LOCUS       NM_013378                567 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens V-set pre-B cell surrogate light chain 3 (VPREB3),
            mRNA.
ACCESSION   NM_013378
VERSION     NM_013378.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 567)
  AUTHORS   Felizola,S.J., Katsu,K., Ise,K., Nakamura,Y., Arai,Y., Satoh,F. and
            Sasano,H.
  TITLE     Pre-B Lymphocyte Protein 3 (VPREB3) Expression in the Adrenal
            Cortex: Precedent for non-Immunological Roles in Normal and
            Neoplastic Human Tissues
  JOURNAL   Endocr Pathol 26 (2), 119-128 (2015)
   PUBMED   25861052
  REMARK    GeneRIF: A possible role for VPREB3 in aldosterone biosynthesis.
            GeneRIF: levels of VPREB3 mRNA in aldosterone-producing adenomas
            directly correlate to plasma aldosterone concentrations in
            peripheral blood of respective patients
REFERENCE   2  (bases 1 to 567)
  AUTHORS   Soldini,D., Georgis,A., Montagna,C., Schuffler,P.J., Martin,V.,
            Curioni-Fontecedro,A., Martinez,A. and Tinguely,M.
  TITLE     The combined expression of VPREB3 and ID3 represents a new helpful
            tool for the routine diagnosis of mature aggressive B-cell
            lymphomas
  JOURNAL   Hematol Oncol 32 (3), 120-125 (2014)
   PUBMED   24493312
  REMARK    GeneRIF: the combined immunohistochemical detection of VPREB3 and
            ID3 is applicable to the routine diagnostic in case of mature
            aggressive B-cell lymphomas.
REFERENCE   3  (bases 1 to 567)
  AUTHORS   Rodig,S.J., Kutok,J.L., Paterson,J.C., Nitta,H., Zhang,W.,
            Chapuy,B., Tumwine,L.K., Montes-Moreno,S., Agostinelli,C.,
            Johnson,N.A., Ben-Neriah,S., Farinha,P., Shipp,M.A., Piris,M.A.,
            Grogan,T.M., Pileri,S.A., Gascoyne,R.D. and Marafioti,T.
  TITLE     The pre-B-cell receptor associated protein VpreB3 is a useful
            diagnostic marker for identifying c-MYC translocated lymphomas
  JOURNAL   Haematologica 95 (12), 2056-2062 (2010)
   PUBMED   20823132
  REMARK    GeneRIF: Data show that the absence of VpreB3 is virtually always
            associated with wild-type c-MYC alleles.
REFERENCE   4  (bases 1 to 567)
  AUTHORS   Rangel,R., McKeller,M.R., Sims-Mourtada,J.C., Kashi,C., Cain,K.,
            Wieder,E.D., Molldrem,J.J., Pham,L.V., Ford,R.J., Yotnda,P.,
            Guret,C., Frances,V. and Martinez-Valdez,H.
  TITLE     Assembly of the kappa preB receptor requires a V kappa-like protein
            encoded by a germline transcript
  JOURNAL   J Biol Chem 280 (18), 17807-17814 (2005)
   PUBMED   15757909
  REMARK    GeneRIF: the present study confirms the co-existence of surrogate
            lambda and kappa receptors that are proposed to work in concert to
            promote B lymphocyte maturation.
REFERENCE   5  (bases 1 to 567)
  AUTHORS   Rosnet,O., Blanco-Betancourt,C., Grivel,K., Richter,K. and
            Schiff,C.
  TITLE     Binding of free immunoglobulin light chains to VpreB3 inhibits
            their maturation and secretion in chicken B cells
  JOURNAL   J Biol Chem 279 (11), 10228-10236 (2004)
   PUBMED   14670953
  REMARK    GeneRIF: VpreB3 may play a role in the regulation of the maturation
            and secretion of free IgLC in chicken B cells
REFERENCE   6  (bases 1 to 567)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   7  (bases 1 to 567)
  AUTHORS   Rosnet,O., Mattei,M.G., Delattre,O. and Schiff,C.
  TITLE     VPREB3: cDNA characterization and expression in human and
            chromosome mapping in human and mouse
  JOURNAL   Cytogenet Cell Genet 87 (3-4), 205-208 (1999)
   PUBMED   10702669
REFERENCE   8  (bases 1 to 567)
  AUTHORS   Ohnishi,K. and Takemori,T.
  TITLE     Molecular components and assembly of mu.surrogate light chain
            complexes in pre-B cell lines
  JOURNAL   J Biol Chem 269 (45), 28347-28353 (1994)
   PUBMED   7961773
REFERENCE   9  (bases 1 to 567)
  AUTHORS   Shirasawa,T., Ohnishi,K., Hagiwara,S., Shigemoto,K., Takebe,Y.,
            Rajewsky,K. and Takemori,T.
