LOCUS       NM_004665               2014 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens vanin 2 (VNN2), transcript variant 1, mRNA.
ACCESSION   NM_004665
VERSION     NM_004665.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2014)
  AUTHORS   Takeda,Y., Kurota,Y., Kato,T., Ito,H., Araki,A., Nara,H.,
            Saitoh,S., Tanaka,N., Tsuchiya,N. and Asao,H.
  TITLE     GPI-80 Augments NF-kappaB Activation in Tumor Cells
  JOURNAL   Int J Mol Sci 22 (21), 12027 (2021)
   PUBMED   34769456
  REMARK    GeneRIF: GPI-80 Augments NF-kappaB Activation in Tumor Cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2014)
  AUTHORS   Bornhauser,B., Cario,G., Rinaldi,A., Risch,T., Rodriguez
            Martinez,V., Schutte,M., Warnatz,H.J., Scheidegger,N.,
            Mirkowska,P., Temperli,M., Moller,C., Schumich,A., Dworzak,M.,
            Attarbaschi,A., Bruggemann,M., Ritgen,M., Mejstrikova,E.,
            Hofmann,A., Buldini,B., Scarparo,P., Basso,G., Maglia,O., Gaipa,G.,
            Skroblyn,T.L., Ngo,Q., Te Kronnie,G., Vendramini,E.,
            Panzer-Grumayer,R., Barz,M.J., Marovca,B., Hauri-Hohl,M.,
            Niggli,F., Eckert,C., Schrappe,M., Stanulla,M., Zimmermann,M.,
            Wollscheid,B., Yaspo,M.L. and Bourquin,J.P.
  TITLE     The hematopoietic stem cell marker VNN2 is associated with
            chemoresistance in pediatric B-cell precursor ALL
  JOURNAL   Blood Adv 4 (17), 4052-4064 (2020)
   PUBMED   32853382
  REMARK    GeneRIF: The hematopoietic stem cell marker VNN2 is associated with
            chemoresistance in pediatric B-cell precursor ALL.
            Erratum:[Blood Adv. 2022 Apr 26;6(8):2700. doi:
            10.1182/bloodadvances.2021005366.. PMID: 35467707]
REFERENCE   3  (bases 1 to 2014)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 2014)
  AUTHORS   Kato,T., Takeda,Y., Ito,H., Kurota,Y., Yamagishi,A., Sakurai,T.,
            Naito,S., Araki,A., Nara,H., Asao,H. and Tsuchiya,N.
  TITLE     GPI-80 as a Useful Index for Myeloid Cell Heterogeneity and a
            Potential Prognostic Biomarker for Metastatic Renal Cell Carcinoma
  JOURNAL   Tohoku J Exp Med 249 (3), 203-212 (2019)
   PUBMED   31776298
  REMARK    GeneRIF: the expression of GPI-80 on myeloid cells, a useful index
            for the heterogeneity of Myeloid-derived suppressor cells, serves
            as a potential prognostic biomarker for Metastatic Renal Cell
            Carcinoma.
REFERENCE   5  (bases 1 to 2014)
  AUTHORS   Chen,Y., Huang,T., Yang,X., Liu,C., Li,P., Wang,Z. and Zhi,S.
  TITLE     MicroRNA-106a regulates the proliferation and invasion of human
            osteosarcoma cells by targeting VNN2
  JOURNAL   Oncol Rep 40 (4), 2251-2259 (2018)
   PUBMED   30066949
  REMARK    GeneRIF: Low VNN2 expression is associated with invasion of
            osteosarcoma.
REFERENCE   6  (bases 1 to 2014)
  AUTHORS   Watanabe,T. and Sendo,F.
  TITLE     Physical association of beta 2 integrin with GPI-80, a novel
            glycosylphosphatidylinositol-anchored protein with potential for
            regulating adhesion and migration
  JOURNAL   Biochem Biophys Res Commun 294 (3), 692-694 (2002)
   PUBMED   12056825
REFERENCE   7  (bases 1 to 2014)
  AUTHORS   Martin,F., Malergue,F., Pitari,G., Philippe,J.M., Philips,S.,
            Chabret,C., Granjeaud,S., Mattei,M.G., Mungall,A.J., Naquet,P. and
            Galland,F.
  TITLE     Vanin genes are clustered (human 6q22-24 and mouse 10A2B1) and
            encode isoforms of pantetheinase ectoenzymes
  JOURNAL   Immunogenetics 53 (4), 296-306 (2001)
   PUBMED   11491533
REFERENCE   8  (bases 1 to 2014)
  AUTHORS   Dahlgren,C., Karlsson,A. and Sendo,F.
  TITLE     Neutrophil secretory vesicles are the intracellular reservoir for
            GPI-80, a protein with adhesion-regulating potential
  JOURNAL   J Leukoc Biol 69 (1), 57-62 (2001)
   PUBMED   11200068
REFERENCE   9  (bases 1 to 2014)
  AUTHORS   Suzuki,K., Watanabe,T., Sakurai,S., Ohtake,K., Kinoshita,T.,
            Araki,A., Fujita,T., Takei,H., Takeda,Y., Sato,Y., Yamashita,T.,
            Araki,Y. and Sendo,F.
