LOCUS       NM_004666               3853 bp    mRNA    linear   PRI 24-SEP-2024
DEFINITION  Homo sapiens vanin 1 (VNN1), mRNA.
ACCESSION   NM_004666
VERSION     NM_004666.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3853)
  AUTHORS   Zierfuss,B., Karlinger,A., Bojic,M., Koppensteiner,R.,
            Schernthaner,G.H. and Hobaus,C.
  TITLE     Urinary vanin-1 as a novel biomarker for survival in peripheral
            artery disease
  JOURNAL   Vasc Med 29 (4), 390-397 (2024)
   PUBMED   38607943
  REMARK    GeneRIF: Urinary vanin-1 as a novel biomarker for survival in
            peripheral artery disease.
REFERENCE   2  (bases 1 to 3853)
  AUTHORS   Lu,P., Zhang,C., Fu,L., Wei,Y., Huang,Y., Wang,X., Lv,C. and
            Chen,L.
  TITLE     Near-Infrared Fluorescent Probe for Imaging and Evaluating the Role
            of Vanin-1 in Chemotherapy
  JOURNAL   Anal Chem 93 (29), 10378-10387 (2021)
   PUBMED   34275284
  REMARK    GeneRIF: Near-Infrared Fluorescent Probe for Imaging and Evaluating
            the Role of Vanin-1 in Chemotherapy.
REFERENCE   3  (bases 1 to 3853)
  AUTHORS   Krzemien,G., Panczyk-Tomaszewska,M., Gorska,E. and Szmigielska,A.
  TITLE     Urinary vanin-1 for predicting acute pyelonephritis in young
            children with urinary tract infection: a pilot study
  JOURNAL   Biomarkers 26 (4), 318-324 (2021)
   PUBMED   33656956
  REMARK    GeneRIF: Urinary vanin-1 for predicting acute pyelonephritis in
            young children with urinary tract infection: a pilot study.
REFERENCE   4  (bases 1 to 3853)
  AUTHORS   Xiang,H., Guo,F., Tao,X., Zhou,Q., Xia,S., Deng,D., Li,L. and
            Shang,D.
  TITLE     Pancreatic ductal deletion of S100A9 alleviates acute pancreatitis
            by targeting VNN1-mediated ROS release to inhibit NLRP3 activation
  JOURNAL   Theranostics 11 (9), 4467-4482 (2021)
   PUBMED   33754072
  REMARK    GeneRIF: Pancreatic ductal deletion of S100A9 alleviates acute
            pancreatitis by targeting VNN1-mediated ROS release to inhibit
            NLRP3 activation.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3853)
  AUTHORS   Bartucci,R., Salvati,A., Olinga,P. and Boersma,Y.L.
  TITLE     Vanin 1: Its Physiological Function and Role in Diseases
  JOURNAL   Int J Mol Sci 20 (16), 3891 (2019)
   PUBMED   31404995
  REMARK    GeneRIF: This review discusses the role of vanin 1 in the liver,
            kidney, intestine, and lung under physiological as well as
            pathophysiological conditions. [review]
            Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3853)
  AUTHORS   Martin,F., Penet,M.F., Malergue,F., Lepidi,H., Dessein,A.,
            Galland,F., de Reggi,M., Naquet,P. and Gharib,B.
  TITLE     Vanin-1(-/-) mice show decreased NSAID- and Schistosoma-induced
            intestinal inflammation associated with higher glutathione stores
  JOURNAL   J Clin Invest 113 (4), 591-597 (2004)
   PUBMED   14966568
REFERENCE   7  (bases 1 to 3853)
  AUTHORS   Martin,F., Malergue,F., Pitari,G., Philippe,J.M., Philips,S.,
            Chabret,C., Granjeaud,S., Mattei,M.G., Mungall,A.J., Naquet,P. and
            Galland,F.
  TITLE     Vanin genes are clustered (human 6q22-24 and mouse 10A2B1) and
            encode isoforms of pantetheinase ectoenzymes
  JOURNAL   Immunogenetics 53 (4), 296-306 (2001)
   PUBMED   11491533
REFERENCE   8  (bases 1 to 3853)
  AUTHORS   Maras,B., Barra,D., Dupre,S. and Pitari,G.
  TITLE     Is pantetheinase the actual identity of mouse and human vanin-1
            proteins?
