LOCUS       NM_030796               2939 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens VOPP1 WW domain binding protein (VOPP1), transcript
            variant 1, mRNA.
ACCESSION   NM_030796
VERSION     NM_030796.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2939)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 2939)
  AUTHORS   Fang,Z., Wu,L., Dai,H., Hu,P., Wang,B., Han,Q., Xu,Y., Lv,S.,
            Zhu,Y., Gan,M., Zhou,W. and Zhang,W.
  TITLE     The role of vesicular overexpressed in cancer pro-survival protein
            1 in hepatocellular carcinoma proliferation
  JOURNAL   Cancer Biomark 28 (1), 9-20 (2020)
   PUBMED   32083568
  REMARK    GeneRIF: The role of vesicular overexpressed in cancer pro-survival
            protein 1 in hepatocellular carcinoma proliferation.
REFERENCE   3  (bases 1 to 2939)
  AUTHORS   Bonin,F., Taouis,K., Azorin,P., Petitalot,A., Tariq,Z., Nola,S.,
            Bouteille,N., Tury,S., Vacher,S., Bieche,I., Rais,K.A., Pierron,G.,
            Fuhrmann,L., Vincent-Salomon,A., Formstecher,E., Camonis,J.,
            Lidereau,R., Lallemand,F. and Driouch,K.
  TITLE     VOPP1 promotes breast tumorigenesis by interacting with the tumor
            suppressor WWOX
  JOURNAL   BMC Biol 16 (1), 109 (2018)
   PUBMED   30285739
  REMARK    GeneRIF: The findings emphasize the importance of the sequestration
            of WWOX by VOPP1 in addition to WWOX loss in breast tumors and
            define VOPP1 as a novel oncogene promoting breast carcinogenesis by
            inhibiting the anti-tumoral effect of WWOX.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2939)
  AUTHORS   Li,J.M., Zhang,H. and Zuo,Y.J.
  TITLE     MicroRNA-218 alleviates sepsis inflammation by negatively
            regulating VOPP1 via JAK/STAT pathway
  JOURNAL   Eur Rev Med Pharmacol Sci 22 (17), 5620-5626 (2018)
   PUBMED   30229837
  REMARK    GeneRIF: VOPP1 expression was negatively regulated by microRNA-218.
REFERENCE   5  (bases 1 to 2939)
  AUTHORS   Li,Y.J., Zhang,W., Xia,H., Zhang,B.S., Chen,P., Zhao,Y.L. and Li,J.
  TITLE     miR-218 suppresses epithelial-to-mesenchymal transition by
            targeting Robo1 and Ecop in lung adenocarcinoma cells
  JOURNAL   Future Oncol 13 (28), 2571-2582 (2017)
   PUBMED   28936884
  REMARK    GeneRIF: miR-218 inhibits human lung adenocarcinoma cell migration
            and invasion via the suppression of Ecop and Robo1 expression
REFERENCE   6  (bases 1 to 2939)
  AUTHORS   Brem,H., Stojadinovic,O., Diegelmann,R.F., Entero,H., Lee,B.,
            Pastar,I., Golinko,M., Rosenberg,H. and Tomic-Canic,M.
  TITLE     Molecular markers in patients with chronic wounds to guide surgical
            debridement
  JOURNAL   Mol Med 13 (1-2), 30-39 (2007)
   PUBMED   17515955
  REMARK    GeneRIF: ECOP was used as a molecular marker in patients with
            chronic wounds to guide surgical debridement.
REFERENCE   7  (bases 1 to 2939)
  AUTHORS   Chung,C.H., Ely,K., McGavran,L., Varella-Garcia,M., Parker,J.,
            Parker,N., Jarrett,C., Carter,J., Murphy,B.A., Netterville,J.,
            Burkey,B.B., Sinard,R., Cmelak,A., Levy,S., Yarbrough,W.G.,
            Slebos,R.J. and Hirsch,F.R.
  TITLE     Increased epidermal growth factor receptor gene copy number is
            associated with poor prognosis in head and neck squamous cell
            carcinomas
  JOURNAL   J Clin Oncol 24 (25), 4170-4176 (2006)
   PUBMED   16943533
REFERENCE   8  (bases 1 to 2939)
  AUTHORS   Park,S. and James,C.D.
  TITLE     ECop (EGFR-coamplified and overexpressed protein), a novel protein,
            regulates NF-kappaB transcriptional activity and associated
            apoptotic response in an IkappaBalpha-dependent manner
  JOURNAL   Oncogene 24 (15), 2495-2502 (2005)
   PUBMED   15735698
REFERENCE   9  (bases 1 to 2939)
  AUTHORS   Matsuda,A., Suzuki,Y., Honda,G., Muramatsu,S., Matsuzaki,O.,
            Nagano,Y., Doi,T., Shimotohno,K., Harada,T., Nishida,E., Hayashi,H.
            and Sugano,S.