  TITLE     A novel gene product associated with mu chains in immature B cells
  JOURNAL   EMBO J 12 (5), 1827-1834 (1993)
   PUBMED   8491176
  REMARK    GeneRIF: mouse VpreB3 associates with mu heavy chains early in
            pre-B cell receptor biosynthesis
REFERENCE   10 (bases 1 to 567)
  AUTHORS   Melchers,F., Karasuyama,H., Haasner,D., Bauer,S., Kudo,A.,
            Sakaguchi,N., Jameson,B. and Rolink,A.
  TITLE     The surrogate light chain in B-cell development
  JOURNAL   Immunol Today 14 (2), 60-68 (1993)
   PUBMED   8166770
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AY359000.1, AF163825.1 and
            BQ899182.1.
            
            On Nov 22, 2018 this sequence version replaced NM_013378.2.
            
            Summary: The protein encoded by this gene is the human ortholog of
            the mouse VpreB3 (8HS20) protein, is thought to be involved in
            B-cell maturation, and may play a role in assembly of the pre-B
            cell receptor (pre-BCR). While the role of this protein in B-cell
            development has not yet been elucidated, studies with the chicken
            ortholog of this protein have found that when overexpressed, this
            protein localizes to the endoplasmic reticulum. The mouse ortholog
            of this protein has been shown to associate with membrane mu heavy
            chains early in the course of pre-B cell receptor biosynthesis.
            Expression of this gene has been observed in some lymphomas.
            [provided by RefSeq, Apr 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC020666.1, AY359000.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2149876, SAMEA2150385
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000248948.4/ ENSP00000248948.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-20                AY359000.1         19-38
            21-565              AF163825.1         1-545
            566-567             BQ899182.1         517-518
FEATURES             Location/Qualifiers
     source          1..567
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q11.23"
     gene            1..567
                     /gene="VPREB3"
                     /gene_synonym="8HS20; N27C7-2"
                     /note="V-set pre-B cell surrogate light chain 3"
                     /db_xref="GeneID:29802"
                     /db_xref="HGNC:HGNC:12710"
                     /db_xref="IMGT/GENE-DB:VPREB3"
                     /db_xref="MIM:605017"
     exon            1..111
                     /gene="VPREB3"
                     /gene_synonym="8HS20; N27C7-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             63..434
                     /gene="VPREB3"
                     /gene_synonym="8HS20; N27C7-2"
                     /note="pre-B lymphocyte gene 3; pre-B lymphocyte protein
                     3; pre-B lymphocyte 3"
                     /codon_start=1
                     /product="pre-B lymphocyte protein 3 precursor"
                     /protein_id="NP_037510.1"
                     /db_xref="CCDS:CCDS13813.1"
                     /db_xref="GeneID:29802"
                     /db_xref="HGNC:HGNC:12710"
                     /db_xref="IMGT/GENE-DB:VPREB3"
                     /db_xref="MIM:605017"
                     /translation="MACRCLSFLLMGTFLSVSQTVLAQLDALLVFPGQVAQLSCTLSP
                     QHVTIRDYGVSWYQQRAGSAPRYLLYYRSEEDHHRPADIPDRFSAAKDEAHNACVLTI
                     SPVQPEDDADYYCSVGYGFSP"
     exon            112..567
                     /gene="VPREB3"
                     /gene_synonym="8HS20; N27C7-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      543..548
                     /regulatory_class="polyA_signal_sequence"
                     /gene="VPREB3"
                     /gene_synonym="8HS20; N27C7-2"
                     /note="hexamer: AATAAT"
     polyA_site      567
                     /gene="VPREB3"
                     /gene_synonym="8HS20; N27C7-2"
                     /note="major polyA site"
ORIGIN      
        1 caaagcacct ggagcatata gccttgcaga acttctactt gcctgcctcc ctgcctctgg
       61 ccatggcctg ccggtgcctc agcttccttc tgatggggac cttcctgtca gtttcccaga
      121 cagtcctggc ccagctggat gcactgctgg tcttcccagg ccaagtggct caactctcct
      181 gcacgctcag cccccagcac gtcaccatca gggactacgg tgtgtcctgg taccagcagc
      241 gggcaggcag tgcccctcga tatctcctct actaccgctc ggaggaggat caccaccggc
      301 ctgctgacat ccccgatcga ttctcggcag ccaaggatga ggcccacaat gcctgtgtcc
      361 tcaccattag tcccgtgcag cctgaagacg acgcggatta ctactgctct gttggctacg
      421 gctttagtcc ctaggggtgg ggtgtgagat gggtgcctcc cctctgcctc ccatttctgc
      481 ccctgacctt gggtcccttt taaactttct ctgagccttg cttcccctct gtaaaatggg
      541 ttaataatat tcaacatgtc aacaaca
//