  TITLE     A novel glycosylphosphatidyl inositol-anchored protein on human
            leukocytes: a possible role for regulation of neutrophil adherence
            and migration
  JOURNAL   J Immunol 162 (7), 4277-4284 (1999)
   PUBMED   10201959
REFERENCE   10 (bases 1 to 2014)
  AUTHORS   Galland,F., Malergue,F., Bazin,H., Mattei,M.G., Aurrand-Lions,M.,
            Theillet,C. and Naquet,P.
  TITLE     Two human genes related to murine vanin-1 are located on the long
            arm of human chromosome 6
  JOURNAL   Genomics 53 (2), 203-213 (1998)
   PUBMED   9790769
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL032821.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 21, 2020 this sequence version replaced NM_004665.5.
            
            Summary: This gene product is a member of the Vanin family of
            proteins that share extensive sequence similarity with each other,
            and also with biotinidase. The family includes secreted and
            membrane-associated proteins, a few of which have been reported to
            participate in hematopoietic cell trafficking. No biotinidase
            activity has been demonstrated for any of the vanin proteins,
            however, they possess pantetheinase activity, which may play a role
            in oxidative-stress response. The encoded protein is a GPI-anchored
            cell surface molecule that plays a role in transendothelial
            migration of neutrophils. This gene lies in close proximity to, and
            in same transcriptional orientation as two other vanin genes on
            chromosome 6q23-q24. Alternatively spliced transcript variants
            encoding different isoforms have been described for this gene.
            [provided by RefSeq, May 2011].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB026705.1, AK290908.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2146236, SAMEA2159764
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000326499.11/ ENSP00000322276.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-234               AL032821.2         102909-103142       c
            235-365             AL032821.2         102654-102784       c
            366-558             AL032821.2         101081-101273       c
            559-847             AL032821.2         97699-97987         c
            848-1221            AL032821.2         96383-96756         c
            1222-1392           AL032821.2         94933-95103         c
            1393-2014           AL032821.2         89108-89729         c
FEATURES             Location/Qualifiers
     source          1..2014
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q23.2"
     gene            1..2014
                     /gene="VNN2"
                     /gene_synonym="FOAP-4; GPI-80"
                     /note="vanin 2"
                     /db_xref="GeneID:8875"
                     /db_xref="HGNC:HGNC:12706"
                     /db_xref="MIM:603571"
     exon            1..234
                     /gene="VNN2"
                     /gene_synonym="FOAP-4; GPI-80"
                     /inference="alignment:Splign:2.1.0"
     CDS             22..1584
                     /gene="VNN2"
                     /gene_synonym="FOAP-4; GPI-80"
                     /EC_number="3.5.1.92"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; Vannin 2; pantetheinase; vascular
                     non-inflammatory molecule 2; pantetheine hydrolase VNN2;
                     glycosylphosphatidyl inositol-anchored protein GPI-80"
                     /codon_start=1
                     /product="pantetheine hydrolase VNN2 isoform 1 precursor"
                     /protein_id="NP_004656.3"
                     /db_xref="CCDS:CCDS5161.1"
                     /db_xref="GeneID:8875"
                     /db_xref="HGNC:HGNC:12706"
                     /db_xref="MIM:603571"
                     /translation="MVTSSFPISVAVFALITLQVGTQDSFIAAVYEHAVILPNKTETP
                     VSQEDALNLMNENIDILETAIKQAAEQGARIIVTPEDALYGWKFTRETVFPYLEDIPD
                     PQVNWIPCQDPHRFGHTPVQARLSCLAKDNSIYVLANLGDKKPCNSRDSTCPPNGYFQ
                     YNTNVVYNTEGKLVARYHKYHLYSEPQFNVPEKPELVTFNTAFGRFGIFTCFDIFFYD
                     PGVTLVKDFHVDTILFPTAWMNVLPLLTAIEFHSAWAMGMGVNLLVANTHHVSLNMTG