  JOURNAL   FEBS Lett 461 (3), 149-152 (1999)
   PUBMED   10567687
REFERENCE   9  (bases 1 to 3853)
  AUTHORS   Galland,F., Malergue,F., Bazin,H., Mattei,M.G., Aurrand-Lions,M.,
            Theillet,C. and Naquet,P.
  TITLE     Two human genes related to murine vanin-1 are located on the long
            arm of human chromosome 6
  JOURNAL   Genomics 53 (2), 203-213 (1998)
   PUBMED   9790769
REFERENCE   10 (bases 1 to 3853)
  AUTHORS   Aurrand-Lions,M., Galland,F., Bazin,H., Zakharyev,V.M., Imhof,B.A.
            and Naquet,P.
  TITLE     Vanin-1, a novel GPI-linked perivascular molecule involved in
            thymus homing
  JOURNAL   Immunity 5 (5), 391-405 (1996)
   PUBMED   8934567
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BJ995136.1, BC096266.3 and
            AL032821.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_004666.2.
            
            Summary: This gene encodes a member of the vanin family of
            proteins, which share extensive sequence similarity with each
            other, and also with biotinidase. The family includes secreted and
            membrane-associated proteins, a few of which have been reported to
            participate in hematopoietic cell trafficking. No biotinidase
            activity has been demonstrated for any of the vanin proteins,
            however, they possess pantetheinase activity, which may play a role
            in oxidative-stress response. This protein, like its mouse homolog,
            is likely a GPI-anchored cell surface molecule. The mouse protein
            is expressed by the perivascular thymic stromal cells and regulates
            migration of T-cell progenitors to the thymus. This gene lies in
            close proximity to, and in the same transcriptional orientation as,
            two other vanin genes on chromosome 6q23-q24. [provided by RefSeq,
            Feb 2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.177032.1, AJ132099.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000367928.5/ ENSP00000356905.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6                 BJ995136.1         1-6
            7-1699              BC096266.3         1-1693
            1700-3853           AL032821.2         26087-28240         c
FEATURES             Location/Qualifiers
     source          1..3853
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q23.2"
     gene            1..3853
                     /gene="VNN1"
                     /gene_synonym="HDLCQ8; Tiff66"
                     /note="vanin 1"
                     /db_xref="GeneID:8876"
                     /db_xref="HGNC:HGNC:12705"
                     /db_xref="MIM:603570"
     exon            1..230
                     /gene="VNN1"
                     /gene_synonym="HDLCQ8; Tiff66"
                     /inference="alignment:Splign:2.1.0"
     CDS             21..1562
                     /gene="VNN1"
                     /gene_synonym="HDLCQ8; Tiff66"
                     /EC_number="3.5.1.92"
                     /note="pantetheinase; vannin 1; pantetheine hydrolase;
                     vascular non-inflammatory molecule 1"
                     /codon_start=1
                     /product="pantetheinase precursor"
                     /protein_id="NP_004657.2"
                     /db_xref="CCDS:CCDS5159.1"
                     /db_xref="GeneID:8876"
                     /db_xref="HGNC:HGNC:12705"
                     /db_xref="MIM:603570"
                     /translation="MTTQLPAYVAILLFYVSRASCQDTFTAAVYEHAAILPNATLTPV
                     SREEALALMNRNLDILEGAITSAADQGAHIIVTPEDAIYGWNFNRDSLYPYLEDIPDP