  TITLE     Large-scale identification and characterization of human genes that
            activate NF-kappaB and MAPK signaling pathways
  JOURNAL   Oncogene 22 (21), 3307-3318 (2003)
   PUBMED   12761501
REFERENCE   10 (bases 1 to 2939)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB496308.1, AK225755.1, AC073347.3 and HY076549.1.
            
            On Nov 24, 2018 this sequence version replaced NM_030796.4.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC016650.1, AK075391.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2154405 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000285279.10/ ENSP00000285279.5
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-42                DB496308.1         24-65
            43-763              AK225755.1         6-726
            764-2517            AC073347.3         158291-160044       c
            2518-2939           HY076549.1         28-449              c
FEATURES             Location/Qualifiers
     source          1..2939
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p11.2"
     gene            1..2939
                     /gene="VOPP1"
                     /gene_synonym="ECOP; GASP; WBP1L2"
                     /note="VOPP1 WW domain binding protein"
                     /db_xref="GeneID:81552"
                     /db_xref="HGNC:HGNC:34518"
                     /db_xref="MIM:611915"
     exon            1..232
                     /gene="VOPP1"
                     /gene_synonym="ECOP; GASP; WBP1L2"
                     /inference="alignment:Splign:2.1.0"
     CDS             179..697
                     /gene="VOPP1"
                     /gene_synonym="ECOP; GASP; WBP1L2"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; EGFR-coamplified and overexpressed protein;
                     vesicular, overexpressed in cancer, prosurvival protein 1;
                     Glioblastoma-amplified secreted protein; putative
                     NF-kappa-B-activating protein 055N; hypothetical protein
                     DKFZp564K0822; VOPP1, WBP1/VOPP1 family member; WW domain
                     binding protein VOPP1"
                     /codon_start=1
                     /product="WW domain binding protein VOPP1 isoform 1
                     precursor"
                     /protein_id="NP_110423.3"
                     /db_xref="CCDS:CCDS47588.1"
                     /db_xref="GeneID:81552"
                     /db_xref="HGNC:HGNC:34518"
                     /db_xref="MIM:611915"
                     /translation="MRRQPAKVAALLLGLLLECTEAKKHCWYFEGLYPTYYICRSYED
                     CCGSRCCVRALSIQRLWYFWFLLMMGVLFCCGAGFFIRRRMYPPPLIEEPAFNVSYTR
                     QPPNPGPGAQQPGPPYYTDPGGPGMNPVGNSMAMAFQVPPNSPQGSVACPPPPAYCNT
                     PPPPYEQVVKAK"
     exon            233..291
                     /gene="VOPP1"
                     /gene_synonym="ECOP; GASP; WBP1L2"
                     /inference="alignment:Splign:2.1.0"
     exon            292..369
                     /gene="VOPP1"
                     /gene_synonym="ECOP; GASP; WBP1L2"
                     /inference="alignment:Splign:2.1.0"
     exon            370..506
                     /gene="VOPP1"
                     /gene_synonym="ECOP; GASP; WBP1L2"
                     /inference="alignment:Splign:2.1.0"
     exon            507..2939
                     /gene="VOPP1"
                     /gene_synonym="ECOP; GASP; WBP1L2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2818..2823
                     /regulatory_class="polyA_signal_sequence"
                     /gene="VOPP1"
                     /gene_synonym="ECOP; GASP; WBP1L2"
                     /note="hexamer: AGTAAA"
     polyA_site      2858
                     /gene="VOPP1"
                     /gene_synonym="ECOP; GASP; WBP1L2"
     regulatory      2920..2925
                     /regulatory_class="polyA_signal_sequence"
                     /gene="VOPP1"