                     SGIYAPNGPKVYHYDMKTELGKLLLSEVDSHPLSSLAYPTAVNWNAYATTIKPFPVQK
                     NTFRGFISRDGFNFTELFENAGNLTVCQKELCCHLSYRMLQKEENEVYVLGAFTGLHG
                     RRRREYWQVCTLLKCKTTNLTTCGRPVETASTRFEMFSLSGTFGTEYVFPEVLLTEIH
                     LSPGKFEVLKDGRLVNKNGSSGPILTVSLFGRWYTKDSLYSSCGTSNSAITYLLIFIL
                     LMIIALQNIVML"
     exon            235..365
                     /gene="VNN2"
                     /gene_synonym="FOAP-4; GPI-80"
                     /inference="alignment:Splign:2.1.0"
     exon            366..558
                     /gene="VNN2"
                     /gene_synonym="FOAP-4; GPI-80"
                     /inference="alignment:Splign:2.1.0"
     exon            559..847
                     /gene="VNN2"
                     /gene_synonym="FOAP-4; GPI-80"
                     /inference="alignment:Splign:2.1.0"
     exon            848..1221
                     /gene="VNN2"
                     /gene_synonym="FOAP-4; GPI-80"
                     /inference="alignment:Splign:2.1.0"
     exon            1222..1392
                     /gene="VNN2"
                     /gene_synonym="FOAP-4; GPI-80"
                     /inference="alignment:Splign:2.1.0"
     exon            1393..2014
                     /gene="VNN2"
                     /gene_synonym="FOAP-4; GPI-80"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1994..1999
                     /regulatory_class="polyA_signal_sequence"
                     /gene="VNN2"
                     /gene_synonym="FOAP-4; GPI-80"
                     /note="hexamer: ATTAAA"
     polyA_site      2014
                     /gene="VNN2"
                     /gene_synonym="FOAP-4; GPI-80"
                     /note="major polyA site"
ORIGIN      
        1 agaaatcact aaaccttggc catggtcact tcctcttttc caatctctgt ggcagttttt
       61 gccctaataa ccctgcaggt tggtactcag gacagtttta tagctgcagt gtatgaacat
      121 gctgtcattt tgccaaataa aacagaaaca ccagtttctc aggaggatgc cttgaatctc
      181 atgaacgaga atatagacat tctggagaca gcgatcaagc aggcagctga gcagggtgct
      241 cgaatcattg tgactccaga agatgcactt tatggatgga aatttaccag ggaaactgtt
      301 ttcccttatc tggaggatat cccagaccct caggtgaact ggattccgtg tcaagacccc
      361 cacagatttg gtcacacacc agtacaagca agactcagct gcctggccaa ggacaactct
      421 atctatgtct tggcaaattt gggggacaaa aagccatgta attcccgtga ctccacatgt
      481 cctcctaatg gctactttca atacaatacc aatgtggtgt ataatacaga aggaaaactc
      541 gtggcacgtt accataagta ccacctgtac tctgagcctc agtttaatgt ccctgaaaag
      601 ccggagttgg tgactttcaa caccgcattt ggaaggtttg gcattttcac gtgctttgat
      661 atattcttct atgatcctgg tgttaccctg gtgaaagatt tccatgtgga caccatactg
      721 tttcccacag cttggatgaa cgttttgccc cttttgacag ctattgaatt ccattcagct
      781 tgggcaatgg gaatgggagt taatcttctt gtggccaaca cacatcatgt cagcctaaat
      841 atgacaggaa gtggtattta tgcaccaaat ggtcccaaag tgtatcatta tgacatgaag
      901 acagagttgg gaaaacttct cctttcagag gtggattcac atcccctatc ctcgcttgcc
      961 tacccaacag ctgttaattg gaatgcctac gccaccacca tcaaaccatt tccagtacag
     1021 aaaaacactt tcaggggatt tatttccagg gatgggttca acttcacaga actttttgaa
     1081 aatgcaggaa accttacagt ctgtcaaaag gagctttgct gtcatttaag ctacagaatg
     1141 ttacaaaaag aagagaatga agtatacgtt ctaggagctt ttacaggatt acatggccga
     1201 aggagaagag agtactggca ggtctgcaca ctgctgaagt gcaaaactac taatttgaca
     1261 acttgtggac ggccagtaga aactgcttct acaagatttg aaatgttctc cctcagtggc
     1321 acatttggaa cagagtatgt ttttcctgaa gtgctactta ccgaaattca tctgtcacct
     1381 ggaaaatttg aggtgctgaa agatgggcgt ttggtaaaca agaatggatc atctgggcct
     1441 atactaacag tgtcactctt tgggaggtgg tacacaaagg actcacttta cagctcatgt
     1501 gggaccagca attcagcaat aacttacctg ctaatattca tattattaat gatcatagct
     1561 ttgcaaaata ttgtaatgtt atagggcgtc tctttatcac tcagcttctg catcatatgc
     1621 ttggctgaat gtgtttatcg gcttcccaag tttactaaga aactttgaag ggctatttca
     1681 gtagtataga ccagtgagtc ctaaatattt tttctcatca ataattattt tttaagtatt
     1741 atgataatgt tgtccatttt tttggctact ctgaaatgtt gcagtgtgga acaatggaaa
     1801 gagcctgggt gtttgggtca gataaatgaa gatcaaactc cagctccagc ctcatttgct
     1861 tgagactttg tgtgtatggg ggacttgtat gtatgggagt gaggagtttc agggccattg
     1921 caaacatagc tgtgcccttg aagagaatag taatgatggg aatttagagg tttatgactg
     1981 aattcccttt gacattaaag actatttgaa ttca
//