                     EVNWIPCNNRNRFGQTPVQERLSCLAKNNSIYVVANIGDKKPCDTSDPQCPPDGRYQY
                     NTDVVFDSQGKLVARYHKQNLFMGENQFNVPKEPEIVTFNTTFGSFGIFTCFDILFHD
                     PAVTLVKDFHVDTIVFPTAWMNVLPHLSAVEFHSAWAMGMRVNFLASNIHYPSKKMTG
                     SGIYAPNSSRAFHYDMKTEEGKLLLSQLDSHPSHSAVVNWTSYASSIEALSSGNKEFK
                     GTVFFDEFTFVKLTGVAGNYTVCQKDLCCHLSYKMSENIPNEVYALGAFDGLHTVEGR
                     YYLQICTLLKCKTTNLNTCGDSAETASTRFEMFSLSGTFGTQYVFPEVLLSENQLAPG
                     EFQVSTDGRLFSLKPTSGPVLTVTLFGRLYEKDWASNASSGLTAQARIIMLIVIAPIV
                     CSLSW"
     exon            231..361
                     /gene="VNN1"
                     /gene_synonym="HDLCQ8; Tiff66"
                     /inference="alignment:Splign:2.1.0"
     exon            362..554
                     /gene="VNN1"
                     /gene_synonym="HDLCQ8; Tiff66"
                     /inference="alignment:Splign:2.1.0"
     exon            555..846
                     /gene="VNN1"
                     /gene_synonym="HDLCQ8; Tiff66"
                     /inference="alignment:Splign:2.1.0"
     exon            847..1208
                     /gene="VNN1"
                     /gene_synonym="HDLCQ8; Tiff66"
                     /inference="alignment:Splign:2.1.0"
     exon            1209..1379
                     /gene="VNN1"
                     /gene_synonym="HDLCQ8; Tiff66"
                     /inference="alignment:Splign:2.1.0"
     exon            1380..3853
                     /gene="VNN1"
                     /gene_synonym="HDLCQ8; Tiff66"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3094..3099
                     /regulatory_class="polyA_signal_sequence"
                     /gene="VNN1"
                     /gene_synonym="HDLCQ8; Tiff66"
                     /note="hexamer: ATTAAA"
     polyA_site      3112
                     /gene="VNN1"
                     /gene_synonym="HDLCQ8; Tiff66"
                     /note="major polyA site"
     regulatory      3831..3836
                     /regulatory_class="polyA_signal_sequence"
                     /gene="VNN1"
                     /gene_synonym="HDLCQ8; Tiff66"
                     /note="hexamer: ATTAAA"
     polyA_site      3853
                     /gene="VNN1"
                     /gene_synonym="HDLCQ8; Tiff66"
ORIGIN      
        1 agcactcatt ggacttcagc atgactactc agttgccagc ttacgtggca attttgcttt
       61 tctatgtctc aagagccagc tgccaggaca ctttcactgc agctgtttat gagcatgcag
      121 cgatattgcc caatgccacc ctaacaccag tgtctcgtga ggaggctttg gcattaatga
      181 atcggaatct ggacattttg gaaggagcga tcacatcagc agcagatcag ggtgcgcata
      241 ttattgtgac tccagaagat gctatttatg gctggaactt caacagggac tctctctacc
      301 catatttgga ggacatccca gaccctgaag taaactggat cccctgtaat aatcgtaaca
      361 gatttggcca gaccccagta caagaaagac tcagctgcct ggccaagaac aactctatct
      421 atgttgtggc aaatattggg gacaagaagc catgcgatac cagtgatcct cagtgtcccc
      481 ctgatggccg ttaccaatac aacactgatg tggtatttga ttctcaagga aaactggtgg
      541 cacgctacca taagcaaaac cttttcatgg gtgaaaatca attcaatgta cccaaggagc
      601 ctgagattgt gactttcaat accacctttg gaagttttgg cattttcaca tgctttgata
      661 tactcttcca tgatcctgct gttaccttgg tgaaagattt ccacgtggac accatagtat
      721 tcccaacagc ttggatgaat gttttgccac atttgtcagc tgttgaattc cactcagctt
      781 gggctatggg catgagggtc aatttccttg catccaacat acattacccc tcaaagaaaa
      841 tgacaggaag tggcatctat gcacccaatt cttcaagagc atttcattat gatatgaaga
      901 cagaagaggg aaaactcctc ctctcgcaac tggattccca cccatcccat tctgcagtgg
      961 tgaactggac ttcctatgcc agcagtatag aagcgctctc atcaggaaac aaggaattta
