LOCUS       NM_007128                644 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens V-set pre-B cell surrogate light chain 1 (VPREB1),
            transcript variant 1, mRNA.
ACCESSION   NM_007128
VERSION     NM_007128.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 644)
  AUTHORS   Naji,P., Khatami,M., Heidari,M.M., Hashemi,A., Jenabzadeh,A.,
            Chamani,R. and Khanjarpanah,Z.
  TITLE     Mutational Analysis of the VPREB1 Gene of Pre-BCR Complex in a
            Cohort of Sporadic Pediatric Patients With B-Cell Acute
            Lymphoblastic Leukemia
  JOURNAL   J Pediatr Hematol Oncol 44 (5), 210-219 (2022)
   PUBMED   35398858
  REMARK    GeneRIF: Mutational Analysis of the VPREB1 Gene of Pre-BCR Complex
            in a Cohort of Sporadic Pediatric Patients With B-Cell Acute
            Lymphoblastic Leukemia.
REFERENCE   2  (bases 1 to 644)
  AUTHORS   Khaled,M., Moustafa,A.S., El-Khazragy,N., Ahmed,M.I., Abd
            Elkhalek,M.A. and El Salahy,E.M.
  TITLE     CRISPR/Cas9 mediated knock-out of VPREB1 gene induces a cytotoxic
            effect in myeloma cells
  JOURNAL   PLoS One 16 (1), e0245349 (2021)
   PUBMED   33418558
  REMARK    GeneRIF: CRISPR/Cas9 mediated knock-out of VPREB1 gene induces a
            cytotoxic effect in myeloma cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 644)
  AUTHORS   Aslam,M.M., John,P., Fan,K.H., Bhatti,A., Feingold,E., Demirci,F.Y.
            and Kamboh,M.I.
  TITLE     Association of VPREB1 Gene Copy Number Variation and Rheumatoid
            Arthritis Susceptibility
  JOURNAL   Dis Markers 2020, 7189626 (2020)
   PUBMED   33101545
  REMARK    GeneRIF: Association of VPREB1 Gene Copy Number Variation and
            Rheumatoid Arthritis Susceptibility.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 644)
  AUTHORS   Chen,D., Zheng,J., Gerasimcik,N., Lagerstedt,K., Sjogren,H.,
            Abrahamsson,J., Fogelstrand,L. and Martensson,I.L.
  TITLE     The Expression Pattern of the Pre-B Cell Receptor Components
            Correlates with Cellular Stage and Clinical Outcome in Acute
            Lymphoblastic Leukemia
  JOURNAL   PLoS One 11 (9), e0162638 (2016)
   PUBMED   27611867
  REMARK    GeneRIF: Irrespective of subtype, Acute Lymphoblastic Leukemia with
            high levels of IGHM, IGLL1 and VPREB1 are arrested at the pre-B
            stage and correlate with good prognosis in high-risk pediatric
            B-cell precursor acute lymphoblastic leukemia.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 644)
  AUTHORS   Mangum,D.S., Downie,J., Mason,C.C., Jahromi,M.S., Joshi,D.,
            Rodic,V., Muschen,M., Meeker,N., Trede,N., Frazer,J.K., Zhou,Y.,
            Cheng,C., Jeha,S., Pui,C.H., Willman,C.L., Harvey,R.C.,
            Hunger,S.P., Yang,J.J., Barnette,P., Mullighan,C.G., Miles,R.R. and
            Schiffman,J.D.
  TITLE     VPREB1 deletions occur independent of lambda light chain
            rearrangement in childhood acute lymphoblastic leukemia
  JOURNAL   Leukemia 28 (1), 216-220 (2014)
   PUBMED   23881307
  REMARK    GeneRIF: VPREB1 focal deletions are common in B-ALL and occur
            independent of V(D)J light chain recombination. Focal deletions of
            VPREB1 correlate with decreased expression levels and high-risk
            patients with focal deletions tend to have poorer overall survival
REFERENCE   6  (bases 1 to 644)
  AUTHORS   Gisler,R. and Sigvardsson,M.
  TITLE     The human V-preB promoter is a target for coordinated activation by
            early B cell factor and E47
  JOURNAL   J Immunol 168 (10), 5130-5138 (2002)
   PUBMED   11994467
  REMARK    GeneRIF: The 5' region of the VpreB gene contains a promoter which
            displays higher relative activity in preB cells compared with cells
            at other stages or from other lineages.
REFERENCE   7  (bases 1 to 644)
  AUTHORS   Mattei,M.G., Fumoux,F., Roeckel,N., Fougereau,M. and Schiff,C.
  TITLE     The human pre-B-specific lambda-like cluster is located in the
            22q11.2-22q12.3 region, distal to the IgC lambda locus
  JOURNAL   Genomics 9 (3), 544-546 (1991)
   PUBMED   1903358
REFERENCE   8  (bases 1 to 644)
  AUTHORS   Tsubata,T. and Reth,M.