                     /gene_synonym="ECOP; GASP; WBP1L2"
                     /note="hexamer: AATAAA"
     polyA_site      2939
                     /gene="VOPP1"
                     /gene_synonym="ECOP; GASP; WBP1L2"
                     /note="major polyA site"
ORIGIN      
        1 ggagcgcagc cagggctgcg cggcgcgccc cggctcccgc ccgctcccag ccgggccccc
       61 cagcggtcgg cgggacggct cccggctgca gtctgcccgc ccgccccgcg cgggggccga
      121 gtcgcgaagc gcgcctgcga cccggcgtcc gggcgcgctg gagaggacgc gaggagccat
      181 gaggcgccag cctgcgaagg tggcggcgct gctgctcggg ctgctcttgg agtgcacaga
      241 agccaaaaag cattgctggt atttcgaagg actctatcca acctattata tatgccgctc
      301 ctacgaggac tgctgtggct ccaggtgctg tgtgcgggcc ctctccatac agaggctgtg
      361 gtacttctgg ttccttctga tgatgggcgt gcttttctgc tgcggagccg gcttcttcat
      421 ccggaggcgc atgtaccccc cgccgctgat cgaggagcca gccttcaatg tgtcctacac
      481 caggcagccc ccaaatcccg gcccaggagc ccagcagccg gggccgccct attacaccga
      541 cccaggagga ccggggatga accctgtcgg gaattccatg gcaatggctt tccaggtccc
      601 acccaactca ccccagggga gtgtggcctg cccgccccct ccagcctact gcaacacgcc
      661 tccgcccccg tacgaacagg tagtgaaggc caagtagtgg ggtgcccacg tgcaagagga
      721 gagacaggag agggcctttc cctggccttt ctgtcttcgt tgatgttcac ttccaggaac
      781 ggtctcgtgg gctgctaagg gcagttcctc tgatatcctc acagcaagca cagctctctt
      841 tcaggctttc catggagtac aatatatgaa ctcacacttt gtctcctctg ttgcttctgt
      901 ttctgacgca gtctgtgctc tcacatggta gtgtggtgac agtccccgag ggctgacgtc
      961 cttacggtgg cgtgaccaga tctacaggag agagactgag aggaagaagg cagtgctgga
     1021 ggtgcaggtg gcatgtagag gggccaggcc gagcatccca ggcaagcatc cttctgcccg
     1081 ggtattaata ggaagcccca tgccgggcgg ctcagccgat gaagcagcag ccgactgagc
     1141 tgagcccagc aggtcatctg ctccagcctg tcctctcgtc agccttcctc ttccagaagc
     1201 tgttggagag acattcagga gagagcaagc cccttgtcat gtttctgtct ctgttcatat
     1261 cctaaagata gacttctcct gcaccgccag ggaagggtag cacgtgcagc tctcaccgca
     1321 ggatggggcc tagaatcagg cttgccttgg aggcctgaca gtgatctgac atccactaag
     1381 caaatttatt taaattcatg ggaaatcact tcctgcccca aactgagaca ttgcattttg
     1441 tgagctcttg gtctgatttg gagaaaggac tgttacccat ttttttggtg tgtttatgga
     1501 agtgcatgta gagcgtcctg ccctttgaaa tcagactggg tgtgtgtctt ccctggacat
     1561 cactgcctct ccagggcatt ctcaggcccg ggggtctcct tccctcaggc agctccagtg
     1621 gtgggttctg aagggtgctt tcaaaacggg gcacatctgg ctgggaagtc acatggactc
     1681 ttccagggag agagaccagc tgaggcgtct ctctctgagg ttgtgttggg tctaagcggg
     1741 tgtgtgctgg gctccaagga ggaggagctt gctgggaaaa gacaggagaa gtactgactc
     1801 aactgcactg accatgttgt cataattaga ataaagaaga agtggtcgga aatgcacatt
     1861 cctggatagg aatcacagct caccccagga tctcacaggt agtctcctga gtagttgacg
     1921 gctagcgggg agctagttcc gccgcatagt tatagtgttg atgtgtgaac gctgacctgt
     1981 cctgtgtgct aagagctatg cagcttagct gaggcgccta gattactaga tgtgctgtat
     2041 cacggggaat gaggtggggg tgcttatttt ttaatgaact aatcagagcc tcttgagaaa
     2101 ttgttactca ttgaactgga gcatcaagac atctcatgga agtggatacg gagtgatttg
     2161 gtgtccatgc ttttcactct gaggacattt aatcggagaa cctcctgggg aattttgtgg
     2221 gagacacttg ggaacaaaac agacaccctg ggaatgcagt tgcaagcaca gatgctgcca
     2281 ccagtgtctc tgaccaccct ggtgtgactg ctgactgcca gcgtggtacc tcccatgctg
     2341 caggcctcca tctaaatgag acaacaaagc acaatgttca ctgtttacaa ccaagacaac
     2401 tgcgtgggtc caaacactcc tcttcctcca ggtcatttgt tttgcatttt taatgtcttt
     2461 attttttgta atgaaaaagc acactaagct gcccctggaa tcgggtgcag ctgaataggc
     2521 acccaaaagt ccgtgactaa atttcgtttg tctttttgat agcaaattat gttaagagac
     2581 agtgatggct agggctcaac aattttgtat tcccatgttt gtgtgagaca gagtttgttt
     2641 tcccttgaac ttggttagaa ttgtgctact gtgaacgctg atcctgcata tggaagtccc
     2701 acttcggtga catttcctgg ccattcttgt ttccattgtg tggatggtgg gttgtgccca
     2761 cttcctggag tgagacagct cctggtgtgt agaattcccg gagcgtccgt ggttcagagt
     2821 aaacttgaag cagatctgtg catgcttttc ctctgcaaca attggctcgt ttctcttttt
     2881 tgttctcttt tgataggatc ctgtttccta tgtgtgcaaa ataaaaataa atttgggca
//