     1021 aaggcactgt ctttttcgat gaattcactt ttgtgaagct cacaggagtt gcaggaaatt
     1081 atacagtttg tcagaaagat ctctgctgtc atttaagcta caaaatgtct gagaacatac
     1141 caaatgaagt gtacgctcta ggggcatttg acggactgca cactgtggaa gggcgctatt
     1201 atctacagat ttgtaccctg ttgaaatgta aaacgactaa tttaaacact tgcggtgact
     1261 cagctgaaac agcttctacc aggtttgaaa tgttctccct cagtggcact ttcggaaccc
     1321 agtatgtctt tcctgaggtg ttgctgagtg aaaatcagct tgcacctgga gaatttcagg
     1381 tgtcaactga cggacgcttg tttagtctga agccaacatc cggacctgtc ttaacagtaa
     1441 ctctgtttgg gaggttgtat gagaaggact gggcatcaaa tgcttcatca ggcctcacag
     1501 cacaagcaag aataataatg ctaatagtta tagcacctat tgtatgctca ttaagttggt
     1561 agaatattga ctttttctct tttttatttg ggataattta aaaaatgatg gatgagaaaa
     1621 gaaagattgg tccgggttaa tattatcctc tagtataagt gaattactag tttctcttta
     1681 tttagacaaa cacacacaca ccagataata taaacttaat aaattatctg ttaatgtaga
     1741 ttttatttaa aaaactatat ttgaacattg gtctttcttg gacgtgagct aattatatca
     1801 aataagtatc acaaatcttt tacgcagaag aaataaaaac tacgggtaga aaacataaga
     1861 actatcataa aatttactta caaggaggct gctcttgtta ccacttttat tatattacgt
     1921 atcacttatt cagctctgct gaaaatttcc aatgactttg tttgtttgct ctttttgttt
     1981 tttacctaaa caatacattt tgattctctt gtgggttgat aatgtctccc caaaatttac
     2041 atgttgaagc acctcagaat gtgactgtat ttggagacag ggtctttaaa gaggtaaaat
     2101 aaggtcatta ggatagaccc taattcaata tgactgatga tcataaaaga agaggcgagt
     2161 agggcacaac aggcacaaag ggagaccata aggagacaca gaggaaggac aactctttac
     2221 aagctaagaa gagagggcct cagaagaaac caaccctgcc aacaccttga tcttggactt
     2281 ccagcctcca aaactatgag aaataaattt ctattgttta agtcacccag tccatggtac
     2341 tttgttaggc agccctggca aatgaatcaa agacccattc ctgttcctct ccccaccact
     2401 actgttttct actgtaatct gaagcttcaa caaaaggctt acctggtaag aatattcagc
     2461 tggtctgggt cctcaagact ccaatagaca ctcttagaga aggattgctg atggattgat
     2521 agtgaaacca ttagatcatt gaattcctct ggaattagaa aaccagagag tcccatttta
     2581 agaaattaga tatttaatat agcattgtgt gttctatttt agtaacagca gaatctcttg
     2641 acattacaca actcagtgaa acaacatcat ttaagccaaa atatctccca actgactgat
     2701 agactctgag cactaatatc atagtgctgt gatgatggac aattacatag taccgataac
     2761 agccatgcac tgtgcaaagc atgcccttct gcacaggaga gcaaggcact tgcagtagtg
     2821 atctatgcca gcaaaacatc attttgagac aaacattttt gtggcagatg tttttcctaa
     2881 aaagtactat atcatccaag aaatatttga gtaaaatccc ttgttctttt gggtgacatt
     2941 aactgacatt tgcttttttt caagacctaa tagaaaataa gaaagcccat aatgtattta
     3001 gaaacaggaa tcctcagagc aattctctgt attctcatat aatttcaatg taaaacagaa
     3061 aacatattga tgtgttggtg ataggcttga attattaaaa acttcaaaaa catcctaagt
     3121 gtttcttttt tgctcaacgt tgtcaactat agtaggtctc ccttgtggtg taatgaattg
     3181 cccccaaact attatcttaa aacaacaaac atttattatc ttatagcatt tctgagggtc
     3241 aggatctggg actggcttag tggagttgtt ctggatcagg gcctttggaa agttgtagtt
     3301 aacttgtccc cagggctgcc atcatctcaa ggctcgggtg gggctggaga aaatctgctt
     3361 ctcagctcac tcacggcggt tgccaggcct ccattcttta ggatgctaga aaaactttca
     3421 taaaatgtca tctggcttct cctagagcaa tgatactgag agagaaagca catgagagaa
     3481 agagcgaggg aacttggatg taagccacag tctttgaaaa cctaatcaca gaagtgacat
     3541 ctcttcttcc acatgatgtt ggtcacatgg accaacaatg gcacaacgtg gacagaatca
     3601 aacagagttg agaatatcag gaggtggggc ttcatggggg ccattttgga tgctatcata
     3661 gtgaatatat gtatttatat ttatatctgt atatattgca atgtaattta aaaaatagga
     3721 ttgttttcct tttctttttg ctatatgtga tatgtatttc aaaatacact cccaatagtt
     3781 acgtctgaaa agcactacac taaaaaactt tctatacatt gaataattaa attaaataat
     3841 ctaataatct cta
//