  TITLE     The products of pre-B cell-specific genes (lambda 5 and VpreB) and
            the immunoglobulin mu chain form a complex that is transported onto
            the cell surface
  JOURNAL   J Exp Med 172 (3), 973-976 (1990)
   PUBMED   2117639
REFERENCE   9  (bases 1 to 644)
  AUTHORS   Bauer,S.R., Kudo,A. and Melchers,F.
  TITLE     Structure and pre-B lymphocyte restricted expression of the VpreB
            in humans and conservation of its structure in other mammalian
            species
  JOURNAL   EMBO J 7 (1), 111-116 (1988)
   PUBMED   3258819
REFERENCE   10 (bases 1 to 644)
  AUTHORS   Bauer,S.R., Huebner,K., Budarf,M., Finan,J., Erikson,J.,
            Emanuel,B.S., Nowell,P.C., Croce,C.M. and Melchers,F.
  TITLE     The human Vpre B gene is located on chromosome 22 near a cluster of
            V lambda gene segments
  JOURNAL   Immunogenetics 28 (5), 328-333 (1988)
   PUBMED   3139558
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BG502270.1, BC017922.1 and
            AC245060.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_007128.3.
            
            Summary: The protein encoded by this gene belongs to the
            immunoglobulin superfamily and is expressed selectively at the
            early stages of B cell development, namely, in proB and early preB
            cells. This gene encodes the iota polypeptide chain that is
            associated with the Ig-mu chain to form a molecular complex which
            is expressed on the surface of pre-B cells. The complex is thought
            to regulate Ig gene rearrangements in the early steps of B-cell
            differentiation. Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, Jan 2015].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BG531255.1, BC017922.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000403807.4/ ENSP00000385361.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 BG502270.1         7-8
            3-343               BC017922.1         1-341
            344-644             AC245060.1         117057-117357
FEATURES             Location/Qualifiers
     source          1..644
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q11.22"
     gene            1..644
                     /gene="VPREB1"
                     /gene_synonym="CD179a; IGI; IGVPB; VPREB"
                     /note="V-set pre-B cell surrogate light chain 1"
                     /db_xref="GeneID:7441"
                     /db_xref="HGNC:HGNC:12709"
                     /db_xref="IMGT/GENE-DB:VPREB1"
                     /db_xref="MIM:605141"
     exon            1..74
                     /gene="VPREB1"
                     /gene_synonym="CD179a; IGI; IGVPB; VPREB"
                     /inference="alignment:Splign:2.1.0"
     CDS             29..466
                     /gene="VPREB1"
                     /gene_synonym="CD179a; IGI; IGVPB; VPREB"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; immunoglobulin iota chain; v(pre)B protein;
                     CD179 antigen-like family member A; pre-B lymphocyte 1"
                     /codon_start=1
                     /product="immunoglobulin iota chain isoform 1 precursor"
                     /protein_id="NP_009059.1"
                     /db_xref="CCDS:CCDS13798.1"
                     /db_xref="GeneID:7441"
                     /db_xref="HGNC:HGNC:12709"
                     /db_xref="IMGT/GENE-DB:VPREB1"
                     /db_xref="MIM:605141"
                     /translation="MSWAPVLLMLFVYCTGCGPQPVLHQPPAMSSALGTTIRLTCTLR
                     NDHDIGVYSVYWYQQRPGHPPRFLLRYFSQSDKSQGPQVPPRFSGSKDVARNRGYLSI
                     SELQPEDEAMYYCAMGARSSEKEEREREWEEEMEPTAARTRVP"
     exon            75..644
                     /gene="VPREB1"
                     /gene_synonym="CD179a; IGI; IGVPB; VPREB"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggagtcaga gctctgcatg tctgcaccat gtcctgggct cctgtcctgc tcatgctgtt
       61 tgtctactgc acaggttgtg gtcctcagcc ggtgctgcat cagccgccgg ccatgtcctc
      121 ggcccttgga accacaatcc gcctcacctg caccctgagg aacgaccatg acatcggtgt
      181 gtacagcgtc tactggtacc agcagaggcc gggccaccct cccaggttcc tgctgagata
      241 tttctcacaa tcagacaaga gccagggccc ccaggtcccc cctcgcttct ctggatccaa
      301 agatgtggcc aggaacaggg ggtatttgag catctctgag ctgcagcctg aggacgaggc
      361 tatgtattac tgtgctatgg gggcccgcag ctcggagaag gaggagaggg agagggagtg
      421 ggaggaagaa atggaaccca ctgcagccag gacacgtgtc ccttgaactg aagacagcag
      481 aggcacgcat ccccttggag agactgtcat ggaagagggt ggagtcgccg cccgaagcgc
      541 cgaggaggct gagccactca gcatctcctg gtcctgcagt gttgctgtaa atccccattg
      601 gagactgcat tagggaatta aagctgcttg tcactttttg ctga
//
