atgcacatca tgagtggtac ctgaagatcc
      901 agctagaaga cattaagaat tatcaggaag cccttcgata catcggcaag ctgccttttg
      961 agcaggcaga gagcaacatg aagcgctacg gcaagatcct catgcaccac ataccagagc
     1021 agacaactca gttgctgaag ggactttgta ctgattatcg gcccagcctc gaaggccgca
     1081 gcgataggga ggccccaggc tgcagggcca actctgagga gttcatcccc atctttgcca
     1141 ataacccgcg agagctgaaa gccttcctag agcacatgag tgaagtgcag ccagactcac
     1201 cccaggggat ctacgacaca ctccttgagc tgcgactgca gaactgggcc cacgagaagg
     1261 atccacaggt caaagagaag cttcacgcag aggccatttc cctgctgaag agtggtcgct
     1321 tctgcgacgt ctttgacaag gccctggtcc tgtgccagat gcacgacttc caggatggtg
     1381 tcctttacct ttatgagcag gggaagctgt tccagcagat catgcactac cacatgcagc
     1441 acgagcagta ccggcaggtc atcagcgtgt gtgagcgcca tggggagcag gacccctcct
     1501 tgtgggagca ggccctcagc tacttcgctc gcaaggagga ggactgcaag gagtatgtgg
     1561 cagctgtcct caagcatatc gagaacaaga acctcatgcc acctcttcta gtggtgcaga
     1621 ccctggccca caactccaca gccacactct ccgtcatcag ggactacctg gtccaaaaac
     1681 tacagaaaca gagccagcag attgcacagg atgagctgcg ggtgcggcgg taccgagagg
     1741 agaccacccg tatccgccag gagatccaag agctcaaggc cagtcctaag attttccaaa
     1801 agaccaagtg cagcatctgt aacagtgcct tggagttgcc ctcagtccac ttcctgtgtg
     1861 gccactcctt ccaccaacac tgctttgaga gttactcgga aagtgatgct gactgcccca
     1921 cctgcctccc tgaaaaccgg aaggtcatgg atatgatccg ggcccaggaa cagaaacgag
     1981 atctccatga tcaattccag catcagctca agtgctccaa tgacagcttt tctgtgattg
     2041 ctgactactt tggcagaggt gttttcaaca aattgactct gctgaccgac cctcccacag
     2101 ccagactgac ctccagcctg gaggctgggc tgcaacgcga cctactcatg cactccagga
     2161 ggggcactta agcagcctgg aggaagatgt gggcaacagt ggaggaccaa gagaacagac
     2221 acaatgggac ctgggcgggc gttacacaga aggctggctg acatgcccag ggctccactc
     2281 tcatctaatg tcacagccct cagaactaaa gcggactttc tttccctgcc ttcttattta
     2341 gtcagcttgc catccctcct cttcactagc agtgtagatc attccagatc agtgggggag
     2401 ggcacctcag caacctctga gtgtggacaa tagctgcttt cttctctatc caagagcacc
     2461 aggctgtgct tgggtccttg ctctcagagt ctataaataa aagaatataa tgatttggga
//
